19,930 research outputs found
Charlie May Simon materials
No full textThis collection contains materials relating to Arkansas author Charlie May Simon
Combined Targeting of Pathogenetic Mechanisms in Pancreatic Neuroendocrine Tumors Elicits Synergistic Antitumor Effects
No full textPancreatic neuroendocrine neoplasms (PanNENs) are the second most common malignancy of the pancreas. Surgery remains the only curative treatment for localized disease. For patients with inoperable advanced or metastatic disease, few targeted therapies are available, but their efficacy is unpredictable and variable. Exploiting prior knowledge on pathogenetic processes involved in PanNEN tumorigenesis, we tested buparlisib (PI3K inhibitor) and ribociclib (CDK4/6 inhibitor), as single agents or in combination, in different preclinical models. First, we used cell lines representative of well-differentiated (INS-1E, NT-3) and poorly differentiated (BON-1) PanNENs. The combination of buparlisib with ribociclib reduced the proliferation of 2D and 3D spheroid cultures more potently than the individual drugs. Buparlisib, but not ribociclib, induced apoptosis. The anti-proliferative activity of the drugs correlated with downstream target inhibition at mRNA and protein levels. We then tested the drugs on primary islet microtissues from a genetic PanNET animal model (Men1-defective mice) and from wild-type mice: the drug combination was effective against the former without altering islet cell physiology. Finally, we treated PanNET patient-derived islet-like 3D tumoroids: the combination of buparlisib with ribociclib was effective in three out of four samples. Combined targeting of PI3K and CDK4/6 is a promising strategy for PanNENs spanning various molecular and histo-pathological features
African program with Simon Ottenberg, April 23, 1969
No full textAfrican program with Simon Ottenberg isa program hosted by professor of anthropology Simon Ottenberg regarding subjects pertaining to Africa. In this specific program, Ottenburg refers to recent articles to discusses interactions between African individuals and black Americans, including the spread of American music through Africa brought by visiting African American people, as well as African music in the United States, April 23, 1969
Simon Weir - The Sydney Surrealist
No full textExhibition catalogue of "Simon Weir - The Sydney Surrealist", Exhibition at Disorder Gallery, Darlinghurst NSW, Australia, in April 2024. The catalogue contains images of exhibited works and statements by the artist Simon Weir, the gallery Director Elliott Cole, and author and journalist Margie Smithurst
EZH2 Inhibition as New Epigenetic Treatment Option for Pancreatic Neuroendocrine Neoplasms (PanNENs).
No full textPancreatic neuroendocrine neoplasms are epigenetically driven tumors, but therapies against underlying epigenetic drivers are currently not available in the clinical practice. We aimed to investigate EZH2 (Enhancer of Zest homolog) expression in PanNEN and the impact of EZH2 inhibition in three different PanNEN preclinical models. EZH2 expression in PanNEN patient samples (n = 172) was assessed by immunohistochemistry and correlated with clinico-pathological data. Viability of PanNEN cell lines treated with EZH2 inhibitor (GSK126) was determined in vitro. Lentiviral transduction of shRNA targeting EZH2 was performed in QGP1 cells, and cell proliferation was measured. Rip1TAG2 mice underwent GSK126 treatment for three weeks starting from week 10 of age. Primary cells isolated from PanNEN patients (n = 6) were cultivated in 3D as islet-like tumoroids and monitored for 10 consecutive days upon GSK126 treatment. Viability was measured continuously for the whole duration of the treatment. We found that high EZH2 expression correlated with higher tumor grade (p < 0.001), presence of distant metastases (p < 0.001), and shorter disease-free survival (p < 0.001) in PanNEN patients. Inhibition of EZH2 in vitro in PanNEN cell lines and in patient-derived islet-like tumoroids reduced cell viability and impaired cell proliferation, while inhibition of EZH2 in vivo in Rip1TAG2 mice reduced tumor burden. Our results show that EZH2 is highly expressed in high-grade PanNENs, and during disease progression it may contribute to aberrations in the epigenetic cellular landscape. Targeting EZH2 may represent a valuable epigenetic treatment option for patients with PanNEN
Simon Nyakot
No full textabstract: Simon Nyakot left his village when he was six years old.
“Lost Boys Found” is an ongoing, interdisciplinary project that is collecting, recording and archiving the oral histories of the Lost Boys/Girls of Sudan. The collection is a work-in-progress, seeking to record the oral history of as many Lost Boys/Girls as are willing, and will be used in a future book.Age: 27Region: LakeThis picture and bio was donated to the Lost Boys Found project from The Arizona Lost Boys Cente
Cahiers Saint-Simon
No full texthttps://www.persee.fr/renderCollectionCover/simon.pngThe Société Saint-Simon was founded in 1972 in order to promote studies about the Duke of Saint-Simon (1675-1755), namely about the work, life, and thinking of the Mémoires’s author. Each year it issues a Cahier Saint-Simon. It contains the Acts of the annual Journée d’étude in Versailles, but also Notes and Documents, News of the Society and Book reviews.Fondée en 1972, la Société Saint-Simon a pour but de développer les études concernant l'oeuvre, la personne et la pensée du duc de Saint-Simon (1675-1755), l’auteur des Mémoires. Chaque année, paraît un numéro de Cahiers Saint-Simon contenant les actes de la journée annuelle de Versailles, ainsi que des Mélanges, des Notes et Documents et une Chronique bibliographique détaillée
Cahiers Saint-Simon
No full texthttps://www.persee.fr/renderCollectionCover/simon.pngThe Société Saint-Simon was founded in 1972 in order to promote studies about the Duke of Saint-Simon (1675-1755), namely about the work, life, and thinking of the Mémoires’s author. Each year it issues a Cahier Saint-Simon. It contains the Acts of the annual Journée d’étude in Versailles, but also Notes and Documents, News of the Society and Book reviews.Fondée en 1972, la Société Saint-Simon a pour but de développer les études concernant l'oeuvre, la personne et la pensée du duc de Saint-Simon (1675-1755), l’auteur des Mémoires. Chaque année, paraît un numéro de Cahiers Saint-Simon contenant les actes de la journée annuelle de Versailles, ainsi que des Mélanges, des Notes et Documents et une Chronique bibliographique détaillée
Luck or Skill? An Examination of the Ehrlich - Simon Bet
No full textIn 1980, Paul Ehrlich and Julian Simon placed a famous bet on whether the prices of a bundle of natural resources would rise or fall over the ensuing decade. Simon won the bet as the real price of the bundle fell significantly, and the result of this bet has been taken as proof that technological progress is likely overcome any Neo-Malthusian concerns about natural resource scarcity. Contrary to the popular perception, however, an examination of the price history of the identical bundle of goods from 1900-2007 shows that Ehrlich and not Simon would have won a majority of the bets over the past century and would have done so by a wide margin.Natural resources, scarcity, Neo-Malthusian
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