186,384 research outputs found
J. Auberger, Le monde gréco-romain
No full textLévêque Pierre. J. Auberger, Le monde gréco-romain. In: Dialogues d'histoire ancienne, vol. 23, n°1, 1997. p. 323
Janick Auberger, Ctésias. Histoires de l'Orient. Introduction, traduction et notes
No full textColin Frédéric. Janick Auberger, Ctésias. Histoires de l'Orient. Introduction, traduction et notes. In: L'antiquité classique, Tome 62, 1993. p. 279
Janick Auberger, Ctésias. Histoires de l'Orient. Introduction, traduction et notes
No full textColin Frédéric. Janick Auberger, Ctésias. Histoires de l'Orient. Introduction, traduction et notes. In: L'antiquité classique, Tome 62, 1993. p. 279
9. Auberger (J.), Historiens d'Alexandre. Textes traduits et annotés
No full textLefèvre François. 9. Auberger (J.), Historiens d'Alexandre. Textes traduits et annotés. In: Revue des Études Grecques, tome 115, Janvier-juin 2002. p. 426
Fertilisers used in MEANS-InOut: compositions and characteristics useful for environmental assessment
No full textThis dataset lists the fertilisers available in the MEANS-InOut software and their main characteristics. The fertilisers concerned are organic fertilisers, mineral fertilisers, soil improvers (calcium, dolomitic) and mineral-based products that do not contain N, P or K. The characteristics of the fertilisers taken into account are: nitrogen (N), phosphorus (P), potassium (K), seven heavy metals, and direct emission model parameters.
The mapping between these fertilisers and Life Cycle Inventories (LCI) from reference databases (ecoinvent, Agribalyse) will be included in another dataset.
Ce jeu de données liste les engrais disponibles dans le logiciel MEANS-InOut et leurs principales caractéristiques. Les engrais concernés sont des engrais organiques, des engrais minéraux, ainsi que des amendements (calcique, dolomitique) ou des produits à base de minéraux mais ne contenant pas de N, P ou K. Les caractéristiques des engrais prises en compte sont : teneurs en azote (N), phosphore (P, sous forme P2O5), potassium (K sous forme K2O), en sept éléments traces métalliques, et des paramètres de modèles d'émissions directes associés à ces engrais.
La correspondance entre ces engrais et des Inventaires de Cycle de Vie (ICV) de bases de données de référence (ecoinvent, Agribalyse) fera l'objet d'un autre jeu de données.<p
Inventaires de cycles de vie externes de la plateforme Means
No full textCe jeu de données liste les inventaires de cycle de vie (ICVs) présents dans la bibliothèque externe Means. Ce sont des ICVs agricoles de matériels, bâtiments, infrastructures, opérations culturales, aliments. Ils ont été construits en suivant le cadre méthodologique d'Agribalyse en terme de construction d'ICVs. La majorité de ces ICVs sont associés à des systèmes aquacoles ou équins. Il est nécessaire d'importer ces ICVs dans son logiciel d'ACV avant l'import des étapes de MEANS-InOut.
Les ICVs Externes sont fournis sous la forme de plusieurs fichiers texte CSV), importables dans un projet du logiciel d'ACV Simapro.
La procédure d'importation est décrite dans le document Manuel utilisateur import bibliothèque Simapro.pdf
This dataset lists the life cycle inventories (LCIs) present in the Means external library. These are agricultural LCIs for equipment, buildings, infrastructure, cultivation operations and foodstuffs. They were built using the Agribalyse methodological framework for LCI construction. The majority (not exhaustive) of these LCIs are associated with aquaculture or equine systems. It is necessary to import these LCIs into your LCA software before importing the MEANS-InOut steps.
External LCIs are supplied in the form of several text files (CSV), which can be imported into a Simapro LCA software project.
The import procedure is described in the document Simapro library import user manual.pdf
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Synthesis of Neisseria meningitidis serogroup A carba analogues as hydrolytically stable antigens for antimeningococcal glycoconjugate vaccines
No full textSynthesis of Neisseria meningitidis serogroup A carba analogues as hydrolytically stable antigens for antimeningococcal glycoconjugate vaccines
Ludovic Auberger, Jacopo Enotarpi, Jeroen Codeé, Roberto Adamo, Laura Polito, Luigi Lay
The Gram-negative encapsulated bacterium Neisseria meningitidis type A (MenA) is a major cause of meningitis in developing countries, especially in the sub-Saharan region of Africa [1]. The development and manufacture of an efficient glycoconjugate vaccine against MenA is largely hampered by the poor stability in water of the natural capsular polysaccharide (CPS)[2], composed of (1→6)-linked 2-acetamido-2-deoxy-α-D-mannopyranosyl phosphate repeating units, with acetyl substituents. As a consequence, most of MenA glycoconjugates currently available have been licensed as lyophilisates. The availability of MenA polysaccharide mimics resistant to hydrolysis, however, is highly attractive for the development of a more stable glycoconjugate vaccine in liquid formulation. To this end, we envisaged that the replacement of the endocyclic ring oxygen with a methylene group to get a carbocyclic analogue will lead to the loss of the acetalic character of the phosphodiester and consequently to the enhancement of its chemical stability [3], [4]. Furthermore, the 3-O-acetylation aims to strengthen the immunological profile of our neo-glycoconjugates, structurally designed even closer to the natural CPS MenA oligomer, partially acetylated at the position 3-OH with a rate of 75-95% [5].
Thus, we describe our synthetic approaches to 3-O-acetylated phosphodiester-linked carba oligomers of N-acetyl mannosamine (the repeating unit of MenA CPS, containing up to 8 repeating units. The increased stability of the synthetic carba oligomers was first confirmed by an accelerated stability study, then selected fragments were conjugated to CRM197 (a diphtheria toxin mutant) as a protein carrier. Finally, the immunological profile of the resulting neo-glycoconjugates will be carefully investigated, with the purpose to highlight the effect of the carbohydrate chain length and of the 3-O-acetylation on the immunoactivity [6].
[1] Tan L. K. K.; Carlone G. M.; Borrow R. Advances in the development of vaccines against Neisseria meningitidis. N. Engl. J. Med. 2010, 362, 1511-1520.
[2] Frasch, C. E. Production and control of Neisseria meningitidis vaccines. Adv. Biotechnol. Processes 1990, 13, 123-145.
[3] Gao, Q.; Zaccaria, C.; Tontini, M.; Poletti, L.; Costantino, P.; Lay, L. Synthesis and preliminary biological evaluation of carba analogues from Neisseria meningitidis A capsular polysaccharide. Org. Biomol. Chem. 2012, 10, 6673-6681.
[4] Gao Q.; Tontini M.; Brogioni G.; Nilo A.; Filippini S.; Harfouche C.; Polito L.; Romano M. R.; Costantino P.; Berti F.; Adamo R.; Lay L. ACS Chem. Biol. 2013, 8, 2561-2567.
[5] Berry DS.; Lynn F.; Lee C-H.; Frasch CE.; Bash MC. Effect of O-Acetylation of Neisseria Meningitis serogroup A capsular polysaccharide on development of functional immune responses, Infection and Immunity, 2002, 70(7), 3707-3713.
[6] This project has received funding from the H2020-MSCA-ITN-2015 “Glycovax” under grant agreement No 675671
Effect of Helicobacter pylori on polymorphonuclear leukocyte migration across polarized T84 epithelial cell monolayers: role of vacuolating toxin VacA and cag pathogenicity island.
No full textHuman polymorphonuclear leukocytes are sensitive in vitro to Helicobacter pylori VacA toxin
No full textAuthor-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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