16 research outputs found
Spontaneous angina bullosa hemorrhagica of tongue: An unusual problem following prosthodontic procedure
No full textIntroduction: Angina Bullosa Hemorrhagica (ABH) is the term used to describe benign subepitilial oral mucosal blood filled blisters, which are not attributed to any systemic disorder. It is a very uncommon condition, mostly seen in elderly patients. The exact etiopathogenesis of the ABH is not known. Herewith, we present a case of 50-year-old male patient who developed ABH on right lateral border of the tongue, following prosthodontics impression making for completely edentulous mouth. Methods: The case management method was topical application of chlorhexidine gel (1%) and lignocaine gel (2%) with avoidance of hot and spicy food. Result and discussion: After one week in treating with topical therapy, the lesion became normal. The diagnosis of ABH is difficult in patients because of its asymptomatic nature. The early diagnosis of the lesion is very important as a rapidly expanding blood-filled bulla in the oropharynx can cause upper airway obstruction. Therefore, a high level of suspicion is warranted on part of dentists who may the first to encounter the lesion. Conclusion: Spontaneous Angina Bullosa Hemorrhagica of tongue was an unusual problem that can occur following prosthodontic procedure. The management of the lession were intended to reduce pain or discomfort and prevent secondary infections
Coronavirus Disease 2019 (COVID-19): a new challenge in untreated wastewater
No full textCOVID-19 outbreak was declared a pandemic by the WHO on 12 March 2020. As of 27 May 2020, WHO statistics exhibited that more than five million confirmed cases have been reported globally. Much remains unclear about the fate and impact of SARS-CoV-2, the novel coronavirus 2019, in wastewater. SARS-CoV-2 infection, the etiologic agent of the current COVID-19 pandemic, is followed by virus shedding in the stool. The quantification of SARS-CoV-2 in wastewater, therefore, enables monitoring of the prevalence of infections among the population through wastewater-based epidemiology. This review discusses the possible spread of the SARS-CoV-2 virus in wastewater and its impact on human health, if any. The information and resources outlined in this paper are based on recently published studies and provide information to decision-makers on the successful management of COVID-19 and reduce the risk of human exposure to COVID-19. Additionally, systems-based approaches to curtail COVID-19 spread are also discussed.The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
Efficiency and equity considerations in pricing and allocating irrigation water
No full textEconomic efficiency has to do with how much wealth a given resource base can generate. Equity has to do with how that wealth is to be distributed in society. Economic efficiency gets far more attention, in part because equity considerations involve value judgements that vary from person to person. The authors examine both the efficiency and the equity of different methods of pricing irrigation water. After describing water pricing practices in a number of countries, they evaluate their efficiency and equity. In general they find that water use is most efficient when pricing affects the demand for water. The volumetric, output, input, tiered, and two-part tariff schemes all satisfy this condition and can be efficient although whether efficiency is short-run or long-run, first- or second-best, varies. Pricing schemes that do not directly influence water input -- per-unit areas fees for example -- lead to inefficient allocation. But they are usually easier to implement and administer and require less information. The extent to which water pricing methods can effect income redistribution is limited, the authors conclude. Disparities in farm income are mainly the result of factors such as farm size and location and soil quality, but not water (or other input) prices. Pricing schemes that do not involve quantity quotas cannot be used in policies aimed at affecting income inequality. The results somewhat support the view that water prices should not be used to effect income redistribution because water prices are a poor vehicle for reducing income inequality. But pricing schemes that involve water quota rules can reduce income inequality. The authors demonstrate this with a two-rate tiered pricing scheme combined with equal quotas of the cheaper water.Water Conservation,Environmental Economics&Policies,Water and Industry,Drylands&Desertification,Economic Theory&Research,Town Water Supply and Sanitation,Water Supply and Sanitation Governance and Institutions,Water Conservation,Water and Industry,Environmental Economics&Policies
You stab my back, I'll stab yours: Management experience and perceptions of organization political behaviour
No full textThis paper reports the findings of a survey of 250 British managers, exploring
their experience and perceptions of organization politics. Political behaviour
appeared to be common. Most managers viewed political behaviour as ethical and
necessary, and aspects of organizational effectiveness, change, resourcing and
reputation were attributed to political tactics, although 80% had no training in
this area. Tactics experienced frequently included networking, using 'key
players' to support initiatives, making friends with power brokers, bending the
rules, and self-promotion. Tactics experienced as rare, but not unknown,
included misinformation, spreading rumours, and keeping 'dirt files' for
blackmail. A consistent pattern of responses concerning willingness to engage in
politics, the need to act ruthlessly and the appropriateness of reciprocity when
faced with political behaviour implies an attitude of 'you stab my back, I'll
stab yours'. Findings are discussed using an
'antecedents–behaviours–consequences' framework of perceived organization
politics to guide rese
Multi-level annotation of germline MEN1 variants of synonymous, non-synonymous and uncertain significance in Indian patients with sporadic primary hyperparathyroidism
No full textPrimary hyperthyroidism (PHPT) is third most common endocrine disorder characterized by hypercalcemia with elevated or non-suppressed parathyroid hormone levels by parathyroid tumors. Familial PHPT, as part of multiple endocrine type-1, occurs due to the germline mutation in the MEN1 gene. The involvement and the role of germline MEN1 variations in sporadic PHPT of Indian PHPT patients are unknown. Precise classifications of different types of MEN1 variations are fundamental for determining clinical relevance and diagnostic role. This prospective cohort study was performed on 82 patients with PHPT (with no clinical or history of MEN1) who underwent screening for MEN 1 variations through Sanger sequencing. Multilevel computational analysis was performed to determine the structure-function relationship of synonymous, non-synonymous, and variants of uncertain significance. Of the 82 PHPT patients, 42 (51%) had 26 germline MEN1 variants, including 8 non-synonymous, 7 synonymous, 9 Variants of uncertain significance (VUS), one-splice site, and one regulatory variation. Five most common germline variations (c.1838A\u3eG, c.1817C\u3eT, c.1525C\u3eA, c.-35A\u3eT, and c.250T\u3eC) were observed in this study. c.-35A\u3eT(5\u27UTR region) was associated with recurrence of PHPT (OR = 5.4; p = 0.04 and subsequent detection of other endocrine tumors (OR = 13.6, p = 0.035). c.1525C\u3eA was associated with multi glandular parathyroid tumor (OR = 13.6, p = 0.035). Align-GVDV, FATHMM and mutation taster analysis reported the disease-specific potential of VUS and synonymous variations. Significant linkage disequilibrium was observed in c.1785G\u3eA and c.1817C\u3eT (r(2) =0.3859, p= 0.0001), c.1475C\u3eG and c.1525C\u3eA (r(2) =0.385, p= 0.0004) and c.1569T\u3eC and c.1838A\u3eG (r(2) =0.488, p= 0.0001). The detection of MEN1 variations, especially those with disease-specific potential, can prompt early screening for other MEN1-related tumors and disease recurrence
Diverse values of nature for sustainability
No full textTwenty-five years since foundational publications on valuing ecosystem services for human well-being1,2, addressing the global biodiversity crisis3 still implies confronting barriers to incorporating nature’s diverse values into decision-making. These barriers include powerful interests supported by current norms and legal rules such as property rights, which determine whose values and which values of nature are acted on. A better understanding of how and why nature is (under)valued is more urgent than ever4. Notwithstanding agreements to incorporate nature’s values into actions, including the Kunming-Montreal Global Biodiversity Framework (GBF)5 and the UN Sustainable Development Goals6, predominant environmental and development policies still prioritize a subset of values, particularly those linked to markets, and ignore other ways people relate to and benefit from nature7. Arguably, a ‘values crisis’ underpins the intertwined crises of biodiversity loss and climate change8, pandemic emergence9 and socio-environmental injustices10. On the basis of more than 50,000 scientific publications, policy documents and Indigenous and local knowledge sources, the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES) assessed knowledge on nature’s diverse values and valuation methods to gain insights into their role in policymaking and fuller integration into decisions7,11. Applying this evidence, combinations of values-centred approaches are proposed to improve valuation and address barriers to uptake, ultimately leveraging transformative changes towards more just (that is, fair treatment of people and nature, including inter- and intragenerational equity) and sustainable futures. © 2023, The Author(s).We are grateful to the IPBES, whose 139-member states commissioned the Values Assessment and approved its Summary for Policymakers. We are also grateful for the contributions to the assessment’s review editors: S. Anderson, S. Baker, J. Camilo Cardenas, J. Cariño, K. Chan, J. Farley, C. Okereke, L. Pereira, E. Raez, H. Vessuri and R. Watson; the members of the management committee: B. Vilá, A. Díaz-de-León, C. Diaw, M. Avdibegovic, J. Marton-Lefevre and R. Allahverdiyev, and the more than 200 contributing authors who provided specific input to the full report. We express our gratitude to IPBES Executive Secretary A. Larigauderie and IPBES Chair A. M. Hernández for their strategic vision and continued advice. We received no specific funding for this work; all authors involved in IPBES do so on a voluntary basis. The IPBES Values Assessment was made possible thanks to many generous contributions, including non-earmarked contributions to the IPBES trust fund from governments. All donors are listed on the IPBES website www.ipbes.net/donors . U.P. acknowledges BC3’s Maria de Maeztu excellence accreditation 2023–2026 (reference no. CEX2021-001201-M) provided by grant no. MCIN/AEI/10.13039/501100011033
Diverse values of nature for sustainability
No full textData availability:
All the data are freely available online. The supplementary information provides links to Zenodo with specific DOIs where the data are stored for free use.Supplementary information is available online at https://static-content.springer.com/esm/art%3A10.1038%2Fs41586-023-06406-9/MediaObjects/41586_2023_6406_MOESM1_ESM.docx . The Supplementary Information includes three parts. Part A explains how the paper is associated with the IPBES Values Assessment. Part B provides details about each of the 29 review protocols. Part C offers information about the case study of Chilika Lagoon, India, that is used in the main paper.Copyright © The Author(s) 2023. Twenty-five years since foundational publications on valuing ecosystem services for human well-being1,2, addressing the global biodiversity crisis3 still implies confronting barriers to incorporating nature’s diverse values into decision-making. These barriers include powerful interests supported by current norms and legal rules such as property rights, which determine whose values and which values of nature are acted on. A better understanding of how and why nature is (under)valued is more urgent than ever4. Notwithstanding agreements to incorporate nature’s values into actions, including the Kunming-Montreal Global Biodiversity Framework (GBF)5 and the UN Sustainable Development Goals6, predominant environmental and development policies still prioritize a subset of values, particularly those linked to markets, and ignore other ways people relate to and benefit from nature7. Arguably, a ‘values crisis’ underpins the intertwined crises of biodiversity loss and climate change8, pandemic emergence9 and socio-environmental injustices10. On the basis of more than 50,000 scientific publications, policy documents and Indigenous and local knowledge sources, the Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES) assessed knowledge on nature’s diverse values and valuation methods to gain insights into their role in policymaking and fuller integration into decisions7,11. Applying this evidence, combinations of values-centred approaches are proposed to improve valuation and address barriers to uptake, ultimately leveraging transformative changes towards more just (that is, fair treatment of people and nature, including inter- and intragenerational equity) and sustainable futures.We received no specific funding for this work; all authors involved in IPBES do so on a voluntary basis. The IPBES Values Assessment was made possible thanks to many generous contributions, including non-earmarked contributions to the IPBES trust fund from governments. All donors are listed on the IPBES website www.ipbes.net/donors. U.P. acknowledges BC3’s Maria de Maeztu excellence accreditation 2023–2026 (reference no. CEX2021-001201-M) provided by grant no. MCIN/AEI/10.13039/501100011033
