1,721,148 research outputs found
Pharmacogenomics and Personalized Medicine in Mood Disorders
No full textPharmacogenomics and the search for personalized medicine focus on the attainment of
individualized pharmacotherapies that cover genetic variation and target groups of patients that
present neurodevelopmental aspects of symptom profiles and biomarkers underlying the
pathophysiology of mood disorders. The identification of genetic biomarkers facilitates choice of
treatment, prediction of response, and prognosis of outcome over a wide spectrum of symptoms
associated with affective states thereby optimizing clinical practice procedures. Several strategies,
under development and refinement, show the propensity for derivation of essential elements in the
etiopathogenesis of disorder affecting drug efficacy, drug metabolism, and drug adverse effects,
e.g., with regard to SSRIs; these include the following: transporter gene expression and genes
encoding receptor systems, hypothalamic-pituitary-adrenal axis factors, neurotrophic factors, and
inflammatory factors affecting neuroimmune function. Nevertheless, procedural considerations of
pharmacogenetics presume the parallel investment of policies and regulations to withstand
eventual attempts at misuse thereby ensuring patient integrity
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Neurodegenerative Aspects in Vulnerability to Schizophrenia Spectrum Disorders
No full textThe neurodegenerative and neurotoxic aspects
of schizophrenia and/or psychosis involve genetic, epigenetic, and neurotoxic propensities that impinge upon both
the symptom domains and the biomarkers of the disorder,
involving cellular apoptosis/excitotoxicity, increased reactive oxygen species formation, viral and bacterial infections, anoxic birth injury, maternal starvation, drugs of
abuse, particularly cannabis, metabolic accidents, and other
chemical agents that disrupt normal brain development or
the integrity of brain tissues. Evidence for premorbid and
prodromal psychotic phases, aspects of neuroimaging,
dopamine, and psychosis vulnerability, and perinatal
aspects provide substance for neurodegenerative influences. Not least, the agencies of antipsychotic contribute to
the destructive spiral that disrupts normal structure and
function. The etiopathogenesis of psychosis is distinences. Not least, the agencies of antipsychotic contribute to
the destructive spiral that disrupts normal structure and
function. The etiopathogenesis of psychosis is distinguished also by disruptions of the normal functioning of
the neurotrophins, in particular brain-derived neurotrophic
factor, dyskinesic aspects, immune system disturbances,
and metabolic aspects. Whether detrimental to neurodevelopment or tissue-destructive, or an acceleration of
neurotoxic pathways, the notion of neurodegeneration in
the pathophysiology of schizophrenia spectrum and psychotic disorders continues to gather momentum
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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