100,344 research outputs found
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Alt ekstremite amputasyonu olan bireylerde algılanan sosyal destek, işlevsellik ve ruhsal belirtiler
No full textALT EKSTREMİTE AMPUTASYONU OLAN BİREYLERDE ALGILANAN SOSYAL DESTEK, İŞLEVSELLİK VE RUHSAL BELİRTİLER Öğrenci: Neşe AZAK Danışman: Doç. Dr. Semra KARACA Hemşirelik yatri Hemşireliği Bölümü Giriş: Amputasyon yalnızca uzuv kaybıyla sınırlı kalmayıp, bireylerin yaşamında fiziksel ve psikososyal yönden zorluklara da neden olmaktadır. Amaç: Bu çalışma, alt ekstremite amputasyonu olan bireylerde algılanan sosyal destek, işlevsellik ve ruhsal belirtileri incelemek amacıyla yapılmıştır. Gereç ve Yöntem: Tanımlayıcı ve analitik tipte olan çalışmanın örneklemini, çalışma grubunda amputasyon ameliyatı geçirmiş 69 birey ve konrol grubunda amputasyonu olmayan 85 birey oluşturmuştur. Veriler, Kişisel Bilgi Formu (KBF), Çok Boyutlu Algılanan Sosyal Destek Ölçeği (ÇBASDÖ), Yaşam Kalitesi Ölçeği (SF-36)’nin Fiziksel İşlevsellik, Sosyal İşlevsellik, Rol Güçlükleri Alt Boyutları ve Kısa Semptom Envanteri (KSE) kullanılarak toplanmış; tanımlayıcı istatistiksel analizler, kolmogorov smirnov testi, bağımsız gruplar t testi, mann whitney u testi ve pearson korelasyon analizi ile değerlendirilmiştir. Bulgular: Ampute bireyler kontrol grubuna oranla ÇBASDÖ’nün ve SF-36’nın fiziksel rol güçlüğü hariç tüm alt boyutlarında daha düşük; KSE’nin ise anksiyete, depresyon alt boyutlarında ve toplam puanında daha yüksek puan almışlardır ve aralarındaki fark istatistiksel olarak anlamlıdır (p<.05). ÇBASDÖ ile KSE toplam puanı ve alt boyutları arasında negatif yönde ve istatistiksel olarak anlamlı ilişkiler bulunmaktadır (r=,226 ile ,630). SF-36 alt boyutları ile KSE toplam puanı ve alt boyutları arasında negatif ve anlamlı ilişkiler bulunmaktadır (r=,208 ile ,570). ÇBASDÖ ile SF-36 arasında fiziksel işlevsellik ile aile desteği alt boyutunda, fiziksel rol güçlüğü ile arkadaş desteği alt boyutu arasında pozitif yönde ve istatistiksel olarak anlamlı ilişkiler bulunmaktadır. Sonuç: Alt ekstremite amputasyonu olan bireyler sağlıklı bireylere göre daha düşük sosyal destek ve işlevsellik düzeylerine sahipken, ruhsal belirti açısından daha fazla risk altındadır. Sosyal desteği ve işlevselliği yüksek düzeyde olan bireylerin ruhsal belirti riski azalmaktadır.PERCEIVED SOCIAL SUPPORT, FUNCTIONING AND MENTAL SYMPTOMS IN INDIVIDUALS WITH LOWER EXTREMITY AMPUTATION Student: Neşe AZAK Supervisor: Ass. Dr. Semra KARACA Department: School of Nursing, Department of Psychiatry Nursing Introduction: Amputation is not only limited to the loss of a limb, but also causes physical and psychosocial difficulties in the lives of individuals. Aim: This study was conducted to examine perceived social support, functionality and psychological symptoms in individuals with lower extremity amputation. Materials and Method: The sample of the descriptive and analytical study consists of 69 amputees and 85 individuals who have not had an amputation. Data were collected using Personal Information Form (PIF), Multidimensional Scale of Perceived Social Support (MSPSS), Physical Functionality, Social Functionality, Role Difficulties Sub-Dimensions of Quality of Life Scale (SF-36) and Brief Symptom Inventory (BSI); descriptive statistical analyses, Kolmogorov Smirnov, Independent Samples t, Mann Whitney U test and Pearson Correlation Analysis. Results: Amputee individuals were lower than the control group in all sub-dimensions of MSPSS and SF-36 except for physical role difficulty; On the other hand, they had higher scores in anxiety, depression sub-dimensions and total scores of BSI, and the difference between them was statistically significant (p<.05). There are negative and statistically significant relationships between MSPSS and BSI total score and sub-dimensions (r=.226 vs. .630). There are negative and significant relationships between SF-36 sub-dimensions and BSI total score and sub-dimensions (r=.208 to .570). There are positive and statistically significant relationships between physical functionality and family support sub-dimension between MSPSS and SF-36, and between physical role difficulty and friend support sub-dimension. Conclusion: While individuals with lower extremity amputation have lower levels of social support and functionality than healthy individuals, they are at higher risk for mental symptoms. Individuals with high levels of social support and functionality have a reduced risk of mental symptoms
Determination of University Students’ Self-efficacy and Attitudes towards Analytic Geometry Course
No full textAbstractThe purpose of this study to investigate self-efficacy and attitude of the pre-service elementary mathematics teachers and university students enrolling in mathematics department toward Analytic Geometry with respect to gender, department. There are 336 participants. The self efficacy and attitude toward analytic geometry scale (SAAG-S) developed by Ilgun, Azak ve Takunyaci (2012) was used. In order to analyze data, t-test and ANOVA were conducted and Pearson Correlation Coefficient was found. Results of this study showed that while there is a significant difference between the self-efficacy and attitudes of the pre-service elementary mathematics teachers and university students enrolling in mathematics department toward Analytic Geometry, there is no significant difference between the self-efficacy and attitudes of females and males
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
Get PDFIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Measuring industry-science links through inventor-author relations: A profiling method
Get PDFIn this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
Wave turbulence of a rotating array of quantized vortices in the T → 0 temperature limit
No full textThe dynamics of quantized vortices in the zero temperature limit is currently of great interest, particularly in the case of the Fermi superfluid He-B. Here we study wave turbulence, generated by the librating motion of a rotating cylindrical container filled with He-B, in the limit of vanishing viscous forces at temperatures . The polarization of the quantized vortices with respect to the axis of rotation is measured using non-invasive NMR techniques. We observe a decrease of the polarization when the librating motion is started, and a two-stage relaxation process when the modulation of the rotation velocity is stopped. The first relaxation process is associated with the dissipation of large-scale flow stored in inertial waves and the solid body rotation of the vortex array. From the decay of these energy reservoirs we determine the rate of energy dissipation of large-scale flow. The later second process is related to the relaxation of Kelvin waves on individual vortices. This process is monitored by the recovery of the polarization. The existence of a Kelvin wave cascade at the lowest temperatures is currently a central open question. We supply some evidence for the cascade
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
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