1,535 research outputs found
Hematopoietic Cell Transplantation for Juvenile Myelomonocytic Leukemia
No full textJuvenile myelomonocytic leukemia (JMML) is a rare myeloproliferative disorder of early childhood; it is characterized by hepatosplenomegaly and organ infiltration due to excessive proliferation of cells of the monocytic and granulocytic lineages. Approximately 85% of JMML patients harbor in their leukemia cells either somatic or germline mutations in the genes PTPN-11, NRAS, KRAS, NF1, or CBL. Allogeneic hematopoietic stem cell transplantation (HSCT) remains the therapy of choice for the majority of affected children. Available data indicate that transplantation from an HLA-identical sibling or a matched unrelated volunteer can cure more than 50% of patients. A similar proportion of children with JMML, especially when transplanted from donors with limited HLA disparity, can be cured with umbilical cord blood transplantation, which can represent a suitable option for children with JMML lacking either a related or an unrelated HSCT donor
Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia.
No full textAllogeneic stem cell transplantation is an increasingly important treatment option in the management of adult acute myeloid leukemia (AML). The major causes of treatment failure remain disease relapse and treatment toxicity. In this review, Dr Vyas presents an overview of important recent data defining molecular factors associated with treatment failure in AML. He also identifies the emerging importance of leukemia stem cell biology in determining both response to therapy and relapse risk in AML. Dr Appelbaum discusses advances in the design and delivery of both myeloablative and reduced-intensity conditioning regimens, highlighting novel strategies with the potential to improve outcome. Dr Craddock discusses the development of both novel conditioning regimens and post-transplantation strategies aimed at reducing the risk of disease relapse
The Foregoing Letter was sent for Comment to Drs. Appelbaum and Deisseroth who Reply as Follows:
No full textAn interview with Frederick R. Dickinson, Associate Professor, Department of History, University of Pennsylvania
No full textBorn in Tokyo and raised in Kanazawa and Kyoto, Japan, Frederick R. Dickinson teaches courses on modern Japan, East Asian diplomacy and politics and nationalism in Asia. He is the author of War and National Reinvention : Japan in the Great War, 1914 - 1919 (Harvard University Asia Center, 1999) and Taisho tenno (Taisho Emperor, Minerva Press, 2009). Currently, he is working on a study of Japanese political and cultural reconstruction following the First World War (1919-1931). 1. What is your ..
An interview with Frederick R. Dickinson, Associate Professor, Department of History, University of Pennsylvania
No full textBorn in Tokyo and raised in Kanazawa and Kyoto, Japan, Frederick R. Dickinson teaches courses on modern Japan, East Asian diplomacy and politics and nationalism in Asia. He is the author of War and National Reinvention : Japan in the Great War, 1914 - 1919 (Harvard University Asia Center, 1999) and Taisho tenno (Taisho Emperor, Minerva Press, 2009). Currently, he is working on a study of Japanese political and cultural reconstruction following the First World War (1919-1931). 1. What is your ..
Reprint of: Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia
No full textAbstractAllogeneic stem cell transplantation is an increasingly important treatment option in the management of adult acute myeloid leukemia (AML). The major causes of treatment failure remain disease relapse and treatment toxicity. In this review, Dr Vyas presents an overview of important recent data defining molecular factors associated with treatment failure in AML. He also identifies the emerging importance of leukemia stem cell biology in determining both response to therapy and relapse risk in AML. Dr Appelbaum discusses advances in the design and delivery of both myeloablative and reduced-intensity conditioning regimens, highlighting novel strategies with the potential to improve outcome. Dr Craddock discusses the development of both novel conditioning regimens and post-transplantation strategies aimed at reducing the risk of disease relapse
Unrelated hematopoietic stem cell donors as research subjects
No full texthttp://dx.doi.org/10.1038/bmt.2010.26
Structural and Functional Alterations of FLT3 in Acute Myeloid Leukemia
No full textHematopoiesis is highly regulated through cytokine-induced stimulation of multiple signal transduction pathways in order to mediate appropriate differentiation and proliferation of specific progenitor populations. Ligand-induced stimulation of the FMS-like tyrosine kinase 3 (FLT3) leads to activation of multiple downstream effector pathways resulting in differentiation and proliferation of specific progenitor cell populations. Genomic alterations of the FLT3 gene leads to autonomous receptor activation, dysregulation of FLT3 signal transduction pathways, contributes to myeloid pathogenesis, and have been linked to response to therapy and clinical outcome. Exploring the mechanisms by which these FLT3 alterations lead to dysregulated proliferation would provide a better understanding of the molecular pathogenesis of AML and may provide insights into potential therapeutic interventions
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