75 research outputs found

    Author response image 1.

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    SATB2 is a risk locus for schizophrenia and encodes a DNA-binding protein that regulates higher-order chromatin configuration. In the adult brain Satb2 is almost exclusively expressed in pyramidal neurons of two brain regions important for memory formation, the cerebral cortex and the CA1-hippocampal field. Here we show that Satb2 is required for key hippocampal functions since deletion of Satb2 from the adult mouse forebrain prevents the stabilization of synaptic long-term potentiation and markedly impairs long-term fear and object discrimination memory. At the molecular level, we find that synaptic activity and BDNF up-regulate Satb2, which itself binds to the promoters of coding and non-coding genes. Satb2 controls the hippocampal levels of a large cohort of miRNAs, many of which are implicated in synaptic plasticity and memory formation. Together, our findings demonstrate that Satb2 is critically involved in long-term plasticity processes in the adult forebrain that underlie the consolidation and stabilization of context-linked memory

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    Biodegradable and nontoxic nanogels as nonviral gene delivery systems

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    Needs of family caregivers of the patients with Alzheimer disease: Analyzing of family caregivers experiences

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    Needs of family caregivers of the patients with Alzheimer disease: Analyzing of family caregivers experiences  Mohammadi F 1 (PhD), Fallahi khoshknab M 2 (PhD), khanke H3 (PhD) 1. Assistant Professor, Dept of Gerontology & Research Center on Aging, Social Welfare and Rehabilitation Sciences University, Tehran, Iran. 2. Assistant Professor, Dept of Nursing, Social Welfare and Rehabilitation Sciences University, Tehran, Iran. 3. Assistant Professor, Dept of Nursing,  Social Welfare and Rehabilitation Sciences University, Tehran, Iran.    Abstract Background and aimWith the increasing elder population, providing effective family care is turning to be the most important challenge in health and welfare of elder people. The aim of this study was to explore needs of family caregivers of the patients with Alzheimer disease by analyzing of family caregivers experiences Materials and methodsThis qualitative study was conducted by latent conventional content analysis. 35 family caregivers of elder patients with Alzheimer disease participated in the study. Participants were selected based on purposive sampling.  Sources of information included documents of  participant's diaries, about their problematic and complicated days of caring. Data were analyzed through reading and rereading documents, determining meaning units, extracting of codes and categorizing of them.  Findings Most of participants (80%) were female, with mean age of 56/2 and literate (under diploma level). The findings generated 794 initial codes, which were grouped in 7 categories of: need to knowledge, receiving help from other family members in caring, modification of the home environment, self caring of caregivers, need "to be visible", compatible and complimentary health care system and caring equipments. ConclusionRegarding to Global expansion of Alzheimer disease, considering the family care giving issue of elders with Alzheimer disease is essential. Therefore, providing suitable information, establishing education for caregivers related to disease and patient care management, management of caregivers’ health, psych–social support and establishing of appropriate complimentary health care system for elderly patients should be considered. These   strategies would facilitate the family care giving and support the caregivers on their journey. Keywords: Elderly, Alzheimer, Need, Family caregiver  *Corresponding Author: Farahnaz Mohammadi, Assistant Professor at Social Welfare and Rehabilitation Sciences University, Department of gerontology & Research center on Aging. E-mail: [email protected]    

    Corrigendum to “The effect of topical endometrial scratching on pregnancy outcome in women with previous failure of intrauterine insemination: A non-randomized clinical trial” [Int J Reprod BioMed 2021; 19: 465-470]

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    The publisher has been informed of an error that occurred on page 465 in which the first author affiliation order is incorrect and should be replaced with each other. On behalf of the author, the publisher wishes to apologize for this error. The online version of article has been updated on 31 March 2024 and can be found at https://doi.org/10.18502/ijrm.v19i5.9256

    NASA DEAP Institute: A Three-University Consortium toward Improving Satellite Data-Based Coastal Flood Segmentation using Machine Learning

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    NASA DEAP Institute: A Three-University Consortium toward Improving Satellite Data-Based Coastal Flood Segmentation using Machine Learning Presenting author: Kisha Mulenga1, Justin T. Grant1 Other authors: Kelly M. San Antonio1, Hyun J. Cho1, Juan Calderon1, Seenith Sivasundaram1, Farahnaz Golroo1 1 Bethune-Cookman University Rising sea levels and climate change are causing growing concern, especially in areas like Florida\u27s northern Atlantic shoreline and the Indian River Lagoon. To tackle concerns of coastal resources for local communities, the NASA MUREP DEAP Institute formed a research partnership led by Bethune-Cookman University, Alabama A&M University, and Embry-Riddle Aeronautical University to expand scientific knowledge on the spatial and temporal consequences of variations in water levels. Our current research incorporates data from NASA\u27s satellite imagery, tidal data, weather predictions, and photos from beach cameras with machine learning to increase the accuracy of predicting overall water levels and better understand short-term storm events to long-term sea level rise. Field methods include use of RTK technology to measure shoreline changes, with a goal to generate digital elevation models during routine beach-profile surveys. Our primary areas of interest are sites along the Indian River Lagoon and the northern Atlantic coastline of Florida, which can provide various hydrological conditions for model validation. In addition to such technical improvements, community resilience through early warning for flooding and better resource management strategies are also in focus under the venture known as DEAP. These inputs will support improved coastal management and protection methods by assisting our model in forecasting water levels, including wave run-up and storm surge during future extreme weather conditions

    Political Sociology novel The Kite Runner(Badbadak baz) by Goldman constructivism critique of

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    the literary text is a tool for society studying. In other words, the literary text itself, is sociological that can be considered to be the most reliable source for knowledge and self-awareness in investigate the relationship between the individual and the world around him. According to researchers in this field such as René Wellek, Austin Warren, Goldman, Hauser and ... every story and other literary work, tells the events of his time, and in fact the story is the true form of artistic expression as social events, with the exception that the community speaking out on those issues by scientific language. The literature review can be known as social science that is a part of the consciousness and social action and studying the essence of literary works, conditions and requirements of the social environment in the receiver and nurturing poet and writer and world view and the position of the intellectual and cultural of them according to the social order by scientific method. The author of this article is tried to review the socio-political novel, The Kite Runner by Khaled Hosseini, author of Afghan descent living in America according to the Goldman's constructivism where briefly the commentary spirits and the living conditions of people in three different political periods and behaviors, structures and socio-political ups and downs of life on behalf of the class that the author has referred in his book, is addressed

    Conceptualizing and measuring the firm-level transition risk in the auto sector

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    Auto sector corporations are increasingly disclosing climate targets given the need to transition, which presents risks. However, institutional investors have yet to develop knowledge in climate science to assess the risk concretely. Instead, they rely on qualitative measurement such as the Environmental, Social, Governance factors for climate risk assessment. Therefore, the research seeks to reconcile the scientific gap present in the climate risk assessment framework in the auto sector. The research relies on a participatory modeling process with 11 expert practitioners, supplemented with a case study of an auto manufacturer for model testing. The research conceptualizes and designs a spreadsheet techno-economic model to measure the firm-level transition risk in the auto sector, defined as the capital requirement and regulatory risks, operationalized using cash flow. The model results show that the policy risk influences the degree to which the auto manufacturers invest to address transition risk. In addition, the expert practitioners agreed that the model is useful. In conclusion, since there is no transition risk assessment available in academia, the techno-economic assessment model is a novel addition that serves as an alternative to the qualitative ESG assessment approach.Engineering and Policy Analysi
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