239 research outputs found
Monadology and Sociology
No full textGabriel Tarde’s Monadology and Sociology, originally published in 1893, is a remarkable and unclassifiable book. It sets out a theory of 'universal sociology', which aims to explicate the essentially social nature of all phenomena, including the behaviour of atoms, stars, chemical substances and living beings. He argues that all of nature consists of elements animated by belief and desire, which form social aggregates analogous to those of human societies and institutions. In developing this central insight, Tarde outlines a metaphysical system which builds on both classical rationalist philosophy and the latest scientific theories of the time, in a speculative synthesis of extraordinary range and power.
Tarde’s work has only recently returned to prominence after a long eclipse. His work was an important influence on later theorists including Deleuze and Latour, and has been widely discussed in the social sciences, but has rarely been a focus of philosophical interest. The translator’s afterword provides an explication of the key ideas in the text and situates Tarde’s theory within the context of the philosophical tradition, arguing for the importance of the text as a highly original work of systematic ontology, and for its importance for contemporary theoretical debates.
About the Author
Gabriel Tarde (1843-1904) was a French sociologist, criminologist and social theorist. He originally trained in law and worked as a judge. Subsequently he was director of criminal statistics at the French Ministry of Justice, and then held the chair in modern philosophy at the Collège de France. His works cover a wide range of interests; he is best known for his theories of imitation and his work on crowd psychology, and for his debates on sociological theory with Émile Durkheim.
Theo Lorenc is Research Fellow at the London School of Hygiene and Tropical Medicine
Hypandrium as a key character in resolving species-level taxonomy on the example of Perisama oppelii (Latreille) (Lepidoptera : Nymphalidae, Biblidinae)
No full textFIGURE 5. Distribution map of P. oppelii and P. bleuzeni stat. n.Published as part of Zubek, Anna, Lorenc-Brudecka, Jadwiga & Pyrcz, Tomasz W., 2015, Zootaxa 3990 (1), DOI: 10.11646/zootaxa.3990.1.2, http://zenodo.org/record/23595
Cheimas opalinus subsp. dominici Pyrcz & Lorenc-Brudecka & Boyer & Zubek 2018, n. ssp.
No full text<i>Cheimas opalinus dominici</i> Pyrcz & Boyer, n. ssp. <p>(Figs. 5C–F, 6C–F, 9E–F, 11C)</p> <p> <b>Type locality:</b> El Baho, Valle de Santo Domingo, Cordillera de Mérida, Venezuela</p> <p> <b>Material examined:</b> HOLOTYPE ♂: VENEZUELA, Cordillera de Mérida, Mérida State, El Baho (transect)</p> <p> via El Páramo, 2900 m, 24.XI.2005, T. Pyrcz leg., CEP-MZUJ (to be deposited in MIZA); PARATYPES: VENEZUELA, Cordillera de Mérida, Mérida State: 14 ♂: Pueblo Llano, Cańotal, 2750–2800 m, 29.XII.2004, M. Costa leg., 1 prep. genit. 402/ 21.06.2016 J. Lorenc, 2 prep. genit. 406/ 21.06.2016 J. Lorenc; 6 ♂: Pueblo Llano—Tuñame, Qda. Ranchería, 2900–2950 m, 27.XI.2005, T. Pyrcz leg.; 1 ♂: El Baho (transect) via El Páramo, 2900 m, 22.XI.2005, T. Pyrcz leg.; 4 ♂: El Baho (transect) via El Páramo, 2900 –2950 m, 26.XI.2005, T. Pyrcz leg.; 1 ♂: El Baho (transect) via El Páramo, 2700 m, 26.XI.2005, T. Pyrcz leg.; 3 ♂: El Baho (transect) via El Páramo, 2900 –2950 m, 21.XI.2005, T. Pyrcz leg., 1 prep. genit. 389/ 21.06.2016 J. Lorenc; 2 ♂: El Baho (transect) via El Páramo, 2900 m, 21.XI.2005, T. Pyrcz leg.; 2 ♂: El Baho (transect) via El Páramo, 2850 m, 21.XI.2005, T. Pyrcz leg.; 1 ♂: El Baho (transect) via El Páramo, 3100 m, 24.XI.2005, T. Pyrcz leg.; 1 ♂: El Baho (transect) via El Páramo, 2900 –2950 m, 14.XI.2005, T. Pyrcz leg.; 1 ♂: El Baho (transect) via El Páramo, 2800 m, 22.XI.2005, T. Pyrcz leg., prep. genit. 401/ 21.06.2016 J. Lorenc; 1 ♂: El Baho—El Hatico, La Ciénaga, 2900–2950 m, 21.X.2005, T. Pyrcz leg., prep. genit. 399/ 21.06.2016 J. Lorenc; 1 ♂: no data; 10 ♂: Mucubají—Santo Domingo, Los Frailes, 3000–3050 m, 08.VII.2006, T. Pyrcz leg., 1 prep. genit. 400/ 21.06.2016 J. Lorenc; Barinas State: 5 ♂: P. N. Sierra Nevada, Los Morritos, 3000–3050 m, 06.I.2006, M. Costa leg.; 1 ♂: P. N. Sierra Nevada, Los Morritos, 3100–3250 m, 11.II.2010, T. Pyrcz leg., prep. genit. 385/ 30.05.2016 J. Lorenc; 9 ♂: Trujillo State, vía Páramo Ortíz, Qda. Ortíz, 2900 –2950 m, 05.II.2008, T. Pyrcz leg., 1 prep. genit. 398/ 21.06.2016 J. Lorenc; 1 ♀: El Baho, El Hatico, 3300–3350 m, 24.XI.2005, T. Pyrcz leg.; 1 ♀: El Baho, El Hatico, 2900–2950 m, 14.II.2007, T. Pyrcz leg., prep. genit. 485/ 17.11.2016 J. Lorenc; 1 ♀: El Baho, P. N. Sierra Nevada, 3000–3050 m, 28.I.2008, T. Pyrcz leg., <b>CEP- MZUJ</b>; 2 ♂: El Baho, La Ciénaga, 2900 m, 21.XI.2005, T. Pyrcz leg., 2016-221, kölcsön anyag 2007. IX.26; 1 ♂: El Baho, La Ciénaga, 2900 m, 26.XI.2005, T. Pyrcz leg., 2016-221, kölcsön anyag 2007. IX.26, 1 ♂: El Baho, vęa El Páramo, 2800 –2850 m, 22.XI.2005, T. Pyrcz leg., 2016-221, kölcsön anyag 2007. IX.26; 1 ♂: Mucubají-Santo Domingo, Los Frailes, 3000–3050 m, 08.VI.2006, T. Pyrcz leg., kölcsön anyag 2007. IX.26, 1 ♂: El Baho, Sto Domingo-Apartaderos, 2850–3100 m, 21.XI.2005, Zs. Bálint & B. Benedek leg., No,. 2 Biophot expedition, <b>HMNH</b>; 3 ♂: El Baho, Sto Domingo vers Apartaderos km 4, 3050 m, 21.XI.2005, P. Boyer leg.; 1 ♂: El Baho, Sto Domingo vers Apartaderos km 4, 2950 m, 22.XI.2005, P. Boyer leg.; 1 ♂ and 3 ♀: El Baho, Sto Domingo vers Apartaderos km4, 2850/ 3100 m, 21.XI.2005, P. Boyer leg.; 2 ♂: El Baho, Sto Domingo vers Apartaderos km4, 2800/ 3000 m, 28.I.2008, P. Boyer leg.; 4 ♂ and 1 ♀: Pueblo Llano vers Niquitao, Ranchería, 2700 m, 27.XI.2005, P. Boyer leg.; 1 ♂: Pueblo Llano vers Niquitao, 2.5km après Ranchería, 2850 m, 25.XI.2005, P. Boyer leg.; 1 ♂ and 1 ♀: Pueblo Llano vers Niquitao, 2.5km après Ranchería, 2850 m, 27.XI.2005, P. Boyer leg.; <b>PBF</b>; 1 ♂: Mérida, Los Frailes, 25.II.2010, H. Warren-Gash leg., <b>HWG</b>.</p> <p> <b>Diagnosis.</b> In both sexes the HWD patch does not enter discal cell in most examined individuals or enters it only marginally, but it extends further towards the HW base than in the nominotypical or <i>C. opalinus iosephi</i> n. ssp., which makes it look triangular rather than rounded or oval. Female’s ductus bursae (Fig. 11C) is longer and slightly wider than in <i>C. opalinus rosalinus</i> n. ssp. but narrower than in the nominate subspecies, similar to <i>C. opalinus iosephi</i> n. ssp (Fig. 11B).</p> <p>FWL: 27.5– 32 mm, mean: 29.7 mm (n=54).</p> <p>D colour: coffee brown</p> <p>HWP colour: metallic greenish blue</p> <p>HWP shape: oval and always elongated along anal margin, not entering or entering marginally the discal cell, usually as a few scales, entering basal part of cell M3–CuA1 but never M2–M3</p> <p> <b>Individual variation.</b> Considerable, evident mostly in the varying size of the HWP, which is however not related to any particular population.</p> <p> <b>Etymology.</b> This subspecies epithet is derived from its type locality the valley of Santo Domingo, in Latin— <i>Sanctus Dominicus</i>.</p> <p> <b>Geographic range.</b> Both, northern and southern slopes of the valley of Santo Domingo, and the valley of Pueblo Llano.</p> <p> <b>Altitudinal range.</b> 2750–3350 m a.s.l.</p> <p> A. <i>Cheimas opalinus iosephi</i> male, PARATYPE, Páramo de San José</p> <p> B. <i>Cheimas opalinus iosephi</i> female, PARATYPE, Páramo de San José</p> <p> C. <i>Cheimas opalinus dominici</i> male, PARATYPE, Los Frailes</p> <p> D. <i>Cheimas opalinus dominici</i> female, PARATYPE, El Baho</p> <p> E. <i>Cheimas opalinus dominici</i> male, PARATYPE, Qda. Ranchería</p> <p> F. <i>Cheimas opalinus dominici</i> female, PARATYPE, El Baho</p> <p> A. <i>Cheimas opalinus iosephi</i> male, PARATYPE, Páramo de San José</p> <p> B. <i>Cheimas opalinus iosephi</i> female, PARATYPE, Páramo de San José</p> <p> C. <i>Cheimas opalinus dominici</i> male, PARATYPE, Los Frailes</p> <p> D. <i>Cheimas opalinus dominici</i> female, PARATYPE, El Baho</p> <p> E. <i>Cheimas opalinus dominici</i> male, PARATYPE, Qda. Ranchería</p> <p> F. <i>Cheimas opalinus dominici</i> female, PARATYPE, El Baho</p>Published as part of <i>Pyrcz, Tomasz W., Lorenc-Brudecka, Jadwiga, Boyer, Pierre & Zubek, Anna, 2018, Subspecies-level systematics and affinities of Cheimas Thieme - an endemic genus of the subparamo of the Venezuelan Cordillera de Mérida (Lepidoptera: Nymphalidae, Satyrinae), pp. 219-243 in Zootaxa 4422 (2)</i> on pages 229-232, DOI: 10.11646/zootaxa.4422.2.4, <a href="http://zenodo.org/record/1251513">http://zenodo.org/record/1251513</a>
Cheimas opalinus subsp. cristalinus Pyrcz & Lorenc-Brudecka & Boyer & Zubek 2018, n. ssp.
No full textCheimas opalinus cristalinus Pyrcz & Boyer, n. ssp. (Figs. 7A–F, 8A–F, 10A–D, 11D–E) Type locality: Pico Tonojo sector, Km 27 Boconó—Trujillo old road, Trujillo State, Cordillera de Mérida, Venezuela. Material examined: HOLOTYPE ♂: VENEZUELA, Cordillera de Mérida, Trujillo State, Trujillo—Boconó old road, Sector Pico Tonojo, Km 27, 2400–2450 m, 25.II.2010, T. Pyrcz leg., CEP-MZUJ (to be deposited in MIZA); PARATYPES: VENEZUELA, Cordillera de Mérida, Trujillo State: 2 ♂: P. N. Guaramacal, via La Vega de Guaramacal, 2800–2850 m, 22.XII.2004, M. Costa leg.; 2 ♂: P. N. Guaramacal, Qda. El Caote, 2700–2750 m, 16.II.2007, T. Pyrcz leg.; 4 ♂: P. N. Guaramacal, Qda. El Caote, 2700–2750 m, 26.II.2009, T. Pyrcz leg., 1 prep. genit. 387/ 21.06.2016 J. Lorenc; 3 ♂: P. N. Guaramacal, Qda. El Caote, 2700–2750 m, 15.II.2007, T. Pyrcz leg., 1 prep. genit. 408/ 21.06.2016 J. Lorenc; 1 ♂: P. N. Guaramacal, Qda. El Caote, 2550–2600 m, 08.XII.2005, T. Pyrcz leg.; 14 ♂: Boconó—Burbusay, Cambimbú de San Miguel, 2900–2950 m, 19.II.2007, T. Pyrcz leg.; 2 ♂: P. N. Dinira, Páramo Cendé, 3000–3050 m, 13.II.2010, T. Pyrcz leg., 1 prep. genit. 395/ 21.06.2016 J. Lorenc; 2 ♂: P. N. Dinira, Páramo de Las Rosas, 3100–3150 m, 07.II.2010, T. Pyrcz leg.; 1 ♂: P. N. Dinira, Agua de Obispo, 2600– 2550 m, 14.VIII.2003, T. Pyrcz leg., prep. genit. 04/ 05.01.2005 T. Pyrcz; 18 ♂: Trujillo—Boconó old road, Sector Pico Tonojo, Km 27, 2400–2450 m, 25.II.2010, T. Pyrcz leg., 1 prep. genit. 387/ 30.05.2016 J. Lorenc; 9 ♂: Trujillo—Boconó old road, Sector Pico Tonojo, Km 27, 2300–2350 m, 28.VII.2009, T. Pyrcz leg., 1 prep. genit. 407/ 21.06.2016 J. Lorenc, 1 wing prep.; 16 ♂: Trujillo—Boconó old road, Sector Pico Tonojo, Km 27, 2450– 2500 m, 18.IV.2006, T. Pyrcz leg.; 13 ♂: Trujillo—Boconó old road, Sector Pico Tonojo, Km 27, 2450– 2500 m, 17.IV.2006, T. Pyrcz leg.; 1 ♂: Trujillo—Boconó old road, Sector Pico Tonojo, Km 27, 2450– 2500 m, 19.IV.2006, T. Pyrcz leg.; 1 ♂: Trujillo—Boconó old road, Sector Pico Tonojo, Km 27, 2450– 2500 m, 16.IV.2006, T. Pyrcz leg.; 5 ♂: Trujillo, Pico Tonojo, 2500 m, 28.III.2011, T. Pyrcz leg.; 6 ♀: Trujillo—Boconó old road, Sector Pico Tonojo, Km 27, 2400–2450 m, 25.II.2010, T. Pyrcz leg., 1 prep. genit. 486/ 17.11.2016 J. Lorenc; 2 ♀: Trujillo—Boconó old road, Sector Pico Tonojo, Km 27, 2400–2450 m, 18.IV.2006, T. Pyrcz leg.; 1 ♀: Trujillo—Boconó old road, Sector Pico Tonojo, Km 27, 2300–2350 m, 28.VII.2009, T. Pyrcz leg.; 1 ♀: P. N. Guaramacal, Qda. El Caote, 2700–2750 m, 16.II.2007, T. Pyrcz leg., prep. genit. 488/ 22.11.2016 J. Lorenc; 1 ♀: P. N. Guaramacal, Qda. El Caote, 2700–2750 m, 15.II.2007, T. Pyrcz leg.; 1 ♀: P. N. Guaramacal, Qda. El Caote, 2600–2650 m, 26.II.2009, T. Pyrcz leg.; 1 ♀: P. N. Dinira, Páramo Cendé, 3000–3050 m, 13.II.2010, T. Pyrcz leg., CEP-MZUJ; 1 ♂: Guaramacal, Qda. El Caote, 2700–2750 m, 15.II.2007, T. Pyrcz leg., 2016 -221, köcsön anyag 2007. IX.29, HMNH; 2 ♂: Páramo de Ortíz, 2900 m, 5.II.2008, P. Boyer leg.; 2 ♂: Boconó vers Guaramacal, quebrada el Caote, 2650 m, 8.XII.2005, P. Boyer leg.; 5 ♂: massif du Guaramacal, quebrada el Caote, 2600 m, 8.XII.2005, P. Boyer leg.; 30 ♂ and 2 ♀: carretera vieja a Trujillo km8, “ El Rucio ”, pie del Pico Tonojo (30km sud de Boconó), 2500 m, 16.IV.2006, P. Boyer leg.; 1 ♀: via antigua de Boconó a Trujillo km8, 2400 m, 28.VII.2009, P. Boyer leg., PBF; 5 ♂ and 1 ♀: Trujillo, Trujillo-Boconó old road, Sector Pico Tonojo, 2400–2500 m, 24.II.2010, H. Warren-Gash leg., HWG. Diagnosis. Both sexes of this subspecies are characterized by a regular, rounded HW patch always entering discal cell, in this respect similar to the nominotypical, but considerably smaller. Female’s ductus bursae (Fig. 11D–E) is narrow and longer than in other subspecies except the nominate. FWL: 26–30.5 mm, mean: 27.6 mm (n=95). D colour: blackish brown, uniform. HWP colour: metallic bluish, usually with a greenish sheen HWP shape: oval or rounded, small, but always entering discal cell, covering one–third or one–fourth marginally, but not reaching as far basally or distally as in other subspecies, extending distally considerably along vein CuA1, in some individuals distal edge slightly undulated. Individual variation. Individuals from Guaramacal are consistently larger than in other populations. Also, in Cendé and Guaramacal the patch has usually a more bluish, whereas in the Pico Tonojo specimens a greenish sheen. Etymology. The epithet of subspecies is derived from the Páramo La Cristalina, a mountain situated just south from its type locality. A. Cheimas opalinus cristalinus male, PARATYPE, Pico Tonojo B. Cheimas opalinus cristalinus female, PARATYPE, Pico Tonojo C. Cheimas opalinus cristalinus male, PARATYPE, Guaramacal D. Cheimas opalinus cristalinus female, PARATYPE, Guaramacal E. Cheimas opalinus cristalinus male, PARATYPE, Páramo de Las Rosas F. Cheimas opalinus cristalinus female, PARATYPE, Páramo de Las Rosas A. Cheimas opalinus cristalinus male, PARATYPE, Pico Tonojo B. Cheimas opalinus cristalinus female, PARATYPE, Pico Tonojo C. Cheimas opalinus cristalinus male, PARATYPE, Páramo de Guaramacal D. Cheimas opalinus cristalinus female, PARATYPE, Páramo de Guaramacal E. Cheimas opalinus cristalinus male, PARATYPE, Páramo de Las Rosas F. Cheimas opalinus cristalinus female, PARATYPE, Páramo de Las Rosas B. Cheimas opalinus opalinus, Qda. La Boba (prep. genit. 403/ 21.08.2016) C. Cheimas opalinus iosephi, Páramo de San José (prep. genit. 405/ 21.06.2016) D. Cheimas opalinus iosephi, Mesa Alta (prep. genit. 564/ 12.07.2017) E. Cheimas opalinus dominici, La Ciénaga (prep. genit. 399/ 21.06.2016) F. Cheimas opalinus dominici, Los Morritos (prep. genit. 385/ 30.05.2016) B. Cheimas opalinus cristalinus, Guaramacal (prep. genit. 408/ 21.06.2016) C. Cheimas opalinus cristalinus, Páramo de Ortíz (prep. genit. 398/ 21.06.2016) D. Cheimas opalinus cristalinus, Pico Tonojo (prep. genit. 486/ 17.11.2016) E. Cheimas opalinus rosalinus, El Rosal (prep. 388/ 30.05.2016) F. Cheimas opalinus iosephi x Ch. opalinus rosalinus, El Batallón (prep. genit. 386/ 30.05.2016) A. Cheimas opalinus opalinus, La Culata (prep. genit. 392/ 08.06.2016) B. Cheimas opalinus iosephi, Páramo de San José (prep. genit. 487/ 17.11.2016) C. Cheimas opalinus dominici, El Baho (prep. genit. 485/ 17.11.2016) D. Cheimas opalinus cristalinus, Pico Tonojo (prep. genit. 486/ 17.11.2016) E. Cheimas opalinus cristalinus, Guaramacal (prep. genit. 488/ 22.11.2016) F. Cheimas opalinus rosalinus, El Rosal (prep. genit. 391/ 08.06.2016) Geographic range. Throughout northern Cordillera de Mérida, north of the Niquitao range, including the massifs of Guaramacal and Cendé. Altitudinal range. 2300–3150 m a.s.l.Published as part of Pyrcz, Tomasz W., Lorenc-Brudecka, Jadwiga, Boyer, Pierre & Zubek, Anna, 2018, Subspecies-level systematics and affinities of Cheimas Thieme - an endemic genus of the subparamo of the Venezuelan Cordillera de Mérida (Lepidoptera: Nymphalidae, Satyrinae), pp. 219-243 in Zootaxa 4422 (2) on pages 233-240, DOI: 10.11646/zootaxa.4422.2.4, http://zenodo.org/record/125151
Johnsonita zubkova Balint, Boyer & Lorenc-Brudecka 2021, sp. n.
No full textJohnsonita zubkova Bálint, Boyer & Lorenc –Brudecka sp. n. (Figs 15, 19G–H, 22J–L, 23H, 31) Type material. Holotype male in perfect condition, set dorsally, with data: PERU, Dept. Cuczo, Paucartambo, Abra Acjanacovers Pillcopata km 10, 3000-3100 m, 24.II.2005, P. Boyer. (dissected: gen. prep. 6301/ J. Lorenc) (CB; will be deposited in MUSM). Paratypes (n=2), all from Peru: Dept. Puno, Vallée de Limbani, Carcel Punco, 8km nord de Limbani, 2600–2700 m, V.2005, J. Böttger (CB: female); Dept. Cuzco, Puente Huayllayoc, via Marcapata vers Ocongate, km 4, 3100 m, 8.X.2009, P. Boyer (CB: female). Description. Wings. FW costa length: 14 mm (n=3), apical area of costa and outer margin is straight resulting in a somewhat pointed shape; dorsal wing surface colouration pale violet blue, black border inner margin reaching the erection of vein M3; HW dorsal surface discal area structurally coloured; tornal area pale brown; ventral FW submedial and medial pattern running parallel, submarginal area conspicuously lighter than medial and basal regions, antemargin area lighter brown; HW medial pattern composed by ruptive band brown coloured bordered basally by a thin white line, submarginal area not lighter than medial and basal regions, antemargin area brown. Genitalia. Male valva thin and narrow with rounded costal margin flip, valval terminus extremely pointed and very long. Female ductus thin with divergent edges, no lower plate, upper plate symmetric and large, frame sclerotized with delicate dentation.Androconia present in ventral FW along Cubital 2 vein as a wide black streak in the median- and postmedian area. Diagnosis. On the basis of the ventral HW pattern and presence of androconia in the FW ventral surface it is only confusable with J. pardoa, which has a deeper blue dorsal wing surface colouration and the HW ventral surface pattern is far more contrasted. The male genitalia valva possesses the longest apical process in the genus. Distribution. Geographical: PERU (Cuzco, Puno) (Fig. 31); spatial: recorded between 2600–3100 m a.s.l; temporal: recorded in January, May and October. Etymology. The species is named after Anna Zubek (Nature Education Centre, Jagiellonian University, Krakow), entomologist and molecular genetist, good friend and colleague of the authors. The species name “zubkova” is freely formed by Latinising the word “zubek” and treating it as a female noun in apposition.Published as part of Bálint, Zsolt, Boyer, Pierre, Cerdeña, José, Larico, Jackie Farfán, Brudecka, Jadwiga Lorenc-, Prieto, Carlos & Pyrcz, Tomasz W., 2021, Contributions to the knowledge of Neotropical Lycaenidae: taxonomy of Johnsonita Salazar & Constantino, 1995 with descriptions of seven new species (Theclinae Eumaeini), pp. 11-57 in Zootaxa 4963 (1) on pages 35-36, DOI: 10.11646/zootaxa.4963.1.2, http://zenodo.org/record/471124
FIGURE 11 in Subspecies-level systematics and affinities of Cheimas Thieme - an endemic genus of the subparamo of the Venezuelan Cordillera de Mérida (Lepidoptera: Nymphalidae, Satyrinae)
No full textFIGURE 11. Cheimas female genitalia (lateral view)Published as part of Pyrcz, Tomasz W., Lorenc-Brudecka, Jadwiga, Boyer, Pierre & Zubek, Anna, 2018, Subspecies-level systematics and affinities of Cheimas Thieme - an endemic genus of the subparamo of the Venezuelan Cordillera de Mérida (Lepidoptera: Nymphalidae, Satyrinae), pp. 219-243 in Zootaxa 4422 (2) on page 238, DOI: 10.11646/zootaxa.4422.2.4, http://zenodo.org/record/125151
Bifunctional silk nanospheres for targeted delivery of oligonucleotide therapeutics to VEGFR-positive cells in the tumor microenvironment
No full textThis dataset contains experimental data supporting the publication “Bifunctional silk nanospheres for targeted delivery of oligonucleotide therapeutics to VEGFR-positive cells in the tumor microenvironment.” The study was conducted as part of a research project funded by the National Science Centre (grant no. 2021/43/D/NZ7/00622).The purpose of the study was to develop and evaluate a targeted drug delivery system based on functionalized silk nanospheres for the selective delivery of oligonucleotide therapeutics to vascular endothelial growth factor receptor (VEGFR)-overexpressing cells in the tumor microenvironment.The dataset includes data generated during the engineering and characterization of five hybrid silk proteins produced by fusing bioengineered MS1 silk with peptides targeting VEGFR-1 (VE1MS1, VE1bMS1, VE1cMS1) and VEGFR-2 (VE2bMS1, VE2cMS1). These constructs were assessed for receptor binding and cellular internalization in VEGFR-overexpressing cells, resulting in the selection of VE1MS1 and VE2bMS1 as lead candidates for drug delivery system development.Further data document the formation of bifunctional silk nanospheres obtained by blending VE1MS1 or VE2bMS1 with the nucleic acid–binding silk protein MS2KN. The dataset covers nanoparticle physicochemical characterization, nucleic acid-binding capacity, cytotoxicity, cellular uptake, selective interaction with VEGFR-overexpressing non-small-cell lung cancer cells, and therapeutic efficacy, including siRNA-mediated gene silencing.The dataset provides comprehensive experimental evidence demonstrating that incorporation of VEGFR-targeting enhances receptor-specific cellular interactions, and, in combination with MS2KN, enables efficient and targeted delivery of siRNA therapeutics to the VEGFR-overexpressing cells of the tumor microenvironment.</p
Systematic revision of the Andean butterfly genus Orophila Staudinger, 1886 (Lepidoptera: Nymphalidae: Biblidinae)
No full textZubek, Anna, Pyrcz, Tomasz, Lorenc-Brudecka, Jadwiga, Boyer, Pierre, Cerdeña, Jose, Mahecha-Jiménez, Oscar, Huertas, Blanca (2017): Systematic revision of the Andean butterfly genus Orophila Staudinger, 1886 (Lepidoptera: Nymphalidae: Biblidinae). Zootaxa 4258 (5): 443-461, DOI: https://doi.org/10.11646/zootaxa.4258.5.
The role of diet in development of acne vulgaris
No full textPawlicki Mateusz, Pawlicki Bartłomiej, Łopuszyńska Anna, Misztal Zofia, Lorenc Karol, Kozioł Magdalena. The role of diet in development of acne vulgaris. Journal of Education, Health and Sport. 2019;9(8):857-862. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3370436
http://ojs.ukw.edu.pl/index.php/johs/article/view/7256
The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017).
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© The Authors 2019;
This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
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Received: 05.07.2019. Revised: 25.07.2019. Accepted: 18.08.2019.
The role of diet in development of acne vulgaris
Mateusz Pawlicki1, Bartłomiej Pawlicki2, Anna Łopuszyńska1, Zofia Misztal3, Karol Lorenc1, Magdalena Kozioł1
1Student Scientific Association at Department of Epidemiology and Clinical Research Methodology, Medical University of Lublin, ul. Radziwiłłowska 11, Lublin 20-080, Poland
2Apteka “Pod Łysicą”, Ostrowiec Świętokrzyski
3Medical University of Łódź, al. Tadeusza Kościuszki 4, 90-419 Łodź, Poland
Corresponding author: Mateusz Pawlicki, [email protected]
ORCID ID:
Mateusz Pawlicki https://orcid.org/0000-0001-8318-6573, [email protected]
Bartłomiej Pawlicki https://orcid.org/0000-0003-4278-4168, [email protected]
Anna Łopuszyńska https://orcid.org/0000-0001-5133-4180, [email protected]
Zofia Misztal https://orcid.org/0000-0003-2317-9667, [email protected]
Magdalena Kozioł https://orcid.org/0000-0002-8671-5968, [email protected]
Karol Lorenc https://orcid.org/0000-0002-6414-5984, [email protected]
Abstract:
Acne is one of the most widely spread dermatoses in the world mainly among adolescents and young adults. Because of its problematic symptoms it is very willingly treated with diverse available drugs. Despite its popularity, there is still lack of precise information about this disease. Even though risk factors like infections or hormonal changes are said to be well known, medicine is still not certain about some of them. Diet is one of the examples. It is supposed to play a huge role in acne genesis. Considering the ease of diet modifications it is crucial to understand its participation.
Keywords: acne; acne vulgaris; die
Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations
No full textSomatic mitochondrial DNA (mtDNA) mutations
have been found in a subset of endometrial cancers (EC) from
different populations. We have investigated the relationship
between mtDNA changes and clinical and pathological
variables of women affected by EC. mtDNA mutations were
detected both in early (3/32; 9%) and in advanced (1/8;
12%) stages of uterine tumors. However, patients carrying
the mtDNA mutations or the normal mtDNA sequence had
indistinguishable clinicopathological data, including age,
clinical stage, histological grade and type or depth of myometrial
invasion. It is noteworthy that mtDNA mutations
were not detected in hyperplastic endometrial tissues or in
ECs coexisting with hyperplasia, nor in a single case of
endometrial stromal sarcoma. LOH at the tumor suppressor
genes RB1 and TP53 as well as p16INK4A alterations (LOH,
gene deletion) were found in tumors carrying mtDNA
mutations. These results suggest that somatic mtDNA
mutations are detected in a subset of ECs, although they are
unrelated to clinicopathological variables of cancer
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