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Geç preterm bebeklerde maternal risk faktörlerinin ve plasenta histopatolojilerinin neonatal morbiditeye etkisi
No full textPreterm doğumlar, neonatal morbidite ve mortaliteyi oluşturan en önemli risk faktörüdür. Gebelik haftası 37 haftadan önce olan tüm bebekler preterm olarak tanımlanmaktadır. Bu bebeklerin yaklaşık %65-70’ini 340/7- 366/7 hafta arasında doğan geç preterm bebekler oluşturmaktadır. Geç preterm bebekler çoğunlukla fonksiyonel ve gelişimsel olarak matür olarak düşünülür ve term bebekler gibi ele alınırlar, bu nedenle sorunları gözden kaçabilir.
Bu çalışmaya Ocak 2018-Temmuz 2018 tarihleri arasında Başkent Üniversitesi Tıp Fakültesi Ankara Uygulama ve Araştırma Hastanesi Yenidoğan ünitesinde izlenen gebelik yaşı 340/7- 366/7 hafta olan toplam 62 bebek dahil edilmiştir. Çalışmamızda plasental patoloji ve maternal risk faktörlerine göre bu bebeklerde oluşan neonatal morbiditeler değerlendirilmiştir. Multipl konjenital anomalisi, kromozomal bozukluğu olan bebekler ve farklı hastanelerde doğup hastanemize yatırılan geç preterm yenidoğanlar çalışma dışında bırakıldı. Bu çalışmada en sık görülen morbiditeler beslenme intoleransı (%56.5), hiperbilirübinemi (%50), hipoglisemi (%32.3), yenidoğanın geçici takipnesi (%16.1), polisitemi (%9.7), sepsis (%8.1) ve respiratuvar distres sendromu (%6.5) olarak saptandı. Geç preterm bebeklerde gebelik haftalarına (34., 35. ve 36. haftalar) göre karşılaştırdığımızda; yenidoğan yoğun bakım ünitesindeki yatış süreleri, morbidite sıklığı ve tedavi gereksinimi en yüksek oranda 34. gebelik haftasında doğan bebeklerde görüldü. Plasentasında maternal uterin malperfüzyon patolojisi görülen bebeklerde hiperbilirubinemi ve intrakranial kanamanın; kronik inflamasyon patolojisi olanlarda polisitemi, beslenme intoleransı ve tekrarlayan hastaneye yatış riskinin; fetal obliteratif vaskülopati patolojisi olanlarda polisiteminin; plasentomegalisi olanlarda erken neonatal sepsis ve beslenme intoleransının ve plasentasında hematomu olan bebeklerde ise pnömötoraksın istatistiksel olarak yüksek görüldüğü belirlendi. Preeklamptik anne bebeklerinde hiperbilirubinemi ve beslenme intoleransının; EMR’li anne bebeklerinde beslenme intoleransının; oligohidroamniyotik anne bebeklerinde hiperbilirubinemi ve beslenme intoleransının; plasenta previası olan anne bebeklerinde RDS ve intrakranial kanamanın; trombofilisi olan anne bebeklerinde hiperbilirubinemi, erken neonatal sepsis ve beslenme intoleransının ve maternal enfeksiyonu olan anne bebeklerinde ise erken neonatal sepsis ve tekrarlayan hastane yatış riskinin anlamlı şekilde yüksek görüldüğü belirlendi.Sonuç olarak; çalışmamızda 34.gebelik haftasında doğan bebeklerde, diğer gebelik haftalarına göre daha çok morbidite saptanmıştır. Annede preeklampsi, oligohidroamniyoz, trombofili, enfeksiyon gibi risk faktörlerinin ve maternal uterin malperfüzyon, kronik inflamasyon, plasentomegali gibi plasentaya ait problemlerin olmasının bebeklerde morbiditeyi artırdığı belirlenmiştir.
Preterm births are the most important risk factor for neonatal morbidity and mortality. All infants born before 37 gestational weeks are defined as preterm. About 65-70% of these babies are late preterm infants who were born between 340/7- 366/7 gestational weeks. Late preterm infants are often considered to be mature functionally and developmentally, they were also considered as full-term babies. Therefore, these problems can be overlooked in late preterm infants.
This study was carried out between January 2018 and July 2018 at Baskent University Faculty of Medicine including a total of 62 late preterm infants. We evaluated neonatal morbidities in these infants according to placental pathology and maternal risk factors. Multiple congenital anomalies, chromosomal abnormalities and late preterm newborns who were born at the other hospitals were excluded from the study. The most frequent morbidities were feeding intolerance (56.5%), hyperbilirubinemia (50%), hypoglycemia (32.3%), neonatal transient tachypnea (16.1%), polycythemia (9.7%), sepsis (8.1%) and respiratory distress syndrome (6.5%). When we compared according to gestational weeks (34th, 35th and 36th weeks) of late preterm infants; the length of hospitalization, morbidities and treatment requirement were found to be highest in 34th weeks of gestation. Maternal malperfusion pathology in the placenta was related to hyperbilirubinemia and intracranial hemorrhage; chronic inflammation pathology was related to polycythemia, feeding intolerance and recurrent hospitalization; fetal obliterative vasculopathy pathology was related to polycythemia; placentomegaly was related to early neonatal sepsis and feeding intolerance; placental hematomas were related to pneumothorax that all were found to be statistically significant. The following diseases were observed more frequently in the presence of these maternal risk factors, respectively. These included hyperbilirubinemia and feeding intolerance which were mostly observed in infants of preeclamptic mothers; also feeding intolerance in infants of mothers who have PPROM; hyperbilirubinemia and feeding intolerance in infants of oligohydramniotic mothers; RDS and intracranial hemorrhage in infants of mothers with placenta previa; hyperbilirubinemia, early neonatal sepsis and feeding intolerance in infants of mothers with maternal thrombophilia and early neonatal sepsis and re-hospitalization in infants of mothers with maternal infections that were found to be statistically significant.
Consequently; in our study, the babies who were born at the 34th gestational weeks have more morbidities than the late preterm infants born in other gestational weeks. It has been determined that risk factors such as preeclampsia, oligohydramnios, thrombophilia, infection and placental problems such as maternal malperfusion, chronic inflammation and placentomegaly increase morbidities in late preterm infants
Bronkopulmoner displazide plazminojen aktivatör inhibitör-1 4G/5G gen polimorfizminin rolünün araştırılması
Get PDFVücutta koagülasyon ve antikoagülasyon bir denge içinde çalışmaktadır. İnflamatuvar hastalıklarda proinflamatuvar sitokinlerin uyarısı sonucu alveoler boşlukta doku faktörü salınımı gerçekleşmekte, plazminojen aktivatör inhibitörünün fazla oluşu fibrinin yıkılmasını engellemekte ve böylece fibrozis gelişimine yatkınlık ortaya çıkmaktadır. Bronkopulmoner displazi (BPD), günümüzde de prematüre bebeklerde en önemli morbidite ve mortalite nedenlerinden biri olmaya devam etmektedir. Aynı gebelik haftası ve doğum ağırlığında doğan bebeklerin tümünde BPD gelişmemesi, hastalığın patogenezinde farklı nedenlerin rolünü düşündürmektedir. Bu nedenler arasında plazminojen aktivatör inhibitör- ı (PAl- ı) gen polimorfizmi olası genetik faktörlerden biri olarak ön plana çıkmaktadır. Çalışmamızda prematüre infantlarda PAı-ı geni 40/50 polimorfizminin BPD gelişimindeki rolünü araştırdık. Yenidoğan dönemi sonrası hayatta olan ve BPD tanısı konulan 98 preterm bebek çalışma grubunu, BPD gelişmeyen 94 preterm bebek ise kontrol grubunu oluşturdu. Çalışmada hasta ve kontrol grubundaki bebeklerin PAı-ı 40/50 genotiplemesi için periferik kandan DNA elde edildi. Hedef bölgelere özgü primerler kullanılarak yapılan polimeraz zincir reaksiyonunu (PZR) takiben uygun restriksiyon enzimi ile DNA parçacığı kesildi (Restriction fragment length polymorphism; RFLP analizi). Sonuçlar 40/40, 40/50 ve 50/50 olmak üzere üç genotip şeklinde sınıflandırıldı. Bronkopulmoner displazi grubunda 40/40 (n..43; %43,9), 40/50 (n..27; %27,6) ve 50/50 genotipi (n..28; %28,6), kontrol grubunda ise 40/40 (n..40; %42,6) ,40/50 (n..27; %28,7) ve 50/50 genotipi (n..27; %28,7) bulundu. İki grup arasında genelolarak veya alt gruplara ayrıldığında PAl- ı gen polimorfizmi dağılımında anlamlı fark bulunmadı. Sonuç olarak bizim çalışmamızda BPD gelişiminde Palı 40/50 gen polimorfizminin rolü bulunmadığı gösterilmiştir.
Coagulation and anticoagulation work in a balance in human body. Activation of the coagulation cascade leads to intraalveoler fibrin deposition in many inflammatory pulmonary disorders. Proinflammatory cytokines activate coagulation via tissue factor and attenuate fibrinolysis by increasing the level of plasminogen activator inhibitors. Bronchopulmonary dysplasia (BPD) continues to be one of the important causes of morbidity and mortality in preterm neonates. While some preterm infants develop BPD, some infants with the same gestational age and birth weight do not develop such a disease. Therefore, different individual factors may have role in the pathogenesis of BPD. Plasminogen activator inhibitor-l is one ofthe genetic factors that may have a role in the pathogenesis of the disease. We investigated the role of plasminogen activator inhibitor (PAI)-l 40/50 gene polymorphism in BPD. The study group comprised of 98 preterm infants with BPD and control group included 94 preterm infants without BPD. The neonates with congenital anomalies and the neonates who died during the first 28 days of life were excluded from the study. We analysed PAI-l 40/50 gene polymorphism by polymerase chain reaction and restriction enzyme digestion (RFLP). Preterm infants were divided into three groups according to their genotype including 40/40, 40/50 and 50/50. Of the BPD group, 43,9% had 40/40 (n..43), 27,6% the 40/50 (n..27) and 28,6% had 50/50 (n..28) genotype. On the other hand, control group 42,6% had 40/40 (n..40), 28,7% had 40/50 (n..27) and 28,7% had 50/50 (n..27) genotype. There was no statistically significant difference between two groups. In conclusion, we couldn't show any association between PAI-l 40/50 gene polymorphism and BPD in our study group
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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