87,716 research outputs found
In Vivo Tests of Hybrid Nano Composite Modified Implants
No full textA biomimetic approach has been applied to design and realize new odontostomatological Titanium (Ti) implants using a multifunctional bioactive ceramo-polymeric hybrid material. The proposed biomimetic/biomechanical approach consists in combining mechanical and physical characterization of the hybrid nanocomposite to biosolid mechanics Finite Element Analysis of the new design implants. Hybrid ceramo-polymeric nanocomposites based on Hydroxyl-Ethyl-Methacrylate polymer (pHEMA) filled with nanosilica particles are presented as biomimetic-scaffolding materials. Cytotoxicity and Osteoblast cells adhesion tests have shown good material biocompatibility and osteoconductivity [1]. Dynamic Mechanical Analysis (DMA) confirmed the hybrid mechanical behaviour of these nanocomposites. Moreover, this class of material swells in presence of aqueous physiological solution according to limiting Case II sorption mode turning from glassy and rigid to soft and rubbery while presenting a mechanical behaviour, at 5 to 10 % nanosilica volume loadings, that is comparable with that of bone (when glassy) and to that of the cartilage and Ligaments (when rubbery).
The use of mechanically compatible hybrid hydrogels as scaffolding materials are expected to increase prosthesis adaptation mechanisms introducing active interfaces that improve implant biomimetics while reproducing cartilage and ligaments biomechanical functions.
[1] C Schiraldi, A D'Agostino, A Oliva, ... R Aversa, M De Rosa, Biomaterials, 25 (17), 3645-3653 (2004).
[2] R Aversa, D Apicella, L Perillo, R Sorrentino, F Zarone, M Ferrari, A Apicella, Dental Materials, 25(5), 678-690 (2009).
[3] D Apicella, R Aversa, F Ferro, D Ianniello, A Apicella, J. of Biomedical Material Research: Part B, Applied Biomaterials, vol-93(1), 150-163 (2010)
Biomechanically Active Hybrid nano composite for early osteointegration implants
No full textA biomimetic approach has been applied to design and realize new odontostomatological Titanium (Ti) implants using a multifunctional bioactive ceramopolymeric hybrid material. The proposed biomimetic/biomechanical approach consists in combining mechanical and physical characterization of the hybrid nanocomposite to biosolid mechanics Finite Element Analysis of the new design implants. Hybrid ceramopolymeric nanocomposites based on Hydroxyl-Ethyl-Methacrylate polymer (pHEMA) filled with nanosilica particles are presented as biomimetic-scaffolding materials. Cytotoxicity and Osteoblast cells adhesion tests have shown good material biocompatibility and osteoconductivity [1]. Dynamic Mechanical Analysis (DMA) confirmed the hybrid mechanical behaviour of these nanocomposites. Moreover, this class of material swells in presence of aqueous physiological solution according to limiting Case II sorption mode turning from glassy and rigid to soft and rubbery while presenting a mechanical behaviour, at 5 to 10 % nanosilica volume loadings, that is comparable with that of bone (when glassy) and to that of the cartilage and Ligaments (when rubbery). Materials swelling behaviour and mechanical characterizations are presented. Design criteria and FEM simulation are discussed. The use of mechanically compatible hybrid hydrogels as scaffolding materials are expected to increase prosthesis adaptation mechanisms introducing active interfaces that improve implant biomimetics while reproducing cartilage and ligaments biomechanical functions.
[1] C Schiraldi, A D'Agostino, A Oliva, ... R Aversa, M De Rosa, Biomaterials, 25 (17), 3645-3653 (2004).
[2] R Aversa, D Apicella, L Perillo, R Sorrentino, F Zarone, M Ferrari, A Apicella, Dental Materials, 25(5), 678-690 (2009).
[3] D Apicella, R Aversa, F Ferro, D Ianniello, A Apicella, J. of Biomedical Material Research: Part B, Applied Biomaterials, vol-93(1), 150-163 (2010)
Hybrid Ceramo-Polymeric Scaffolds with Biomimetic Characteristics
No full textThe research develops and tests new hybrid biomimetic materials that work as mechanically stimulating "scaffolds" to promote early regeneration in implanted bone healing phases. A biomimetic nanostructured osteoconductive material coated apparatus is presented. Bioinspired approaches to materials and templated growth of hybrid networks using self-assembled hybrid organic-inorganic interfaces is finalized to extend the use of hybrids in the medical field. Combined in vivo, in vitro and computeraided simulations have been carried out. A new experimental methodology for the identification of design criteria for new innovative prosthetic implant systems is presented. The new implant design minimizes the invasiveness of treatments while improving implant functional integration [1]. A new bioactive ceramo-polymeric hybrid material was used to modify odontostomatological Titanium implants in order to promote early fixation, biomechanical stimulation for improved scaffold mineralization and ossification. It is a hybrid ceramo-polymeric nanocomposites based on Hydroxyl-Ethyl- Methacrylate polymer (pHEMA) filled with nanosilica particles that have shown biomimetic characteristics [2,3]. This material swells in presence of aqueous physiological solution leading to the achievement of two biomechanical functions: prosthesis early fixation after and bone growth stimulation. Such multidisciplinary approach explores novel ideas in modelling, design and fabrication of new nanostructured biomaterials with enhanced functionality and improved interaction with OB cells.
[1] R Aversa, D Apicella, L Perillo, R Sorrentino, F Zarone, M Ferrari, A Apicella, Dental Materials, 25(5), 678-690 (2009).
[2] C Schiraldi, A D'Agostino, A Oliva, ... R Aversa, M De Rosa, Biomaterials, 25 (17), 3645-3653 (2004).
[3] G R. Beck, Shin-Woo Ha, C E Camalier, M Yamaguchi, Y Li, J K Lee, M. N Weitzmann, Nanomedicine, 8(6), 793-803 (2012)
Peculiarità del paziente pediatrico. In “Profilassi delle Infezioni Fungine”.
No full textMonografia sulle caratteristiche delle infezioni fungine nel paziente pediatrico oncoematologic
NK cell alloreactivity and allogeneic hematopoietic stem cell transplantation.
No full textAs only 60% of leukaemia patients find a matched donor, the Perugia Bone Marrow Transplant Centre developed transplantation from HLA haplotype-mismatched family donors to provide a cure for more patients [F. Aversa, A. Tabilio, A. Terenzi, et al., Successful engraftment of T-cell-depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum, Blood 84 (1994) 3948-3955] [F. Aversa, A. Tabilio, A. Velardi, et al., Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype, N. Engl. J. Med. 339 (1998) 1186-1193] [F. Aversa, A. Terenzi, A. Tabilio, et al., Full haplotype-mismatched hematopoietic stem-cell transplantation: a phase II study in patients with acute leukemia at high risk of relapse, J. Clin. Oncol. 23 (2005) 3447-3454]. HLA-mismatches trigger donor vs. recipient NK cell alloreactivity which improves engraftment, protects from GvHD and reduces relapse in AML patients [L. Ruggeri, M. Capanni, E. Urbani, et al., Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants, Science 295 (2002) 2097-2100], [L. Ruggeri, A. Mancusi, M. Capanni, E. Urbani, A. Carotti, T. Aloisi, M. Stern, D. Pende, K. Perruccio, E. Burchielli, F. Topini, E. Bianchi, F. Aversa, M.F. Martelli, A. Velardi, Donor natural killer cell allorecognition of missing self in haploidentical hematopoietic transplantation for acute myeloid leukemia: challenging its predictive value, Blood, in press]. We are using murine transplant models to determine whether NK cell alloreactivity can be exploited to reduce transplant-related mortality (TRM) which remains a major issue. Data from these on-going studies show pre-transplant infusion of alloreactive NK cells: (1) ablates AML cells, (2) kills recipient T cells, permitting a reduced toxicity conditioning regimen, and (3) ablates the recipient dendritic cells (DCs) which trigger GvHD, thus protecting from GvHD while permitting a higher T cell content in the graft. We are designing a clinical haploidentical transplant trial using alloreactive NK cells in the conditioning regimen, with the aim of reducing TRM and improving outcomes and overall survival
Haploidentical transplants using ex vivo T-cell depletion
No full textAllogeneic hematopoietic stem cell transplantation (HSCT) is the best post-remission therapy for patients with acute leukemia (AL) at high risk of relapse. Advantages of having a family member as donor include: no undue delay in obtaining the graft; choice of best donor with regards to natural killer (NK) alloreactivity and cytomegalovirus (CMV) status from a panel of candidate family members; easy access to post-transplant cellular therapies like donor lymphocyte infusions and opportunity for a second graft from the original donor, or another family member in case of graft failure. This review will explore how the biological obstacles to HLA-haploidentical (haplo)-HSCT were overcome and how transplant modalities have evolved over time to potentiate the graft-versus-leukemia (GvL) effect in the absence of graft-versus-host disease (GvHD)
Aversa F., Tripodi F., NIMBI F.M., Baiocco R., Simonelli C. (2016). Attitudes towards same-sex marriage and parenting: association with sexism, homophobia and internalized sexual stigma. Klinicka Psihologija, 9(1), pp.46-47. doi: 10.21465/2016-KP-OP-0034
No full text- …
