395 research outputs found
Japanese Encephalitis Virus Latency Following Congenital Infection in Mice
Get PDFLatent Japanese encephalitis virus (JEV) infection was shown in inapparently congenitally infected Swiss albino mice after their mothers had been given JEV intraperitoneally during pregnancy. Only one of 37 (2-7%) of the baby mice showed persistence of infectious virus at 5 weeks of age. Reactivation of JEV in Swiss albino mice was demonstrated by stimulation with allogeneic spleen cells from Parks strain mice at 21 weeks of age; reactivation was demonstrated in 41 % of the inapparently infected mice. The spleen cells of congenitally infected mice had depressed [3H]thymidine uptake following stimulation with concanavalin A, and depressed ability to induce a graft-versus-host response. A persistent infection followed by a latent infection with Japanese encephalitis virus (JEV) has been observed in Swiss albino mice (Mathur et al., 1982). The latent virus could be activated by giving cyclophosphamide even 1 year after infection (Mathur et al., 1986). Abortion or congenital infection can occur when mice are infected with JEV during pregnancy (Mathur et al., 1981; Sugamata & Miura, 1982) and similar effects of JEV infection have been observed at different periods of gestation in human cases (Chaturvedi et al., 1980; Mathur et al., 1985)
Book Ends & Odd Books : Publications Refuting Conventional Form from the Banff Centre Library Collection
No full textMathur explains how he "unselected" nearly 200 works for this exhibition of unconventional publications by international artists and authors, recognizing the influence of Ulises Carrion's article "The New Art of Making Books." The author reflects upon the roles of language and poetics, the distinction between book and text, and how politics and power affect the making and reception of these works. 2 bibl. ref
Book review: paper tiger: law, bureaucracy and the developmental state in Himalayan India by Nayanika Mathur
Get PDFFollowing eighteen months of intensive fieldwork, in Paper Tiger: Law, Bureaucracy and the Developmental State in Himalayan India author Nayanika Mathur details the everyday absurdities of bureaucracy in the Himalayan borderlands, showing the frequent gulf between ‘real life’ and the abstract workings of the law. Elisabetta Iob highly recommends this accessible, witty and vividly written book as an outstanding and essential example of ethnographic research
FINANCING COMMUNITY FACILITIES: A CASE STUDY OF THE PARKS AND RECREATIONAL GENERAL OBLIGATION BOND MEASURE OF SAN JOSE, CALIFORNIA
Get PDFThis study of the City of San Jose’s Parks and Recreation General Obligation (GO) Bond Measure seeks to identify the politics-, management-, and planning-related lessons learned by the City as it developed its community facilities using the GO bonds proceeds. The study finds that these lessons include: be conservative in what you promise the residents; be prepared for changes in economic environment by identifying supplementary funding sources should the primary source not yield adequate funds; make sure that the jurisdiction is organizationally capable of handling the increased workload; and prepare detailed project plans prior to the bond issuance.Community Infrastructure and Services; Municipal Bonds; Public Finance
An Analytical Criterion for Centrifugal Instability in Non-Axisymmetric Vortices
No full textNon-axisymmetric vortices are ubiquitous in nature; examples include polar vortices in planets, the giant red spot in Jupiter, tornadoes and cyclones on Earth, mesoscale eddies in the ocean. Turbulent flows are furthermore known to be dominated by small- and large-scale vortex structures. Owing to the wide range of applications, knowledge of conditions under which a given vortex becomes unstable is beneficial. Here, the centrifugal instability of two-dimensional, non-axisymmetric vortices in the presence of an axial flow and a background rotation is studied using the local stability approach. The local stability approach, based on geometric optics and similar in formulation to the rapid distortion theory \cite{bib:godeferd2001}, considers the evolution of shortwavelength perturbations along streamlines in the base flow. This approach, developed by Lifschitz Hameiri \cite{bib:lifschitz1991}, is particularly useful for base flows for which a global stability analysis is computationally expensive. A sufficient criterion for centrifugal instability in an axisymmetric vortex with and is first derived by analytically solving the local stability equations for wave vectors that are periodic upon evolution around a closed streamline. This criterion is then heuristically extended to non-axisymmetric vortices and written in terms of integral quantities on a streamline. The criterion is then shown to be accurate in describing centrifugal instability over a reasonably large range of parameters that specify Stuart vortices and Taylor-Green vortices
Immune Response to Japanese Encephalitis Virus in Mother Mice and their Congenitally Infected Offspring
Get PDFThe immune response to Japanese ncephalitis virus (JEV) was assessed in JEV-infected mice (mothers) and their offspring. The congenitally infected baby mice responded poorly in all assays for cell-mediated immunity. The total number of their splenic cells remained unaltered but the percentage of T cells was significantly reduced; a depressed elayed hypersensitivity response was seen against both homologous (JEV) and heterologous (sheep erythrocytes) antigens. In addition, significantly higher leukocyte migration inhibition (LM]) of spleen cells in the presence of specific antigen was observed. Adult mice infected during pregnancy demonstrated animpaired elayed hypersensitivity response to JEV antigen only. LMI was positive in mothers at 2 weeks post-partum, but not at later periods. During studies on the transplacental transmission of Japanese ncephalitis virus (JEV) in mice, we have shown persistence of the virus in thymus and brown fat for up to 17 weeks after infection and its reactivation during a consecutive pregnancy in spite of the presence of maternal antibodies (Mathur et al., 1982). Persistent infections can be produced by failure of the host's defence mechanism to eliminate invading viruses; on the other hand, viruses may develo
Introduction of suppressor T cells in vitro in Japanese encephalitis virus infection
No full textGeneration of suppressor cells to Japanese encephalitis virus (JEV) in vitro have been demonstrated. The suppressor cells were effective in mediating the suppression of the CMI and humora) response as assayed by DTH or direct antibody plaque forming cells (IgM PFC). The suppressor cells for IgM PFC were Thyl, 2 and Lyl-2+ and for DTH Thyl. 2 and Lyl+2-. These suppression. The suppressor factors was found to be genetically restricted in its activity and to act at the effector phase of immune response
An Interactive Dialogue for the Creation, Maintenance and Querying of a Data Base Representative of the Anatomy of an Administrative System
Get PDFTitle: An Interactive Dialogue for the Creation, Maintenance and Querying of a Data Base Representative of the Anatomy of an Administrative System, Author: Pratima Mathur, Location: ThodeThe logical structure of a database is given, and is
representative of the anatomy of an administrative system,
and of the personnel organization by which it is operated.
This project will adopt an appropriate host computer,
terminal, and physical representation of the database, for
the main purpose of developing a user-terminal dialogue by
which the database can be created and maintained. The
dialogue should be as easy and flexible to use by an audit
analyst as is possible, while at the same time imposing a
systematic and disciplined approach to the task.ThesisMaster of Science (MS
Uncovering a novel role for FXR-SHP axis in liver physiology, diseases and beyond
Get PDFLiver performs a multitude of functions ranging from detoxification, metabolism and digestion. To execute these tasks, one of the mechanisms that the liver utilizes is nuclear receptor signaling, which in turn can transcriptionally regulate gene networks. My doctoral thesis focuses on studying the role of two nuclear receptors, FXR and SHP in maintaining liver function. Farnesoid X Receptor (FXR) and Small Heterodimer Partner (SHP) are well-known regulators of glucose, fat and bile acid homeostasis. Here, I uncover novel roles for FXR-SHP axis not only in the liver but also in extrahepatic organs, like heart. In Chapter 2, I discuss how hepatic loss of FXR and SHP results in increased glycosylation of liver proteins and structural defects in Golgi apparatus, and ultimately liver cancer. Chapter 3 focuses on comprehending how FXR-SHP ablation results in increased drug metabolic capacity of the liver. Finally, chapter 4 discusses how liver dysfunction, caused by loss of FXR and SHP, can induce metabolic and functional defects in heart. Taken together, these projects will help understand some of the FXR and SHP transcriptional networks under different physiological and pathological contexts and may open avenues for pharmacological manipulation to treat various diseases.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2021-08-01The student, Bhoomika Mathur, accepted the attached license on 2019-07-04 at 01:18.The student, Bhoomika Mathur, submitted this Dissertation for approval on 2019-07-04 at 01:31.This Dissertation was approved for publication on 2019-07-09 at 15:41.DSpace SAF Submission Ingestion Package generated from Vireo submission #14170 on 2019-11-26 at 13:04:27Made available in DSpace on 2019-11-26T20:49:21Z (GMT). No. of bitstreams: 3
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Preface to the 18th annual ASHA-NIH research symposium: Neurobiological determinants of communication development
Get PDFNeurobiological studies of the mammalian brain in health and disease have contributed greatly towards an improved understanding of the maturation-dependent vulnerability of the late preterm brain, the plasticity of the immature nervous system, and the evolution of specialized mechanisms for a communication or ‘language-ready’ neural substrate. Advances in developmental neurobiology have important implications for speech-language pathologists and audiologists working with neonates who, by virtue of their prematurity, are at risk for developmental disabilities. The extra-uterine environment during this critical period (24–40 weeks gestation) in brain development has a profound and long lasting impact on the premature infant. Prior barriers to research on very young children and infants have recently been overcome with the development of non-invasive techniques for neuroimaging and recording biological events. Researchers from a variety of disciplines are now using these techniques to derive knowledge about early communication development, and to evaluate the efficacy of treatments designed to facilitate early communication and feeding development. The 18th annual research symposium, co-sponsored by the American Speech-Language-Hearing Association (ASHA) and the National Institutes of Health (NIH-NIDCD), was convened on November 21st, 2008 in Chicago, Illinois. The title of this day-long symposium was Neurobiological Determinants of Communication Development, with a special focus on prematurity, developing brain, plasticity, early childhood, and neurodevelopmental outcome. This meeting provided ASHA attendees with a showcase of innovative methods for early detection of brain and behavioral anomalies in the premature infant, introduced translational research on mechanisms of plasticity to improve auditory function, and considered evidence on the specialized nature of mirror neuron brain systems to support the acquisition of language. This symposium featured four internationally recognized scholars including Amit Mathur, MD (Washington University), Ira Adams-Chapman, MD (Emory University), Michael Arbib, PhD (University of Southern California), and Anu Sharma, PhD (University of Colorado). The symposium also included a special session that featured the work of the following four early-career scientists whose research focuses on neurobiologic aspects of communication development: Meredith Estep, ABD (University of Kansas), Ignatius Nip, PhD (San Diego State University), Jayanthi Sasisekaran, PhD (University of Minnesota), and Ronald LeBel, ABD (University of Colorado)
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