3,869 research outputs found
Emirs of Uzbek Khan and Janibek Khan
No full textThis article explores the question about the origin of the Golden Horde emirs’ dynasties during the reign of Uzbek and Janibek khan. Based on numerous Venetian, Arabic, Turkish, Persian primary sources the author provides his own version of origin and genealogical relationships of various emirs. Based on a list of emirs of Janibek khan from «Daftar-i Chingiz-name», the author traces the origins of Mogul-buga to Kipchak tribe and the origins of Kutlu buga to Naiman tribe. Author argues that during the reign of Uzbek khan, the Kungirat and Kiyat were the most influential clans. The Kipchak and Nayman were the most influential clans during the reign of Janibek khan. The author considers three-level hierarchy of emirs. The first level includes the emirs – clan rulers in every district (ulus). There were 4 tribes in each ulus. The second level includes the emirs who were the rulers of ulus. After the administrative reform of Uzbek khan, they replaced the Jochids in the political system of the Golden Horde. If formerly the governance of ulus was inherited by one of the Jochids, then during the reign of Uzbek khan emirs were appointed directly from the center. The third level includes four Karachi Beys who were advisers of the khan. The author also examines the origin of Nanguday from Kungirat clan. The author puts forward his own version of a genealogy of Nanguday. Additionally, this article contains the author’s assumptions about biography of Isatay Kiyat and Isa Uysun. According to these assumptions, Isatay Kiyat can be identified with well-known Gourgen Isa. And Isa Uysun, in turn, can be identified with the brother of Tuluk Timur, who was a governor of the Crimea in the era of Uzbek khan
A conversation with Ausma Zehanat Khan
No full textAusma Zehanat Khan is a multi-award-winning author of crime and fantasy fiction that features Muslim protagonists and Islamic cultural milieus. Her work also engages with a wide range of contemporary global issues including genocide, terrorism, police violence, and refugee crossings. To date she has published 12 novels, which include two mystery series and the fantasy series The Khorasan Archives. Her first novel, The Unquiet Dead, which opens her Khattak/Getty crime series, was the winner of the Barry Award, the Arthur Ellis Award, and the Romantic Times Award for Best First Novel. Her latest crime series is set in Colorado and introduces us to a new detective who is female and Muslim. In this interview, Khan discusses the influence of her Pashtun roots and her work as an international human rights lawyer on her writing, the importance of diverse characters in genre fiction, the challenges of “translation” in the process of publishing and marketing books, and the global nature of her chosen genres
HERStory Makers 2022: Shazray Khan
No full textShazray Khan is a PhD candidate at the Atlantic Technological University studying Lean Six Sigma systems in management. She took part in HERStory Makers 2022.What is HERStory Makers?HERStory Makers is a social media competition for female-identifying early career researchers to share their research, their career journeys, and to inspire the next generation. Winners are selected by public vote. HERStory Makers is also part of EXPLORATHON, Scotland's contribution to European Researchers' Night.In 2022-23, EXPLORATHON was supported by the Engineering & Physical Sciences Research Council [grant number EP/X020894/1].Author contributions to contentShazray Khan conceived, planned, and recorded the video content. Kirsty Ross edited the video content to insert HERStory Maker credits, add subtitles, and maintain video length below Twitter/X limit of 2 mins and 20 secs, prior to scheduling the social media posts.</p
Over expression of a synthetic gene encoding interferon lambda using relative synonymous codon usage bias in Escherichia coli
No full textInterferon Lambda (IFN-λ) is a type III interferon which belongs to a novel family of cytokines and possesses antiviral and antitumor properties. It is unique in its own class of cytokines; because of the specificity towards its heterodimer receptors and its structural similarities with cytokines of other classes. This renders IFN-λ a better choice for the treatment against many diseases including viral hepatitis and human coronavirus (HCoV-EMC). The present study describes a computational approach known as relative synonymous codon usage (RSCU); used to enhance the expression of IFN-λ protein in a eukaryotic expression system. Manually designed and commercially synthesized IFN-λ gene was cloned into pET-22b expression plasmid under the control of inducible T7-lac promoter. Maximum levels of IFN-λ expression was observed with 0.4 mM IPTG in transformed E. coli incubated for 4 hours in LB medium. Higher concentrations of IPTG had no or negative effect on the expression of IFN-λ. This synthetically over expressed IFN-λ can be tested as a targeted treatment option for viral hepatitis after purification
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Rangeland Development in Dera Ghazi Khan, Pakistan
No full textThe first attempt at scientific management of rangelands ini Dera Ghazi Khan, Pakistan, was made in 1960. However, the efforts failed to yield good results, and the area, being extremely arid, was declared unsuitable for range improvement (GOWP 1970). The senior author surveyed the area and prepared another range management project for the area in 1982. Range improvement techniques were designed keeping in view the local ecological conditions. The results obtained so far are very encouraging. The story of failure and success of range improvements in D. G. Khan is presented here for the benefit of the readers.This material was digitized as part of a cooperative project between the Society for Range Management, the National Agricultural Library, and the University of Arizona Libraries.The Rangelands archives are made available by the Society for Range Management and the University of Arizona Libraries. Contact [email protected] for further information.Migrated from OJS platform March 202
What microglia depletion approaches tell us about the role of microglia on synaptic function and behavior
No full textMicroglia are dynamic cells, constantly surveying their surroundings and interacting with neurons and synapses. Indeed, a wealth of knowledge has revealed a critical role of microglia in modulating synaptic transmission and plasticity in the developing brain. In the past decade, novel pharmacological and genetic strategies have allowed the acute removal of microglia, opening the possibility to explore and understand the role of microglia also in the adult brain. In this review, we summarized and discussed the contribution of microglia depletion strategies to the current understanding of the role of microglia on synaptic function, learning and memory, and behavior both in physiological and pathological conditions. We first described the available microglia depletion methods highlighting their main strengths and weaknesses. We then reviewed the impact of microglia depletion on structural and functional synaptic plasticity. Next, we focused our analysis on the effects of microglia depletion on behavior, including general locomotor activity, sensory perception, motor function, sociability, learning and memory both in healthy animals and animal models of disease. Finally, we integrated the findings from the reviewed studies and discussed the emerging roles of microglia on the maintenance of synaptic function, learning, memory strength and forgetfulness, and the implications of microglia depletion in models of brain disease
The contemporary khan: a housing and employment hub in Istanbul
No full textIn this project, the design of a contemporary version of the historic khan for new arrivals in present-day Istanbul is explored through architectural research. The research for this project focused on three aspects: (1) Istanbul, a tumultuous city between the east and west as the context. (2) The migrant trying to make his way in the city as the user. (3) The Khan, or han in Turkish, an architectural legacy specific to old Istanbul as the building type. The khan is the urban variant of the caravanserai: a roadside-inn for merchants and travellers along long-distance trade routes in the Middle East and Asia. As khans are no longer in use for lodging of merchants, these mystique historical buildings are in threat of deterioration. The project explores how the khans concepts can be transformed to a contemporary reinterpretation. In this reinterpretation, the khan is a place for arrivals: migrants who recently came to Istanbul in search of work, drawing parallels with the past use of khans. The contemporary khan offers temporary housing and a base for finding work in order for migrants to build up a future in Istanbul. The architectural design does not only play with the architectural legacy of the khan typology, but also with the existing urban fabric of Istanbul as well of the ruins of a former flour factory.Architecture, Urbanism and Building Science
Mozammel Khan: A legendary Canadian quality guru
No full textThe author met Dr. Mozammel Khan in 2003 after having immigrated to Canada and pursuing further education in Quality Assurance. In this article, they outline their interactions with Dr. Khan and his role in their life as a mentor
Ayaanella M.T. Khan & Anis 2017, gen. nov.
No full textAyaanella M.T. Khan & Anis gen. nov. (Figs 1–10) Type species. Ayaanella globugaster M.T. Khan & Anis sp. nov. Description. Female. Head (Fig. 1); antennal torulus placed slightly above lower margin of eye; malar space dark, as long as or shorter than eye width; ocelli arranged in obtuse triangle; mandible (Fig. 2) 4-dentate, third tooth shorter, and a concavity between third and fourth teeth; maxillary palp (Fig. 3) unsegmented, swollen basally, with one seta at apex. Antennal formula 1, 1, (2), 2, 3; antenna (Figs 5–8) with 2 anelli (Figs 7, 8: A1 and A2); funicle 2 segmented, segments asymmetrical, with PLS, F2 broader than long; clava 3-segmented with very long setae and PLS. Mesosoma with pronotum medially divided into two plates; mid lobe of mesoscutum and scutellum each with 2 pairs (2+2) setae; side lobe of mesoscutum with 1 seta along anterolateral corner and axilla; propodeal margin almost straight posteriorly and about as long as metanotum medially; posterior two-thirds of mesoscutum, and scutellum with longitudinally cellulate sculpture, anterior one-third of mesoscutum with polygonal cells. Fore wing hyaline with venation extending to slightly less than half wing length; costal cell very narrow; marginal vein longer than premarginal or stigmal veins; premarginal vein broader than marginal vein; RS1 absent [except two or three setae below stigmal vein]; disc moderately densely setose with setae arranged in rows. Legs with tarsal formula 3-3-3. Metasoma longer than mesosoma; ovipositor short, extending from TV of gaster and hardly exserted. Male. Unknown. Etymology. The genus is named after the son of the second author (SBA), Ayaan + ‘-ella’ Latin suffix added to generic name.Published as part of Khan, Mohd Talib & Anis, Shoeba Binte, 2017, A new genus of Trichogrammatidae (Hymenoptera: Chalcidoidea) from India, pp. 165-168 in Zootaxa 4344 (1) on pages 165-166, DOI: 10.11646/zootaxa.4344.1.9, http://zenodo.org/record/104236
Juchi Khan Mausoleum: realities, legends and rituals
No full textLore and folk legends designate the burial of Jochi Khan, the eldest son of Genghis Khan, in the eponymous mausoleum in Ulytau, Kazakhstan. The mausoleum was built according to Islamic architecture of the 14th-15th centuries. A.Kh. Margulan, the author of archeological excavations, relying mostly on the folk legends designated the mausoleum’s burial to Jochi Khan. Radiocarbon dating of mausoleum determines two stages of its construction throughout the 14th century and the burial box age later than the death of Jochi Khan in 1225. New evidence from the mausoleum architecture and artifacts suggests that Jochi's burial is not in the mausoleum but a secret place prescribed by the Chinggisid canon. The assembly of Islamic and pre-Islamic traditions and the camel skull found in the burial indicates that the burial was made for a person of Islamic faith from the Golden Horde. Whereas the mausoleum was named in the honor of Jochi Khan
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