70 research outputs found
A PARTIAL EDITION OF LES FAIS DES ROMMAINS
No full textLes Fais des Rommains is an early fifteenth century copy of an anonymous prose translation of Roman history with Julius Caesar as the central figure. The subject matter is primarily based upon histories of Sallust, Suetonius, Julius Caesar, and Lucan. Less frequently used sources are works by Isidore of Seville, Flavius Josephus, Petrus Comestor, St. Augustine, as well as the Bible. It is an ambitious attempt on the part of the author to glean from the best Roman historians a history of Roman civilization with intentional didactic emendations suitable to a medieval audience. These changes include instructions on leading a life of virtue and invented battle scenes similar to those in the chansons de geste. Fifty-nine manuscripts of the translation are accounted for to date. The oldest known one was written in the thirteenth century and is the only edited manuscript on the subject. It is supplemented by another from the same century. The manuscript discussed in this study is located in the British Museum. It is perhaps that manuscript of the best group which is most representative of the fifteenth century. Therefore, it is the most suitable for a new edition. In spite of the widely extended popularity of the topic during the Middle Ages, relatively scant scholarship has been devoted to the subject until more recent years. Because of the need for a new and modern edition of the translation, the author of this dissertation intends to publish a complete critical edition, incorporating substantial portions of the material of the study into the introduction and notes. In the dissertation, Les Fais des Rommains is partially edited, ending with Book IV of Julius Ceasar\u27s De bello Gallico. It is demonstrated that the most noteworthy feature and that which best illustrates the value in translating and editing this particular version is to be found in the changes in syntax and style as well as in miscellaneous unclassifiable changes which are occasioned consciously or unconsciously in the course of perhaps two centuries, between the edited thirteenth century verion and the fifteenth century rendition under discussion in this study. The procedure used is to present an explanation of the type of change taking place, while indicating the particular variants by means of striking contrasting examples from both the fifteenth and thirteenth century versions of the subject matter. It is shown that while the scribe of the fifteenth century copy frequently condenses the style found in the older work, at times he is much more elaborate. The copyist of the newer version tends to replace parts of speech in the older rendition with more recent forms which often better clarify the material. His work also includes examples indicative of more recent French syntax. His manuscript likewise presents examples which are the antithesis of the equivalents in the earlier edition, and which at times are lacking in sense. There are many instances in which the Latin proper names in both versions differ from each other. However, it is shown that there are many more instances in which proper names in both works differ from the original Latin sources. Many of the changes between the two versions show the imagination of a scribe raisonneur. On the eve of the introduction of printing when the ideal of complete fidelity to the author\u27s words would be realized, the scribe of Les Fais des Rommains reminds one that no two manuscripts are identical. Here a scribe is faithful to his text, but echoes the thoughts and language of his times
Butyrylcholinesterase Inhibitors: Structure-Activity Relationships of 2-Phenylbenzofuran derivatives.
No full textButyrylcholinesterase Inhibitors: Structure-Activity
Relationships of 2-Phenylbenzofuran derivatives
Antonella Fais1*, Giovanna L. Delogu 1, Benedetta Era 1, Amalia Di Petrillo1,
Amit Kumar2,3, Paola Caria4, Sonia Floris1, Francesca Pintus1
1Department of Life and Environmental Sciences, University of Cagliari , Cagliari , Italy;
2Department of Mech., Chem. and Material Engineering , University of Cagliari , Cagliari , Italy;
3Biosciences Sector, CRS4 ,Pula , Italy
4Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
*Corresponding author: [email protected]
Alzheimer’s disease (AD) is an irreversible and progressive brain disorder which is characterized by
progressive memory loss and a wide range of cognitive impairments.1 Although the precise cause of AD is
not completely known, there are some factors that seem to play a significant role in the pathogenesis of AD.
Since AD is characterized by a forebrain cholinergic neuron loss and a progressive decline in acetylcholine, a
possible therapeutic strategy involves the use of cholinesterase (ChE) inhibitors to restore the
neurotransmitter level and thus alleviate AD symptoms.2
Benzofuran scaffold has drawn considerable attention over the last few years due to its profound
physiological and chemotherapeutic properties. Recent studies have also investigated their inhibitory activity
towards ChEs.3,4
In this study, a series of 2-phenylbezonfurans compounds were synthesized and their inhibition
activity towards the ChE enzymes were investigated. We further combined biochemical analysis and
molecular modelling studies to identify selective butyrylcholinesterase (BChE) inhibition by benzofuran
scaffold. In particular, two compounds exhibited the highest BChE inhibition with IC50 values better than the
standard cholinesterase inhibitor compound. Molecular modelling studies highlighted the importance of
catalytic and peripheral site residues in BChE inhibition. Subsequently, the biosafety of the two promising
compounds was evaluated, in NSC-34 cells at the concentration in which BChE activity is inhibited, and no
considerable cytotoxic effect was found.
References
1. Schuster et al. Bioorg. Med. Chem. (2010) 18, 5071.
2. Zemek et al. Expert Opin Drug Saf (2014) 13, 759.
3. Mostofi et al. Eur. J. Med. Chem. (2015) 103, 361.
4. Delogu et al. Bioorg. Med. Chem. (2016) 26, 2308
The Livre des fais d'armes et de chevalerie by Christine de Pizan. Critical edition
No full textCette thèse de doctorat a pour principal objet l'édition critique complète du dernier texte inédit de Christine de Pizan, son Livre des fais d'armes et de chevalerie, écrit en 1410 lors des prémices de la guerre civile entre Armagnacs et Bourguignons, trois ans après l'assassinat de Louis d'Orléans par Jean sans Peur et cinq ans avant la bataille d'Azincourt.Chef-d’œuvre oublié de Pizan, ce texte fut destiné à l'éducation des hommes d'armes en général et du dauphin Louis de Guyenne en particulier. Réécriture autant que compilation, les Fais d'armes ont été dès leur publication une référence sur « la chose de chevalerie », sollicitant Végèce, Valère Maxime, Frontin, L'Arbre des batailles d'Honorat Bovet ainsi que des sources orales demeurées anonymes. Leur édition permet de combler une lacune importante dans notre connaissance de la production christinienne de miroirs aux princes, et devrait être utile aux médiévistes comme aux juristes et polémologues.Cette édition, qui se veut génétique, s'appuie sur la première étude exhaustive de la tradition textuelle entière (25 témoins, manuscrits et imprimés) qui a mis au jour plusieurs versions d'auteure, découverte qui vient s'ajouter à l'exploration des versions remaniées d'un point de vue politique, ce qui avait déjà été remarqué par la critique. En outre, l'établissement d'un stemma codicum permet de préciser les liens entre deux familles de manuscrits, ceux qui respectent l'auctorialité de Christine de Pizan (famille A) et ceux qui oblitèrent son nom et sa féminité (famille B).En plus de donner à lire le texte en moyen français, assorti d'un appareil de notesphilologiques, linguistiques et historiques, l'édition permet, grâce à un apparat critique génétique, d'ouvrir la voie à des études stylistiques et linguistiques sur l'auteure à sa table de travail, modifiant son texte à deux reprises. La recherche des sources du traité permettra également de mieux connaître les techniques de Christine de Pizan en compilatrice. Nous proposons une édition des extraits de Valère Maxime et Frontin traduits par Simon de Hesdin pour y inciter nos lecteur·rice·s.Le texte s'accompagne d'une description codicologique des 25 témoins, d'unglossaire, d'éléments de contexte historique et littéraire, et enfin d'une étude linguistique qui verse une nouvelle pièce au dossier débattu de la possible autographie d'un manuscrit des Fais d'armes.The principle study of this doctoral thesis is the critical edition of the last unedited text of Christine de Pizan, the Livre des fais d’armes et de chevalerie. It was composed in 1410, at the outbreak of the first civil war posing Bourguignons against Armagnacs, three years after the assassination of Louis d’Orléans on the orders of Jean the Fearless and five years preceding the Battle of Azincourt. This forgotten masterpiece of Pizan was destined generally to educate young men of arms, and particularly for the instruction of the Dauphin, Louis de Guyenne. The Fais d’armes, a re-writing as much as it is a compilation, was upon its publication a reference work on chivalry, soliciting the authority of Vegetius, Valerius Maximus, Frontinus, L’Arbre des batailles by Honorat Bovet, as well as other oral sources that remain anonymous. This critical edition will allow us to fill significant gaps in the christinienne production of the specula principum and will be equally useful to medievalists as much to jurists and to specialists of military history.This edition, which goes back to the origins of the text, leans on the first exhaustive study of the entire textual tradition (25 text sources, in printed and manuscript forms) that identifies several different versions by the author. This discovery adds a new dimension to the study of this text when considered alongside versions that were re-worked for political purposes. What’s more, the establishment of a stemma codicum allows us to define the relationship between two manuscript families : Family A, which respects Christine de Pizan’s auctorialité ; and Family B, which obliterates her name and femininity.Furthermore, the edition of the text in Middle French, accompanied by philological,linguistic and historical notes and commentaries, allows for future stylistique andlinguistic studies on the author-at-work, changing her text on two occasions. Research on her sources also reveal Christine de Pizan’s techniques as “compilator”. This study also proposes an edition of quotes from Valerius Maximus and Frontinus as translated by Simon de Hesdin to inspire further reading.The edition includes a codicological description of the 25 manuscripts and printed copies, elements describing historical and literary context, and, finally, a linguistic study that adds another voice to the debate surrounding a manuscript containing the Fais d'armes and the question of its potentially “autographic” nature
Management of FAIS in professional soccer athletes and return to sports
No full textBudde S, Ezechieli M. Management der FAIS-Sportlerhüfte im Profifußball und „return to sports“. Orthopäde. 2022.The prevalence of femoroacetabular impingement syndrome in professional soccer athletes is high. Professional training and treatment conditions ensure an effective conservative therapy focusing on dynamic stability, motion control, muscle balance and core stability. In the case of persistent limitations, indication for surgery has to be considered carefully. The probability is high that return to aprofessional level of soccer is feasible. However, the period of rehabilitation is long, leading to apotential conflict area between economic and medical interests. Good communication and intensive patient education are essential. © 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.Die Prävalenz des femoroazetabulären Impingement-Syndroms unter professionellen Fußballspielern ist hoch. Die professionellen Trainings- und Behandlungsbedingungen stellen eine effektive konservative Therapie sicher, bei der es vor allem auf dynamische Stabilität, Bewegungskontrolle, Muskelbalance und Rumpfstabilisierung ankommt. Bei dennoch bestehenden Einschränkungen muss eine Operationsindikation sorgfältig geprüft werden. Nach einer Operation ist die Wahrscheinlichkeit hoch, dass Sport auf professionellem Niveau fortgeführt werden kann, jedoch ist die notwendige Rehabilitationsphase lang. Daraus resultiert ein Spannungsfeld zwischen wirtschaftlichen und medizinischen Interessen, in dem einer guten Kommunikation und intensiven Patientenaufklärung eine große Bedeutung zukommt
A New Type of Royal Consecration: The King’s Intellectual Conver-sion in the Livre des fais et bonnes meurs du sage roy Charles V
No full textEn el Livre des fais et bonnes meurs du sage Roy Charles V, escrito en 1404, se constata laausencia de la unción entre los argumentos legitimadores de la monarquía francesa.Mientras la figura del rey ungido es silenciada, por el contrario, vemos aparecer confuerza la figura del rey coronado. De este modo, la escritora altera la jerarquía de losordines de consagración real al reducir la compleja ceremonia de consagración al ritode la coronación. Curiosamente, en los cinco capítulos que la autora dedica a describirel paso de la juventud a la madurez del rey, la coronación se inscribe dentro de unaexposición sobre el ciclo natural de la vida de los hombres de tradición aristotélicamedieval. No obstante, cabe preguntarse si la inserción de la consagración dentro delargumento etario puede considerarse como una simple casualidad o una mera cuestiónde cronología. La ausencia de los atributos sagrados de la realeza provenientes de laleyenda monárquica, así como la omisión de toda mediación eclesiástica permitensuponer que la consagración propuesta por la autora es de una especie distinta alrito de pasaje que por medio de la unción asemejaba al monarca a un rex et sacerdos.Por consiguiente, este trabajo se propone analizar en qué consiste este nuevo tipo deconsagración y la función que cumple en la teoría política de la escritora esbozadaen el Livre des fais et bonnes meurs du sage Roy Charles V.The Livre des fais et bonnes meurs du sage Roy Charles V, written in 1404, shows the absence of the anointing as a necessary element to legitimate the French monar-chy. While the figure of the anointed king is silenced, we see, on the contrary, the Esta obra está bajo una Licencia Creative Commons Atribución-CompartirIgual 4.0 Internacional. strong emergence of the figure of the crowned king. In doing so, the writer alters the hierarchy of the royal consecration orders by reducing the complex ceremony of consecration to the coronation rite. Curiously, within the five chapters dedi-cated by the author to describe the transition from the youth to the maturity of the king, the coronation is taken as part of the natural cycle of the life of men, according to the medieval Aristotelian tradition. However, the question arises as to whether the insertion of the consecration into the age- issue can be considered as a mere coincidence, or a simple question of chronology. The absence of sacred attributes of royalty typical from monarchical legends, as well as the omission of ecclesiastical mediations, allow us to suppose that the consecration proposed by the author is of a different kind than those rites of passage that, through anoin-ting, assimilated the monarch with the figure of rex et sacerdos. Therefore, this paper aims to analyze the meaning of this new type of consecration and the role it plays in the political theory of the writer outlined in the Livre des fais et bonnes meurs du sage Roy Charles V.Fil: Rodriguez, Juliana Eva. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Multidisciplinario de Historia y Ciencias Humanas; Argentin
Periodic inventory system in cafeteria using linear programming
No full textInventory management is an important factor in running a business. It plays a big role of managing the stock in cafeteria. If the inventories are failed to be managed wisely, it will affect the profit of the cafeteria. Therefore, the purpose of this study is to find the solution of the inventory management in cafeteria. Most of the cafeteria in Malaysia did not manage their stock well. Therefore, this study is to propose a database system of inventory management and to develop the inventory model in cafeteria management. In this study, new database system to improve the management of the stock in a weekly basis will be provided using Linear Programming Model to get the optimal range of the inventory needed for selected categories. Data that were collected by using the Periodic Inventory System at the end of the week within three months period being analyzed by using the Food Stock-take Database. The inventory model was developed from the collected data according to the category of the inventory in the cafeteria. Results showed the effectiveness of using the Periodic Inventory System and will be very helpful to the cafeteria management in organizing the inventory. Moreover, the findings in this study can reduce the cost of operation and increased the profit
Epidemiological Characteristics of Foot and Ankle Injuries in 2 Professional Ballet Companies: A 3-Season Cohort Study of 588 Medical Attention Injuries and 255 Time-Loss Injuries.
No full textThe foot and ankle are often reported as the most common sites of injury in professional ballet dancers; however, epidemiological research focusing on foot and ankle injuries in isolation and investigating specific diagnoses is limited. To investigate the incidence rate, severity, burden, and mechanisms of foot and ankle injuries that (1) required visiting a medical team (medical attention foot and ankle injuries; MA-FAIs) and (2) prevented a dancer from fully participating in all dance-related activities for at least 24 hours after the injury (time-loss foot and ankle injuries; TL-FAIs) in 2 professional ballet companies. Descriptive epidemiological study. Foot and ankle injury data across 3 seasons (2016-2017 to 2018-2019) were extracted from the medical databases of 2 professional ballet companies. Injury-incidence rate (per dancer-season), severity, and burden were calculated and reported with reference to the mechanism of injury. A total of 588 MA-FAIs and 255 TL-FAIs were observed across 455 dancer-seasons. The incidence rates of MA-FAIs and TL-FAIs were significantly higher in women (1.20 MA-FAIs and 0.55 TL-FAIs per dancer-season) than in men (0.83 MA-FAIs and 0.35 TL-FAIs per dancer-season) (MA-FAIs, = .002; TL-FAIs, = .008). The highest incidence rates for any specific injury pathology were ankle impingement syndrome and synovitis for MA-FAIs (women 0.27 and men 0.25 MA-FAIs per dancer-season) and ankle sprain for TL-FAIs (women 0.15 and men 0.08 TL-FAIs per dancer-season). work and jumping actions in women and jumping actions in men were the most common mechanisms of injury. The primary mechanism of injury of ankle sprains was jumping activities, but the primary mechanisms of ankle synovitis and impingement in women were related to dancing . The results of this study highlight the importance of further investigation of injury prevention strategies targeting work and jumping actions in ballet dancers. Further research for injury prevention and rehabilitation strategies targeting posterior ankle impingement syndromes and ankle sprains are warranted. [Abstract copyright: © The Author(s) 2023.
The political language of youth in the Livre des fais et bonnes meurs du sage roy Charles V
No full textEn el Livre des fais et bonnes meurs du sage roy Charles V (1404) Christine de Pizan elabora un modelo de gobernante ideal en la tradición del aristotelismo medieval. Siguiendo la estructura de los espejos de príncipes de la época, la autora dedica los primeros capítulos de la obra a la juventud del rey, partiendo de la teoría aristotélica de las edades del hombre y de las categorías hipocráticas de los humores corporales. Si la juventud aparece como una etapa común a todos los hombres, gobernada por los vicios y deseos carnales, su poder de destrucción se intensifica en el caso del heredero al trono, en tanto resulta una amenaza para la integridad y continuidad del reino. En este sentido, por fuera de los elementos recurrentes del tópico de la juventud, resulta interesante plantearse en qué medida la materia aristotélica tomada de la literatura de los espejos adquiere un significado particular en la economía de la obra. ¿En qué medida las etapas de vida de los hombres escapan a la mera aplicación de un modelo para transformarse en un relato político del presente y devenir del reino de Francia?In the Livre des fais et bonnes meurs du sage roy Charles V (1404), Christine de Pizan elaborates a model of the ideal ruler of the medieval Aristotelian tradition. Following the structure of the mirrors of princes of the time, the author devotes the first chapters of her work to the king’s youth, drawing from the Aristotelian theory of the stages of life and the Hippocratic categories of corporal humors. If youth appears as a common stage to all men that is governed by vices and carnal desires, its power of destruction is intensified in the case of the heir to the throne, while it is a threat to the integrity and continuity of the kingdom. In this sense, outside the recurring elements of the topic of youth, it is interesting to consider to what extent the drawn from mirror literature acquires a particular meaning within the economy of the work. To what extent do the stages of men’s life escape the simple application of a model to become a political tale on the present and future of the kingdom of France?Fil: Rodriguez, Juliana Eva. Universidad de Buenos Aires. Facultad de Filosofía y Letras; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15. Instituto Multidisciplinario de Historia y Ciencias Humanas; Argentin
The Role of Pelvic Tilt in Femoroacetabular Impingement Syndrome, Hip Dysplasia, and Osteoarthritis
No full textThe general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.BACKGROUND: In femoroacetabular impingement syndrome (FAIS), pelvic tilt is believed to impact disease progression and symptomology by influencing impingement free range of motion, with similar associations observed in hip dysplasia through modification of acetabular coverage and osteoarthritis via alterations in joint movements. While the apparent role of pelvic tilt in hip pathology has been reported, the exact effects of many therapeutic interventions on pelvic tilt are unknown.
OBJECTIVE: The primary purpose of these studies are two-fold: first, to investigate the relationship between preoperative pelvic tilt and change in postoperative outcomes in patients undergoing surgery for either FAIS or hip dysplasia. Second, to investigate the role of surgical intervention on pelvic tilt in FAIS, dysplasia, and osteoarthritis patients.
METHODS: A prospective hip preservation registry of demographic, radiographic, and outcomes data for all patients operated on by the senior author between October 2016 and January 2020 were queried, and all patients who underwent surgery with a primary diagnosis of FAIS, hip dysplasia, or osteoarthritis were considered for inclusion. Pelvic tilt was assessed in the standing position on the AP radiograph with the PS-SI distance both pre and postoperatively, and the outcomes were assessed with the HOS, iHOT-12, UCLA Activity Score, EQ-VAS, and HHS.
RESULTS: Regarding the first study question, the average PS-SI distance was 86.4±18.3 mm for the FAIS group and 96.2±15.1 mm for the dysplasia group. Analysis demonstrated a positive relationship between pelvic tilt and change in iHOT12 (rs = 0.262, p=0.019) for all 89 patients with hip pathology. No other significant relationships were observed. Regarding the second research question, the FAIS + dysplasia + OA cohort had an average preoperative PS-SI distance of 73.9±22.9 mm and an average postoperative PS-SI distance of 64.9±25.5 mm on the standing AP radiograph. The results from the linear regression revealed a significant negative predictive association between standing preoperative PS-SI distance and standing postoperative PS-SI distance for all 3 cohorts of patients (p<0.0001 for all groups).
CONCLUSION: The improvement in iHOT12 was greater for patients with more anterior tilt and less for patients with posterior pelvic tilt regardless of underlying hip etiology. There is a statistically significant decrease in pelvic tilt from pre to postoperatively in FAIS, dysplasia, and OA patients undergoing hip surgery. These results confirm that surgical intervention alters the pelvic orientation and indicate that impact of hip surgery on pelvic tilt should be considered within the therapeutic plan in order to optimize pelvic orientation
Evaluation of outcome reporting trends for femoroacetabular impingement syndrome- a systematic review
No full textPurpose: The aim of this systematic review was to evaluate the trends in the literature regarding surgical treatment for femoroacetabular impingement syndrome (FAIS) and to present which patient-reported outcome-measures (PROMs) and surgical approaches are included. Methods: This systematic review was conducted with the PRISMA guidelines. The literature search was performed on PubMed and Embase, covering studies from 1999 to 2020. Inclusion criteria were clinical studies with surgical treatment for FAIS, the use of PROMs as evaluation tool and studies in English. Exclusion criteria were studies with patients < 18years, cohorts with < 8 patients, studies with primarily purpose to evaluate other diagnoses than FAIS and studies with radiographs as only outcomes without using PROMs. Data extracted were author, year, surgical intervention, type of study, level of evidence, demographics of included patients, and PROMs. Results: The initial search yielded 2,559 studies, of which 196 were included. There was an increase of 2,043% in the number of studies from the first to the last five years (2004–2008)—(2016–2020). There were 135 (69%) retrospective, 55 (28%) prospective and 6 (3%) Randomized Controlled Trials. Level of evidence ranged from I-IV where Level III was most common (44%). More than half of the studies (58%) originated from USA. Arthroscopic surgery was the most common surgical treatment (85%). Mean follow-up was 27.0months (± 17 SD), (range 1.5–120months). Between 1–10 PROMs were included, and the modified Harris Hip Score (mHHS) was most commonly used (61%). Conclusion: There has been a continuous increase in the number of published studies regarding FAIS with the majority evaluating arthroscopic surgery. The mHHS remains being the most commonly used PROM. © 2021, The Author(s)
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