79 research outputs found
sj-docx-1-cpc-10.1177_10556656231210085 - Supplemental material for Whole Exome Sequencing Identifies Damaging Variants in Indonesians with Clefts
No full textSupplemental material, sj-docx-1-cpc-10.1177_10556656231210085 for Whole Exome Sequencing Identifies Damaging Variants in Indonesians
with Clefts by Emmanuel Aladenika, Ani Maskoen, Waheed Awotoye, Rasyid Abdulaziz, Azeez Alade, Saskia Lenggogeni Nasroen, Abimbola Oladayo, Tamara Busch, Erli Sarilita, and Azeez Butali in The Cleft Palate Craniofacial Journal</p
sj-docx-1-cpc-10.1177_10556656221135926 - Supplemental material for Damaging Mutations in <b><i>AFDN</i></b> Contribute to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate
No full textSupplemental material, sj-docx-1-cpc-10.1177_10556656221135926 for Damaging Mutations in AFDN Contribute
to Risk of Nonsyndromic Cleft Lip With or Without Cleft Palate by Waheed Awotoye, Peter A Mossey, Jacqueline B Hetmanski, Lord J J Gowans, Mekonen A Eshete and
Wasiu L Adeyemo, Azeez Alade, Erliang Zeng, Olawale Adamson, Olutayo James,
Azeez Fashina, Modupe O Ogunlewe,
Thirona Naicker, Chinyere Adeleke, Tamara Busch,
Mary Li, Aline Petrin, Abimbola Oladayo, Sami Kayali, Joy Olotu, Veronica Sule, Mohaned Hassan, John Pape, Emmanuel T Aladenika, Peter Donkor, Fareed K N Arthur, Solomon Obiri-Yeboah, Daniel K Sabbah, Pius Agbenorku, Debashree Ray,
Gyikua Plange-Rhule, Alexander Acheampong Oti,
Daniah Albokhari, Nara Sobreira, Martine Dunnwald, Terri H Beaty, Margaret Taub, Mary L Marazita,
Adebowale A Adeyemo, Jeffrey C Murray, Azeez Butali in The Cleft Palate-Craniofacial Journal</p
Managing Conflicts in Relationships and Networks : A case study of IT-Firms in Nigeria and Uganda
No full textABSTRACT Title: Managing Conflicts in Relationships and Networks. A case study of IT-firms in Nigeria and Uganda. Level: Master thesis in Business administration. Author: Kudirat Toyin Alade. Supervisor: Dr. Sarah Philipson. Examiner: Dr. Maria Fregidou-Malama. Aim: The aim of this study is to investigate on how the information technology (IT) firms in Nigeria and Uganda manage conflicts, to understand how conflicts among employees can be minimized with the help of managerial training, and to also understand how improved performance of their employees can influence the network performance. Method: This study uses a qualitative method, the data was collected through interviews with top employees from AfriLabs (Nigeria), Hive Colab (Uganda), and Wennovation Hub (Nigeria). The interviews were conducted through Skype, respondents were selected using purposive sampling technique. The analysis was done with the help of a grounded theory. Result & Conclusions: The findings from this study are that Managerial training can help minimize conflicts among employees, if the training is been administered properly. Conflicts among organizations in business relationships and networks are properly managed through negotiations, and by signing a valid contract with their members with whom they have formed relationships and networks. The study also reveals that, when employees put in too much effort in accomplishing a task, or too few or too many employees are chosen for task, this will affect the network performance. Suggestions for future research: Future studies should delve more on managerial training to minimize issues of conflicts, as there are few established theories on this. It may be interesting to use different countries in Africa, to test the results of this study. Contribution: This study provides business managers with strategies to minimize issues of conflicts among employees. It also provides ways in which they can manage conflicts in organizational relationships and networks. Keywords: Business Relationships, Business Networks, Conflicts, Managerial training, Performance
Alveolar ridge preservation reduces the need for ancillary bone augmentation in the context of implant therapy
Get PDFBACKGROUND: There is limited information on the need for bone augmentation in the context of delayed implant placement whether alveolar ridge preservation (ARP) is previously performed or not. The primary aim of this retrospective cohort study was to evaluate the efficacy of ARP therapy after tooth extraction compared with unassisted socket healing (USH) in reducing the need for ancillary bone augmentation before or at the time of implant placement. METHODS: Adult subjects that underwent non‐molar single tooth extraction with or without simultaneous ARP therapy were included in this study. Cone beam computed tomography scans obtained before tooth extraction and after a variable healing period were used to record the baseline facial bone thickness and to virtually plan implant placement according to a standard method. A logistic regression model was used to evaluate the effect of facial alveolar bone thickness upon tooth extraction and baseline therapy (USH or ARP) on the need for additional bone augmentation, adjusting for several covariates (i.e., age, sex, baseline KMW, and tooth type). RESULTS: One hundred and forty subjects that were equally distributed between both baseline therapy groups constituted the study population. Implant placement was deemed virtually feasible in all study sites. Simultaneous bone augmentation was considered necessary in 60% and 11.4% of the sites in the USH and ARP group, respectively. Most of these sites (64.2% in the USH group and 87.5% in the ARP group) exhibited a thin facial bone phenotype (<1 mm) at baseline. Logistic regression revealed that the odds of not needing ancillary bone augmentation were 17.8 times higher in sites that received ARP therapy. Furthermore, the need for additional bone augmentation was reduced 7.7 times for every 1 mm increase in facial bone thickness, regardless of baseline therapy. CONCLUSIONS: Based on a digital analysis, ARP therapy, compared with USH, and thick facial alveolar bone largely reduce the need for ancillary bone augmentation at the time of implant placement in non‐molar sites
Gender Stereotyping and Empowerment in Nigeria Society: Implications for Women Repositioning in Curriculum Delivery
Get PDFGender inequality is one of the contemporary issues which have featured prominently in both national and international debates for quite some time now in both developed and developing countries of the world. This has obviously thwarted women status in curriculum implementation in Nigeria education. This observation prompted the author to examine gender stereotyping and empowerment in Nigeria society with implications for women repositioning in curriculum delivery. The overview of religious records and gender position at creation were discussed. Likewise, the available reports of some studies in Africa in respect of disparity in gender enrolment, academic achievement as determined by gender and status were enumerated along with gender spread in commonwealth universities and some parliamentary seats worldwide. Human rights versus gender stereotyping were also discussed vis-a-vis women empowerment. Thereafter, the implications of gender stereotyping for women re-positioning in curriculum delivery was logically dealt with. The paper recommends among other things that the National Human Rights Commission (NHRC) should be reinforced to carry out its duties more effectively so as to enhance the promotion and protection of human rights all the time, and that women in both administrative and academic positions should be given adequate support by their male counterparts to take care of their weaknesses, for there is no human personality without weaknesses.Key words: Curriculum, Empowerment, Gender, Stereotypin
Marc Epprecht, Welcome to Greater Edendale: Histories of Environment, Health, and Gender in an African City
No full textMarc Epprecht examines South Africa’s unsettling continuities between pre-colonial, colonial, apartheid, and post-apartheid policies in an attempt to reconstruct the country’s environmental history. The author hints that the themes referenced in thesubtitle are key to the historical narrative. Thus, he studies contestation over land, housing, sanitation, public health, and the meaning of development in Pietermaritzburg, KwaZulu-Natal. The book is divided into seven chapters. The first introduces key theoretical concepts and chapter outlines. The second and third make gestures towards the goal of decolonising knowledge about Msunduzi. These chapters show how the local environment has been seriously misrepresented and used for political purposes in the process of reconstructing the eco-health history of the city. The fourth critiques Maynard Swanson\u27s theory of sanitation syndrome in the historiography of African cities using the “native village” debate of Pietermaritzburg as a case study. The fifth and sixth chapters are devoted to an investigation of colonial development interventions in Edendale through a close examination of some key decisions that ultimately led to the abandonment of the liberal promise in favour of so-called separate development and racial zoning. The concluding chapter documents industrialisation, environmental activism and health from the period of apartheid to democracy in South Africa. This book will certainly be regarded as a classic in the literature on Greater Edendale
Mutations in Van Der Woude Families From Ethiopia
No full textBackground: Van der Woude syndrome (VWS) is the most common syndromic orofacial cleft which accounts for approximately 2% of all cleft lip (CL) and/or palate cases. It is characterized by the presence of lower lip pits, in addition to CL, CL with or without cleft palate, cleft palate only, and hypodontia. It is inherited as an autosomal-dominant trait with almost complete penetrance but variable expressivity, and different variants in IRF6 gene have been reported in different populations around the world including African populations (Ethiopian, Ghanaian, and Nigerian).Methods and Findings: The authors investigated the role of IRF6 in Ethiopian families with VWS. The DNA of 7 families with VWS from Ethiopia were screened by Sanger sequencing. The authors screened all 9 exons of IRF6 and found a novel missense variant in exon 4 (p. Gly65Glu). This variant was predicted to be deleterious/probably damaging by Sift and PolyPhen, respectively. The IRF6 variant (p. Gly65Glu) segregates in the family since it was identified in the father and a sibling.Conclusion: Several of the individuals with lower lip pits in this study did not seek treatment. This is due to lack of awareness about the significance of this minor looking deformity and its consequences, and availability of treatment for birth defects. Therefore, it is important to educate families. Finally, screening for novel variants in known genes has a role in counseling and prenatal diagnosis for high-risk families.</p
Parental Age and Severity of Non-Syndromic Orofacial Clefts: Relationship with De Novo Mutations
No full textBackground: This study investigates the relationship between paternal and maternal age, and the severity of orofacial clefts and the presence of de novo mutations in children.
Methods: This was a retrospective study of individuals who were diagnosed with non-syndromic cleft lip and/or palate (CL/P) and their unaffected parents, from 2012 to 2019. We obtained data from the AfriCRAN project database for Nigerians with non-syndromic orofacial clefts. These individuals were recruited at the Oral and Maxillofacial Surgery Clinic, Lagos University Teaching Hospital, Lagos.
Results: There was no statistically significant association between type of CL ± P and parental age in young fathers (p = 0.93). When older fathers were considered, the percentage of complete (more severe) CL ± P cases increased, especially when they were married to older mothers, and this was statistically significant (p = 0.036). In older fathers, the risk of CL ± P in their offspring was increased (OR: 2.66, CI: 1.04-6.80), and there was also an increased risk of developing right-sided CL ± P (OR: 1.61, CI: 1.0-2.59). There was a reduced risk of isolated clefts of the soft palate in younger fathers (OR: 0.36, CI: 0.07–1.71), but the risk increased when considering complete types (more severe) of isolated clefts of the hard and soft palates (OR: 1.63, CI: 0.7–1.7). There was an increase in de novo mutation in children as the difference between paternal and maternal age increased.
Conclusion: The study showed that a higher risk of CL ± P and de novo mutations in children is associated with increased parental age
Optimisation of the mineral grading wind sifter separator for coal beneficiation
No full textA research report submitted in fulfillment of the requirements for the Doctor of Philosophy in Engineering, In the Faculty of Engineering and the Built Environment, School of Chemical and Metallurgical Engineering, University of the Witwatersrand, Johannesburg, 2024The concept of wind sifting for particle separation has been successfully implemented for various concentration purposes. Diverse configurations based on this concept have been fabricated over many decades. It has been used in recycling, agriculture, electronic waste sorting, furniture, food and beverages, and mineral processing industries to some extent. The approach’s effectiveness stems from the capability of separating lighter particles from heavier ones. This study utilised an optimised version of the wind-sifter that was designed and fabricated by the author during his master's degree. The drawback experienced while testing the first prototype wind-sifting separator led to this investigation. This study used a computer simulation technique (the Lagrangian particle tracking method). This resulted in observing the effectiveness of the separation process in the newly designed separator. The design of the new separator was made flexible in its mode of operation by fabricating detachable collecting bins to the separator assembly. This means the optimised separator can be operated with or without the coal collecting bins, unlike the prototype version, which could only run with its bins. The design of the separator was done with the aid of Autodesk Inventor, and simulation was carried out using Star-CCM+TM computer software. The simulation tests were performed for different particle sizes (−6.7+3.35 mm), (−3.35+1.0 mm) and (−1.0+0.2 mm) at different airstream velocities. The optimal airstream velocities from the previous study (at a cut point of 1.6 g/cm3) were also used in this study when the separator was run with its bins. These airstream velocities were 6.0 to 4.0 m/sec, 4.2 to 2.0 m/sec and 1.7 to 1.0 m/sec for the (−6.7+3.35 mm), (−3.35+1.0 mm) and (−1.0+0.2 mm) particle sizes, respectively. A simulation was used to determine the airstream velocity ranges of the separator without collecting bins. These were 10.5 to 9.0 m/sec for the (−6.7+3.35 mm), 7.0 to 5.0 m/sec for the (−3.35+1.0 mm) and 3.5 to 2.5 m/sec for the (−1.0+0.2 mm) particles. For the –1.0 mm size faction, three particle size distributions (–1.0+0.1 mm), (–1.0+0.15 mm) and (–1.0+0.2 mm) were simulated. The best airstream velocities of 1.7 m/sec and 3.5 m/sec were achieved, respectively, for the closed and opened bins. The results of the simulation study led to the fabrication of the optimised wind sifter used in this study. From the sink and float test conducted on two sets of feed-coal (coal A and coal B), the extent to which the separator could beneficiate coal was determined. The sink and float analysis revealed that coal A has a higher ash content than coal B. Coal A, at (−1.0+0.2 mm) size iii fraction, has an ash content of 4.29% at 1.3 relative density (RD). This is followed by the (−3.35+1.0 mm) particle size with 5.55% ash content and the (−6.7+3.35 mm) size fraction with an ash content of 5.89%. At an RD of 1.5, coal A has a specific ash content of 16.65%, and coal B has an ash content of 13.56% for the (−6.7+3.35 mm) fraction. Upon separating with the wind sifter, the clean coal products from coal A have a higher ash content compared to those from coal B. Running the separator without the bins, clean coal products with cumulative ash content ranging from 22.42% to 19.44% for the (−6.7+3.35 mm), 24.61% to 21.43% for the (–3.35+1.0 mm) and 27.54% to 22.51% for the (–1.0+0.2 mm) fractions were obtained. For the particle size of (−6.7+3.3 mm) and with the bins closed, a clean coal product of 20.21% was obtained from coal A (feed coal with 37.38% ash content). A coal product with 19.55% ash content was obtained from coal B (from feed coal of 26.65% ash). A second-stage test conducted on a first-stage coal product of 23.48% ash content yielded a coal product of 21.79% ash and 80% yield for coal A at (6.7+3.35 mm). This trend was also observed for other first-stage products at the three particle sizes used in this study. The Ep values obtained from this separator ranged between 0.035 and 0.16, with the Ep values increasing as the airstream velocity was reduced. For the (6.7+3.35 mm) fraction, Ep values (Probable Error of Separation) of 0.035, 0.095, and 0.16 were obtained at 6.0, 5.0, and 4.0 m/sec air velocities, respectively. Overall, the cleanest coal product with 16.73% ash and 26.70 MJ/kg was obtained in this study from coal A at bin 2. According to the study’s results, the separator was highly adaptable. The separator could also be used for upgrading and pre- concentrating other minerals in the mineral processing industry.MM202
Glimepiride prevents paraquat‐induced Parkinsonism in mice: involvement of oxidative stress and neuroinflammation
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