1,846 research outputs found

    Review: Evidence-Based Management of Acute Heart Failure

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    Acute heart failure (AHF) is a complex, heterogeneous clinical syndrome with high morbidity and mortality, incurring significant healthcare costs. Patients transition from home to the emergency department, the hospital and home again, and require decisions surrounding diagnosis, treatment and prognosis at each step of the way. The purpose of this review is to examine the epidemiology, etiologies and classifications of AHF, and specifically focus on practical information relevant to the clinician. We examine the mechanisms of decompensation relevant to clinical presentations, including precipitating factors, neuroendocrine interactions and inflammation, along with how consideration of these factors these may help select therapies for an individual patient. The prevalence and significance of end-organ manifestations like renal, gastrointestinal, respiratory and neurologic manifestations are discussed. We also highlight how the development of renal dysfunction relates to the choice of a variety of diuretics that may be useful in specific circumstances and review guideline-directed medical therapy. We discuss the practical use (and pitfalls) of a variety of evidence-based clinical scoring criteria available to risk stratify patients with AHF. Finally, evidence-based management of AHF is discussed, including both pharmacologic and nonpharmacologic therapies, including the lack of evidence for using old and new vasodilators and the recent evidence regarding initiation of newer therapies in hospital. Overall, we suggest that clinicians consider implementing the newer data in AHF and subject existing practice patterns and treatments to the same rigor as new therapies

    Erratum to: Is Sensory Loss an Understudied Risk Factor for Frailty? A Systematic Review and Meta-analysis

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    In the article “Is Sensory Loss an Understudied Risk Factor for Frailty? A Systematic Review and Meta-analysis,” an author was missing. Ana Maseda should be listed as the 11th author. The correct author list is: Benjamin Kye Jyn Tan, Ryan Eyn Kidd Man, Alfred Tau Liang Gan, Eva K Fenwick, Varshini Varadaraj, Bonnielin K Swenor, Preeti Gupta, Tien Yin Wong, Caterina Trevisan, Laura Lorenzo-López, Ana Maseda, José Carlos Millán-Calenti, Carla Helena Augustin Schwanke, Ann Liljas, Soham Al Snih, Yasuharu Tokuda, Ecosse Luc Lamoureux. This error has been corrected

    Engineering materials : research, applications and advances / author, K.M. Gupta.

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    "A CRC title."Includes bibliographical references and index.596 p.

    Selfcoelum mertensis Gupta 1970, n. comb.

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    S. mertensis (Gupta, 1970) n. comb. Type host. Common sandpiper, Actitis hypoleucos (Linnaeus) (Charadriiformes: Scolopacidae). Type locality. Merta, Nagaur District, Rajasthan, India. Remarks. This species was originally described as Ophthalmophagus mertensis Gupta, 1970. On the one hand, the position of the posttesticular ovary may have been confused with the “receptaculum seminis uterinum”, as shown in Fig. 3 of the original description and may be more posteriorly situated nearer to the posterior arch of the cyclocoel, which is more typically the case in members of this genus. On the other hand, the “receptaculum seminis uterinum” may be the posterior testis and the anterior testis which is shown as being situated near the midbody may be part of the uterus. If the second situation is true, then this species would have an intertesticular ovary froming a triangle with the diagonal testes and would be assigned to Cyclocoelinae. However, the species was described from a single damaged specimen and it appears that the anterior end is rotated somewhat to the left causing the cirrus sac to be shifted more laterally than normal. We assume that the author is correct and that the ovary is situated off the midline of the body some distance posterior to the anterior testis as is shown in Fig. 3 of the original description (apparently a dorsal view). It should be noted that although both the diameters of the oral sucker (200, but about 690 calculated using the scale provided) and the pharynx (200, but about 350 calculated using the scale provided) are given as being the same, the oral sucker is shown in Fig. 3 as being much wider than the pharynx (about twice as wide). The length of the intertesticular and posttesticular spaces could not be calculated from the original figures because of the lack of verifiable reference measurements and the scale provided. As originally described, the ovary is posttesticular forming an elongate triangle with the testes (Szidatitreminae), the genital pore is postpharyngeal and the vitelline fields are not confluent posteriorly, placing this species in Szidatitrema. Rudimentary oral sucker present—Gupta (1970).Published as part of Dronen, Norman O. & Blend, Charles K., 2015, Updated keys to the genera in the subfamilies of Cyclocoelidae Stossich, 1902, including a reconsideration of species assignments, species keys and the proposal of a new genus in Szidatitreminae Dronen, 2007, pp. 1-100 in Zootaxa 4053 (1) on page 87, DOI: 10.11646/zootaxa.4053.1.1, http://zenodo.org/record/23711

    Scientometric study of exploration geophysics-author productivity trends

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    145-152<span style="font-size:12.0pt;line-height: 115%;font-family:" times="" new="" roman";mso-fareast-font-family:"times="" roman";="" mso-ansi-language:en-us;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-US">A cumulative index of geophysics for the two most important journals "Geophysics" and "Geophysical Prospecting" in the field of exploration geophysics for the period 1936-1985 was analyzed for author productivity trends. Author Productivity trends were tested for the application of Lotka's law by applying K-S statistical test. Two files were generated out of this data base; one for the period 1936-1985 and the other for the period 1936-1976 to test the time sensitivity of Lotka's law. Lotka's law did not apply as inverse square law but could apply satisfactorily with exponent value of 2. 1 on author productivity distribution patterns of both the files.</span

    Erratum: NuSTAR view of Be/X-ray binary pulsar 2S 1417–624 during 2018 giant outburst (Monthly Notices of the Royal Astronomical Society (2019) 490 (2458-2466) DOI: 10.1093/mnras/stz2795)

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    This is an erratum to the paper ‘NuSTAR view of Be/X-ray binary pulsar 2S 1417–624 during 2018 giant outburst’ (2019, MNRAS, 490, 2458–2466). In the original version of this article an affiliation of Shivangi Gupta was missing. This has now been corrected and the Indian Institute of Technology has been added. The author apologies for the error

    Testing equality of several correlation matrices

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    igualdad de varias matrices de correlación, puede ser considerado como unestadístico modificado del test de razón de verosimilitud cuando se muestreanpoblaciones normales multivariadas. Derivamos la distribución asintóticanula de L* en series que involucran variables independientes chi-cuadrado,mediante la expansión de L* en términos de otras variables aleatorias yluego invertir la expansión término a término. Se da también un ejemplopara mostrar el procedimiento a ser usado cuando se prueba igualdad dematrices de correlación mediante el estadístico L

    Transported PDF Modeling of Jet-in-Hot-Coflow Flames

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    A probability density function (PDF)-based combustion modeling approach for RANS simulation of a jet issuing into a hot and diluted coflow is performed. A tabulated chemistry-based model, i.e., flamelet-generated manifold (FGM), is adopted in the PDF method. The manifolds are constructed using igniting counterflow diffusion flamelets with different coflow compositions. To handle the inhomogeneity of the coflow and the entrainment of the ambient air, a second mixture fraction is defined to quantify the mixing of a representative coflow composition with the ambient air. The chemistry is then parameterized as a function of two mixture fractions and a reaction progress variable. To assess the modeling approach, Adelaide JHC flames, namely HM1, HM2, and HM3, having different oxygen concentrations in the hot coflow, 3%, 6%, and 9% O2, respectively, have been simulated for Reynolds number (Re) = 10,000. Profiles of mean mixture fraction and major species are accurately captured by the model along with the mean temperature. The mean temperature profiles are also captured nicely, while the sensitivity of progress variable (PV) on the predictions is highlighted.Accepted Author ManuscriptFluid Mechanic

    Adaptive channel queue routing on k-ary n-cubes

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    This paper introduces a new adaptive method, Channel Queue Routing (CQR), for load-balanced routing on k-ary n-cube interconnection networks. CQR estimates global congestion in the network from its channel queues while relying on the implicit network backpressure to transfer congestion information to these queues. It uses this estimate to decide the directions to route in each dimension. It further load balances the network by routing in the selected directions adaptively. The only other algorithm that uses global congestion in its routing decision is the Globally Adaptive Load-Balance (GAL) algorithm introduced in [13]. GAL performs better than any other known routing algorithm on a wide variety of throughput and latency metrics. However, there are four serious issues with GAL. First, it has very high latency once it starts routing traffic non-minimally. Second, it is slow to adapt to changes in traffic. Third, it requires a complex method to achieve stability. Finally, it is complex to implement. These issues are all related to GAL’s use of injection queue length to infer global congestion. CQR uses channel queues rather than injection queues to estimate global congestion. In doing so, it overcomes the limitations of GAL described above while matching its high performance on all the performance metrics described in [13]. CQR gives much lower latency than GAL at loads where non-minimal routing is required. It adapts rapidly to changes in traffic, is unconditionally stable, and is simple to implement
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