1,721,015 research outputs found
Identification of DNA transposable elements in the Tasmanian devil (Sarcophilus harrisii) genome
No full textThe Tasmanian devil (Sarcophilus harrissi) is a carnivorous marsupial residing in Tasmania. Its population is being driven to extinction by a transmissible cancer, devil facial tumor disease (DFTD), which has already caused a decline in the population by 60% since 1996 [4]. Very few transmissible cancers have been identified and include a non-fatal cancer in canines. By comparison DFTD in nearly 100% fatal [5]. As a result of their diminishing population, Tasmanian devils were classified as an endangered species in 2009 by the IUCN (International Union for Conservation of Nature). Efforts to repopulate Tasmanian devils are underway with a captive breeding program (Conservation Society of Australia). The possibilities of developing a vaccine may not be unreasonable because DFTD cells are genetically identical [ 4]. In order to understand DFTD, the genome of the Tasmanian devil (which has been sequenced and data are publicly available) needs to be better examined. Cancer may be associated with transposable elements [ 1]. Mobility of these DNA sequences may be associated with the development of cancers in human cell lines. Identification of transposable elements within the Tasmanian devil genome could be a step towards understanding of the causes DFTD and perhaps help save this species
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Identification of The Genes That Regulate Silk Production In Spiders: A Computational Biology Approach
No full textThe molecular basis of spider silk production is of broad interest because of its possible mechanical applications. For instance, dragline silk, which is produced in the major ampullate gland of certain spiders, has been found to be tougher than nylon and Kevlar®. However, even though there is research on the mechanical and structural properties of spider silk, the gene expression and regulation responsible for spider silk production remains largely unexplored. In this project, I will try to identify the genes that regulate spider silk production by analyzing several RNAseq libraries from major ampullate glands of Holocnemus pluchei and Lactrodectus hesperus. A de novo transcriptome assembly will be constructed from these RNAseq libraries using the program Trinity because neither species have fully sequenced genomes available. This transcriptome will be used to reference back the mRNA transcripts using the program BOWTIE2 in order to analyze their different levels of gene expression. Statistical analysis of the gene expression will be performed using the Bioconductor package. This analysis will provide insight into the genes that are either upregulated or downregulated during silk production in spiders
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Identification of the Genes that Regulate Silk Production in Spiders: A Computational Biology Approach
No full textThe molecular basis of spider silk production is of broad interest because of its possible mechanical applications. For instance, dragline silk, which is produced in the major ampullate gland of certain spiders, has been found to be tougher than nylon and Kevlar®. However, even though there is research on the mechanical and structural properties of spider silk, the gene expression and regulation responsible for spider silk production remains largely unexplored. In this project, we tried to identify the genes that regulate spider silk production by analyzing 8 RNAseq libraries from silk glands of male and female Dysdera spiders. Using a reference transcriptome, a differential expression analysis is done to identify statistically relevant expressed genes. The programs BowTie2 and TopHat were used to perform alignment to the reference transcriptome. To perform differential expression analysis, tuxedo tool suite of programs (CuffLinks, CuffMerge, CuffCompare), HTSeq, and DESeq, were used to determine statistically significant differentially expressed genes. This analysis will provide insights regarding the genes that are either upregulated or downregulated during silk production in Dysdera spiders
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
- …
