11 research outputs found

    Comparative Evaluation of Different Properties of Zirconia and Peek Abutments in Dental Implants: A Systematic Review

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    Objectives: The aim of this review was comparative evaluation of mechanical and biological properties of zirconia and PEEK abutments in titanium dental implant supported restorations. Methods: A comprehensive search was done in PubMed and Cochrane library electronic databases. In addition to this, manual search of the references mentioned in the studies and gray literature were done. Published articles in English languages and in vivo studies only included in this review. Keywords used in this study were “zirconia abutment” “PEEK abutment,” “dental implants,” “mechanical properties,” and “biological properties”. Boolean operators (AND, OR) were used with the combination of these keywords. Result: The literature search yielded total 49 studies through search in electronic databases (PubMed – 45, Cochrane library – 4). Thirty five studies were removed after screening of title and abstracts. Total 6 studies were included for full text reading. Six studies were included in the review. Two out of 6 included studies compared surface roughness of different biomaterials. Fracture resistance and pattern of fracture were evaluated by two studies. Different Biological properties like accumulation of biofilm and different strains of bacteria, inflammatory cytokine level, active matrix metalloproteinase -8 levels, probing depth and marginal bone loss were the other parameters that were checked in these studies. Conclusion: Overall no significant difference found in terms of mechanical and biological properties in between Zirconia and PEEK abutments. PEEK abutments can be used as an alternative option to zirconia abutments in esthetic region of oral cavity

    GASTROINTESTINAL HELMINTH PARASITES OF SLAUGHTERED SHEEP WITH SPECIAL REFERENCE TO AGE, SEX AND SEASONAL DISTRIBUTION IN

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    *Author for Correspondence The presence of helminth parasites in Sheep impairs their growth. With this background the present study was carried out to determine the prevalence of different endohelminth parasites in Doda district of Jammu and Kashmir State. Visceral samples were collected from different abattoirs of different areas of district doda and were examined for any probable helminth parasite. Results showed that various helminth parasites were prevalent with different levels of infestation. Nematode parasites were more prevalent followed by trematodes and cestodes. The different helminth parasites observed included Trichuris ovis, Chabertia ovina, Dicrocoelium dendriticum and Monieza expansa. The occurrence of various endohelminth parasites calls for intervention measures like mass chaemotherapy of all the sheep in the district

    Societal problems in the novels of Kamala Markandaya with special reference to A Handful of Rice

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    Markandaya’s novels are pregnant with different themes and as a woman novelist her novels give us a glimpse of personal life as well.Markandaya’s novels give a glimpse of all such social issues that have roots in the Indian culture and are still existing in many rural Indian societies.A Handful of Rice is a bolt from blue by Kamala Markandaya to make the readers aware about the plight of people. The author depicts the trauma that people face because of hunger and starvation. The novelist highlights that hunger is the root cause of all social evils. It forces a person to go from bad to worse. This thing has been highlighted in the character of Ravi

    Effect of dietary Sargassum wightii and its fucoidan-rich extract on growth, immunity, disease resistance and antimicrobial peptide gene expression in Labeo rohita

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    Abstract This work aimed to appraise growth performance, immune responsiveness, bacterial disease resistance and mRNA expression of two antimicrobial peptides in Labeo rohita fingerlings fed diets supplemented with seaweed Sargassum wightii and its fucoidan-rich extract. Two hundred and twenty-five fingerlings were divided into five experimental groups in triplicates, each replicate having 15 fish in a 90-L tank. Different groups were fed with isonitrogenous (35% crude protein) and isoenergetic (1408.16 kJ/100 g) diets containing either 0% fucoidan-rich seaweed extract (FRSE), 1% FRSE, 2% FRSE, 3% seaweed powder and 6% seaweed powder for 60 days. Partial nucleotide sequences of the antimicrobial peptides, hepcidin and defensin, were characterized in Labeo rohita fingerlings, and gene expression in the different tissues of experimental fish was studied. The fish-fed FRSE-supplemented diets showed significant increase (P < 0.05) in the mRNA expression of antimicrobial peptides in liver, skin and intestine tissues. Bacterial challenge study using Aeromonas hydrophila showed higher survival in the FRSE-fed groups. Fish-fed FRSE-supplemented diets also showed better non-specific immune response (NBT reduction, serum lysozyme activity, serum albumin: globulin ratio and phagocytic activity) in pre-challenge and post-challenge periods. No significant difference was observed in the growth performance in the different experimental groups. The study indicates that although dietary FRSE is a potential immunostimulant in Labeo rohita fingerlings, it does not improve growth performance

    WITHDRAWN: Bioanalytical strategies for isolation and characterization of pharmacological chaperones – A class of protein pharmaceuticals from medicinal plants

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    This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy

    Synthesis of molecular imprinting polymers for extraction of gallic acid from urine

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    The molecularly imprinted polymers for gallic acid were synthesized by precipitation polymerization. During the process of synthesis a non-covalent approach was used for the interaction of template and monomer. In the polymerization process, gallic acid was used as a template, acrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker and 2,2'-azobisisobutyronitrile as an initiator and acetonitrile as a solvent. The synthesized imprinted and non-imprinted polymer particles were characterized by using Fourier-transform infrared spectroscopy and scanning electron microscopy. The rebinding efficiency of synthesized polymer particles was evaluated by batch binding assay. The highly selective imprinted polymer for gallic acid was MIPI1 with a composition (molar ratio) of 1:4:20, template: monomer: cross-linker, respectively. The MIPI1 showed highest binding efficiency (79.50%) as compared to other imprinted and non-imprinted polymers. The highly selective imprinted polymers have successfully extracted about 80% of gallic acid from spiked urine sample. © The Author(s) 2018

    Molecular and insecticidal characterization of Vip3A protein producing Bacillus thuringiensis strains toxic against Helicoverpa armigera (Lepidoptera: Noctuidae)

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    Vegetative insecticidal proteins (Vip) represent the second generation of insecticidal proteins produced by Bacillus thuringiensis (Bt) during the vegetative growth stage of growth. Bt based biopesticides are recognized as viable alternatives to chemical insecticides, the latter cause environmental pollution and lead to emergence of pest resistance. In order to perform a systematic study of vip genes encoding toxic proteins a total of 30 soil samples were collected from diverse locations of Kashmir valley, India and characterized by molecular and analytical methods. 86 colonies showing Bacillus like morphology were selected. Scanning Electron Microscopy observations confirmed the presence of different crystal shapes, PCR analysis of insecticidal genes revealed predominance of lepidopteran specific vip3 (43.18%) followed by coleopteran specific vip1 (22.72%) and vip2 (15.90%) genes in the isolates tested. Multi-alignment of the deduced amino acid sequences revealed that vip3 sequences were highly conserved whereas vip1 and vip2 showed adequate differences in amino acid sequences compared to already reported sequences. Screening for toxicity against Helicoverpa armigera larvae was performed using partially purified soluble fractions containing Vip3A protein, mortality levels observed ranged between 70% and 96.6% in the isolates. LC50 values of two of the native isolates JK37 and JK88 against H. armigera was found to be at par with that of Bt kurstaki HD1, suggesting that these isolates could be developed as effective biopesticides against H. armigera.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

    Febuxostat efficiently reduces the progression of chronic kidney disease in asymptomatic hyperuricemia: an interventional study

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    Abstract Background Therapeutic approaches for addressing asymptomatic chronic kidney disease (CKD) with renal impairment requires careful consideration, as there is a lack of substantial evidence endorsing specific medications. This study examined the outcomes of administering febuxostat to persons diagnosed with asymptomatic hyperuricemia in CKD (stages 3 and 4). Methods A single-patient blinded; placebo-controlled study was carried out at Chittagong Medical College Hospital in Chattogram 4203 over a 1-year period. Participants were randomly assigned to two groups: one group received a daily dose of 40 mg of febuxostat while the other was given placebo tablets. As necessary, diuretics, antihypertensives, and antidiabetics were administered. Evaluations, which included patient history, physical examinations, outcomes, and pertinent tests, were performed at baseline, the 3rd month, and the 6th month. Results There were 105 similar-baseline patients in each group. The mean serum uric acid (SUA) level in the febuxostat group lowered from 8.55 to 4.92 mg/dL after 6 months, while in the placebo control it elevated from 8.10 to 8.99. In febuxostat group, the mean eGFR elevated from 25.28 to 27.01 ml/min/1.73 m2, while in the placebo control it reduced from 26.81 to 23.32. In the febuxostat group, at the 6-month mark, eGFR differed across groups following a substantial decrease in systolic and diastolic blood pressure (P < 0.05). Conclusions In our clinical setting, febuxostat proved more effective than a placebo in reducing serum uric acid levels and maintaining eGFR in patients with stage 3 and 4 CKD. Hence, febuxostat could be employed to treat hyperuricemia-associated asymptomatic chronic renal disease
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