101,317 research outputs found
The tree model of a meromorphic plane curve
No full textWe associate with a plane meromorphic curve f a tree model T(f) based on its contact structure. Then we give a description of the y-derivative of f (resp. the Jacobian J(f, g)) in terms of T(f) (resp. T(f, g)). We also characterize the regularity of f in terms of its tree. © 2013 Springer-Verlag Italia.Abhyankar S. S., 1977, P INT S ALG GEOM KYO, P240; Abhyankar SS, 1999, P INDIAN AS-MATH SCI, V109, P117, DOI 10.1007-BF02841532; Assi A., 1999, MATH Z, V230, P16; Assi A, 1999, CR ACAD SCI I-MATH, V329, P625, DOI 10.1016-S0764-4442(00)80013-0; Barroso ERG, 2000, P LOND MATH SOC, V81, P1, DOI 10.1112-S0024611500012430; DELAMATA FD, 1994, COMPOS MATH, V92, P327; DELAMATA FD, 1994, LOND MATH S, V201, P61; KUO TC, 1977, TOPOLOGY, V16, P299, DOI 10.1016-0040-9383(77)90037-4; Maugendre H, 1998, ANN FS TOULOUSE, V7, P497; Maugendre H., J LONDON MATH SOC, V59, P207; Merle M., 1977, INVENT MATH, V41, P299; Wall C.T.C., 2004, LMS STUDENT TEXTS, V63; Zariski O., 1973, LECT CTR MATH ECOLE0
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Advances in urothelial bladder cancer immunotherapy, dawn of a new age of treatment
No full textUrothelial bladder cancer displays a high number of somatic mutations that render these tumors more responsive to immunotherapy. Several immunotherapeutic agents were examined in patients with advanced stage urothelial bladder cancer and recently atezolizumab - an (PDL-1) immune checkpoint inhibitor antibody - was approved for the treatment of patients with metastatic disease progressing after platinum combination therapy. Despite the great success, there are still some unanswered questions and ongoing trials that are in progress to define the role of combination therapy and sequencing strategies. The objective of our manuscript is to summarize the most recent data on immunotherapy in advanced urothelial cancer. Current challenges and future perspectives of immunotherapy as a monotherapy or in combination strategies will also be analyzed
Prevalence of coincidental correctness and mitigation of its impact on fault localization
No full textThe article examines the prevalence of coincidental correctness and mitigation of its impact on fault localization. Coverage-Based Fault Localization (CBFL) techniques seek to identify failure correlated program elements using test suites in which tests are tagged as failing or passing, that is, elements that are induced by all (or most) failing runs and not induced by any (or most) passing runs; and locate the faulty code using some examination strategy. To evaluate the effectiveness of research techniques, researchers empirically quantified their accuracy in identifying CC tests in test suites involving programs with seeded faults as well as real faults. The results were promising, for example, the better performing technique, using 105 test suites and statement coverage, exhibited 9percent false negatives, 30percent false positives, and no false negatives nor false positives in 14.3percent of the test suites.Abou-Assi R., 2011, P 1 INT WORKSH TEST; Abreu R, 2009, IEEE INT CONF AUTOM, P88, DOI 10.1109-ASE.2009.25; Abreu R, 2009, J SYST SOFTWARE, V82, P1780, DOI 10.1016-j.jss.2009.06.035; Abreu R., 2006, P 12 PAC RIM INT S D, P39, DOI DOI 10.1109-PRDC.2006.18; Agrawal H., 1995, Proceedings. The Sixth International Symposium on Software Reliability Engineering (Cat. No.95TB8129), DOI 10.1109-ISSRE.1995.497652; Ammann P., 2008, INTRO SOFTWARE TESTI; Baudry B., 2006, P 28 INT C SOFTW ENG, P82, DOI 10.1145-1134285.1134299; Cadar C., 2008, P 8 USENIX C OP SYST, P209; Chen M. Y., 2002, Proceedings International Conference on Dependable Systems and Networks, DOI 10.1109-DSN.2002.1029005; Dallmeier V., 2005, P 6 INT S AUT AN DRI, P99, DOI 10.1145-1085130.1085143; Dallmeier V, 2005, LECT NOTES COMPUT SC, V3586, P528; Dickinson W, 2001, PROC INT CONF SOFTW, P339, DOI 10.1109-ICSE.2001.919107; Do HS, 2005, EMPIR SOFTW ENG, V10, P405, DOI 10.1007-s10664-005-3861-2; Han J., 2001, DATA MINING CONCEPTS, P335; Harman M, 2006, INFORM SOFTWARE TECH, V48, P549, DOI 10.1016-j.infsof.2005.06.001; Hierons RM, 2006, ACM T SOFTW ENG METH, V15, P227, DOI 10.1145-1151695.1151696; HOWDEN WE, 1982, IEEE T SOFTWARE ENG, V8, P371, DOI 10.1109-TSE.1982.235571; Jiawei H. M. K., 2001, DATA MINING CONCEPTS, P335; Jones J., 2001, P 24 INT C SOFTW ENG, P467; Jones J., 2007, P 2007 ACM SIGSOFT I, P16, DOI 10.1145-1273463.1273468; Jones J. A., 2005, P 20 IEEE ACM INT C, P273, DOI 10.1145-1101908.1101949; Korels B, 1994, P INT S SOFTW TEST A, P66, DOI 10.1145-186258.186514; Leon D., 2000, Proceedings of the 2000 International Conference on Software Engineering. ICSE 2000 the New Millennium, DOI 10.1109-ICSE.2000.870403; Leon D., 2005, P 16 IEEE INT S SOFT, P311; Liblit B, 2003, ACM SIGPLAN NOTICES, V38, P141, DOI 10.1145-780822.781148; Liblit B, 2005, ACM SIGPLAN NOTICES, V40, P15, DOI 10.1145-1064978.1065014; Liu CJ, 2006, PME CONFERENCE PROCE, P286; Liu C, 2005, SIAM PROC S, P286, DOI 10.1145-1081706.1081753; Liu C, 2006, IEEE T SOFTWARE ENG, V32, P831; Marick B., 1991, P 4 S SOFTW TEST AN, P190, DOI 10.1145-120807.120825; Masri W, 2008, EMPIR SOFTW ENG, V13, P369, DOI 10.1007-s10664-008-9071-y; Masri W, 2007, IEEE T SOFTWARE ENG, V33, P454, DOI 10.1109-TSE.2007.1020; Masri W., 2009, ACM T SOFTW ENG METH, V19, P2; Masri W, 2010, SOFTW TEST VERIF REL, V20, P121, DOI 10.1002-stvr.409; Masri W., 2009, INT WORKSH DEF LARG; Masri W., 2006, P 4 INT WORKSH DYN A; Masri W, 2008, COMPUT SECUR, V27, P176, DOI 10.1016-j.cose.2008.06.002; Masri W, 2011, J SYST SOFTWARE, V84, P1171, DOI 10.1016-j.jss.2011.02.007; Masri W., 2009, INFORM SOFTWARE TECH, V51, P395; Masri W., 2010, P 3 INT C SOFTW TEST; Masri W., 2012, P IEEE 5 INT C SOFTW, P737; Parnin C., 2011, P INT S SOFTW TEST A, P199; Podgurski A, 2003, PROC INT CONF SOFTW, P465, DOI 10.1109-ICSE.2003.1201224; Renieres M., 2003, Proceedings 18th IEEE International Conference on Automated Software Engineering; RICHARDSON DJ, 1993, IEEE T SOFTWARE ENG, V19, P533, DOI 10.1109-32.232020; Santelices R, 2009, PROC INT CONF SOFTW, P56, DOI 10.1109-ICSE.2009.5070508; Singh S., 2011, P NAT C REC TRENDS E; VOAS JM, 1993, J SYST SOFTWARE, V20, P207, DOI 10.1016-0164-1212(93)90064-5; VOAS JM, 1992, IEEE T SOFTWARE ENG, V18, P717, DOI 10.1109-32.153381; Wang X., 2009, P 31 IEEE INT C SOFT, P45; WEISER M, 1984, IEEE T SOFTWARE ENG, V10, P352; Wong E, 2008, P 1 INT C SOFTW TEST, P42; ZADEH LA, 1965, INFORM CONTROL, V8, P338, DOI 10.1016-S0019-9958(65)90241-X; Zheng A. X., 2006, P 23 INT C MACH LEAR, P1105, DOI 10.1145-1143844.1143983; Zoeteweij P., 2007, P TEST AC IND C PRAC, P89; Zoeteweij P., 2007, P 14 C WORKSH ENG CO0
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
ROLE OF ACID SPHINGOMYELINASE IN THE TUMOUR MICROENVIRONMENT
No full textDefective apoptosis represents one of the major causative factors in the development and progression of cancer. The ability of tumour cells to evade engagement of apoptosis can play a significant role in their resistance to conventional therapeutic regimens. In the last few years, preclinical and clinical studies have indicated ceramide and the enzymes of its metabolism, in particular Acid Sphingomyelinase (A-SMase) which hydrolyzes sphingomyelin to ceramide and phosphocoline, as key players in tumour physiopathology. Different cancers have been shown to have reduced ceramide levels and, of interest, in our previous work we showed that A-SMase down-regulation was a key event in melanoma progression. This event is crucial for the tumours to become more aggressive, but the mechanisms responsible of it haven’t been investigated yet.
Taking into account that there is a complex crosstalk between tumour cells and its immunological microenvironment, in this work we first investigated its possible role in A-SMase downregulation in a melanoma model.
To this purpose we performed in vivo and in vitro experiments which led us to identify tumour associate macrophages (TAM) as possible responsible of A-SMase downregulation through the Ap2-α transcription factor. Moreover, we demonstrated that these molecular changes in tumour cells give, in turn, pro-tumoural and immunosuppressive features to the surrounding microenvironment, with the recruitment of Myeloid-derived suppressor (MDSCs) cells and Regulatory T lymphocytes (TREGS). From these and our previous data, we clearly showed that the ability to create this immunosuppression together with the acquisition of a more aggressive phenotype, both depend on the naturally occurring A-SMase decrease in melanoma cells during tumour progression.
The broad role of A-SMase in tumour pathogenesis we identified, indicates that the enzyme is at the crossroad of key pathways in tumourigenesis. This aspects has clear potential in therapeutic perspective in which A-SMase overexpression or administration might be consider as an useful adjuvant for cancer therapy.
Here we demonstrated for the first time that restoring A-SMase expression in melanoma cells not only reduces tumour growth and immunosuppression, but moreover accounts for a high, unexpected recruitment of immune cells with an anti-tumoural function in the tumour microenvironment, such as Dendritic cells (DCs) and CD4+ and CD8+ T lymphocytes.
In conclusion our results reveal the central role of A-SMase expressed by melanoma cells in orchestrating the cross-talk with the surrounding microenvironment. These interactions are crucial for tumour fate, lying on its rejection or progression. Our observation that A-SMase overexpression “educate” tumour microenvironment against cancer cells, further encourage the use of this enzyme as an adjuvant for cancer therapy
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Measuring industry-science links through inventor-author relations: A profiling method
No full textIn this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
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