1,720,959 research outputs found
Prophylactic cranial irradiation in non small cell lung cancer ??? should this be included in radical treatment
No full textParameters predicting survival outcome in glioblastoma
No full textBackgroundGlioblastoma is the commonest primary brain tumour in adults with reported median survival of less than a year. Concurrent radiotherapy (RT) and temozolomide (TMZ) has produced clinical benefits and a statistically significant improvement in survival. We present a review of our experience at the Royal Free Hospital.AimRetrospective review of patients with glioblastoma over a period of 54 months assessing whether age of the patient, site of the tumour or surgery prior to commencing RT/TMZ affected median survival (MS). The importance and incidence of pseudo-progression was also reviewed.MethodPatients who received RT/TMZ over a 54 month period were identified from electronic patient records and via multidisciplinary meetings. Data including age, site of tumour, surgery (debulking or biopsy), response (radiological and clinical) and median survival was obtained from case notes.ResultsTotal number of patients identified was 75 with a median follow-up of 24 months. Patients under 50 years of age had a MS of 14 months compared to 10 months in those over 50
Breast Cancer and Pregnancy
Get PDFBreast cancer is one of the most commonly diagnosed cancers in pregnant women. Diagnosis and treatment in these women are particularly challenging as the necessary investigations and treatment modalities may potentially harm the developing foetus. Nonetheless, it appears that initial diagnostic investigations may be carried out as for non-pregnant women, but bearing in mind the risks of exposing the foetus to ionising radiation. Surgery can be carried out with little risk to the mother or foetus but radiotherapy is generally avoided. Chemotherapy can be given relatively safely when administered after the first trimester, but large volume prospective data and, in particular, data regarding the long-term implications of in utero exposure, are awaited
Docetaxel extravasation resulting in vesicant type skin reaction:Case report
No full textExtravasations – pain at the intravenous site and local blistering – are caused by the leakage of fluids used in chemotherapy from blood vessels into surrounding tissue. Although the condition is rare, occurring in 0.1-1 per cent of all chemotherapy treatments, it can be extremely debilitating and requires immediate intervention from those administering chemotherapy. Although not normally considered to be a vesicant (causes blistering when applied to the skin), this article adds to recent evidence that the commonly used chemotherapy drug, docetaxel, should be considered as a superficial vesicant and special precautions taken to minimise extravasation hazards.<br/
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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