248 research outputs found
Author Correction: Smartphone‑based device for point‑of‑care diagnostics of pulmonary infammation using convolutional neural networks (CNNs)
Get PDFCorrection to: Scientific Reportshttps://doi.org/10.1038/s41598-024-54939-4, published online 22 March 2024 The original version of this Article contained an error in the author name S. Mohammad-Reza Taheri which was incorrectly given as Seyed Mohammad Reza Taheri. In addition, an affiliation was omitted for S. Mohammad-Reza Taheri. The correct affiliations for S. Mohammad-Reza Taheri are listed below. Groningen University, University Medical Center groningen, Antonius Deusinglaan 1, 9713AW Groningen, the Netherlands. Condensed Matter National Laboratory, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran. Moreover, Hossein Simaee was incorrectly affiliated with ‘Institute of Biochemistry and Biophysics, University of Tehran, Tehran 1417614335, Iran’ and ‘Integrated Biophysics and Bioengineering Lab (iBL), Institute of Biochemistry and Biophysics, University of Tehran, Tehran 1417614335, Iran’. The correct affiliation for Hossein Simaee is listed below. Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. The original Article has been corrected.</p
Expression analysis of protein inhibitor of activated STAT (PIAS) genes in IFNβ-treated multiple sclerosis patients [Corrigendum]
No full textTaheri M, Azimi G, Sayad A, et al. J Inflamm Res. 2018;11:457–463.On page 457, Author list and Correspondence, the last author’s name was misspelt. The correct name is Soudeh Ghafouri-Fard.Read the original articl
Open-source projects for edge computing
No full textIn this chapter, the author covered an overview to the EC technologies as well as a scope classification to its entire paradigm. The author also reviewed the state-of-the-art reference architectures and standardization, as well as top ten open-source projects and platforms in EC. Moreover, the author mentioned open issues and challenges in the EC paradigm and discussed them in detail
RETRACTED: Numerical modeling of hydraulic fracture propagation: Accounting for the effect of stresses on the interaction between hydraulic and parallel natural fractures
No full textThis article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).This article has been retracted at the request of According to EGYJP committee’s decision and after precise investigation ,It is ultimately obvious that the article titled: “Numerical Modeling of Hydraulic Fracture Propagation: Accounting for the Effect of Stresses on The Interaction Between Hydraulic and Parallel Natural Fractures” by its auther Jaber Taheri Shakib is totally plagiarized from the thesis titled: “Analysis of hydraulic fracture propagation in fractured reservoirs: an improved model for the interaction between induced and natural fractures” by Arash Dahi Taleghani; http://hdl.handle.net/2152/18381; beginning from the abstract passing through chapter 3. Even the conclusion of chapter 3 is copied directly from the thesis: “Analysis of hydraulic fracture propagation in fractured reservoirs: an improved model for the interaction between induced and natural fractures” A matter which leads the committee to take its final decision of retracting the mentioned article from volume no. 22 issue 4 and blacklisting its author Dr. Jaber Taheri Shakib from our journal. Hoping that this decision is taken promptly from your honored side
On the importance of time-resolved electrochemical evaluation in corrosion inhibitor-screening studies
No full textEfficiency of corrosion inhibitors in aqueous solutions depends on several interfacial parameters, which may vary over time. Therefore, reliable electrochemical techniques are demanded for screening the efficiency of corrosion inhibitors and monitoring their performance over time. Here, we evaluate corrosion inhibition efficiency of imidazole-based compounds on bare Cu surfaces and highlight the importance of electrochemical evaluation of the inhibitor over time, characterized by linear polarization resistance techniques as a reliable, instantaneous and non-invasive method for assessing intrinsic inhibitor performance in lab screening studies.Team Peyman Taheri(OLD) MSE-6Team Arjan Mo
Use of biotin targeted methotrexate&ndash;human serum albumin conjugated nanoparticles to enhance methotrexate antitumor efficacy
No full textAzade Taheri1, Rassoul Dinarvand1,2, Faranak Salman Nouri1, Mohammad Reza Khorramizadeh3, Atefeh Taheri Borougeni4, Pooria Mansoori5, Fatemeh Atyabi1,21Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 2Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical sciences, Tehran, Iran; 3Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; 4Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran; 5Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranAbstract: Biotin molecules could be used as suitable targeting moieties in targeted drug delivery systems against tumors. To develop a biotin targeted drug delivery system, we employed human serum albumin (HSA) as a carrier. Methotrexate (MTX) molecules were conjugated to HSA. MTX-HSA nanoparticles (MTX-HSA NPs) were prepared from these conjugates by cross-linking the HSA molecules. Biotin molecules were then conjugated on the surface of MTX-HSA NPs. The anticancer efficacy of biotin targeted MTX-HSA NPs was evaluated in mice bearing 4T1 breast carcinoma. A single dose of biotin targeted MTX-HSA NPs showed stronger in vivo antitumor activity than non-targeted MTX-HSA NPs and free MTX. By 7 days after treatment, average tumor volume in the biotin targeted MTX-HSA NPs-treated group decreased to 17.6% of the initial tumor volume when the number of attached biotin molecules on MTX-HSA-NPs was the highest. Average tumor volume in non-targeted MTX-HSA NPs-treated mice grew rapidly and reached 250.7% of the initial tumor volume. Biotin targeted MTX-HSA NPs increased the survival of tumor-bearing mice to 47.5 &plusmn; 0.71 days and increased their life span up to 216.7%. Mice treated with biotin targeted MTX-HSA NPs showed slight body weight loss (8%) 21 days after treatment, whereas non-targeted MTX-HSA NPs treatment at the same dose caused a body weight loss of 27.05% &plusmn; 3.1%.Keywords: biotin, targeted drug delivery, in vivo anticancer delivery, human serum albumin, methotrexate, conjugate
Preparation and characterization of solid dispersions of celecoxib obtained by spray-drying ethanolic suspensions containing PVP-K30 or isomalt
No full textCelecoxib (CLX) is an anti-inflammatory drug that is used for acute pain treatment, but it has very low oral bioavailability owing to its poor water solubility. In this study, CLX solid dispersions are prepared by spray-drying using hydrophilic carriers with the aim of improving its apparent solubility and dissolution rate. Blends with different ratios of CLX, isomalt (ISO) and PVP were prepared in ethanol, and solid dispersions were obtained using a spray dryer. The saturation solubility and dissolution kinetics in 0.25 SLS and 0.04 M Na3PO4 containing media were determined. Also, SEM, DSC, XRPD, and stability studies were used to characterize the systems. Physicochemical analysis demonstrated the presence of amorphous CLX in the spray dried samples. The saturation solubility and dissolution rate of CLX from these formulations were higher than those for pure celecoxib and its physical mixtures. Amorphous CLX showed a lower dissolution rate compared to its crystalline form in 0.25 SLS medium, while this tendency was reversed under alkaline conditions. The CLX:PVP:ISO 3:5:2 spray dried sample showed the highest dissolution rate in both media. Exposure of samples to high moisture (75 humidity) recrystallized some of the amorphous CLX. Thus, the results showed that the dissolution rate of CLX was enhanced in 0.25 SLS, whereas a reduction in dissolution rate was observed in 0.04 M Na3PO4
Preparation and characterization of metformin surface modified cellulose nanofiber gel and evaluation of its anti-metastatic potentials
No full textMetastasis is the main problem in successful treatment of many types of cancer such as melanoma. The extracellular matrix degradation has a crucial role in the cancer metastasis. Nanofibers can mimic the structure of extracellular matrix and limit the cancer cells migration if they are implanted in and around the tumors. Moreover, local delivery of anti-metastatic drugs such as metformin to tumor can be useful. In this study, Metformin surface modified cellulose nanofibers (Met-Cel-NFs) were successfully prepared by attachment of metformin on the surface of cellulose nanofibers through electrostatic interaction. FTIR spectroscopy and zeta potential of Met-Cel-NFs proved the occurrence of this attachment. SEM images showed the nanofibrous structure of Met-Cel-NFs. Met-Cel-NFs significantly suppressed the migration of melanoma cells. Additionally the sufficient adhesion of the melanoma cells on the Met-CelNFs can decrease melanoma cells invasion. Therefore, Met-Cel-NFs present a promising approach to the prevention of melanoma metastasis. (C) 2017 Elsevier Ltd. All rights reserved
A novel lignin-based nanofibrous dressing containing arginine for wound-healing applications
No full textNanofiber-based wound dressings have attracted much attention in wound care owing to their unique properties such as high aspect ratio and three-dimensional structure. Arginine is a precursor of nitric oxide that plays an important role in the wound-healing process. Therefore, in this study, we have developed a gel which contains lignin nanofibers (Lig-NFs) that were surface modified by arginine molecules via electrostatic interaction (Arg-Lig-NF gel). The effect of pH on the amount of arginine attached on Lig-NF surface was evaluated at three different pH values-5, 6, and 7. Fourier transform infrared spectroscopy and zeta potential of Lig-NFs before and after surface modification confirmed the surface modification of Lig-NFs with arginine molecules. The optimum gel composed of uniform Arg-Lig-NFs with diameter ranging from 100 to 250 nm. There was 184.60 +/- 4.85 mg arginine in each gram of optimum gel. The release of arginine from Arg-Lig-NF gel showed a sustained release manner, and about 86.28 +/- 3.50 of attached arginine were released after 24 h. Moreover, the optimum gel presented suitable viscosity and spreadability for topical application. The in vivo full thickness wound-healing assay carried out in rats demonstrated that the optimum Arg-Lig-NF gel can accelerate wound closure and increase re-epithelialization, collagen deposition, and angiogenesis significantly in Arg-Lig-NF gel-treated wounds compared to Lig-NF gel and arginine solution. Overall, these findings demonstrate that Arg-Lig-NF gel can be a promising material for the future development of effective hydrocolloid wound dressings used in the treatment of acute and chronic wounds
Arginine Functionalized Bacterial Cellulose Nanofibers Containing Gel as an Effective Wound Dressing: In vitro and In vivo Evaluation
No full textBackground: Nanofibers such as bacterial cellulose nanofibers (BC-NFs) have gained increasing attention for use in wound dressings. Topical application of arginine can stimulate wound healing significantly. Objective: In order to promote the wound healing process, arginine functionalized BC-NFs containing gel (Arg-BC-NFs gel) was prepared by the electrostatic attachment of arginine on the surface of BC-NFs. Method: The effect of pH was evaluated on the amount of the attached arginine on the BC-NFs surface. The attachment of arginine on BC-NFs surface was investigated by FTIR spectroscopy. The morphology of Arg-BC-NFs was evaluated using FESEM. The viscosity and spreadability of Arg-BC-NFs and the release of arginine from Arg-BC-NFs were evaluated. The effectiveness of Arg-BC-NFs gel was assessed in a full thickness wound model in rats. Re-epithelization, collagen deposition and neovascularization were investigated in the wound tissues using histological and immunohistochemical analysis. Results: FTIR spectra and the zeta potential of BC-NFs confirmed the surface modification of BC-NFs by arginine. FESEM images showed the nanofibrous structure of Arg-BC-NFs. The release of arginine from Arg-BC-NFs gel was in a sustained release manner for 24 h. The appropriate viscosity and spreadability of Arg-BC-NFs gel confirmed its easy topical application. In vivo studies revealed that Arg-BC-NFs gel promoted wound closure at a faster rate than BC-NFs gel and arginine solution. Moreover, faster and more organized re-epithelialization, angiogenesis and collagen deposition were achieved in Arg-BC-NFs gel treated group in comparison to other groups. Conclusion: Arg-BC-NFs gel can be introduced as an effective wound dressing for acute wounds
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