2,724 research outputs found
Exploring the Role of Guilt in Eating Disorders: A Pilot Study
No full textBackground/Objectives: Eating disorders (EDs) are complex psychopathological conditions involving dysfunctional eating behaviors, excessive body image concerns, and impaired emotional regulation. Among moral emotions, guilt plays a significant role in ED dynamics, influencing both symptomatology and interpersonal relationships. This study examines specific guilt subtypes (normative and altruistic guilt) using a specific psychometric tool. Methods: Forty-three adults with anorexia nervosa (AN), bulimia nervosa (BN), or binge eating disorder (BED) were recruited from the Eating Disorder Center of the University of Campania “Luigi Vanvitelli” or referred by psychotherapists. Diagnoses followed DSM-5 criteria. Participants completed the Moral Orientation Guilt Scale (MOGS), assessing guilt subtypes, and the Eating Disorder Inventory-2 (EDI-2), measuring ED symptomatology. Spearman’s rank correlation and stepwise multiple regression analyses were used to identify relationships between guilt dimensions and ED-related symptoms. Results: MOGS subscales were positively correlated with ED symptomatology. Normative guilt was significantly associated with binging and purging (ρ = 0.26, p < 0.05), while altruistic guilt predicted higher interpersonal distrust (t = 3.4, p < 0.01). Regression analysis revealed that age negatively influenced interpersonal distrust (t = −2.9, p < 0.01). Conclusions: In the population examined, guilt significantly influences ED symptomatology and interpersonal functioning, with specific dimensions linked to distinct behaviors and traits. Therapeutic interventions targeting guilt may enhance treatment outcomes by addressing ED emotional underpinnings. However, the results should be interpreted with caution due to the small sample size and lack of longitudinal data to establish causality. Further research with larger samples and longitudinal designs is necessary to validate these findings
Different Clinical Outcomes of COVID-19 in Two Healthcare Workers Vaccinated with BNT162b2 Vaccine, Infected with the Same Viral Variant but with Different Predisposing Conditions for the Progression of the Disease
No full textSafe and effective vaccines are available to face the global threat of the COVID-19 pandemic. In this article, we report on the clinical cases of two healthcare workers vaccinated with two doses of BNT162b2 vaccine who were infected by the same viral clade but had different clinical outcomes
Non-invasive brain stimulation in generalized anxiety disorder: A systematic review
No full textIn the last years, several studies using non-invasive brain stimulation (NIBS) techniques demonstrated that the dorsolateral prefrontal cortex (DLPFC) plays a key role in the neurobiological bases of anxiety disorders. Both transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) applied primarily over the prefrontal cortex have been shown to modulate anxiety symptomatology and attention allocation in the generalized anxiety disorder. A literature search on PubMed and PsycINFO databases following PRISMA guidelines identified 4 TMS studies (one open-label study and three randomized trials with active/sham conditions) and one tDCS case report study that have applied NIBS in patients with GAD. All the studies targeted the DLPFC except one in which the parietal cortex has been stimulated. Overall, the findings would suggest that NIBS could ameliorate anxiety symptoms and that improvements remained stable in the follow-up. Although a limited number of NIBS studies has been conducted on patients with anxiety disorders, these techniques could represent promising tools for the study of neurofunctional basis of anxiety disorders. Further sham-controlled studies are needed to clarify the mechanisms of action of NIBS in order to optimize stimulation protocols and to verify their effectiveness for treating anxiety symptoms
Direct antiviral treatment of chronic hepatitis C in heart transplant recipients
No full textDirect-acting antiviral agents (DAAs) are a safe and effective treatment for chronic hepatitis C (CHC). This may be particularly valuable for patients with severe comorbidities or baseline conditions, including non-liver solid organ transplant. We report cases of two heart transplant recipients with CHC treated with DAAs (sofosbuvir and daclatasvir) achieving sustained virological response. Treatment was well tolerated and no relevant side effects were observed. The drug-drug interactions and graft function were carefully monitored
Discorso pedagogico e prospettiva sistemico-relazionale
No full textStarting with a few thoughts about the current pedagogical debate expressed within the work, the contribution of Luigi Pati, highlights the importance of relational systems perspective in the pedagogical discourse. The author proposes an analysis and historical evolution of the General Theory of Systems (TGS), illustrating the importance of the same in the action and in the educational relationship between educator and student
Sobre Luigi Ferrajoli y el constitucionalismo
No full textIn this paper, the author poses several general questions on Luigi Ferrajoli’s paper. Firstly, he writes on Ferrajoli’s construction of a theory that comprehensively infers, still always in a deductive way, the scope of a complex set of primitive terms and definitions. Secondly, the author questions his way to understand and particularly to reconstruct the so-called «constitutional paradigm». Thirdly, the author writes about Ferrajoli’s approach to the concepts of «validity» and «enforcement» of rules. Fourthly, he discusses Ferrajoli’s definition of garantist constitutionalism, particularly his conception of this sort of constitutionalism as an improvement or complement to legal positivism -inasmuch as constitutionalism respects both the being of the Law and its normative or ideal (must be) dimension. Finally, he revises the objections that Ferrajoli addressed to constitutionalism (the thesis of the separation between Law and morality, the distinction between principles and rules and the criticism of the weighting) introducing new arguments.El autor plantea una serie de objeciones al texto de Luigi Ferrajoli. En primer lugar, se refiere a la construcción por parte de Ferrajoli de una teoría que infiere de un modo exhaustivo, pero siempre deductivamente, el alcance de un complejo conjunto de términos primitivos y definiciones. En segundo lugar, el autor duda sobre la forma de ver y, sobre todo, de reconstruir el llamado «paradigma constitucional». En tercer lugar, el autor objeta el tratamiento que Ferrajoli hace de los conceptos de «validez» y «vigor» de las normas. En cuarto lugar, hace referencia a la definición que Ferrajoli realiza del constitucionalismo garantista, en concreto a la consideración de éste como mejora o complemento del positivismo jurídico que se logra gracias a que el constitucionalismo observa no sólo el «ser» sino el «deber ser» del Derecho. Finalmente, repasa las críticas que Ferrajoli realiza al constitucionalismo (la tesis de la separación entre Derecho y moral, la distinción entre principios y reglas y la crítica a la ponderación), expresando sus diferencias
Edoxaban in elderly patient with morbid obesity and atrial fibrillation: the role of plasma levels evaluation for selecting the appropriate dose
No full textWe present the case of a 80-year-old man with atrial fibrillation, morbid obesity (weight 123 kg, height 167 cm, BMI 44.1), high clearance of creatinine and pharmacological polytherapy, in which the serial determinations of edoxaban plasma levels help us to choose the appropriate dose
Six Characters in Search of an Author (Text)
No full textSix Characters in Search of an Author (Sei personaggi in cerca d’autore) is an Italian three-act play written by Luigi Pirandello in 1921, considered as one of the earliest examples of absurdist theatre. It’s a play within a play that deals with perceptions of reality and illusion, and plays with the ideas of identity and relative truths
Luigi Pirandello: In Search of an Author
No full textIn 1925 Luigi Pirandello brought his troupe to England as part of a worldwide tour. This classic program re-creates one day in London as "The Einstein of the Theater" watches his plays and, away from the footlights, confronts the paradoxical nature of his life. Portions of Six Characters in Search of an Author; Henry IV; Right You Are, If You Think You Are; and The Rules of the Game are meticulously staged, using actors' accounts, period descriptions, and Pirandello's own comments. Plus, biographical notes written by Pirandello himself provide a new angle on the inner torment that animates his work, while playwright Julian Mitchell and novelist Leonardo Sciascia critically analyze the action as it unfolds. (60 minutes, color
Organizing Chamber Music as Culture
No full textIn this paper Luigi Maria Sicca suggests on the one hand that organization theory offers an interpretation of the reality of arts producing organizations and on the other that the empirical analysis of these realities can supply new input for organization theory. As a practical example of artistic production the Author refers to an international chamber music festival. Close inspection of chamber music will reveal characteristics that apply to any type of organization. Sicca begins by looking at the nature of arts management and the arts manager. L.M.Sicca goes on to analyse the characteristics of the production process in the performing arts, which can be seen as communication taking place on three levels: between audience and performers (concept of “prosumer”); within the performing group (“listening ability”); between the author of the written text and the performer/interpreter (“concept of value”). Luigi Maria Sicca finishes by showing how in a symbolic-cultural framework the features identified in the paper can feed back into organization studies
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