1,246 research outputs found
Heritability and Linkage Analysis of Appendicitis Utilizing Age at Onset
No full textAppendicitis usually afflicts the young, but there is a large tail in the distribution of onset age. The genetics of this disease are still not well understood. A heritability analysis and genome wide linkage analysis of a large twin dataset was undertaken. Treating age of onset of appendicitis as a censored survival trait revealed a heritability of 0.21, and found evidence of linkage to Chromosome 1p37.3. Author(s): Christopher Oldmeadow 1 * | Kerrie Mengersen 2 | Nicholas Martin 3 | David L. Duffy
Matt Christopher Papers - Accession 1309
No full textThe collection includes letters written by the children’s book author, Matt Christopher, to his son, Marty Christopher. Many of the letters also contain newspaper articles of interest to Matt Christopher, which deal with local sports teams, his writing career, his participation in an exhibition baseball game against the New York Giants in 1938, and other of general interest. Most of the letters are personal in nature, however, a majority of the letters delve into Matt Christopher’s writing career, personal interests, the author’s health, as well as his family life.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/2649/thumbnail.jp
Matt Christopher Papers - Accession 1221
No full textMatt Christopher (1917-1997) was a prolific author of children’s books having written over 100 books as well as over 300 short stories, articles, poems, and screenplays. Most of his writings dealt with sports themes, but he also wrote fantasy and mystery themed stories as well. The Matt Christopher Papers consist of both published and unpublished manuscripts, articles, and short stories. Also included are personal and business correspondence, biographical information, scrapbooks, photographs, and memorabilia.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/1976/thumbnail.jp
Book review: Kobrak, Christopher and Martin, Joe, From Wall Street to Bay Street: the origins and evolution of American and Canadian finance
No full textThis is the author accepted manuscript. the final version is available from Wiley via the DOI in this recordBook review of Kobrak, Christopher and Martin, Joe, From Wall Street to Bay Street: the origins and evolution of American and Canadian finance ( Toronto: University of Toronto Press, 2018. Pp. 416. ISBN 9781442648210
A Study of Selected Clarinet Works by Christopher Caliendo
No full textabstract: Christopher Caliendo is a guitarist/composer who has written for a variety of performance mediums. His works been performed on international concert stages and recorded for film and television media. His compositions have garnered him the Henry Mancini Award for Film Composition, the Artin Arslanian Scholarship for Humanities, and the Peabody Grant for Scholarship. He has also received two commissions from the Vatican in 1992 and 1995. In 1988, he received an Emmy nomination for his work with the television series Paradise. The purpose of this project is to present a study of selected clarinet works by Christopher Caliendo: The Tango Concerto No. 1 is a three-movement work that Caliendo arranged for clarinet and piano in 2010, The Little Gypsy was written for solo clarinet, and Jal, Ven a mis Brazos, Amanacer, La Milonga, Acariciame, Amor Perdido, Caliente, Impulso, and Passione comprise a series of nine guitar/clarinet duos that were composed or arranged between 2009 and 2010. The document is comprised of a brief description of the career and compositions of Christopher Caliendo, a performer's guide to the selected works, a track listing for the performance recording, and a list of Caliendo's other clarinet and chamber music compositions that are intended for the concert stage. It is the hope of the author that this project can generate more interest in Christopher Caliendo's clarinet repertoire throughout the clarinet community.Dissertation/ThesisD.M.A. Music 201
Predictive QSAR modeling of compounds inhibiting cytochrome P450 3A4-mediated metabolism of testosterone and 7-benzyloxy-4-trifluoromethylcoumarin
No full textEnzymes in the cytochrome P450 family are responsible for much of the first-pass metabolism of xenobiotic compounds. Within this family, the hepatic 3A4 isoform (CYP3A4) is responsible for the first-pass metabolism of over half of the drug compounds currently on the market. This substrate promiscuity increases the risk of dangerous drug-drug interactions (DDIs), in which a drug compound inhibits the metabolism of other compounds by CYP3A4, leading to drug inactivity or the accumulation of the non-metabolized drug in the body. These risks have led to numerous quantitative structure-activity relationship (QSAR) and SAR studies of CYP3A4 inhibitors to determine the structural characteristics common to inhibitor compounds. Evidence of multiple binding pockets necessitates the use of a variety of probe substrates, resulting in different. From the published literature and patents, we collected compounds with inhibition data against CYP3A4, using either 7-benzyloxy-4-trifluoromethylcoumarin (BFC) or testosterone (TST) as the probe substrate and measuring inhibition as –log10(IC50) (pIC50). We then developed QSAR models using two descriptor selection methods (random forest and genetic algorithm-k nearest neighbors (GA-kNN) and two descriptor sets (MOE and Dragon). The resulting eight models were validated via five-fold cross validation and external validation. While the cross-validation results are good for all models, most models had low external predictivity. By analyzing the models with the best external predictivity (those using Dragon descriptors and GA-kNN descriptor selection), we found several atom-type and P-VSA-like descriptors that showed a sizable difference in importance between the models from the BFC and TST data. These descriptors reflect studies from prior QSAR studies on characteristics of CYP3A4 inhibitors. Results from this study could be used to account for differences in in vitro inhibition screens using multiple probe substrates.M.S.Includes bibliographical referencesby Christopher Mayer-Baco
EVERY GENUS ONE ALGEBRAICALLY SLICE KNOT IS 1-SOLVABLE
No full textCochran, Orr, and Teichner developed a filtration of the knot concordance group indexed by half integers called the solvable filtration. Its terms are denoted by F-n. It has been shown that F-n/F-n.5 is a very large group for n >= 0. For a generalization to the setting of links the third author showed that F-n.5/Fn+1 is non-trivial. In this paper we provide evidence for knots F-0.5 = F-1. In particular we prove that every genus 1 algebraically slice knot is 1-solvable.
Nonanadromous Life History Diversity of Rainbow Trout (Oncorhynchus mykiss)
No full textThesis (Ph.D.)--University of Washington, 2019Rainbow trout (Oncorhynchus mykiss) is a salmonid species, native to Pacific Ocean drainages in North America and eastern Russia, which exhibits fluvial (stream-resident), adfluvial (lake-migrant), and anadromous (ocean-migrant) ecotypes. The differentiation of fluvial and anadromous individuals in sympatry is well-studied, whereas comparatively little research has focused on the adfluvial form and its distinction from fluvial individuals in sympatry. Thus, the purpose of this dissertation was to investigate the ecological, genetic, and phenotypic diversity of nonanadromous rainbow trout in a natural stream-lake system to better understand the differentiation of fluvial and adfluvial individuals in sympatry, the basis of residency versus migration in this species, and the role of lakes in salmonid diversification. Rainbow trout were sampled in the lake (thus, by definition, adfluvial) and in several tributary streams (where adfluvial and fluvial individuals may co-occur), and were examined for a variety of features to develop a holistic understanding of the behavior, ecology, and evolution of these life history pathways. Stomach contents and stable isotopes revealed disparate trophic ecology among rainbow trout in connected stream and lake habitats, suggesting both an ontogenetic shift in the diet of adfluvial fish as well as divergence in diet between adfluvial and fluvial ecotypes. Rainbow trout in streams fed primarily on aquatic insects, while those in the lake largely consumed snails and amphipods; however, partial trophic convergence among trout in these two habitats occurred when they incorporated the marine nutrient subsidy of spawning sockeye salmon eggs. Stable isotope data suggested that the minimum size of migration from stream to lake habitat by adfluvial fish was ~150 mm fork length, suggesting a juvenile stream-rearing period of a year or more prior to lake entry. Dietary niche comparisons with sympatric Salvelinus species suggested a greater degree of dietary overlap between rainbow trout and Dolly Varden (S. malma) in streams than between rainbow trout and Arctic char (S. alpinus) in the lake, which may increase the relative fitness benefits of migration over residency for rainbow trout. Restriction site-associated DNA sequencing revealed an association between habitat type (stream or lake) and a chromosomal inversion in the rainbow trout genome as well as numerous single nucleotide polymorphisms, supporting the genetic divergence of adfluvial and fluvial ecotypes in sympatry. Rainbow trout in streams were nearly fixed for the rearranged haplotype of the Omy05 inversion, whereas trout in the lake exhibited a markedly higher frequency of the ancestral, anadromy-associated haplotype. The functions of outlier genes with nonsynonymous mutations among stream- and lake-caught trout paralleled those documented in studies of fluvial and anadromous O. mykiss, highlighting the migratory nature of the adfluvial ecotype even though it is nonanadromous. Structure was present at both non-outlier and outlier loci among and within streams supporting populations nearly fixed for the rearranged Omy05 haplotype (i.e., with a genetic predisposition for stream-residency), highlighting the roles of local adaptation and genetic drift via spatial isolation in population divergence. Assessment of lateral coloration patterns and multivariate analyses of body shape of rainbow trout from stream and lake habitats over a range of body sizes revealed ontogenetic and ecotypic variation in coloration and morphology. Color differences among trout of different size classes and habitats indicated ecotype-specific pathways resulting in different terminal coloration patterns; banded parr in streams transitioned to either a silver coloration suited to pelagic waters in the lake (when adfluvial) or bronze coloration suited to confined cover in streams (when fluvial). The morphology of lake-caught rainbow trout was distinct from that of stream-caught trout, and their morphological differentiation exhibited many shared but some unique patterns compared to sympatric Dolly Varden in streams and Arctic char in the lake. Patterns of morphological variation in rainbow trout among and within habitats suggested the presence of partial migration, in which both fluvial and adfluvial individuals are produced from the same population. A review of the spawning behaviors, rearing strategies, and trophic polymorphisms in lakes among 16 species of salmonids from the genera Oncorhynchus, Salmo, and Salvelinus identified a negative association between the extent of reliance on lakes and the degree of anadromy. Oncorhynchus exhibits the least lake reliance, Salmo an intermediate level, and Salvelinus the greatest; opposite of the anadromy spectrum identified in previous studies. Lakes support life history forms, reproductive ecotypes, and trophic morphs unique to lacustrine habitat, and also support anadromous and fluvial salmonids by providing spawning, rearing, overwintering, and/or summer refuge habitat. Adfluvial and anadromous salmonids exhibit similar migration-associated traits and behaviors including the parr-smolt transformation, sex-biased partial migration, and the presence of precocious ‘jack’ males
The Catholic Imagination in Martin Scorsese\u27s The Last Waltz
No full textThe author examines Martin Scorsese\u27s rockumentary The Last Waltz of 1978 as an encounter between the communitarian focus of the Catholic imagination (cf. Greeley Catholic Imagination) and the more individualistic ethos dominant in contemporary society (cf. Taylor Ethics of Authenticity). He claims the encounter not only shapes Scorsese\u27s fiction films but also exhibit\u27s his notion of the filmmaker\u27s mission. The subject matter of the film lends itself to this examination because a rock band balances between the individuality of its performers and the communality of its form. Moreover, overt religious values and themes of the film are explored in relation to the above questions
Trophic ecology of nonanadromous rainbow trout in a post-glacial lake system: partial convergence of adfluvial and fluvial forms
No full textThe rainbow trout (Oncorhynchus mykiss Walbaum, 1792) is one of many salmonid species exhibiting a gradient of life histories including fluvial (stream-resident), anadromous (ocean-migrant), and adfluvial (lake-migrant) forms, the last of which is less extensively studied than the other two. Our goal was to determine the extent of diet segregation between fluvial and adfluvial rainbow trout. We collected stomach content and stable isotope data on rainbow trout sampled in stream and lake habitats in a southwestern Alaska watershed during summer, and compared them to data on sympatric stream- and lake-specialist char species (Salvelinus malma Walbaum, 1792 and S. alpinus Linnaeus, 1758, respectively). Rainbow trout in streams fed largely on aquatic insects while those in the lake ate primarily benthic snails and amphipods. The trophic segregation of stream-resident and lake-migrant rainbow trout mirrored but was less extreme than the divergence of lotic Dolly Varden (S. malma) and lentic Arctic char (S. alpinus) in the same system. Spawning sockeye salmon (Oncorhynchus nerka Walbaum, 1792) provided a nutrient subsidy in the form of eggs that supported rainbow trout in both stream and lake (littoral) habitats, causing their isotopic signatures to converge. This study augments knowledge of partial migration and trophic divergence within populations.The presentation of the authors' names and (or) special characters in the title of the pdf file of the accepted manuscript may differ slightly from what is displayed on the item page. The information in the pdf file of the accepted manuscript reflects the original submission by the author
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