55 research outputs found
Meet Edem Awumey
No full textEdem Awumey is an awarded author from Togo who has written short stories and two novels. The central theme in his works is the exile.</p
Targeting EDEM protects against ER stress and improves development and survival in C. elegans
No full textEDEM-1, EDEM-2 and EDEM-3 are key players for the quality control of newly synthesized proteins in the endoplasmic reticulum (ER) by accelerating disposal and degradation of misfolded proteins through ER Associated Degradation (ERAD). Although many previous studies reported the role of individual ERAD components especially in cell-based systems, still little is known about the consequences of ERAD dysfunction under physiological and ER stress conditions in the context of a multicellular organism. Here we report the first individual and combined characterization and functional interplay of EDEM proteins in Caenorhabditis elegans using single, double, and triple mutant combinations. We found that EDEM-2 has a major role in the clearance of misfolded proteins from ER under physiological conditions, whereas EDEM-1 and EDEM-3 roles become prominent under acute ER stress. In contrast to SEL-1 loss, the loss of EDEMs in an intact organism induces only a modest ER stress under physiological conditions. In addition, chronic impairment of EDEM functioning attenuated both XBP-1 activation and up-regulation of the stress chaperone GRP78/BiP, in response to acute ER stress. We also show that pre-conditioning to EDEM loss in acute ER stress restores ER homeostasis and promotes survival by activating ER hormesis. We propose a novel role for EDEM in fine-tuning the ER stress responsiveness that affects ER homeostasis and survival.[Author summary] ER stress and UPRER malfunctions have been implicated in the pathogenesis of neurodegeneration, metabolic and inflammatory diseases as well as tumor progression and diabetes, whereby disturbed ER homeostasis negatively influences the pathology of the disease. Under ER stress conditions, the cells either activate UPRER-dependent cytoprotective mechanisms when ER stress is at subtoxic levels or, in case of an excessive ER stress, the cytotoxic response stimulates cell death. Here, we used Caenorhabditis elegans to study the cellular responses to ER stress at organismal level. We show that EDEMs respond differently to ER stress stimuli, and moreover, EDEMs deficiencies activate an XBP-1 independent adaptive program to promote organism survival under acute ER stress. Corroborated with the fact that loss of EDEM-2 and EDEM-3 induces resistance to acute ER stress in an intact organism, our data implicate EDEM proteins in a broader response to ER stress than previously established, which opens a new avenue for understanding the regulation of ER stress with implications for clinical and therapeutic investigations.This research was funded by Unitatea Executivă pentru Finanțarea Învățământului Superior, a Cercetării, Dezvoltării și Inovării (https://uefiscdi.gov.ro/) grant number PN-II-ID-PCE-2012-4-0350 to SMP. SG is grateful for the support from European Social Fund for Sectorial Operational Program Human Resources Development 2007-2013 grant number POSDRU/89/1.5/S/60746. RT is grateful for the support from the National Authority for Scientific Research and Innovation (https://www.research.gov.ro), and from the Ministry of European Funds(https://mfe.gov.ro/), through the Competitiveness Operational Programme 2014-2020, POC-A.1-A.1.1.4-E-2015 [Grant number: 40/02.09.2016, ID: P_37_778, to RT]. SMP, SG, MC and RT were supported by the Romanian Academy(https://acad.ro/) Projects 1 and 3.Peer reviewe
IBPP Research Associates: Zambia
No full textThe following article - 10 years...and the show must go on, by Edem Djokotoe - was posted in the August 1, 2001 Issue of The Post (Zambia). Copyright permissions for the article were not available, and it is not available for download.
The article discusses the struggles of the author and The Post (Zambia) to remain in journalism business
Раят ([ган èден]) не е червен
No full textThe author finds the explanation why in the orthodox tradition the term for paradise is Edem and not the original Hebrew name Eden
The effects of job satisfaction on publication output among librarians in Africa : a case study from Nigerian universities
No full textStudy on the relationship between job satisfaction and publication by university librarians in Nigeria, based on data collected by the author for his disseration at the University of Ibadan. The author conducted a literature survey on this topic using the resources available to large university libraries in Nigeria and relates it to the data he collected
Discrete Element Analysis on Mechanical Properties of Ballast Bed by Tamping in Railway Turnout Areas
No full textTurnout is the key component of the railway tracks for trains to change direction, which is vital to operational safety and passenger comfort. Therefore, it is of great importance to perform a scientific and reasonable tamping operation for turnout areas. In this paper, based on the commercial software EDEM and RECURDYN, a coupled simulation model of the large machine tamping device-rail-sleeper-ballast bed in the turnout area is jointly established, and the correctness of the model is verified by the test results of the lateral resistance of the ballast bed. The influence of tamping operation on the macro-and micromechanical properties of ballast bed at the switching part of railway turnout areas is studied and recommendations for the optimization of tamping operation are proposed. The results show that in the squeezing stage, strong force chains are distributed concentrately under sleepers, where the distribution range is approximately elliptical with a depth of 150 mm. After tamping, only the 200-mm ballast under the sleepers is compacted, where the compactness is increased by 5.9%. On the contrary, the compactness of the ballast in the sleeper crib is reduced by 27.4%, which is the weakest part. To ensure favorable tamping quality, the tamping sequence at the switching part of railway turnout areas is suggested to be conducted in order of first through track and then diverging track.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Mechanics and Physics of Structure
Dynamic modeling and adapted design of a low cost linear Fresnel power plant for rural areas in West Africa
No full textWarfarin-induced skin necrosis: a rare condition
No full textWarfarin induced skin necrosis is a rare debilitating and, in some cases, life-threatening complication. A 47-year-old male on life-long anticoagulation omits his medication and develops extensive skin necrosis of the left leg complicated by acute renal failure three days after restarting warfarin. Investigations reveal possible Protein S deficiency which is known to be a predisposing condition. Various mechanisms have been proposed as the underlying cause. He was managed on heparin, wound debridement and skin grafting. Warfarin was restarted concurrently with heparin. Knowledge of this complication will enable timely diagnosis and treatment
Biomass pellet breakage: A numerical comparison between contact models
No full textThe breakage behaviour of biomass pellets with a diameter of 6 mm under uniaxial compression test was studied experimentally and numerically using the discrete element method (DEM). Two types of the available bonding contact models in EDEM software were used to compare the macroscopic properties including the maximum stress at failure, strain at failure, and the pellet Young’s Modulus. The models are based on 1) the Timoshenko beam theory and 2) a bonded particle model. The results show that both models reasonably predict the maximum stress values, however, the bonded contact model is not able to predict the strain at failure and the Young’s Modulus while the results show a big deviation from the experimental results
Accountability at borders: between restrictive European border governance and fragmented national landscapes for human rights protection
No full textThis article explores the interrelation between poor accountability for human rights violations at borders and broader deficiencies in ensuring the implementation and enforcement of human rights law at the national level. First, the author provides a brief overview of the complex and diverse landscape in the EU of national bodies with monitoring or accountability functions relevant to responding to human rights violations at borders, including National Human Rights Institutions (NHRIs) and National Preventive Mechanisms (NPM). Building on existing literature on the nature and effectiveness of domestic institutions, this contribution argues that these actors have become central in responding to systematic violations at borders. Yet, the potential of national frameworks for human rights protection at borders is not fully explored, resulting in a missing link for accountability for violations at borders. To illustrate this argument, the article provides a critical analysis of the European Commission’s proposal under the Screening Regulation for the Member States to establish “border monitoring mechanisms”. It is argued that the proposed approach fails to recognise, support, and mobilize existing domestic frameworks for human rights protection, and relies on a short-sighted notion of accountability. The author concludes by placing this debate in the broader context of gaps in human rights governance at the international and EU levels.This article explores the interrelation between poor accountability for human rights violations at borders and broader deficiencies in ensuring the implementation and enforcement of human rights law at the national level. First, the author provides a brief overview of the complex and diverse landscape in the EU of national bodies with monitoring or accountability functions relevant to responding to human rights violations at borders, including National Human Rights Institutions (NHRIs) and National Preventive Mechanisms (NPM). Building on existing literature on the nature and effectiveness of domestic institutions, this contribution argues that these actors have become central in responding to systematic violations at borders. Yet, the potential of national frameworks for human rights protection at borders is not fully explored, resulting in a missing link for accountability for violations at borders. To illustrate this argument, the article provides a critical analysis of the European Commission’s proposal under the Screening Regulation for the Member States to establish “border monitoring mechanisms”. It is argued that the proposed approach fails to recognise, support, and mobilize existing domestic frameworks for human rights protection, and relies on a short-sighted notion of accountability. The author concludes by placing this debate in the broader context of gaps in human rights governance at the international and EU levels
- …
