39 research outputs found
Andrea Malinconico. Sant'Anna con il Bambino, la Vergine e San Giuseppe
No full textPubblicazione di un inedito dipinto di Andrea Malinconico nel convento di San Francesco a Pollic
Paolo De Matteis. Madonna dell'arco con San Gennaro e San Giovanni da Capestrano
No full textDipinto inedito della fase giovanile del De Matteis
Il ruolo del De Matteis tra "centro" e "periferia": la progressiva riscoperta del pittore cilentano
No full textIl percorso artistico di Paolo De Matteis rivisitato in sede critica
Dynamic brain states in spatial neglect after stroke
No full text: Previous studies indicated that spatial neglect is characterized by widespread alteration of resting-state functional connectivity and changes in the functional topology of large-scale brain systems. However, whether such network modulations exhibit temporal fluctuations related to spatial neglect is still largely unknown. This study investigated the association between brain states and spatial neglect after the onset of focal brain lesions. A cohort of right-hemisphere stroke patients (n = 20) underwent neuropsychological assessment of neglect as well as structural and resting-state functional MRI sessions within 2 weeks from stroke onset. Brain states were identified using dynamic functional connectivity as estimated by the sliding window approach followed by clustering of seven resting state networks. The networks included visual, dorsal attention, sensorimotor, cingulo-opercular, language, fronto-parietal, and default mode networks. The analyses on the whole cohort of patients, i.e., with and without neglect, identified two distinct brain states characterized by different degrees of brain modularity and system segregation. Compared to non-neglect patients, neglect subjects spent more time in less modular and segregated state characterized by weak intra-network coupling and sparse inter-network interactions. By contrast, patients without neglect dwelt mainly in more modular and segregated states, which displayed robust intra-network connectivity and anti-correlations among task-positive and task-negative systems. Notably, correlational analyses indicated that patients exhibiting more severe neglect spent more time and dwelt more often in the state featuring low brain modularity and system segregation and vice versa. Furthermore, separate analyses on neglect vs. non-neglect patients yielded two distinct brain states for each sub-cohort. A state featuring widespread strong connections within and between networks and low modularity and system segregation was detected only in the neglect group. Such a connectivity profile blurred the distinction among functional systems. Finally, a state exhibiting a clear separation among modules with strong positive intra-network and negative inter-network connectivity was found only in the non-neglect group. Overall, our results indicate that stroke yielding spatial attention deficits affects the time-varying properties of functional interactions among large-scale networks. These findings provide further insights into the pathophysiology of spatial neglect and its treatment
Brain Topological Reorganization Associated with Visual Neglect After Stroke
No full textBackground/Purpose: To identify brain hubs that are behaviorally relevant for neglect after stroke as well as to characterize their functional architecture of communication. Methods: Twenty acute right hemisphere damaged patients underwent neuropsychological and resting-state functional magnetic resonance imaging sessions. Spatial neglect was assessed by means of the Center of Cancellation on the Bells Cancellation Test. For each patient, resting-state functional connectivity matrices were derived by adopting a brain parcellation scheme consisting of 153 nodes. For every node, we extracted its betweenness centrality (BC) defined as the portion of all shortest paths in the connectome involving such node. Then, neglect hubs were identified as those regions showing a high correlation between their BC and neglect scores. Results: A first set of neglect hubs was identified in multiple systems including dorsal attention and ventral attention, default mode, and frontoparietal executive-control networks within the damaged hemisphere as well as in the posterior and anterior cingulate cortex. Such cortical regions exhibited a loss of BC and increased (i.e., less efficient) weighted shortest path length (WSPL) related to severe neglect. Conversely, a second group of neglect hubs found in visual and motor networks, in the undamaged hemisphere, exhibited a pathological increase of BC and reduction of WSPL associated with severe neglect. Conclusion: The topological reorganization of the brain in neglect patients might reflect a maladaptive shift in processing spatial information from higher level associative-control systems to lower level visual and sensory-motor processing areas after a right hemisphere lesion. Impact statement In this study, by employing the theoretic graph measures of betweenness centrality, we identified a set of neglect hubs, that is a cohort of cortical hubs that are behaviorally relevant for neglect after right hemisphere stroke. Although regions in higher level associative-control systems decreased their centrality and efficacy in communication, lower level visual and sensory-motor processing areas exhibited a dysfunctional increase in centrality. These findings have clinical implications as neglect hubs may be targeted for noninvasive brain stimulation protocols to restore their centrality and in turn to ameliorate the spatial deficit
Brain Topological Reorganization Associated with Visual Neglect After Stroke
No full textBackground/Purpose: To identify brain hubs that are behaviorally relevant for neglect after stroke as well as to characterize their functional architecture of communication. Methods: Twenty acute right hemisphere damaged patients underwent neuropsychological and resting-state functional magnetic resonance imaging sessions. Spatial neglect was assessed by means of the Center of Cancellation on the Bells Cancellation Test. For each patient, resting-state functional connectivity matrices were derived by adopting a brain parcellation scheme consisting of 153 nodes. For every node, we extracted its betweenness centrality (BC) defined as the portion of all shortest paths in the connectome involving such node. Then, neglect hubs were identified as those regions showing a high correlation between their BC and neglect scores. Results: A first set of neglect hubs was identified in multiple systems including dorsal attention and ventral attention, default mode, and frontoparietal executive–control networks within the damaged hemisphere as well as in the posterior and anterior cingulate cortex. Such cortical regions exhibited a loss of BC and increased (i.e., less efficient) weighted shortest path length (WSPL) related to severe neglect. Conversely, a second group of neglect hubs found in visual and motor networks, in the undamaged hemisphere, exhibited a pathological increase of BC and reduction of WSPL associated with severe neglect. Conclusion: The topological reorganization of the brain in neglect patients might reflect a maladaptive shift in processing spatial information from higher level associative-control systems to lower level visual and sensory–motor processing areas after a right hemisphere lesion
Reduced Segregation of Brain Networks in Spatial Neglect After Stroke
No full text: Background/Purpose: To investigate the association between the degree of spatial neglect and the changes of brain system segregation (SyS; i.e., the ratio of the extent to which brain networks interact internally and with each other) after stroke. Methods: A cohort of 20 patients with right hemisphere lesion was submitted to neuropsychological assessment as well as to resting-state functional magnetic resonance imaging session at acute stage after stroke. The severity of spatial neglect was quantified using the Center of Cancellation (CoC) scores of the Bells cancellation test. For each patient, resting-state functional connectivity (FC) matrices were assessed by implementing a brain parcellation of nine networks that included the visual network, dorsal attention network (DAN), ventral attention network (VAN), sensorimotor network (SMN), auditory network, cingulo-opercular network, language network, frontoparietal network, and default mode network (DMN). For each patient and each network, we then computed the SyS derived by subtracting the between-network FC from the within-network FC (normalized by the within-network FC). Finally, for each network, the CoC scores were correlated with the SyS. Results: The correlational analyses indicated a negative association between CoC and SyS in the DAN, VAN, SMN, and DMN (q < 0.05 false discovery rate [FDR]-corrected). Patients with more severe spatial neglect exhibited lower SyS and vice versa. Conclusion: The loss of segregation in multiple and specific networks provides a functional framework for the deficits in spatial and nonspatial attention and motor/exploratory ability observed in neglect patients. Impact statement In a graph-theoretic framework, we identify a loss of system segregation associative and sensorimotor networks in neglect patients who had suffered from right hemisphere stroke. From a theoretical standpoint, our findings corroborate the working hypothesis that the efficient segregation among brain systems is relevant for executing higher functions such as spatial attention. Clinically, the set of networks that exhibit loss of segregation offers a therapeutic opportunity and can be targets of neuromodulation protocols for neglect rehabilitation
Revisione e ampliamento del catalogo delle opere
No full text2012-2013The research was intended to highlight Francesco Solimena’s production between
1674 and 1706 and to prove the contribution of the sources and studies from the
1700’s to the present day, as well as the integration of the knowledge of the artistic
production through the introduction of new works which were deemed worthy of
our attention within his production, starting from the early years to his adulthood.
The documentary research played a major role, and was carried out at the State
Archive of Naples and the Historical Archive of the Fondazione Banco di Napoli,
this has allowed us to broaden the analysis of the relationship which took place
between the Neapolitan and Venetian commissioning of works of art. .. [edited by Author]Il lavoro di ricerca ha inteso puntare l’accento sulla produzione di Francesco
Solimena tra il 1674 e il 1706, sia al fine di comprovare l’apporto delle fonti e degli
studi dal ‘700 ai giorni nostri, sia al fine di integrare la conoscenza della
produzione dell’artista attraverso l’introduzione di nuove opere ritenute degne di
attenzione nell’ambito della sua produzione, a partire dagli anni giovanili fino alla
sua maturità. Un ruolo primario ha avuto la ricerca documentaria, condotta presso
l’Archivio di Stato di Napoli e l’Archivio Storico della Fondazione del Banco di
Napoli, che ha consentito di ampliare l’analisi dei rapporti con la committenza
napoletana e veneziana. .. [a cura dell'Autore]XIII n.s
