37 research outputs found
Interspecies Translation of Disease Networks Increases Robustness and Predictive Accuracy
Get PDF© 2011 Anvar et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Gene regulatory networks give important insights into the mechanisms underlying physiology and pathophysiology. The derivation of gene regulatory networks from high-throughput expression data via machine learning strategies is problematic as the reliability of these models is often compromised by limited and highly variable samples, heterogeneity in transcript isoforms, noise, and other artifacts. Here, we develop a novel algorithm, dubbed Dandelion, in which we construct and train intraspecies Bayesian networks that are translated and assessed on independent test sets from other species in a reiterative procedure. The interspecies disease networks are subjected to multi-layers of analysis and evaluation, leading to the identification of the most consistent relationships within the network structure. In this study, we demonstrate the performance of our algorithms on datasets from animal models of oculopharyngeal muscular dystrophy (OPMD) and patient materials. We show that the interspecies network of genes coding for the proteasome provide highly accurate predictions on gene expression levels and disease phenotype. Moreover, the cross-species translation increases the stability and robustness of these networks. Unlike existing modeling approaches, our algorithms do not require assumptions on notoriously difficult one-to-one mapping of protein orthologues or alternative transcripts and can deal with missing data. We show that the identified key components of the OPMD disease network can be confirmed in an unseen and independent disease model. This study presents a state-of-the-art strategy in constructing interspecies disease networks that provide crucial information on regulatory relationships among genes, leading to better understanding of the disease molecular mechanisms.This work was funded in part by the European Commission (PolyALA LSHM-CT-2005018675) and Muscular Dystrophy Association (68016) to SMvdM and MDA, European Community’s Seventh Framework Programme (FP7/2007–2013), ENGAGE project, grant agreement HEALTH-F4-2007-201413, and the Centre for Medical Systems Biology within the framework of the Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO)
Numerical and experimental analysis of metamaterials with quasi-zero effect for vibration isolation
No full textВОЗМОЖНОСТИ ОБОГАЩЕНИЯ НИЗКОСОРТНЫХ ФОСФОРИТОВЫХ РУД С ИСПОЛЬЗОВАНИЕМ МИКРОФЛОР АКТИВНОГО ИЛА
No full text<p><i>В работе представлены результаты исследования возможности обогащения низкосортных фосфоритовых руд с использованием микрофлор активного ила. Проводены экспериментальные работы в установке биохимической очистки по селективному растворению различных элементов в низкосортных фосфоритовых рудах Джерай-Сардаринского месторождения с использованием аэробных нейтрофильных микроорганизмов в активном иле. Показано, что интенсивное перемешивание воздуха увеличивает растворимую фракцию P2O5, CaO, MgO в азотной, фосфорной, калиевой и фосфоритовой руде, в присутствую активного ила.</i></p><p><i>Maqolada faol loyqa mikrofloralari yordamida past navli fosforit rudalarini boyitish imkoniyatlarini o'rganish natijalari keltirilgan.Jeray-Sardara konining past navli fosforit rudalarida turli elementlarni tanlab eritish bo'yicha biokimyoviy tozalashni o'rnatishda faol loyqadgi aerob neytrofil mikroorganizmlardan foydalangan holda tajriba ishlari olib borildi. Havoning intensiv aralashuvi faollashtirilgan loyqada mavjud bo'lganda azot, fosfor, kaliy va fosforit rudalarida P2O5, CaO, MgO ning eruvchan ulushini oshirishi ko'rsatilgan. Havoning intensiv aralashuvi faol loyqada mavjud bo'lganda azot, fosfor, kaliy va fosforit rudalarida P2O5, CaO, MgO ning eruvchan ulushini oshirishi ko'rsatilgan.</i></p><p><i>The paper presents the results of a study of the possibility of enriching low-grade phosphorite ores using activated sludge microflora. Experimental work was carried out in a biochemical purification installation for the selective dissolution of various elements in low-grade phosphorite ores of the Dzherai-Sardarinsky deposit using aerobic neutrophilic microorganisms in activated sludge. It has been shown that intensive air mixing increases the soluble fraction of P2O5, CaO, MgO in nitrogen, phosphorus, potassium and phosphorite ores, in the presence of activated sludge.</i></p>
Some of the Creations of Olim Otaxon Specific Characteristics
Get PDFThis article talks about a series of short stories of the writer Olim Otakhan. Some of his works are analyzed and the creative features of the author are discussed. The author's translations are also acknowledged throughout the article
THE IMAGE OF BERUNI IN THE NOVEL “IBN SINO” BY MAKSUD QORIEV
No full textThe article analyzes the interpretation of the episodic image of Beruni in the novel by Maksud Koriev “Ibn Sino”. Despite the fact that the image of Beruni in the novel is episodic, the author managed to reveal, within the limits of the novel's capabilities, his characteristic features as a historical personality and a great scientist
Les fables persanes du Anvar-E- Sohayli. <br>: Entretien avec Christine van Ruymbeke (Université de Cambridge).
No full textCorpus ARCResearcher -iranologist, teacher in persian language and literature University of Cambridge (UK) Christine Van Ruymbeke teaches Persian language and literature in the University of Cambridge (UK) at the department of Oriental Studies. In this interview Christine Van Ruymbeke speaks about her research work on the text "Anvar-i Suhayli" by the author Vaez Kashefi. This book is the third version of the famous persian fables of "Kalila and Dimna" ("Kalîla wa Dimna"). These fables, of Indian origin, have been translated first into Pahlavi, the Persian language, in the VI c., then into Arabic by Ibn al-Muqaffa in 757. In the form of the fable, tho heroes - jackals named Kalîla and Dimna relate intrigues of courtyard, give advice and issue rules of behaviour. Christine Van Ruymbeke consideres that Va' ez Kashefi, by eliminating a certain number of additions in Ibn al-Muqaffa 's version, returns to the original sources of the text. Morality disappears to make room for true lessons of political education for the use of the prince. These fables teach to how to do for keeping the power even if it means using the sliest methods. Christine Van Ruymbeke makes a link between these fables and the famous text of Machiavelli “The Prince”.Christine van Ruymbeke enseigne la langue et la littérature persanes à l’Université de Cambridge (UK) au sein du département d’études orientales.Elle s'occupe de littérature médiévale persane, et plus particulièrement de l'étude des moyens rhétoriques, des images, des techniques des poètes classiques tels Ferdusi et Nezami. Elle donne également des cours consacrés à l'art du livre en Orient islamique. Son approche tend à mettre en contexte - historique et littéraire - les grands manuscrits du monde persan. Elle évoque lors de cet entretien son travail de recherche et d’analyse du texte Anvar-E- Sohayli du poète Va'ez Kashefi. Ce livre est en fait la troisième version des fameuses fables persanes de Kalîla wa Dimna. Fables, à l’origine indiennes et traduites en arabe par Ibn al-Muqaffa' vers 750. Sous la forme voilée de la fable, les deux héros, des chacals nommés Kalîla et Dimna, relatent des intrigues de cour, donnent des conseils et édictent des règles de conduite. Pour Christine van Ruymbeke, Va'ez Kashefi, en éliminant un certain nombre d’ajouts que comptait la version d’Ibn al-Muqaffa', revient aux sources originales du texte. La morale disparaît pour faire place à de véritables leçons d’enseignement politique à l’usage du Prince. Il s’agit ici d’une réflexion profonde sur le pouvoir et la manière dont il faut l’exercer si on veut le conserver quitte à utiliser les méthodes les plus sournoises. Christine van Ruymbeke fait d’ailleurs un lien entre ces fables et le fameux texte de Machiavel Le Prince.Интервьюированное лицо Исследователь-иранолог, профессор персидского языка и литературы. Кембриджский Университет, отдел восточных исследований. (UK) Кристина ВАН РЮИМБЕКЕ занимается средневековой персидской литературой и, в особенности, изучением средств риторики, изображений, методов классических поэтов, таких как Фирдовси (персидский поэт) и Низами Генджеви (азербайджанский поэт). Она также читает лекции, посвященные искусству книги на исламском Востоке. Целью её методики является стремление поместить в исторический и литературный контекст большие рукописи персидского мира. В этом интервью Кристина Ван Рюимбеке рассказывает нам о своем исследовании и анализе текста "Анвар-и-Сугаили" поэта Ваэза Кашефи. Эта книга, фактически третья версия замечательных персидских басен о Калиле и Димне. Эти индийские басни были переведены на арабский язык Ибн аль-Мукаффой приблизительно в 750 году. Под аллегорией басни скрываются два героя - шакалы Калила и Димна, которые создают дворцовые интриги, дают советы и диктуют правила поведения. По мнению Кристины Ван Рюимбеке, Ваэз Кашефи возвращается к оригинальным источникам текста, устраняя при этом некоторые добавления, которые насчитывали версии перевода Ибн аль-Мукаффы. Тут исчезает мораль, дабы уступить место настоящим урокам политического образования Принца. Речь идет о глубоком размышлении о власти и о том, каким образом ее добиться и сохранить, используя при этом наиболее скрытные методы. Кристина Ван Рюимбеке создаёт связь между этими баснями и знаменитым текстом «Принца» Макиавелли.Sorunan şahıs Araştırmacı-iranolog, fars dili ve edebiyatı profesörü Kembric Üniversitesi doğu araştırmaları bölümü (UK) Araştırmacı-iranolog, fars dili ve edebiyatı profesörü Kristina Van Ruimbeke Kembric Üniversitesi doğu araştırmaları bölümünde fars dili ve edebiyatından ders veriyor. O ortaçağ fars edebiyatını, esas olarak klasik şairlerden olan Firdovsi (İran şairi) ve Nizaminin (Azerbaycan şairi) eserlerinde tasvir, retorik metodlarını inceliyor. Ayrıca o İslam Doğusunda kitap sanatçılığına dair seminer konuşmaları yapıyor. Onun metodunun hedefi fars dünyasının büyük el yazılarını edebi ve tarihi bağlamda yerleşdirmeğe çalışmaktır.Bu görüş zamanı Kristina Van Ruymbeke kendinin "Anwâr-i-Suhaili" ve Va'ez Kaşefi metnlerinin incelenme ve araştırmasından bahs ediyor. Bu kitap "Kelile ve Dimne" hakkında benzersiz fars fabllarının üçüncü versiyonu sayılıyor. Bu hind temsili arap diline İbnü’l Mukaffa tarafından yaklaşık 750 yılında tercüme olunmuştur. Allegori dalında yazılan eser saray munakaşaları yaratan, edeb kuralları telkin eden ve öğütler veren çakalları- eserin iki kahramanı olan Kelile ve Dimne`yi konu alıyor. Kristina Van Ruymbeke`ye göre, Va'ez Kaşefi metnin orijinal kaynağına baş vuruyor, bunula da İbnü’l Mukaffa`nın çevirisinde rastlanan bir kaç ilaveleri aradan kaldırmıştır. Burada ruh yok oluyor, o kendi yerini Prense verilen poltik eğitim derslerine verıyor. Burada iktidar hakkındaki derin düşünceyi ve bir kadar gizli metodları kullanarak onu elde etmek ve elde tutmayı konu alıyor. Kristina Van Ruymbeke bu temsille Makiaveli`nin 'Prens`inin metni arasında ilişki kurmağa çalışıyor
Les fables persanes du Anvar-E- Sohayli. <br>: Entretien avec Christine van Ruymbeke (Université de Cambridge).
No full textCorpus ARCResearcher -iranologist, teacher in persian language and literature University of Cambridge (UK) Christine Van Ruymbeke teaches Persian language and literature in the University of Cambridge (UK) at the department of Oriental Studies. In this interview Christine Van Ruymbeke speaks about her research work on the text "Anvar-i Suhayli" by the author Vaez Kashefi. This book is the third version of the famous persian fables of "Kalila and Dimna" ("Kalîla wa Dimna"). These fables, of Indian origin, have been translated first into Pahlavi, the Persian language, in the VI c., then into Arabic by Ibn al-Muqaffa in 757. In the form of the fable, tho heroes - jackals named Kalîla and Dimna relate intrigues of courtyard, give advice and issue rules of behaviour. Christine Van Ruymbeke consideres that Va' ez Kashefi, by eliminating a certain number of additions in Ibn al-Muqaffa 's version, returns to the original sources of the text. Morality disappears to make room for true lessons of political education for the use of the prince. These fables teach to how to do for keeping the power even if it means using the sliest methods. Christine Van Ruymbeke makes a link between these fables and the famous text of Machiavelli “The Prince”.Christine van Ruymbeke enseigne la langue et la littérature persanes à l’Université de Cambridge (UK) au sein du département d’études orientales.Elle s'occupe de littérature médiévale persane, et plus particulièrement de l'étude des moyens rhétoriques, des images, des techniques des poètes classiques tels Ferdusi et Nezami. Elle donne également des cours consacrés à l'art du livre en Orient islamique. Son approche tend à mettre en contexte - historique et littéraire - les grands manuscrits du monde persan. Elle évoque lors de cet entretien son travail de recherche et d’analyse du texte Anvar-E- Sohayli du poète Va'ez Kashefi. Ce livre est en fait la troisième version des fameuses fables persanes de Kalîla wa Dimna. Fables, à l’origine indiennes et traduites en arabe par Ibn al-Muqaffa' vers 750. Sous la forme voilée de la fable, les deux héros, des chacals nommés Kalîla et Dimna, relatent des intrigues de cour, donnent des conseils et édictent des règles de conduite. Pour Christine van Ruymbeke, Va'ez Kashefi, en éliminant un certain nombre d’ajouts que comptait la version d’Ibn al-Muqaffa', revient aux sources originales du texte. La morale disparaît pour faire place à de véritables leçons d’enseignement politique à l’usage du Prince. Il s’agit ici d’une réflexion profonde sur le pouvoir et la manière dont il faut l’exercer si on veut le conserver quitte à utiliser les méthodes les plus sournoises. Christine van Ruymbeke fait d’ailleurs un lien entre ces fables et le fameux texte de Machiavel Le Prince.Интервьюированное лицо Исследователь-иранолог, профессор персидского языка и литературы. Кембриджский Университет, отдел восточных исследований. (UK) Кристина ВАН РЮИМБЕКЕ занимается средневековой персидской литературой и, в особенности, изучением средств риторики, изображений, методов классических поэтов, таких как Фирдовси (персидский поэт) и Низами Генджеви (азербайджанский поэт). Она также читает лекции, посвященные искусству книги на исламском Востоке. Целью её методики является стремление поместить в исторический и литературный контекст большие рукописи персидского мира. В этом интервью Кристина Ван Рюимбеке рассказывает нам о своем исследовании и анализе текста "Анвар-и-Сугаили" поэта Ваэза Кашефи. Эта книга, фактически третья версия замечательных персидских басен о Калиле и Димне. Эти индийские басни были переведены на арабский язык Ибн аль-Мукаффой приблизительно в 750 году. Под аллегорией басни скрываются два героя - шакалы Калила и Димна, которые создают дворцовые интриги, дают советы и диктуют правила поведения. По мнению Кристины Ван Рюимбеке, Ваэз Кашефи возвращается к оригинальным источникам текста, устраняя при этом некоторые добавления, которые насчитывали версии перевода Ибн аль-Мукаффы. Тут исчезает мораль, дабы уступить место настоящим урокам политического образования Принца. Речь идет о глубоком размышлении о власти и о том, каким образом ее добиться и сохранить, используя при этом наиболее скрытные методы. Кристина Ван Рюимбеке создаёт связь между этими баснями и знаменитым текстом «Принца» Макиавелли.Sorunan şahıs Araştırmacı-iranolog, fars dili ve edebiyatı profesörü Kembric Üniversitesi doğu araştırmaları bölümü (UK) Araştırmacı-iranolog, fars dili ve edebiyatı profesörü Kristina Van Ruimbeke Kembric Üniversitesi doğu araştırmaları bölümünde fars dili ve edebiyatından ders veriyor. O ortaçağ fars edebiyatını, esas olarak klasik şairlerden olan Firdovsi (İran şairi) ve Nizaminin (Azerbaycan şairi) eserlerinde tasvir, retorik metodlarını inceliyor. Ayrıca o İslam Doğusunda kitap sanatçılığına dair seminer konuşmaları yapıyor. Onun metodunun hedefi fars dünyasının büyük el yazılarını edebi ve tarihi bağlamda yerleşdirmeğe çalışmaktır.Bu görüş zamanı Kristina Van Ruymbeke kendinin "Anwâr-i-Suhaili" ve Va'ez Kaşefi metnlerinin incelenme ve araştırmasından bahs ediyor. Bu kitap "Kelile ve Dimne" hakkında benzersiz fars fabllarının üçüncü versiyonu sayılıyor. Bu hind temsili arap diline İbnü’l Mukaffa tarafından yaklaşık 750 yılında tercüme olunmuştur. Allegori dalında yazılan eser saray munakaşaları yaratan, edeb kuralları telkin eden ve öğütler veren çakalları- eserin iki kahramanı olan Kelile ve Dimne`yi konu alıyor. Kristina Van Ruymbeke`ye göre, Va'ez Kaşefi metnin orijinal kaynağına baş vuruyor, bunula da İbnü’l Mukaffa`nın çevirisinde rastlanan bir kaç ilaveleri aradan kaldırmıştır. Burada ruh yok oluyor, o kendi yerini Prense verilen poltik eğitim derslerine verıyor. Burada iktidar hakkındaki derin düşünceyi ve bir kadar gizli metodları kullanarak onu elde etmek ve elde tutmayı konu alıyor. Kristina Van Ruymbeke bu temsille Makiaveli`nin 'Prens`inin metni arasında ilişki kurmağa çalışıyor
Corresponding Author Bayesian Network and Pest Management: A case study of trap plants on locust population
No full textABSTRACT Bayesian network approach has been effectively used in different experimental fields such as ecological decision making. There is also now growing instance of its usage and effectiveness in pest management. The fundamental principle to optimizing outcomes of agricultural products for pest management is the consideration of all chemical methods, physical methods, mechanical methods, transgenic plants, and trap plants. Some of methods have harmful environmental effects while some others are both environmental friendly and effective. Among them the use of trap plants can be one of the major approaches for pest control. The Locust is one of the most destructive pests and has unpredictable damages on agricultural products especially in poor countries where the volume of product has critical and crucial influence of human life. This research provides a case study on using Bayesian networks on the effect of a number of trap plants have on locust population, and considerations to predict and prevent the pests' harmful effects. According to the findings, the probability methods such as Bayesian networks can contribute effectively on pest management studies particularly trap plants to enhance decision making procedure in national and international perspective
The Formation of Pedagogical Culture of a Foreign Language Teacher in the System of Higher Education
Get PDFThe article is devoted to investigation of formation of pedagogical culture of a foreign language teacher in the system of higher education. The author proves that pedagogical competence is formed through the implementation of the components of the teacher’s personal qualities and professional content, which interact with each other in the educational process
Bridging Idea and Market: Implementing the CustDev Approach in Early-Stage Entrepreneurship
Get PDFIn the environment of increasing uncertainty and markets driven by innovation, early-stage startups are in dire need to cope with the gap between ideation and successful market penetration. CustDev has developed a systematic process of minimizing this uncertainty by testing assumptions with people who will be directly affected by their product. The study tests how the implementation of CustDev positively affects market validation success, strategic pivoting behavior, the firm’s presentation, and performance in Germany in 2022-2024. The author examines the interdependencies among these with secondary data in 275 startups by applying a simultaneous equation model estimated by Three-Stage Least Squares. These findings reveal that CustDev contributes greatly to market validation (β₁ = 0.48, p < 0.001) and directly to the performance of startups (δ₁ = 0.40, p < 0.001). Also, an increase in the success of validation decreases the rate of pivots (γ₂ = -0.28, p < 0.001), indicating that the customer-based development brings stability in the strategic direction. In the German startup landscape, the approach to CustDev is more systematic, and pivoting is somewhere in the middle and is facilitated by the institutional funding and mentorship.
