133,575 research outputs found
[Pubblicità del liquore Arnaldi di Milano]
No full textImmagine incorniciata. Illustrazione al centro in alto. In basso didascalia: “L’asma e la bronchite cronica si guariscono radicalmente col liquore Arnaldi in tutte le buone farmacie.” A sinistra “D. Coen e C. Milano Parigi”. Sotto alla immagine, all’interno della cornice, didascalia: “Asmatici. Prima di intraprendere una cura che non vi sia stata prescritta dal medico, vi consigliamo di chiederci l’interessante opuscolo l’Asma bronchiale e Nervoso, del Dott. C. Salterini, ex-assistente alla Clinica di Parigi, e di informarvi presso i medici, i nostri guariti ed i farmacisti dell’efficicacia del celebre Liquore Arnaldi di Milano. Così facendo vi risparmiereste molte disillusioni. Premiato Stabilimento Carlo Arnaldi di A. Repetto, viale Abruzzi, 57 – Milano.Pubblicità del Liquore Arnaldi di Milano, in cui si riutilizza un manifesto che rappresenta un orso bianco in un paesaggio polare, affiancato da due quinte, a sinistra un paesaggio innevato alpino, a destra un paesaggio desertico con piramidi sullo sfondo, carovana e palme. L’orso si appoggia e abbraccia il prodotto, una bottiglia di Liquore Arnaldi.ope
Brain atrophy in idiopathic REM sleep behaviour disorder is a sign of incipient synucleinopathy
No full textThis scientific commentary refers to ‘Brain atrophy in prodromal synucleinopathy is shaped by structural connectivity and gene expression’ by Rahayel et al. (https://doi.org/10.1093/brain/awac187).</jats:p
Beyond HAT: Harnessing TBADT for photocatalyzed C(sp3)-C(sp3) Bond Formation through Reductive SET
No full textBone metabolism and mass in women with Cushing's syndrome and adrenal incidentaloma.
No full textAbstract
OBJECTIVE:
The aim of this study was to compare bone turnover and mass in women with either Cushing's syndrome (CS) or adrenal incidentaloma (AI), which is a possible model for minimal hypersecretion of cortisol.
DESIGN AND PATIENTS:
We studied 15 patients with CS (seven premenopausal and eight postmenopausal women); 23 patients with AI (five premenopausal and 18 postmenopausal women) and 20 matched controls (seven premenopausal and 13 postmenopausal women). Alkaline phosphatase (ALP), bone alkaline phosphatase (bALP), osteocalcin (BGP), 24-h urinary pyridinoline (Pyr) and deoxypyridinoline (D-Pyr) and serum and 24-h urinary calcium and phosphorus were determined in all subjects. Bone mineral density (BMD) at lumbar spine and proximal femur was measured by dual energy X-ray absorptiometry (DEXA).
RESULTS:
We found a significant reduction of BGP and serum phosphorus in CS and AI (P < 0.05) vs. controls and significantly lower levels of Pyr only in CS (P < 0.05) vs. AI and controls. Spinal and femoral BMD z-values were significantly lower (P < 0.05) in patients with CS (z-score: lumbar spine -1.44 +/- 1.5 and femoral neck -1.07 +/- 1; mean +/- SD) compared to AI and controls.
CONCLUSIONS:
Our data show that hypercortisolism reduces osteoblastic function and bone resorption and that osteocalcin can contribute to the precocious diagnosis of silent glucocorticoid excess. Patients with active CS were found to have lower BMD, particularly at vertebral level
Nanotechnology, uncertainty and regulation. A guest editorial
No full textNanotechnology has been established as a priority research and policy focus, cutting across several R&D fields from pharmaceutics, food and electronics. The raise of nanotechnologies has been accompanied by an enduring uncertainty characterising the developments of the scientific knowledge related to this field, as well as the social trajectories of technological applications. Such a condition inevitably affects regulatory responses to such technologies, their development and their uses. This special issue addresses this junction between uncertainty and regulation. With no ambition of providing a comprehensive assessment of such a complex issue, this collection of articles examines three relevant dimensions for understanding uncertainty in nanotechnology regulation, which can be useful entry points for further reflection and discussion: scientific uncertainty, regulatory fragmentation, social actors’ opinions about and attitudes to nanotechnology and regulation
Ordering Technology, Excluding Society; The Division of Labor and Socio-technical Order in Images of Converging Technologies
No full textThe convergence of nanotechnology with bio- and info- technologies and cognitive sciences (NBIC) and its discourse has been analysed mostly in terms of the dramatic social change that can possibly be induced, the disarticulation of the present sociotechnical order that can consequently be caused and the adjustments of societal and institutional arrangements that are considered necessary to cope with this transformative potential. The literature has paid less attention to the possible role of converging technologies (CT) and their discourse in reproducing the existing sociotechnical order and, in particular, a specific pattern of the current division of technoscientific labour that is consistent with the so-called technocratic logic in the relations between technoscience, government and society. Analysing the Italian daily press coverage of selected applications, we illustrate that the CT media discourse supports indeed such a division of labour, which assigns to scientists and technologists an almost exclusive social mandate to develop technologies and to decision-makers a supporting role, while there is little or no room for the public to discuss and be involved in R&D activities and science policy. The role of the collective belief in technical progress and of the rhetoric of technological promises in sustaining and legitimising such a division of labour is then examined
Changes in adenosine 5'-monophosphate-activated protein kinase as a mechanism of visceral obesity in Cushing's syndrome
No full textOBJECTIVE: Features of the metabolic syndrome such as central obesity with insulin resistance and dyslipidemia are typical signs of Cushing's syndrome and common side effects of prolonged glucocorticoid treatment. AMP-activated protein kinase (AMPK), a key regulatory enzyme of lipid and carbohydrate metabolism as well as appetite, is involved in the development of the deleterious metabolic effects of excess glucocorticoids, but no data are available in humans. In the current study, we demonstrate the effect of high glucocorticoid levels on AMPK activity of human adipose tissue samples from patients with Cushing's syndrome. METHODS: AMPK activity and mRNA expression of genes involved in lipid metabolism were assessed in visceral adipose tissue removed at abdominal surgery of 11 patients with Cushing's syndrome, nine sex-, age-, and weight-matched patients with adrenal incidentalomas, and in visceral adipose tissue from four patients with non-endocrine-related abdominal surgery. RESULTS: The patients with Cushing's syndrome exhibited a 70% lower AMPK activity in visceral adipose tissue as compared with both incidentalomas and control patients (P = 0.007 and P > 0.001, respectively). Downstream targets of AMPK fatty acid synthase and phosphoenol-pyruvate carboxykinase were up-regulated in patients with Cushing's syndrome. AMPK activity was inversely correlated with 0900 h serum cortisol and with urinary free cortisol. CONCLUSIONS: Our data suggest that glucocorticoids inhibit AMPK activity in adipose tissue, suggesting a novel mechanism to explain the deposition of visceral adipose tissue and the consequent central obesity observed in patients with iatrogenic or endogenous Cushing's syndrome
MeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
Ovidiana. Recherches sur Ovide. Publiées à l'occasion du bimillénaire de la naissance du poète, par N. L Herescu, avec le concours de D. Adamesteanu, Vasile Cristea et E. Lozovan. Études, mémoires et notes inédits dus à D. Adamesteanu, L. Alfonsi, F. Arnaldi, etc.. , 1958
No full textLe Bonniec Henri. Ovidiana. Recherches sur Ovide. Publiées à l'occasion du bimillénaire de la naissance du poète, par N. L Herescu, avec le concours de D. Adamesteanu, Vasile Cristea et E. Lozovan. Études, mémoires et notes inédits dus à D. Adamesteanu, L. Alfonsi, F. Arnaldi, etc.. , 1958. In: Revue des Études Anciennes. Tome 62, 1960, n°1-2. pp. 191-195
- …
