84 research outputs found
Retropupillary iris-claw intraocular lens for the surgical correction of aphakia in cases with microspherophakia
No full textPurpose: This study aimed to evaluate the safety and efficacy of retropupillary fixation of an iris-claw intraocular lens (IOL; Verisyse polymethyl methacrylate IOL, Abbott Medical Optics [AMO], Netherlands) for the surgical correction of aphakia in microspherophakic eyes without sufficient capsular support. Design: This was a prospective, interventional, noncomparative case series. Methods: This interventional case series comprised 17 eyes of 9 microspherophakic patients. Retropupillary fixation of the Verisyse iris-claw IOL (AMO) was performed in all cases. The surgical time was measured. Corrected distance visual acuity, astigmatism, intraocular pressure (IOP), tissue reaction, pigment dispersion, and stability of the IOL were studied 1 day, 3 days, 1 week, 2 weeks, 1 month, and 6 months postoperatively. Results: Eight patients had familial microspherophakia and one patient had Marfan's syndrome. Eighty-two percent of the cases achieved a visual acuity of 0.3 or better. There was no significant postoperative inflammatory reaction. Transient elevation of IOP was recorded in two cases in the 1st week only. One IOL developed disengagement of one of the haptics from the iris and was successfully re-engaged. All the other IOLs were well centered and stable. The mean surgical time was 18.0 ± 4.5 min. Conclusions: Retropupillary fixation of an iris-claw IOL is a safe and effective procedure that provides early visual recovery. It is also a time-saving method for correcting aphakia in microspherophakic eyes without sufficient capsular support
Infantile hepatic hemangioendothelioma An 8-month old infant successfully treated with a corticosteroid
No full textInfantile hemangioendothelioma is a rare benign vascular tumor of the liver. We report a case of hepatic hemangioendothelioma in an 8- month-old female infant who presented with hepatomegaly and respiratory distress, which was successfully treated with oral prednisolone for six months
The Effect of Financial Inclusion on Inflation: Implications from Low and High Financially Developed Economies
No full textThis paper studies the effect of financial inclusion on inflation in high and low financially developed countries. The author utilizes country-level annual data of 83 world economies covering the period from 2004 to 2022. The Generalized Method of Moments is utilized to estimate the relationship between six financial inclusion indicators and inflation while combating the endogeneity and heteroskedasticity present in the data. Other macroeconomic variables are added to the model to limit the omitted variables bias. At a second stage, the same relationship is tested using a self-constructed financial inclusion index. The results of the study reveal that when testing the effect of the financial inclusion solely on inflation, as measured by the index, an increase in financial inclusion is associated with an increase in inflation in LFDCs whereas an increase in financial inclusion decreases inflation in HFDCs. The author’s contribution through this paper lays in tackling this specific relationship between financial inclusion and inflation that is still limited in the existing literature. Additionally, this paper studies world economies divided into LFDCs and HFDCs, not a specific country or world region. The author also develops a well-rounded measure for financial inclusion that is built upon the most relevant financial inclusion indicators used in previous studies. Lastly, the paper provides results that could be of great use for policymakers in assessing how their efforts and initiatives in the realm of financial inclusion would impact their ultimate goal, price stability
The role of Plasmodium falciparum var genes in malaria in pregnancy
No full textSequestration of Plasmodium falciparum-infected erythrocytes in the placenta is responsible for many of the harmful effects of malaria during pregnancy. Sequestration occurs as a result of parasite adhesion molecules expressed on the surface of infected erythrocytes binding to host receptors in the placenta such as chondroitin sulphate A (CSA). Identification of the parasite ligand(s) responsible for placental adhesion could lead to the development of a vaccine to induce antibodies to prevent placental sequestration. Such a vaccine would reduce the maternal anaemia and infant deaths that are associated with malaria in pregnancy. Current research indicates that the parasite ligands mediating placental adhesion may be members of the P. falciparum variant surface antigen family PfEMP1, encoded by var genes. Two relatively well-conserved subfamilies of var genes have been implicated in placental adhesion, however, their role remains controversial. This review examines the evidence for and against the involvement of var genes in placental adhesion, and considers whether the most appropriate vaccine candidates have yet been identified
Accès au crédit bancaire, développement du système informel et mobilisation de l’épargne en Afrique
No full textLa compréhension du développement du système informel d’épargne et de prêts constitue pour l’auteur un préalable à toute politique de mobilisation de l’épargne informelle par les institutions officielles dans les pays d’Afrique noire.L’article montre que c’est essentiellement l’existence de nombreuses barrières à l’accès au crédit bancaire à un moment où les populations en ont grand besoin qui, en marginalisant certains agents économiques, les pousserait à innover et à s’organiser par eux-mêmes. La défaillance et l’inadaptation concomitantes des structures officielles de collecte de l’épargne encourageraient en quelque sorte ces agents en laissant entre leurs mains de la monnaie grâce à laquelle leur organisation se développe librement. Cette organisation consistera à créer et à offrir un système avec une liaison très forte entre incitation ou contrainte à l’épargne et possibilité ou certitude d’obtenir automatiquement un prêt.L’auteur pense que le système informel constitue un système de transition devant déboucher sur des systèmes financiers homogènes ayant leur visage propre. Un soutien dont les moyens possibles sont préconisés faciliterait une telle évolution.According to the author, an understanding of development of the informal system of savings and loans must preceed all policy aimed at mobilizing informal savings by official institutions in black african countries.The article shows that it is essentially the existence of numerous barriers to bank credit (at a moment when the populations are in great need of them) that, by marginalizing some economic agents, will eventually drive them to innovate and organize themselves. The failure and concomitant inadaptation of official structures for mobilizing savings will encourage somehow these agents by allowing them to hold to the money which goes to help their organisation develop freely. This organisation will consist in creating and offering a system with a very strong link between incitation or urge to save and possibility or certitude of obtaining a loan automatically.The author thinks that the informal system constitutes a transitional system which finally leads to homogeneous financial systems having apropriate characteristics. The article proposes support for the system and envisages way of sustaining such an evolution
Treating pain in sickle cell disease by means of focused ultrasound neuromodulation (Histology images)
No full textWe have demonstrated a novel transcranial focused ultrasound technology for pain treatment, that promises to provide non-pharmacologic chronic pain treatment for patients associated with underlying conditions such as cancer or sickle cell disease (SCD).Double-blind histological analyses were conducted from HbSS-BERK sickle mice and HbAA-BERK genetic control mice in vivo. This work was supported in part by NIH EB029354, NS124564, and NS131069. Animal care and handling are according to the regulation of Institutional Animal Care and Use Committee of Carnegie Mellon University and Long Beach VA medical Centre and complied with National Institutes of Health guidelines. More information can be found in the corresponding manuscript:Kim MG*, Yu K*, Yeh C-Y, Fouda R, Argueta D, Kiven S, Ni Y, Niu X, Chen Q, Kim K, Gupta K, He B. Low-intensity transcranial focused ultrasound changes pain-associated behaviors by modulating pain processing brain circuits. bioRxiv: https://doi.org/10.1101/2022.12.07.519518 (*Equal contribution, first author)If anyone uses the whole or part of the dataset provided here, we kindly ask you to cite the above publication in any of your publications or presentations:Folders:- Double-blind histological analyses and treatment information- Histology images in HbSS-BERK sickle mice (Slide #1-#3)- Histology images in HbAA-BERK genetic control mice (Slide #4-#8)- Images for Iron and TUNEL positive control</p
Treating pain in sickle cell disease by means of focused ultrasound neuromodulation (Intracranial recordings)
No full textWe have demonstrated a novel transcranial focused ultrasound technology for pain treatment, that promises to provide non-pharmacologic chronic pain treatment for patients associated with underlying conditions such as cancer or sickle cell disease (SCD).The Intracranial recordings were conducted from 2 experimental in vivo mice. This work was supported in part by NIH EB029354, NS124564, and NS131069. Animal care and handling are according to the regulation of Institutional Animal Care and Use Committee of Carnegie Mellon University and complied with National Institutes of Health guidelines. More information can be found in the corresponding manuscript:Kim MG*, Yu K*, Yeh C-Y, Fouda R, Argueta D, Kiven S, Ni Y, Niu X, Chen Q, Kim K, Gupta K, He B. Low-intensity transcranial focused ultrasound changes pain-associated behaviors by modulating pain processing brain circuits. bioRxiv: https://doi.org/10.1101/2022.12.07.519518 (*Equal contribution, first author)If anyone uses the whole or part of the dataset provided here, we kindly ask you to cite the above publication in any of your publications or presentations:</p
Treating pain in sickle cell disease by means of focused ultrasound neuromodulation (Behavior assessments and analyses)
No full textWe have demonstrated a novel transcranial focused ultrasound technology for pain treatment, that promises to provide non-pharmacologic chronic pain treatment for patients associated with underlying conditions such as cancer or sickle cell disease (SCD).The behavioral assessment with analysis were conducted from 114 experimental in vivo mice. This work was supported in part by NIH EB029354, NS124564, and NS131069. Animal care and handling are according to the regulation of Institutional Animal Care and Use Committee of Carnegie Mellon University and Long Beach VA medical Centre and complied with National Institutes of Health guidelines. More information can be found in the corresponding manuscript:Kim MG*, Yu K*, Yeh C-Y, Fouda R, Argueta D, Kiven S, Ni Y, Niu X, Chen Q, Kim K, Gupta K, He B. Low-intensity transcranial focused ultrasound changes pain-associated behaviors by modulating pain processing brain circuits. bioRxiv: https://doi.org/10.1101/2022.12.07.519518 (*Equal contribution, first author)If anyone uses the whole or part of the dataset provided here, we kindly ask you to cite the above publication in any of your publications or presentations:Folders:- Hot-plate test blind assessment and summary- Cold-plate test blind assessment and summary- von Frey test blind assessment and summary- Rotarod test blind assessment and summary</p
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