163 research outputs found
Intra-Rater Reliability and Validity of Neuro-Mobinavigation: A Mobile App and Laser-Guided System of Motor HotSpot Localization
No full textBackground: Optimal transcranial magnetic stimulation (TMS) efficacy depends on precise coil placement and orientation, as even minor deviations can significantly change the excitation evoked when stimulating the primary motor cortex (M1). To compare the intra-rater reliability of a novel method for consistent TMS coil orientation over a predetermined hotspot in M1, and to benchmark its accuracy against non-navigated method. New method: A three-step method was employed. First, a laser-guided-system stabilized head position. Second, a mobile-app monitored coil tilt and orientation. Finally, coil position was marked on participant’s head cap for visual reference for both methods. Twenty-nine healthy-participants underwent six TMS blocks of 20 pulses each. Six experimental blocks, alternating between non-navigated-TMS and Neuro-Mobinavigated-TMS, to investigate the parameters of motor evoked potential (MEP). The experimental blocks were quasi-randomized with a five-minute interval. Results and comparison with existing method(s): The novel method demonstrated excellent intra-rater reliability (ICC = 0.95, 95 % CI: 0.90–0.97) compared to moderate intra-rater reliability of the non-navigated TMS (ICC = 0.73, 95 % CI: 0.57–0.85) for MEP peak amplitude. Repeated measures ANOVA for novel-method showed consistent peak amplitude across three blocks (p = 0.078), non-navigated TMS exhibited significant variations (p < 0.0001). Wilcoxon signed rank test revealed significantly higher mean peak amplitudes for the novel method (1.02 ± 0.74) compared to non-navigated TMS (0.78 ± 0.61) (p < 0.001), small effect size (r = 0.35). Conclusions: Neuro-Mobinavigation is superior to non-navigated method and provides a reliable and cost-effective alternative for MEP studies where gold standard neuronavigation is not available
Is High-Intensity Interval Training More Effective Than Moderate Continuous Training in Rehabilitation of Multiple Sclerosis: A Comprehensive Systematic Review and Meta-analysis
No full textObjectives: The present study aimed to conduct meta-analysis to determine whether the high intensity interval training (HIIT) protocol is more beneficial in improving outcome measures compared to moderate continuous training (MCT) in people with multiple sclerosis (PwMS). It also aimed to systematically review the exercise protocols differences. Data Sources: A search strategy, locating HIIT in PwMS, was executed in six databases, PubMed, EMBASE, Web of Science, Central Cochrane, Pedro, and Ovid MEDLine. Study Selection: Randomized control trials of HIIT utilizing cycle ergometer or recumbent stepper as exercise modalities were included in analysis. Intervention arms should include at least two intervention arms, including HIIT in one arm, and MCT in the other group. Data Extraction: Data extracted from each study includes the following items: basic details of the study (such as author, date of publication, location, and study design), participant characteristics (sample size, mean age, sex, mean disease duration, and extended disability status scale), specif ications of the HITT protocol (exercise modality, session duration, number of intervals/session, interval intensity, recovery intensity, recovery interval, and adverse effect), as well as primary outcomes at baseline and post-intervention (cardiorespiratory fitness, fatigue, body composition, cognitive functions, and blood biomarkers). Data Synthesis: 22 studies included in the systematic review, 11 were included in random effects model pooled analysis. There was a significant effect in favor of HIIT for VO2max of cardiorespiratory functions compared to MCT (ES=0.45 95%, CI [0.14, 0.76], P=.004), and for memory domain of cognitive functions (ES=0.34 95% CI [0.05, 0.63], P=.02). Statistical significance was not achieved for the other variables. Conclusion: HIIT and MCT yield similar results in terms of fatigue, body composition, cognitive functions, and blood biomarkers. However, VO2max of cardiorespiratory functions and memory domain of cognitive functions were in favor of HIIT protocol.No funding was received for this research
Response to Letter to the Editor: “Is High-Intensity Interval Training More Effective Than Moderate Continuous Training in Rehabilitation of Multiple Sclerosis: A Comprehensive Systematic Review and Meta-analysis”
No full texts insightful commentary on our systematic review and meta-analysis. First, because the reporting guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses that we followed during the study did not mandate the level of agreement between authors, 1 we did not include a quantitative assessment of author agreement. We acknowledge its importance for future studies to strengthen the reliability of findings. Second, the authors commented on the level of evidence supporting our results. Thus, we have implemented Grading of Recommendations , Assessment, Development, and Evaluations (GRADE) assessment to determine the level of evidence of results obtained in our review concerning the effect of high-intensity interval training versus moderate-intensity continuous training on people with multiple sclerosis. 2 We found that the level of evidence for cardiorespiratory functions was low. The evidence for fatigue and body composition domains (including lean tissue mass and fat percentage) was also low and very low, respectively. However , for all domains of cognitive functions, it was moderate. Lastly, there was low evidence regarding the effect of different exercise protocols on biomarker levels. Importantly, the level of evidence was downgraded because of participation of different multiple sclerosis phenotypes in each included study, which hinders the generalizability of the obtained results (indirectness domain of GRADE assessment). 3 In addition, there were several included studies with a small sample size, affecting the imprecision domain of GRADE assessment. Furthermore, we acknowledge the limited number of trials available. However, we ensured that this limitation was considered during protocol preparation because 2 studies are the minimum for conducting a meta-analysis. 4 Third, in our study we addressed risk-of-bias analysis by reporting the total score of each article using the Physiotherapy Evidence Database (PEDro) scale. Although a comprehensive assessment of publication bias was desirable, limitations in the number of studies included in the meta-analysis precluded the use of a funnel plot. Funnel plots are known to have limited power to detect asymmetry with <10 studies, making it difficult to distinguish true publication bias from chance findings. 5 Finally, as emphasized in the Study Limitations subsection of the Discussion section, conducting subgroup analyses based on Expanded Disability Status Scale was not feasible in our study because of insufficient data availability. 2 Additionally, most of the studies included in our review aggregated participants across the entire spectrum of Expanded Disability Status Scale scores within either the experimental or control group without accounting for the diverse disease subtypes such as relapse and remitting, primary progressive, or secondary progressive. This aggregation poses challenges for further subgroup analysis, particularly considering the lower prevalence of primary progressive and secondary progressive compared with that of remitting. The current study's conclusion is not definitive, primarily because of the limited quality of evidence stemming from the heterogeneous nature of training characteristics in high-intensity interval training and moderate-intensity continuous training across various studies. In conclusion, we are confident that our review adheres to rigorous methodology and presents relevant findings regarding the effects of different exercise modalities on individuals with MS. We appreciate the constructive feedback provided and will consider these points for future studies to enhance the quality and clarity of our work
Kitâbu'n-Nesâyih (Review-Text-Index)
No full textHâlvetî tarikatının önemli şeyhlerinden ve asıl adı Cemâleddin Mahmud olan Hulvî Cemâleddin, VXII. yüzyılın önemli mutasavvıf şairlerinden biridir. Bu çalışmada, yazarın bilinen tek nüshası olan Kitâbu’n-Nesâyih adlı eserinin incelemesi yapılmıştır.
Çalışma; Giriş, İnceleme, Metin, Dizin/Sözlük adı altında dört ana bölümden oluşmaktadır.
Giriş kısmında; dönemin Türkçesi, müellif ve eserleri, eserin içeriğinin daha iyi anlaşılması açısından da nasihat-nâmeler hakkında bilgiler verilmiştir.
İnceleme bölümünde metin; yazım, ses bilgisi ve biçim bilgisi başlıkları altında ele alınarak incelenmiştir.
Metin bölümünde Arap harfli metin transkribe edilmiştir. Metinde Arapça ve Farsça şiirler, ayet ve hadisler Arap harfleriyle yazılmıştır.
Dizin/Sözlük bölümünde metindeki kelimeler, metinde geçen anlamlarıyla verilerek alfabetik sıraya göre dizilmiş, varak ve satır numaraları verilmiştir.
Sonuç kısmında; eserde elde edilen bulgulardan bahsedilmiş ve bu doğrultuda kısa bir değerlendirme yapılmıştır.Hulvî Cemâleddin, whose real name was Cemâleddin Mahmud and one of the important sheikhs of the Halveti order, VXI. He is one of the most important Sufi poets of the 20th century. In this study, the only known copy of the author, Kitâbu'n-Nesâyih, was analyzed.
Study; Apart from the Preface, Introduction and Conclusion, it consists of three main parts under the name of Review-Text-Index/Dictionary.
In the entrance part; In order to better understand the Turkish of the period, the author and his works, and the content of the work, information is given about the advice-nâmes.
The text in the review section; are shown under the headings of spelling, phonology and morphology.
In the text section, the text in Arabic letters is transcribed. In the text, Arabic and Persian poems, verses and hadiths are written exactly in Arabic letters.
In the Index/Dictionary section, the words in the text are given with their meanings in the text, arranged in alphabetical order, and leaf and line numbers are given.
In the conclusion part; The findings obtained in the work were mentioned and a short evaluation was made in this direction
Phytoremediation ability of Helichrysum arenarium plant for Au and Ag: case study at Demirören village (Gümüşhane, Turkey)
No full textIt was investigated ability of Helichrysum arenarium plant, in phytoextraction, phytostabilization, and phytoremediation in this study. Soil and plant samples were collected from the Demirören alteration site which has the potential of gold mineralization and analyzed for gold and silver. When the results of the analysis were evaluated, it was determined that the gold and silver contents in the soil did not show compatibility with the gold and silver contents of the plants grown at the same point. It was concluded that the high gold and silver concentrations in the plants are related to the hydrothermal alteration and weathering at the point where the plants grow. For investigation of phytoremediation ability of the plant, translocation factor (TF), bio-concentration factor (BCF), and bioaccumulation factor (BAF) were calculated. The values of TF, BAF, and BCF for Ag are equal 0.33, 0.043, and 0.13 and for Au are equal 2.04, 0.59, and 0.29, respectively. So, obtained data show that Helichrysum arenarium is not appropriate for phytoextraction and phytostabilization of gold and silver in this case, but H. arenarium can be used in phyto-mining and for biogeochemical exploration of gold. Considering that the gold and silver concentrations in the developed soil in the study area are low concentrations, it is predicted that a similar study will yield satisfactory-interesting results when it is made in plants grown on the gold mineralization/enrichment areas. © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.WOS:000781884900001 ISSN2364-821
Nezihe Meriç’in eserlerinde kadın kimlikleri ve 1950’lerin kadın sorunları
No full textErenci, Deniz, Nezihe Meriç’in eserlerinde kadın kimlikleri ve 1950’lerin kadın sorunları, Yüksek Lisans Tezi, Danışman: Doç. Dr. Elif Ekin Akşit Vural, 214 s. ÖZET Cumhuriyet dönemi öykücülerinden Nezihe Meriç (1925-2008), verdiği yapıtlarda kadın sorununa gerçekçi boyutta, ciddiyetle eğilen bir yazar olması nedeniyle oldukça önemlidir. Bu tezde Nezihe Meriç’in yapıtlarından yola çıkarak 1950’li yılların kadın sorunları açığa çıkarılmaya çalışılacaktır. Tezde ayrıca Nezihe Meriç’in feminist yazınla ilişkisi irdelenmiş ve kadın kimliklerini kurgulayışı ve 1950-1960 arasında kadın sorunlarına yaklaşımı ortaya koyulmaya çalışılmıştır. Bu çalışmayı yürütürken yazarın 1950’li yıllarda verdiği yapıtlar Bozbulanık (1952), Topal Koşma (1956) adlı öykü kitapları ile Korsan Çıkmazı (1961) adlı romanı odağa alınacaktır. Ayrıca yazarın Menekşeli Bilinç (1965) adlı öykü kitabı da çalışma sırasında kullanılmıştır. Meriç, 1950 ve 1960 yılları arasındaki yapıtlarında ilk Cumhuriyet kuşağı olarak adlandırılabilecek, kentli, eğitimli kadınların bu dönemde ortaya çıkan liberal politikalara karşı gösterdikleri direnç ve çatışmayla “Cumhuriyet’in münevver kadınları” olmakla, geleneksel ataerkil yapılanma arasındaki sıkışmışlıklarını, kadınların bakış açılarından vermeye çalışmaktadır. Yazarın yapıtları incelendiğinde kadınları ve sorunlarını odağa alan, ataerkil yazın geleneğinden ayrılan, kadın dayanışmasına vurgu yapan, yer yer ataerkil düzen ve topluma yönelik eleştiriler içeren yapıtlar verdiği izlenmekle birlikte, farklı sınıflardan kadınlara olan ayrımcı yaklaşımı onu feminizmden uzaklaştırır. Bu nedenle de Nezihe Meriç’in feminist çizgiye yaklaşmakla birlikte feminist bir yazar olduğu söylenemez saptamasında bulunulmuştur. Erenci, Deniz, Woman Identities in Nezihe Meriç’s Works and The Woman Issues in 1950s, Master’s Thesis, Advisor: Assoc. Prof. Elif Ekin Akşit Vural, 214 p. ABSTRACT One of the Republic period novelists Nezihe Meriç (1925-2008), is very important due to the reason that she is an author mentioning the woman issues in realistic format and seriously in the works she has given. In the thesis herewith, starting with Nezihe Meriç’s works, the women issues in 1950s would tried to be addressed. In addition, in the thesis the relationship of Nezihe Meriç with feminist literature was examined and her fictionalizing of women characters and approach to women issues in between 1950 and 1960 were tried to get presented. While implementing this study, the works of the author in 1950s; story books named Bozbulanık (1952) and Topal Koşma (1956) and the novel with the title Korsan Çıkmazı (1961) would be focused. Moreover the story book of the author, called Menekşeli Bilinç (1965) has also been used during the study. Meriç, in her works in the period between the years 1950 and 1960, tries to display looking out of women’s perspective, together with the resistance and conflict that the educated, urban women who could be called the first Republic generation exhibit against the liberal policies arising in this period, their entrappedness in between being the “intellectual women of the Republic” and traditional patriarchal structure. As works of the author analyzed, observed besides that she has given products; focusing the women and their problems, separating apart from the patriarchal literature tradition, highlighting the women collaboration, sometimes including critics directed against patriarchal regulation and society, also her 208 discriminating approach to the women from different classes takes her far away from feminism. For that reason, the determination that even if she is coming close to the feminist line, she is indeed not a feminist author, has been construed
Akut İskemik İnmede Manyetik Duyarlılık Ağırlıklı Görüntüleme (Susceptibility Weighted İmaging, Swı) Bulgularının, Diğer Klinik ve Görüntüleme Bulgularıyla İlişkisinin İncelenmesi
No full textCertain neuroimaging signs detected in SWI and FLAIR sequences are considered to provide information about tissue perfusion and therefore can be useful in making projections regarding clinical/radiological prognosis in acute ischemic stroke. This information is especially critical for many centers in which perfusion imaging cannot be performed routinely. In this study, we aimed to investigate the prevalence of these neuroimaging signs observed on FLAIR and SWI, such as prominent cortical veins (PCV), brush sign and distal FLAIR hyperintense vessel (FHV) sign, assess their correlation with each other and determine the relationship of these signs with clinical and radiological prognosis. We therefore retrospectively analyzed a consecutive series of ischemic stroke patients with proximal MCA occlusion who underwent MR imaging within 24 hours after symptom onset. Among 50 patients who fulfilled the inclusion criteria, PCV, brush sign and FHV sign was positive in 74%, 40% and 92% of patients, respectively. PCV and FHV number were moderately, significantly correlated (r=0.421, p<0.01). In multivariate analysis PCV sign remained significantly associated with high discharge NIHSS (p=0.03) and mRS (p=0.02) scores and also with infarct growth (p=0.02). In bivariate analysis prominent deep medullary veins and associated brush sign was also associated significantly with prognostic scales and follow-up infarct volume, but this association did not persist in multivariate analysis. Prominent distal FHV was not associated with clinical or radiological prognosis. Our findings highlight the prognostic importance of SWI in ischemic stroke.Akut iskemik inmeli hastalarda SWI ve FLAIR gibi kolayca elde edilebilen MR görüntüleme sekanslarında saptanan bazı işaretlerin beynin perfüzyon durumu ve dolayısıyla klinik ve radyolojik prognoz hakkında bilgi verebileceği düşünülmektedir. Bu bilgiler özellikle perfüzyon görüntüleme yapılamayan pek çok merkez için önem taşıma potansiyeline sahiptir. Biz bu çalışmamızda SWI belirgin kortikal ven (BKV) işareti, fırça işareti ve distal FLAIR hiperintens damar (FHD) işareti gibi bazı bulguların sıklığını, birbirleriyle olan korelasyonunu ve ayrıca bu bulguların klinik ve radyolojik prognozla ilişkisini araştırmayı hedefledik. Bu amaçla kliniğimize 3 yıl boyunca proksimal orta serebral arter oklüzyonu ile başvuran ve 24 saat içinde MR görüntüleme yapılmış tüm hastaları retrospektif olarak inceledik. Çalışmaya dâhil edilme kriterlerini karşılayan 50 hastada BKV görünümü %74, fırça işareti %40, FHD işareti %92 oranında mevcuttur. BKV sayısıyla FHD sayısı orta derecede ancak istatistiksel olarak anlamlı bir korelasyon göstermekteydi (r=0,421, p<0,01). Bu işaretlerden BKV bulgusu çok değişkenli analiz sonucunda yüksek taburculuk NIHSS (p=0,03) ve mRS (p=0,02) skorlarıyla ve enfarkt büyümesiyle (p=0,02) ilişkili bulundu. Belirginleşmiş derin medüller venler ve ilişkili fırça işareti de iki değişkenli analizlerde prognostik skalalarla ve takip enfarkt hacmiyle ilişkili bulundu, ancak çok değişkenli analizlerde istatistiksel anlamlılığa ulaşmadı. Distal FHD bulgusunun belirginliği ise klinik ve radyolojik prognozla ilişkili bulunmadı. Çalışmamız SWI görüntüleme bulgularının iskemik inme hastalarındaki prognostik önemini ortaya koymaktadır
Behçet’s Disease: A Comprehensive Review on the Role of HLA-B*51, Antigen Presentation, and Inflammatory Cascade
No full textBehçet’s disease (BD) is a complex, recurring inflammatory disorder with autoinflammatory and autoimmune components. This comprehensive review aims to explore BD’s pathogenesis, focusing on established genetic factors. Studies reveal that HLA-B*51 is the primary genetic risk factor, but non-HLA genes (ERAP1, IL-10, IL23R/IL-12RB2), as well as innate immunity genes (FUT2, MICA, TLRs), also contribute. Genome-wide studies emphasize the significance of ERAP1 and HLA-I epistasis. These variants influence antigen presentation, enzymatic activity, and HLA-I peptidomes, potentially leading to distinct autoimmune responses. We conducted a systematic review of the literature to identify studies exploring the association between HLA-B*51 and BD and further highlighted the roles of innate and adaptive immunity in BD. Dysregulations in Th1/Th2 and Th17/Th1 ratios, heightened clonal cytotoxic (CD8+) T cells, and reduced T regulatory cells characterize BD’s complex immune responses. Various immune cell types (neutrophils, γδ T cells, natural killer cells) further contribute by releasing cytokines (IL-17, IL-8, GM-CSF) that enhance neutrophil activation and mediate interactions between innate and adaptive immunity. In summary, this review advances our understanding of BD pathogenesis while acknowledging the research limitations. Further exploration of genetic interactions, immune dysregulation, and immune cell roles is crucial. Future studies may unveil novel diagnostic and therapeutic strategies, offering improved management for this complex disease
An Energy Management Strategy for a Concept Battery/Ultracapacitor Electric Vehicle With Improved Battery Life
No full textVural, Bulent/0000-0001-8018-5495WOS: 000425280900017Using multi-input converters (MICs) in hybrid energy storage systems (HESSs) presents several advantages, such as low component count, control simplicity, and fully control of source energies. The power levels of sources in these systems need to be determined wisely by an energy management strategy (EMS). This paper presents an EMS for a battery/ ultracapacitor (UC) HESS including a bidirectional MIC for electric vehicles (EVs). Thanks to the fact that energy flow between battery and UC is free in this MIC, the proposed EMS not only regulates the state-of-charge of UC but also smooths the battery power profile by using a fuzzy logic controller and a rate limiter. Therefore, it results in a sustainable HESS with longer battery life. Through a simulation study and an experimental setup including a real EV, the performance of the proposed system is evaluated comprehensively. Then, based on experimental results, battery cycle-life improvement due to the battery/UC hybridization is explored.Scientific and Technological Research Council of Turkey-TUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113M088]This work was supported by The Scientific and Technological Research Council of Turkey-TUBITAK under Grant 113M088. (Corresponding author: Furkan Akar.
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