196,684 research outputs found
Meme kanseri̇ tanisiyla radyoterapi̇ uygulanan hastalarda eğİti̇mi̇n hastalarin anksi̇yetesi̇ üzeri̇ne etki̇si̇
No full textMEME KANSERİ TANSIYLA RADYOTERAPİ UYGULANAN HASTALARDA EĞİTİMİN HASTALARIN ANKSİYETESİ ÜZERİNE ETKİSİ Gül ÇANKAYA, Zerrin ÖZGEN, Bennur GÜLEĞEN, Fatma ÇIRPI, Melek Beste ATASOY Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi, Radyasyon Onkolojisi Kliniği, İstanbul Giriş-Amaç: Bu çalışmada radyoterapi (RT) sürecinde radyasyon onkologları ve meme kanseri eğitim hemşiresiyle birlikte verilen eğitim, bilgilendirilme ve takibin hastanın anksiyetesi ve depresyon skalası üzerine etkisi araştırıldı Gereç-Yöntem: Prospektif planlanan çalışmaya meme kanseri nedeniyle opere olan ve radyoterapi ( RT ) endikasyonu konulan 15 gönüllü (n =15) hasta alındı (Tablo 1). Hastalara ilk muayene sonrası çalışmanın amacı açıklanıp onam alındıktan sonra Hastane Anksiyete ve Depresyon Ölçeği (HAD) uygulandı. Ardından radyoterapi basamakları, similasyon nedir? Sol memeden opere olan hastalara derin solunum egzersi önemi nedir? Derin solunum egzersizi nasıl yapılır? Radyoterapi nasıl bir tedavidir? Radyoterapi tedavisin yan etkileri nelerdir? Radyoterapi tedavisi aldığı sürecince cilt bakımında nelere dikkat etmeli? Lenf ödem nedir? Lenf ödem nasıl önlenebilir? Kendi kendine meme muayenesi nasıl yapılır? adlı eğitimler verildi ve hastaların talebi ve ihtiyaçları doğrultusunda diyetisyen ve psikiyatri desteği almaları sağlandı. Bununla birlikte radyoterapi tedavisi süresince hastanın cildinde gelişebilecek deri reaksiyonları düzenli olarak takip edildi ve bu süreçte hastanın soruları düzenli olarak cevaplandı. Tüm planlanan eğitim ve bilgilendirilmeler sonrası çalışmada kalmayı kabul eden hastalara ikinci kez Hastane Anksiyete ve Depresyon Ölçeği (HAD) uygulandı. Bulgular: Tedavi öncesi ve sonrası hastaların HAD ölçeğinden aldığı anksiyete ve depresyon puanları Tablo 2 de belirtilmiştir. İstatistiksel analiz SSPS 24 sürümü kullanılarak Wilcoxon testi yapıldı. Hastaların eğitim ve bilgilendirme öncesi ve sonrası anksiyete ve depresyon puanlarında istatistiksel anlamlı (HAD-A p:0,001; HAD-D p:0,001) olarak azalmıştır. Başlangıçta depresyon puanı 11’in üzerinde olan 3 hastanın ikisi psikiyatrik destek almıştır. Tartışma-Sonuç: Meme kanseri nedeniyle opere olup radyoterapi uygulanan hastaların tedavileri sürecince bu konularda eğitimli hemşire tarafından düzenli olarak bilgilendirilmesi ve takip edilmesi hastaların tedaviye uyumunu artırmıştır. Aldıkları eğitimler hastalarda davranış ve duygulanım değişikliğine neden olmuştur. Bunun sonucunda hastalarda anksiyete ve depresyon skalasında istatistiksel anlamlı düşüş sağlanmıştır. Anahtar Kelimeler: Meme kanseri, radyoterapi, eğitim, hastane anksiyete ve depresyon ölçeğ
Chemogenetic tools for causal cellular and neuronal biology
No full textWOS: 000424096200008PubMed ID: 29351511Chemogenetic technologies enable selective pharmacological control of specific cell populations. An increasing number of approaches have been developed that modulate different signaling pathways. Selective pharmacological control over G protein-coupled receptor signaling, ion channel conductances, protein association, protein stability, and small molecule targeting allows modulation of cellular processes in distinct cell types. Here, we review these chemogenetic technologies and instances of their applications in complex tissues in vivo and ex vivo.European Molecular Biology Organization (EMBO) Installation Grant; Howard Hughes Medical InstituteD. Atasoy is supported by a European Molecular Biology Organization (EMBO) Installation Grant. S. M. Sternson is funded by the Howard Hughes Medical Institute
Lupus vulgaris: 30 years of experience from eastern Turkey
No full textAtasoy, Mustafa/0000-0003-1904-9878WOS: 000269538800039PubMed: 19456796
A Research on Determining the Effective Teaching Method in Teaching Idioms From French to Turkish
No full textFransızcada deyimler, dilin anlatım gücünü, zenginliğini ve güzelliğini ortaya koyan klişeleşmiş özgün sözlerdir. Fransız dilinde gündelik iletişimde çok önemli bir yeri olan deyimlerin çoğunluğu, çok ileri düzeyde Fransızca bilen yabancılar tarafından bile bilinmemektedir. Zira hala deyim öğretimi gerekli öğretim tekniklerinden yoksundur. Öte yandan, yapılan literatür taramasında, deyim öğretiminde öğrencinin merkeze alındığı güncel öğretim yöntemleri ile başarılı sonuçlar alındığı ve çoğunlukla, görsel ve videolu öğretim metodunun deyimlerin anlaşılmasını ve akılda kalıcılığı geliştirdiği belirlenmiştir. Bu çerçevede, bu çalışmada, Fransızca deyimlerin öğretiminde kullanılan düz anlatım, kısa hikâyeler ve görsellere dayalı öğretim yöntemlerinin öğrencilerin başarısında ne ölçüde etkili olduğu ve en iyi öğretim yönteminin hangisinin olduğunun araştırılarak ortaya konulması amaçlanmıştır. Bu maksatla, Marmara Üniversitesi Fransızca Mütercim ve Tercümanlık Ana Bilim Dalında öğrenim gören 26 öğrencinin katılımıyla nicel bir araştırma yapılmıştır. Araştırmada öncelikle, akademisyenlerin görüşleri esas alınarak belirlenen B2 seviyesine uygun 39 deyime ilişkin bir ön test uygulanmış ve testte bazı deyimlerde düşük sonuçlar elde edilse de öğrencilerin bireysel başarı ortalamasının % 66 olduğu görülmüştür. Daha sonra, düz anlatım, kısa hikâye ve görsel öğretim yöntemleri ile sekiz haftalık bir öğretim programı uygulanmıştır. Yapılan son testteki bulguların analizine göre, düz anlatımda % 81, kısa hikâyelerde % 74 ve görsellerde ise % 93’lik başarı oranı elde edilmiş; dolayısıyla görsellere dayalı öğretimin diğer yöntemlerden daha etkin olduğu belirlenmiştir.
Anahtar Sözcükler: Fransızca Deyimler, Öğretim Yöntemleri, Görseller, Geleneksel YöntemlerIdioms in French are clichéd unique words that reveal the expressive power, richness, and beauty of the language. Most idioms, which have a very important place in daily communication in the French language, are not known even by Turks who know French at a very advanced level. Because teaching idioms still lacks the necessary teaching techniques. On the other hand, in the literature review, it was determined that successful results were obtained with current teaching methods that focused on the student in teaching idioms, and that mostly the visual and video teaching method improved the understanding and memorability of idioms. In this context, the aim of this study is to investigate and reveal to what extent the teaching methods based on direct narration, short stories and visuals used in teaching French idioms are effective in students' success and which teaching method is the best. For this purpose, this research was conducted using the quantitative research method with the participation of 26 students studying at Marmara University French Translation and Interpreting Department. In this research, firstly, a pre-test was applied on 39 idioms suitable for B2 level, which were determined based on the opinions of academicians, and although low results were obtained in some idioms in the test, it was seen that the students' individual success average was 66%. Then, an eight-week teaching program was applied using teaching methods such as direct representation, short story and pictorial representation, and the findings obtained in the post-test were analyzed. According to the analysis of the findings in the post-test, a success rate of 81% was achieved in direct narration, 74% in short stories and 93% in visuals; therefore, it was determined that visual-based teaching was more effective than other methods.
Key Words: French Idioms, Teaching Methods, Pictorial Representation, Traditional Method
Neuroprotective effect of Myrtus communis against ionizing radiation-induced brain injury: Insights from histopathological and biochemical analysis in rats: TROD-GROG 005
No full textAim: To investigate the potential radioprotective effects of Myrtus communis on brain tissue. Methods: Thirty female rats were divided into four groups. The control group (C) was applied with oral saline solution (SF) for four days. Myrtus communis (MC) groups started to receive MC (100 mg/kg, oral) either four days before (R + preMC) or immediately after (R + MC) irradiation for four days. Irradiation was applied 10 Gy in a single fraction. All rats were sacrificed on the fourth day of irradiation. Malondialdehyde (MDA), nitric oxide (NO), and glutathione (GSH) levels, myeloperoxidase (MPO), superoxide dismutase (SOD), and tissue factor activities (TFa) were determined for biochemical analysis. Hematoxylin&Eosin staining was done for histopathological analyses, and electrophoretic analyses were performed. Results: NO, MDA, and MPO levels were higher in all irradiated groups compared with the C group. MC administration decreased NO, MDA, and MPO levels in R + preMC and R + MC groups. MC administration increased GSH levels. TFa activity decreased in R groups but did not change with MC administration compared to the C group. Radiation-induced brain tissue injury decreased, and morphologically normal neurons were observed in both MC-added groups. Conclusion: Myrtus communis has a potential neuroprotective effect on brain tissue, attributed to its antioxidative, anti-inflammatory, and anti-lipid peroxidative properties
Evaluation of Permanent Tooth Development in Pediatric Cancer Survivors: A Single Center Experience
No full textAim: Childhood cancer survival has improved significantly with advances in multimodal treatment. However, treatment-related long-term side effects, including dental developmental abnormalities, remain a concern. The aim of this study was to investigate permanent tooth development and associated risk factors in childhood cancer survivors who were treated before the age of six years, focusing on non-leukemia cases. Materials and Methods: This study was conducted on childhood cancer cases treated with chemotherapy and/or radiotherapy at a single center. Patients diagnosed before the age of six and who were twelve or above at the time of assessment were included. Dental examinations, including Decayed, Missing, Filled Teeth index and radiographic assessments, were performed. Statistical analyses were performed in order to identify associations between treatment modalities and dental findings. Results: Of 914 patients, 90 met the inclusion criteria, with 35 participating in this study. The mean age at diagnosis was four years, with a mean follow-up duration of ten years. Root shortening, hypoplasia, and hypodontia were observed to be common dental anomalies. There was a significant association between alkylating agents, vinca alkaloid plus alkylating agents and root shortening (p<0.001, p<0.001). No significant differences in dental findings were found based on gender, tumor site, or other treatment modalities (p<0.05). As the age at diagnosis increased, the risk of root shortening (p=0.026) and the frequency of hypodontia significantly increased with the duration after diagnosis (p=0.048). Conclusion: Childhood cancer survivors treated during early dentition periods are at risk of dental developmental anomalies, with alkylating agents showing the most significant impact. This emphasizes the necessity of providing these patients and their families with information on the importance of maintaining oral and dental health during and after cancer treatment
Investigating drivers influencing choice behaviour of Islamic investment products
No full textDrawing upon the theory of consumption value (TCV), this research is aimed at investigating factors influencing bank customers\u27 choice behaviour of Islamic investment products. The effects of functional value, emotional value, epistemic value, conditional value and social value on choice behaviour are examined using a questionnaire survey. A total of 350 respondents sourced from bank customers were approached to elicit their choice behaviours of Islamic investment products offered currently by various Islamic banks in Malaysia. Using the Partial Least Squares (PLS), the empirical results obtained indicate that all proposed variables are of their influence on the bank customers’ decision to opt the facility in improving their investment participation for improved well-being in their extended investment portfolios. The results obtained provide novel insights into bank customers concern regarding Islamic investment products in the context of Malaysia. The results firmly confirmed the applicability of the TCV in understanding bank customers\u27 choice behaviour to choose Islamic investment products. Several shortcomings and contributions of this study are provided
Comparison of Three Nutritional Screening Tools to Predict Malnutrition Risk and Detect Distinctions Between Tools in Cancer Patients Receiving Radiochemotherapy
No full textThe aim of this study was to compare three screening tools for malnutrition in patients with head and neck cancers or central nervous system tumors (CNS) who are undergoing radio-chemotherapy. The study evaluated 124 adult cancer patients. The Subjective Global Assessment (SGA), Mini-Nutritional Assessment (MNA), and Nutritional Risk Screening 2002 (NRS-2002) were chosen to assess the risk of malnutrition. The prevalence of patients at nutritional risk was 31% with SGA, 31% with MNA and 23% with NRS-2002 in all patients. The agreement between SGA and MNA was substantial (k = 0.886, P<0.001); the agreement between SGA and NRS-2002 was moderate (k = 0.713, P<0.001); and the agreement between MNA and NRS-2002 was also moderate (k = 0.795, P<0.001). In subgroup analysis, SGA and MNA substantially (k = 0.973, P<0.001), SGA and NRS-2002 moderately (k =0.722, P<0.001), and MNA and NRS-2002 moderately (k =0.747, P<0.001) agreed in head and neck cancer patients. In CNS tumor patients, SGA and MNA slightly (k = 0.390, P = 0.005), SGA and NRS-2002 fairly (k = 0.457, P = 0.001), and MNA and NRS-2002 substantially (k = 0.878, P<0.001) agreed. The best agreement in tools was observed between SGA with MNA in all patients. Further studies in different tumor groups will enhance our understanding of current tools for malnutrition detection of radiotherapy patient
Anxiety and depression level and body appreciation of breast cancer patients who had oncology physician and nurse led education during postoperative radiotherapy
No full textOP-02 Anxiety and depression level and body appreciation of breast cancer patients who had oncology physician and nurse led education during postoperative radiotherapy Gul Cankaya, Zerrin Ozgen, Ayse Korkmaz, Omer Yanartas, Beste Melek Atasoy Department Of Radiation Oncology Marmara University Pendik Training Hospital Istanbul Turkey INTRODUCTION: In this study, we have investigated effect of education on anxiety and depression levels and body perception of breast cancer patients during postoperative radiotherapy (RT) led by physicians and oncology nurse. MATERIAL-METHODS: Ethical approval was obtained from institutional ethical committee. In this prospective study we have enrolled 50 patients with written consent who were operated and had indication for RT (n = 50). Hospital Anxiety and Depression Scale (HAD-A1 and HAD-D1) and Body Appreciation Scale (BAS-1) were applied to patients after first examination. Then the patients had education on these topics: steps of radiotherapy, side effects and precautions, simulation, main points in simulation, deep breathing for patients operated on the left chest, significance of crunches, doing deep breathing exercise, the factors in skin care during RT, lymphedema, protection from lymphedema, making a breast self-examination, importance of inspection, importance of preventive health screenings and its intervals, importance of nutrition and activity in breast cancer. In line with the demands of patients, they had dietician and psychiatry support. However, radiotherapy skin reactions that may develop on the patient\"s skin during treatment was followed up regularly and complaints were answered. HAD (HAD-A2, HAD-D2) and BAS (BAS-2) were applied again after RT completed. RESULTS: Mean HAD-A1 was 4.9 (0 -15) SD 0.36, whereas HAD-A2 was 1.6 (0-5) SD 1.56. HAD-D1 resulted with average 3.7 (0-16) SD at 3.89 and HAD-D2 with mean 1.08 (0-5) SD 1.17. BAS-1 resulted mean 44.50 (33-50) SD 4.67 and BAS-2 with 46.68 (36-50) SD 3.74. HAD-A scores for 39 patients had decreased with only one increased and 10 remained same. Comparison of anxiety before and after treatment were made by Wilcoxon test; statistically it was found decreased significantly (p &lt;0.05). HAD-D scores of 5 patients over 11 points returned to normal in second test. While HAD-D scores of 35 patients had decrement, 3 patients had mild increase and 12 remained stable. There was a statistically significant improvement in the depression scale (p&lt;0.05). After the treatment, BAS scores had statistically significant increase (p&lt;0.05). DISCUSSION: Anxiety in 3 patients and depression in 5 patients were high but regressed to normal. BAS scores had increment. Patients having regularly information had decreased anxiety and depression scales. It has been found increase in BBS scores. CONCLUSION: HAD-A, HAD-D and BAS scales helped monitoring positive effect of information on patients on RT. Keywords: Breast cancer, Radiotherapy, Hospital anxiety depression scale, Body appreciation scale, Breast cancer education nurse
Karaci̇ğer safra kesesi̇ ve safra yolu tömürleri̇ni̇n tedavi̇si̇nde radyoterapi̇ derleme
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