2,325 research outputs found
Botulinum neurotoxin for head and neck disorders/ [edited by] Andrew Blitzer, Brian E. Benson, Diana N. Kirke
No full textIncludes bibliographical references and index"Senior author Dr. Andrew Blitzer is an internationally renowned pioneer on the use of botulinum neurotoxin for functional disorders, with unparalleled expertise on this topic. Joined by co-editors Brian Benson and Diana Kirke, with multidisciplinary contributors, Botulinum Neurotoxin for Head and Neck Disorders Second Edition fills a gap in the medical literature. The unique textbook focuses on the use of botulinum neurotoxins for functional disorders of the head and neck, though with some aesthetic indications. The second edition reflects the latest advances and understanding of existing and emerging applications for botulinum neurotoxins, including new treatment paradigms, revised pharmacology, and an updated review of the literature in all chapters. Twenty superbly illustrated chapters cover the management of hyperfunctional, pain, and hypersecretory syndromes of the head and neck. Hyperfunctional motor disorders are discussed in chapters focused on blepharospasm, facial dystonia, Meige syndrome, oromandibular dystonia, spasmodic dysphonia (laryngeal dystonia), and cervical dystonia. Specific treatment approaches for pain are addressed in chapters on migraine and chronic daily tension headaches, temporomandibular disorders, and trigeminal neuralgia. The treatment of autonomic nervous system disorders is covered in chapters dedicated to Frey syndrome, facial hyperhydrosis, and sialorrhea"--Pharmacology of Botulinum Neurotoxins / Muna I. Bitar, Nikita Kohli, Maya Samman, and Andrew Blitzer -- Botulinum Neurotoxin for Blepharospasm / Amit Patel, Andrew Blitzer, and Boris L. Bentsianov -- Botulinum Neurotoxin for Facial Dystonia / Scott M. Rickert, Amy P. Wu, and Andrew Blitzer Botulinum -- Neurotoxin for Meige Syndrome / Niv Mor and Andrew Blitzer -- Botulinum Neurotoxin for Oromandibular Dystonia / Daniel Novakovic and Ajay E. Chitkara -- Botulinum Neurotoxin for Spasmodic Dysphonia / Phillip C. Song, Lucian Sulica, and Andrew Blitzer -- Botulinum Neurotoxin for Cervical Dystonia / Tanya K. Meyer, Joel Guss, and Ronda E. Alexander -- Botulinum Neurotoxin for Hemifacial Spasm and Facial Synkinesis / Lesley French Childs, Daniel Novakovic, and Scott R. Gibbs -- Botulinum Neurotoxin for Hyperfunctional Facial Lines / Brian E. Benson, Diana N. Kirke, and Andrew Blitzer -- Botulinum Neurotoxin for Upper and Lower Esophageal Spasm / Nwanmegha Young and Brian E. Benson -- Botulinum Neurotoxin for Palatal Myoclonus / Ajay E. Chitkara, Catherine F. Sinclair, and Daniel Novakovic -- Botulinum Neurotoxin for Temporomandibular Disorders, Masseteric Hypertrophy, and Cosmetic Masseter Reduction / Michael Z. Lerner and Andrew Blitzer -- Botulinum Neurotoxin Therapy in the Laryngopharynx / Craig H. Zalvan, Phillip C. Song, Nwanmegha Young, and Andrew Blitzer -- Botulinum Neurotoxin for Migraine / Rachel Kaye, Jerome Schwartz, Brian E. Benson, and William J. Binder -- Botulinum Neurotoxin for Chronic Tension Headache / Nwanmegha Young and Brian E. Benson -- Botulinum Neurotoxin for Trigeminal Neuralgia / Elizabeth Guardiani, Andrew Blitzer, Lesley French Childs, and Ronda E. Alexander -- Botulinum Neurotoxin for Frey's Syndrome / Rachel Kaye, Andrew Blitzer, and Brian E. Benson -- Botulinum Neurotoxin for Facial Hyperhidrosis / Diana N. Kirke, Daniel Novakovic, and Andrew Blitzer -- Botulinum Neurotoxin for Sialorrhea / Brianna K. Crawley, Scott M. Rickert, Senja Tomovic, and Andrew Blitzer -- Botulinum Neurotoxin for Radiation-Induced Spasm and Pain / Diana N. Kirke, Brian E. Benson, and Tanya K. Meyer1 online resourc
"Making New Connections": interview with Brian Chikwava
No full textThis is an interview with Brian Chikwava, the author of critically-acclaimed *Harare North* (2009)
Tyrosine-derived nanoparticles for the topical treatment of psoriasis
No full textAt the New Jersey Center for Biomaterials, a potential topical psoriasis therapy consisting of tyrosine-derived polymeric micelles (TyroSpheres™) with encapsulated drug has been developed. These TyroSpheres™ are composed of copolymers with hydrophobic blocks of oligomers of desaminotyrosyl tyrosine esters and diacids and hydrophilic blocks of poly(ethylene glycol). Encapsulated drugs include a vitamin D3 analogue, betamethasone dipropionate, and paclitaxel. Drug-loaded TyroSpheres™ offer: 1) reproducible particle sizes, 2) control of drug release rates, 3) enhancement of drug stability, 4) increased solubility by high encapsulation capacity, 5) lack of short-term cytotoxicity, and 6) the ability to improve drug delivery into the skin. Additionally, TyroSpheres™ can be incorporated into an elegant viscous formulation for skin application with no impact on homogeneity, release, or skin distribution. Analysis has revealed that TyroSpheres™ are stable for up to 4 months, significantly limiting their shelf-life potential. By implementing a rational design, research on the preparation of a dry formulation of TyroSpheresTM has been undertaken, resulting in a fully re-constitutable formulation that has demonstrated complete stability to date (6 months). A two year-long stability study has been initiated to track the properties of this formulation over time. TyroSpheres™ address the requirements of a pharmaceutically acceptable skin drug delivery carrier and offer potential in the treatment of psoriasis since they allow delivery of difficult to uptake drugs to skin strata where the disease originates.Ph. D.Includes bibliographical referencesby Brian E. Kilfoyl
Frequency Response of the Swim Bladder and Weberian Ossicles of Zebrafish (Danio Rerio)
No full textIn recent years, the use of zebrafish as human disease models has been expanded to include several forms of human deafness. Zebrafish provide convenient hosts for genetic and developmental investigation. However, knowledge of the physical mechanism of zebrafish ���hearing��� is limited compared to other current models and human physiology. Examining the frequency response of the swim bladder and Weberian ossicles would allow the development of a mechanical understanding of the ear and comparison to the human middle ear. The swim bladder and Weberian ossicles are believed to transmit sound stimuli and give zebrafish the ability to determine an extended frequency range, as ���hearing specialists,��� among fish species. In order to understand the ability of the structures to function as a sound transducer, the frequency response of the structures was measured through phase-sensitive OCT. The anterior swim bladder and Weberian ossicles were visualized via magnitude OCT and data collected along a line through the surface and ROIs. The displacement of the structures in the presence of a sound stimulus suggested coupling of the acoustic energy through the tissue to the anterior swim bladder and to the fourth Weberian ossicle. A tuning response on the anterior swim bladder revealed an increase in vibration magnitude with decreasing frequency stimuli and increasing sound intensity. Danio rerio hears over a range of 100-4000 kHz. However owing to limitations in the current experimental system, we were only able to investigate in the range of 2500-4000 kHz
Application of Multi-Tonal Complex with Optical Coherence Tomography Imaging System for Vibrometric Analysis of Inner-Ear Structures
No full textCurrently, research is being conducted on single tone sound transduction within the auditory portion of the inner ear, the cochlea [1]. The study of cochlear mechanics in large rodents has provided important insight into cochlear function [1]. Additionally, multi-tone stimuli can provide a new perspective in vibrometric analyses that could be used in audiometry as a measure of hearing loss for patients in terms of both magnitude and their unique frequency envelope. Therefore, the proposed study was aimed to test the recent implementation of multitone calibration into an existing python program, PyVib2, which was used during Optical Coherence Tomography (OCT) imaging experiments for vibrometric analysis of the structures in the inner-ear. Within PyVib2, the multi-tone stimulus program will be executed in conjunction with the OCT M-scan program for full vibrometric analysis. This research resulted in the further development of the PyVib2 program, the acquisition of insightful image data of structures of the human inner-ear, which was collected using the OCT imaging system, and the verification of extracting the vibratory response of these structures when subjected to a multi-tone stimuli
Barium Titanate Nanoparticles as Exogenous Contrast Agents in Second Harmonic Optical Coherence Tomography
No full textI propose and demonstrate a method by which barium titanate nanoparticle clusters can be used as exogenous contrast agents in Second Harmonic Optical Coherence Tomography imaging systems to localize and highlight desired regions of tissue. SH-OCT has previously been used to identify collagen within OCT images. However, SH-OCT signals from collagen are highly susceptible to inferior reflector artifacts because most of the second harmonic generated light is forward scattered. Second harmonic generating nanoparticle clusters exhibit high scattering properties, which can give them the advantage of backscattering a large quantity of second harmonic light while attenuating the forward scattered light. In this research project, a mathematical model is proposed in which the backward to forward scattering ratio of second harmonic generated light from nanoparticle layers is exponentially proportional to the thickness of the layer. This model was supported by measurements of the backward to forward scattering ratio of second harmonic light in barium titanate nanoparticles layers. This indicates that nanoparticle clusters can be designed and manufactured with the proper thickness so that they generate a large second harmonic signal without creating inferior reflector artifacts
Integrating OCT into Surgical Systems and Monitoring Vibrations
No full textImaging of the hearing structures can yield information regarding their function as well as insight into the abnormalities and adverse conditions that affect them. Improvements in the acquisition techniques and the quality of imaging systems can contribute to the understanding and treatment of these conditions. Optical coherence tomography (OCT) imaging technology has evolved to the point where systems can deliver 2D cross-sectional images, 3D structural volumes, and functional information regarding the motion of the sample. The information is valuable, but while research systems continue to evolve and become more advanced there is a disconnect between the researcher and the clinician. Translation of research based imaging systems into the clinical field is an important step in future development and adaptation. This thesis is focused on the development of a packaged optical coherence tomography system and the design of a phase-stable surgical microscope OCT system that can easily be introduced into the clinical field
Brian Wood : Related Differences = Brian Wood : Différences connexes
No full textHanna successively considers the antithetic process that underlies Wood's creative approach, the hand and the photographic eye considered as instruments, and motifs typical of the artist's drawings. The author analyses photomontages produced between 1976 and 1993. Includes extensive quotes from an interview with the artist. Biographical notes. 6 bibl. ref
JAHN-TELLER ANALYSIS OF THE VIBRONIC STRUCTURE OF THE STATE IN THE CYCLOPENTADIENYL RADICAL
No full textNelson H. H.: Pasternack L.: Mc Donald J.R. Chem. Phys. 1983, 74, 227. Applegate B.E.: Barekholtz T. A.: Miller T.A. to be publishedAuthor Institution: Dept. of Chemistry Laser Spectroscopy Facility, The Ohio State University; Dept. of Chemistry Laser Spectroscopy Facility, The Ohio State University, Dept. of Chemistry, Laser Spectroscopy Facility, 120 W. 18th Avenue, Columbus, Ohio 43210;; JILA, National Institute of Standards and Technology and The Department of Chemistry and Biochemistry, University of Colorado BoulderWhile room temperature wavelength resolved emission spectra of the transition have existed for nearly 20 , the vibrational assignment of these spectra has remained elusive. The major difficulty with the vibrational analysis is attributable to complications arising from the dynamic Jahn-Teller effect in the state. Newly obtained jet-cooled laser excited wavelength resolved fluorescence emmision spectra, in conjunction with calculations aimed at predicting the relevant Jahn-Teller constants have now made the complete analysis of the available spectral data possible. The transitions involving the Jahn-Teller active vibrations have been analyzed in terms of the three lowest energy harmonic vibrations of the appropriate symmetry(), assuming only linear Jahn-Teller interactions. Additional features of the spectrum may be described in terms of the fundamentals, overtones, and combination bands of the non-John-Teller active vibrations as well as combinations involving the Jahn-Teller active modes
Implementation work program
No full textdeveloped for: Oregon Department of Transportation ; developed by: DKS Associates, in partnership with Cambridge Systematics ; Brian Chandler (DKS), Lacy Brown (DKS), and Ryan Klitzsch (CS).This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Mode of access: Internet from the Oregon Government Publications Collection.Text in English
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