124,951 research outputs found
Micro-Drilling of ZTA and ATZ Ceramic Composit: Effect of Cutting Parameters on Surface Roughness
No full textCeramics are a class of materials widely used during last fifteen years for orthopaedic applications. It is well known that they are characterized by low wear rate, and friction coefficient. However, these materials are very difficult to machine into complex shapes because of their brittleness and high hardness. The most effective method to increase the crack resistance is the formation of a composite structure. This class of materials, composed by two or more different ceramics, can present higher characteristic respect to the single component, like fracture toughness and flexural strength. This paper presents a study of the influence of cutting parameters (cutting speed, feed rate and step number) onto the hole surface roughness and deformation due to the drill operation. The ceramic composite materials AZT (alumina toughened zirconia) and ZTA (zirconia toughened alumina) were first characterized in terms of hardness and roughness. After the drilling test, the holes were analyzed using scanning electron microscope (SEM) and an advanced 3-dimensional non-contact optical profilomete
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mechanism of ATZ degradation targeted by GLB.
No full text(A) Effect of GLB on ATZ levels in the HTO/Z cell line in presence or absence of MG132. Cells were incubated for 48 hours with GLB (40 μM) and MG132 (30 μM) was added for the last 6 hours of this incubation period. Relative densitometric values are shown at the top. (B) Effect of GLB on ATZ levels in HTO/Z cell line and autophagy-deficient HTOZATG14KO (ATG14KO) subclone. Cells were incubated for 48 hours with varying doses of GLB (bottom) and then analyzed for ATZ and β-actin by immunoblotting. Blotting for ATG14 is shown on the right.</p
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Effects of <i>S</i>-MET in <i>Pseudomonas</i> sp. ADP Rif<sup>R</sup> (A) survival and (B) ATZ- mineralization in soil.
No full text<p>In (<b>A</b>), soil previously contaminated with 24 µg ATZ g<sup>−1</sup> of soil was supplemented with increasing concentrations of <i>S</i>-MET, namely 0 (⧫), 15 (□), 30 (Δ) or 60 (○) µg g<sup>−1</sup> of soil, prior to inoculation. In (<b>B</b>), soil was spiked with a total of 24 µg ATZ g<sup>−1</sup> of soil (including [<sup>14</sup>C]ATZ) plus 30 µg <i>S</i>-MET g<sup>−1</sup> (Δ) or no <i>S</i>-MET (⧫), or with a total of 40 µg ATZ g<sup>−1</sup> plus 50 µg <i>S</i>-MET g<sup>−1</sup> (▪) or no <i>S</i>-MET (⋄), prior to inoculation. Data are means±SD of measurements from at least duplicate determinations from two or three independent experiments under identical conditions.</p
Albumin-bilirubin (ALBI) scores in hepatocellular carcinoma patients treated with atezolizumab (ATZ) plus bevacizumab (BEV).
No full texta) Score in a total of 73 patients, b) 28 patients with mALBI grade-1 at baseline, c) 16 patients with mALBI grade-2a at baseline, d) 29 patients with mALBI grade-2b at baseline, e) 13 patients without proteinuria within 12 weeks of initiation of ATZ plus BEV treatment. f) 39 patients with grade 1 proteinuria (according to the Common Terminology Criteria for Adverse Events (CTCAE)) within 12 weeks of initiation of ATZ plus BEV treatment, g) 21 patients with grade 2 proteinuria (CTCAE) within 12 weeks of initiation of ATZ plus BEV treatment.</p
ATZ mineralization by <i>Pseudomonas</i> sp. ADP Rif<sup>R</sup> in soil contaminated with Primextra S-Gold.
No full text<p>Time-course formation of <sup>14</sup>CO<sub>2</sub> from [ring-UL-<sup>14</sup>C]ATZ in (<b>A</b>) soil spiked with [<sup>14</sup>C]ATZ plus increasing doses of Primextra S-Gold as follows: 5× (⧫), 20× (□) and 50×RD (▴), without citrate amendment; or (<b>B</b>) soil spiked with [<sup>14</sup>C]ATZ plus 50×RD of Primextra S-Gold and amended with 3.4 mg g<sup>−1</sup> trisodium citrate (Δ) or non-amended (▴). The average amount of <sup>14</sup>CO<sub>2</sub> released from non-inoculated control soil is shown for comparison (○) in (<b>A</b>). Data are means±SD of measurements from three replicated samples from at least two independent experiments under each condition.</p
Hydrothermal Aging of ATZ Composites Based on Zirconia Made of Powders with Different Yttria Content
No full textThe presented work concerns the development and investigation of three different grades of ZrO2 materials containing Al2O3 particles (ATZ-Alumina Toughened Zirconia ceramics with 2.3–20 vol.% of alumina). The zirconia powders containing 3 mol.% of yttria were synthesized by a precipitation/calcination method and fabricated from two different zirconia powders with different yttria content. Then, the selected ATZ composites (ATZ-B, ATZ-10 and ATZ-20) were prepared by means of conventional mixing, compacting and sintering at 1450 °C for 1.5 h. The phase composition, microstructure, relative density and basic mechanical properties were determined. Uniform microstructures with relative densities over 99% of theoretical density, hardness values between 12.0–13.8 GPa, flexural strength up to 1 GPa and outstanding fracture toughness of 12.7 MPa⋅m1/2 were obtained. The aging susceptibility of alumina toughened zirconia materials, as a consequence of hydrothermal treatment, was investigated. The aim of this study was to determine the influence of LTD (low temperature degradation) on the tetragonal to monoclinic phase transitions and on the flexural strength of hydrothermally aged specimens. The results were compared to those obtained for commercially available tetragonal zirconia-based materials containing 3 mol.% of yttria. This research shows that ATZ composites that have excellent mechanical properties and sufficient hydrothermal aging resistance can be attained and later used in technical and biomedical applications
Effect of Flu on steady state levels of ATZ in genetically engineered HeLa HTO/Z cell line.
No full text<p>Separate monolayers were incubated for 48 hours in the absence or presence of Flu or CBZ. Drug was added to the medium daily. Cells were then harvested, homogenized and the cell homogenates separated into soluble and insoluble fractions. The fractions were analyzed by immunoblot for AT (top) as well as loading controls, GelCode Blue (middle) and GAPDH (bottom). A, HTO/Z cell line expressing mutant ATZ; B, Densitometric analysis of 4 separate experiments in HTO/Z cell line. Mean +/− standard error is shown with error bars. Asterisks denote a statistically significant difference (p = 0.0029 for insoluble ATZ; p = 0.0292 for soluble ATZ).</p
Pretreatment with ATZ suppressed the elevation of plasma aminotransferases induced by APAP.
No full text<p>Mice were pretreated with vehicle or indicated doses of ATZ before APAP exposure. The plasma levels of alanine aminotransferase (ALT, A) and aspartate aminotransferase (AST, B) were determined at 8 h after APAP exposure. Data were expressed as mean ± SD, n = 8. * <i>P</i><0.05, ** <i>P</i><0.01, as compared with APAP group (APAP +/ATZ 0). In another set of animals, the mice were treated with either vehicle or ATZ (500 mg/kg) before APAP exposure. The mice were sacrificed at 2 h, 4 h or 6 h after APAP exposure and the plasma levels of ALT (C) and AST (D) were determined. The data were expressed as the mean ± SD, n = 8. <sup>NS</sup><i>P</i>>0.05, ** <i>P</i><0.01, as compared with the CON group; <sup>#</sup><i>P</i><0.05, <sup>##</sup><i>P</i><0.01, as compared with the APAP group.</p
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