305,278 research outputs found
Neuropeptides in temporomandibular joint arthritis
No full textInvolvement of the peripheral and central nervous systems in the pathophysiology of arthritis has been suggested and neuropeptides are thought to participate in the mediation and modulation of the inflammatory process.The main objective of the clinical studies was to investigate the relationship between the presence of neuropeptides in the synovial fluid of the temporomandibular joint (TMJ) and the stomatognathic symptoms and signs, including the intra-articular temperature (IAT), in patients with TMJ arthritis. In addition, intra-articular treatment with glucocorticoids was evaluated by examining the neuropeptide Y (NPY) concentrations in the arthritic TMJ and corresponding symptoms and signs. An experimental animal model of TMJ arthritis was conducted to study the peripheral and central effects of induced monoarthritis in the rat TMJ on the NPY concentrations in TMJ tissue and selected brain regions.Patients with TMJ arthritis and general inflammatory joint disease were subjected to arthrocentesis to enable joint fluid sampling, intra-articular temperature recordings and administration of glucocorticoids. The clinical parameters also included pain (assessed with a visual analog scale), hyperalgesia (determined by a pressure pain threshold), mandibular mobility (indirectly reflected by the mouth opening capacity) and occlusal signs of TMJ tissue destruction. The concentrations of neurokinin A- (NKA-), substance P- (SP-), calcitonin generelated peptide- (CGRP-) and NPY-like immunoreactivity (-LI) were determined with the use of competitive radioimmunoassay technique.NKA-LI, SP-LI, CGRP-LI and NPY-LI were found in concentrations above the plasma level in the synovial fluid of the rheumatoid TMJ. Changes in the IAT corresponded to changes in joint fluid NPY-LI and CGRP-LI and the patients with intra-articular hypothermia had the highest joint fluid concentrations of NPY-LI. Moreover, the IAT was found to be positively correlated to the joint fluid concentrations of SP-LI. Pain, hyperalgesia, restricted mouth opening and occlusal signs of TMJ tissue destruction were associated with the high concentrations of CGRP-LI and NPY-LI. Interestingly, TMJ pain and hyperalgesia were found to be negatively correlated to the high concentrations of SP-LI. Intra-articular glucocorticoid treatment of the arthritic TMJ was associated with a short-term decrease in joint fluid NPY-LI in conjunction with a general improvement of the TMJ symptoms and signs.Monoarthritis in the rat TMJ induced a uni- and/or bilateral decrease in NPY-LI in the TMJ tissue 1, 5 and 10 weeks after inoculation. Concomitant changes in central NPY expression were observed in the hippocampus, the hypothalamus and the pituitary brain regions. It may be concluded that SP, CGRP and NPY are present in the joint fluid of the arthritic TMJ fluid and it is suggested that these neuropeptides may participate in the mediation and modulation of TMJ arthritis involving the peripheral, central and sympathetic nervous systems.List of scientific papersI. Appelgren A, Appelgren B, Eriksson S, Kopp S, Lundeberg T, Nylander M, Theodorsson E (1991). Neuropeptides in temporomandibular joints with rheumatoid arthritis: a clinical study. Scand J Dent Res. 99(6):519-521. https://pubmed.ncbi.nlm.nih.gov/1722347II. Appelgren A, Appelgren B, Kopp S, Lundeberg T, Theodorsson E (1993). Relation between the intra-articular temperature of the temporomandibular joint and the presence of neuropeptide Y-like immunoreactivity in the joint fluid. A clinical study. Acta Odontol Scand. 51(1):1-8. https://pubmed.ncbi.nlm.nih.gov/8451918III. Appelgren A, Appelgren B, Kopp S, Lundeberg T, Theodorsson E (1993). Relation between intra-articular temperature of the arthritic temporomandibular joint and presence of calcitonin gene-related peptide in the joint fluid. A clinical study. Acta Odontol Scand. 51(5):285-91. https://pubmed.ncbi.nlm.nih.gov/8279269IV. Appelgren A, Appelgren B, Kopp S, Lundeberg T, Theodorsson E (1995). Neuropeptides in the arthritic TMJ and symptoms and signs from the stomatognathic system with special consideration to rheumatoid arthritis. J Orofac Pain. 9(3):215-25. https://pubmed.ncbi.nlm.nih.gov/8995921V. Alstergren P, Appelgren A, Appelgren B, Kopp S, Lundeberg T, Theodorsson E (1996). The effect on joint fluid concentration of neuropeptide Y by intra-articular injection of glucocorticoid in temporomandibular joint arthritis. Acta Odontol Scand. 54(1):1-7. https://pubmed.ncbi.nlm.nih.gov/8669234VI. Appelgren A, Appelgren B, Kopp S, Lundeberg T, Theodorsson E (1998). Substance P-associated increase of intra-articular temperature and pain threshold in the arthritic TMJ. J Orofac Pain. 12(2):101-7. https://pubmed.ncbi.nlm.nih.gov/9656887VII. Appelgren A, Appelgren B, Carleson J, Kopp S, Theodorsson E, Lundeberg T. Central and peripheral changes in neuropeptide Y-like immunoreactivity following adjuvant monoarthritis in the rat temporomandibular joint. [Manuscript]</p
Handhyvlade svängda profiler – ett gästhantverkarprojekt
No full textFilm, 60 minuter, på YouTubekanal: HantverkslaboratorietFinsnickare Olof Appelgren nytillverkar handhyvlade, profilerade och svängda snickerier i utvecklingsprojektet Tottieska gården, Skansen, Stockholm. Ett samarbetsprojekt mellan Stiftelsen Skansen och Hantverkslaboratoriet. En film av Tomas Wiedersheim-Paul, 2017
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Vaccino antinfluenzale stagionale in Italia: misurare l’efficacia sul campo e la sicurezza : Stagione 2015-2016
No full textIn Italia, nella stagione influenzale 2015-2016 sono stati condotti dall’Istituto Superiore di Sanità (ISS), con il supporto dell’Agenzia Italiana del Farmaco (AIFA), due studi al fine di stimare l’efficacia sul campo (I-MOVE, Influenza - Monitoring Vaccine Effectiveness) e valutare la sicurezza (SVEVA, Studio sulla Valutazione degli Eventi dopo Vaccinazione Antinfluenzale) del vaccino antinfluenzale. Nel complesso hanno aderito 8 Regioni che corrispondono a oltre metà della popolazione italiana nel 2015 (non tutte le Regioni hanno aderito a entrambi gli obiettivi di studio). Nello studio I-MOVE sono stati reclutati 1.094 casi di ILI (Influenza-Like Illness), dai 64 medici di medicina generale e pediatri di libera scelta partecipanti (506 casi e 498 controlli). I risultati suggeriscono che il vaccino ha conferito una protezione moderata nei confronti del tipo virale A(H1N1)pdm09 e molto bassa per A(H3N2) e B a causa del sostanziale grado di mismatch antigenico osservato, rispetto al ceppo vaccinale. Nello studio SVEVA sono stati monitorati 3.213 soggetti vaccinati e rilevati 854 (26%) eventi dopo 7 giorni dalla vaccinazione, la maggior parte dei quali di lieve entità. Al fine di ottenere stime di efficacia più solide e descrivere eventi avversi rari, è necessario tuttavia raggiungere una numerosità campionaria maggiore.In Italy, during the 2015/2016 flu season, the National Institute of Health (ISS), with the support of the Italian Drug Agency (AIFA), conducted two studies to estimate vaccine effectiveness (I-MOVE) and evaluate safety (SVEVA) of the flu vaccine. A total of 8 regions, among 21, participated to the study which can correspond to more than 50% of the Italian population in 2015 (not all regions participated to both objectives of the study). For the I-MOVE study, 1094 cases of ILI (506 cases and 498 controls) were recruited by 64 general practitioners and pediatricians. The results indicate that the vaccine gave moderate protection against the virus type A (H1N1) pdm09 and very low protection for A (H3N2) and B due to the antigenic mismatch that was observed, compared to the vaccine strain. For SVEVA study, 3213 vaccinated cases were monitored and 854 (26%) side effects were notified after 7 days of vaccination, the major part were mild. In order to obtain more solid data regarding vaccine effectiveness, and to describe rare adverse events, it is necessary to increase the sample size of both studies
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
No full textThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Mining e-mail content for author identification forensics
No full textWe describe an investigation into e-mail content mining for author identification, or authorship attribution, for the purpose of forensic investigation. We focus our discussion on the ability to discriminate between authors for the case of both aggregated e-mail topics as well as across different email topics. An extended set of e-mail document features including structural characteristics and linguistic patterns were derived and, together with a Support Vector Machine learning algorithm, were used for mining the e-mail content. Experiments using a number of e-mail documents generated by different authors on a set of topics gave promising results for both aggregated and multi-topic author categorisation
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