511 research outputs found
The effect of competition between two spatially separated markets - An investigation of two interlinked Bak-Sneppen models
No full textThis paper investigates the effect of competition in a market consisting of interlinked economic agents. In particular, the effect of increased competition from the surrounding markets is demonstrated. The presented work is an extension of the Bak-Sneppen model (Bak and Sneppen 1993). Here are two Bak-Sneppen models interlinked such that if the lowest fitness value of one market exceeds the fitness values of the other market minus transportation cost, all cells lower than this band will receive a new random value. The model shows that interdependency between markets has a strong effect on the competitiveness of the least competitive market. The external competition is able to make the least competitive market perform better as well as worse than on its own.Bak-Sneppen model, interdependency, competition, Marketing,
Volle bak in cijfers: Het NVVK-congres geëvalueerd
No full textOp 13 en 14 maart was weer het 2-jaarlijkse NVVK-congres op de inmiddels vertrouwde locatie van Papendal. Met 588 gasten was het andermaal ‘volle bak’. Achteraf hebben 314 van hen de moeite genomen om de evaluatie in te vullen (een respons van maar liefst 53 procent). Als vereniging en als congrescommissie mogen wij beslist tevreden zijn. Waarom? Dat leest u hieronder.Safety and Security Scienc
Author response: Disordered clusters of Bak dimers rupture mitochondria during apoptosis
No full textDuring apoptosis, Bak and Bax undergo major conformational change and form symmetric dimers that coalesce to perforate the mitochondrial outer membrane via an unknown mechanism. We have employed cysteine labelling and linkage analysis to the full length of Bak in mitochondria. This comprehensive survey showed that in each Bak dimer the N-termini are fully solvent-exposed and mobile, the core is highly structured, and the C-termini are flexible but restrained by their contact with the membrane. Dimer-dimer interactions were more labile than the BH3:groove interaction within dimers, suggesting there is no extensive protein interface between dimers. In addition, linkage in the mobile Bak N-terminus (V61C) specifically quantified association between dimers, allowing mathematical simulations of dimer arrangement. Together, our data show that Bak dimers form disordered clusters to generate lipidic pores. These findings provide a molecular explanation for the observed structural heterogeneity of the apoptotic pore
Hile alan nda bilimsel dergilerde yer alan ulusal makaleler: (2008-2017 literatür taramas )
No full textBu çal ma ile bilimsel dergilerde hile alan nda yay nlanan makalelerin nitelik ve nicelik aç s ndande erlendirmesi amaçlanm t r. Bu amaçla, ulusal dergilerde hile konular n içeren 2008-2017 y llar aras nda yay nlanan makaleler, Google Akademik veri taban nda hile anahtar kelimesi ile taranm -t r. Çal mada ulusal dergilerde yay nlanan 44 makale ara t rman n kapsam n olu turmaktad r. Bukapsamdaki makaleler içerik analizi ile incelenmi tir. Sonuç olarak makaleler 7 ana ba l k alt nda s -n fland r lm olup, en fazla Hilenin Tan m ve Nedenleri konusunda çal ma yap ld görülmü tür.Ayr ca en çok makalenin yazar say s bak m ndan tek yazarl oldu u, mesleki unvan bak m ndan Yrd. Doç. Dr. unvanl , akademisyenler taraf ndan yap ld ve yay nland klar dergi bak m ndanise Mali Çözüm dergisinde yay nland tespit edilmi tir.The purpose of this article is to evaluate the scientific journals in terms of quality and quantity of artic-les published that in the field of fraud. In line with this purpose articles published in national journalswere examined by Scholar Google database with fraud keyword in 2008-2017 years. The scope ofthis research is 44 articles that published in national journals. These articles were investigated withcontent analysis. As a result, the articles were classified under 7 main headings and it was seen that themost studied Fraud Definition and Reasons topics. In addition, it was determined the most articlesare in terms of the number of authors single author , in terms of professional title Assist. Prof. Dr. , academicians and published by Mali Çözüm journal
Towards Sub-Quadratic Diameter Computation in Geometric Intersection Graphs
No full textISSN:1868-896
Lipid unsaturation promotes BAX and BAK pore activity during apoptosis
No full textFunding Information: This work was supported by European Research Council (ERC) under the European Union\u2019s Horizon 2020 research and innovation program (Grant agreement No. 817758), by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), SFB1218, project no. 269925409 and by CANTAR research network \u201CCANcer TARgeting\u201D, Ministry of Culture and Science of the State of Northrhine Westphalia, Germany and by FCT \u2013 Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia, I.P., through MOSTMICRO-ITQB R&D Unit (doi:10.54499/UIDB/04612/2020; doi:10.54499/UIDP/04612/2020), LS4FUTURE Associated Laboratory (doi:10.54499/LA/P/0087/2020) and CEECIND fellowship to M.N.M. (doi:10.54499/CEECIND/04124/2017/CP1428/CT0008). Special thanks to Prof. Christian Frezza and Dr. Nieves Peltzer for providing kidney and lung cancer cell lines. We thank Dr. R. Shalaby, Dr. H. Flores, Dr. L. Pedrera Puentes and Prof. A. Villunger for their technical input and stimulating discussions Publisher Copyright: © The Author(s) 2024.BAX and BAK are proapoptotic members of the BCL2 family that directly mediate mitochondrial outer membrane permeabilition (MOMP), a central step in apoptosis execution. However, the molecular architecture of the mitochondrial apoptotic pore remains a key open question and especially little is known about the contribution of lipids to MOMP. By performing a comparative lipidomics analysis of the proximal membrane environment of BAK isolated in lipid nanodiscs, we find a significant enrichment of unsaturated species nearby BAK and BAX in apoptotic conditions. We then demonstrate that unsaturated lipids promote BAX pore activity in model membranes, isolated mitochondria and cellular systems, which is further supported by molecular dynamics simulations. Accordingly, the fatty acid desaturase FADS2 not only enhances apoptosis sensitivity, but also the activation of the cGAS/STING pathway downstream mtDNA release. The correlation of FADS2 levels with the sensitization to apoptosis of different lung and kidney cancer cell lines by co-treatment with unsaturated fatty acids supports the relevance of our findings. Altogether, our work provides an insight on how local lipid environment affects BAX and BAK function during apoptosis.publishersversionpublishe
Presentations For Powers Of The Augmentation Ideal And Quadratic Forms
No full textrent article. The second named author gratefully acknowledges the support of the Alexander von Humboldt-Stiftung during the preparation of the present article. Typeset by A M S-T E X 2 anthony bak, nikolai vavilov It is a classical unsolved problem in the theory of group rings to find the relations among the generators [g 1 ; : : : ; gn ] for J n (G). There are two obvious relations which hold for any group G. The first is the normalizing relation (N) [g 1 ; : : : ; gn ] = 0 (n 1); whenever some g i = 1: The second is that the symbol [g 1 ; g 2 ] is a 2-cocycle: [g 2 ; g 3 ] \Gamma [g 1 g 2<F
Dynamic Time Warping Under Translation: Approximation Guided by Space-Filling Curves
No full textISSN:1868-896
The impact of propranolol on the predictive validity of estimated VO2 max by the Ekblom-Bak submaximal cycle test : a double-blind crossover study
No full textPurpose Usage of beta-blockers may influence heart rate response during exercise testing. The study aimed to investigate the impact of Propranolol, a non-selective beta-blocker, on the predictive validity of a commonly used submaximal cycle test, the Ekblom-Bak test (EB-test), for the estimation of maximal oxygen uptake (VO2 max). Methods The study was a double-blinded crossover study including 28 participants (14 women), aged 21-59 years. VO2 max was estimated by the EB-test and measured during a maximal incremental exercise test during placebo and 10 mg Propranolol beta-blockade condition. The EB-test estimates VO2 max based on the difference in heart rate, Delta HR, between two work rates (4 min cycling on each), a factor corresponding to the higher rate, heart rate at the lower rate, and age. Results Maximal heart rate (mean +/- SD; 165.5 +/- 16.5 vs. 181.4 +/- 9.8 bpm), Delta HR (36.4 +/- 13.2 vs. 43.0 +/- 11.4 bpm), and measured VO2 max (48.2 +/- 6.2 vs. 50.4 +/- 7.0 ml/kg/min, 3.55 +/- 0.74 vs. 3.67 +/- 0.71 L/min) were significantly lower in the beta-blockade condition compared to placebo (P = < .001). This led to an overestimation of VO2 max by the EB-test during beta-blockade, + 0.377 L/min (95% CI 0.281-0.473 L/min, + 11.2%), with no overestimation seen in the placebo condition, + 0.030 L/min (95% CI (- 0.112)-0.172 L/min + 0.8%). The coefficient of variance, indicating variance of estimated VO2 max on an individual level, was lower during beta-block condition, 6.6%, compared to placebo, 9.9%. Conclusion The EB-test systematically overestimated VO2 max compared to measured VO2 max during beta-blockade condition. Future research is needed to refine the test equation for usage in populations using beta-blockers.This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made.</p
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