5 research outputs found
Pèlerinage à Notre-Dame de Torcé, au diocèse du Mans / [signé J.-L.-A.-M. Lochet]
No full textAppartient à l’ensemble documentaire : PaysLoir1Contient une table des matièresAvec mode text
Holger Fleischer, Jesper Lau Hansen & Wolf-Georg Ringe (eds.), German and Nordic Perspectives on Company Law and Capital Markets Law (Tübingen: Mohr Siebeck, 2015)
No full textBook review of: Holger Fleischer, Jesper Lau Hansen & Wolf-Georg Ringe (eds.), German and Nordic Perspectives on Company Law and Capital Markets Law (Tübingen: Mohr Siebeck, Max-Planck-Institut für ausländisches und internationals Privatrecht, Beiträge zum ausländischen und internationalen Privatrecht, 2015
Surface Engineering by ALD for Superconducting RF Cavities
No full textInternational audienceAtomic Layer Deposition is a synthesis method that enable a unique control of thin films chemical composition and thickness over complex shape objects such as SRF cavities. This level of control opens the way to new surface treatments and to study their effect on RF cavity performances. We will present coupon and, in some cases, preliminary cavity results, from various surface engineering routes based on the deposition of thin oxides and nitrides films combined with post annealing treatments and study their interactions with the niobium. Three main research directions will be presented: 1/ replacing the niobium oxides by other surface layers (Al₂O₃, Y2O3, MgO) and probe their effect on the low and high field performances, 2/ doping with N and combine approaches 1/ and 2/ and finally 3/ optimize the superconducting properties of NbTiN multilayers on Nb and Sapphire
Childhood in the works of Silvina Ocampo and Alejandra Pizarnik
No full textThis thesis
explores childhood as
theme
and perspective
in
the Argentine
cuentista and
poet
Silvina Ocampo (1903-1993)
and traces this thematic
and vital
link to the
Argentine
poet
Alejandra Pizamik (1936-1972). The
study
looks
at childhood not only
in
relation to their literary texts but
also
in the
writers' construction of self-identity
within
their
socio-literary context, and at
the
role played
by
visual art
in their
aesthetic.
Chapter 1
contrasts Silvina
with
her
elder sister
Victoria Ocampo through their
differing literary
appropriation of a shared childhood. It distinguishes Ocampo from
Adolfo Bioy Casares and
Jorge Luis Borges in terms of
her fictional logic
and
her
treatment of games, drawing comparisons instead with Julio Cortdzar.
Chapter 2
undertakes close reading of various Ocampo texts, including
some
for
children,
in
order to explore
her
vision of childhood through nostalgia, adult-child
power relationships, aging and rejuvenation, and moments of
initiation or
imitation.
Chapter 3
turns to Pizarnik
and the myth of the child-poet.
It
analyses
her
child
personae through Andre Breton's Surrealism, Jean Cocteau
and
Octavio Paz, through
her borrowings from Alice in Wonderland
and
Nadja,
and
through
her
obsession with
madness, death,
orphanhood, violation and transgression.
Chapter 4 is
comparative.
It
outlines the context
in
which
Ocampo
and
Pizamik's
passionate friendship developed,
and considers
Pizamik's
essay on
Elpecado
mortal.
It
then explores their broad
mutual
literary
and
thematic
affinities.
My
conclusion is that Ocampo's works achieve equilibrium between childhood and age,
whereas Pizarnik's
much-discussed poetic crisis of exile
from language itself
parallels
her deep sense of anxiety at being
exiled from the world of childhood.
This thesis
contributes to the
study of
Argentine literature by drawing
revealing
comparisons
between
two key
writers
through their shared obsession with childhood,
arguing that
an understanding of their attitudes
to childhood
is fundamental
to
appreciating
fully their
work.
I
refer to unpublished
letters
of
Ocampo,
material
from
private
interviews,
photographs and relevant paintings
by Leonor Fini, Alicia Carletti
and others
The long-term effectiveness of efavirenz-based combination antiretroviral therapy, the impact of pharmacogenomics and pharmacokinetic interaction of artemisinin-based antimalarial therapy on efavirenz exposure among Ghanaian HIV-infected patients
No full textDr. Fred Stephen Sarfo, The long-term effectiveness of efavirenz-based combination antiretroviral therapy, the impact of pharmacogenomics and pharmacokinetic interaction of artemisinin-based antimalarial therapy on efavirenz exposure among Ghanaian HIV-infected patients. PhD dissertation, Durham University, January 2013.
Introduction: In sub-Saharan Africa, HIV treatment is initiated with combination of antiretroviral medications comprising of a backbone of either stavudine or zidovudine plus lamivudine with a non-nucleoside reverse transcriptase inhibitor of either efavirenz or nevirapine. Efavirenz is highly efficacious, durable and well tolerated. The risk for toxicity of efavirenz is determined by several factors including single nucleotide polymorphisms in the hepatic enzymes responsible for its metabolism and concurrently administered medications such as antimalarials, which share common metabolic pathways. The aims of this dissertation are to assess the long-term effectiveness of efavirenz-based antiretroviral therapy and the impact of pharmogenomics and pharmacokinetic interactions of artemisinin-based antimalarial therapy on efavirenz exposure among Ghanaian HIV-infected patients.
Methods: The effectiveness of efavirenz- compared with nevirapine-based antiretroviral therapy was assessed retrospectively in nearly 4000 patients starting treatment between 2004 and 2010. The main outcome measure was a composite of toxicity, disease progression and attrition, and CD4 count changes. A prospective pharmacokinetic study of artesunate and efavirenz was conducted among 22 HIV-infected and 21 controls. Plasma efavirenz and artesunate/ dihydroartemisinin concentrations were measured using validated and standardised methods. Genotyping for single nucleotide polymorphisms in CYP2B6 G516T, T983C; CYP2A6*9B, UGT2B7*735 and *802 as well as CAR rs2307424 were performed for 800 patients with real-time polymerase chain reaction with allelic discrimination.
Results: Antiretroviral therapy was associated with robust CD4 increases. Efavirenz was comparable with nevirapine in composite outcomes but better tolerated. Artesunate was well tolerated when administered to HIV-infected patients on efavirenz. Single nucleotide polymorphisms in the CYP2B6 G516T and T983C were associated with increased plasma efavirenz concentrations.
Conclusions/Recommendation: Among this Ghanaian cohort, both efavirenz and nevirapine-based antiretroviral therapy were effective. The better tolerability of efavirenz compared with nevirapine means it can be safely used as the preferred first line non-nucleoside reverse transcriptase inhibitor in sub-Saharan Africa
