349 research outputs found
Continuous approximation models in freight distribution management
No full textThis paper presents an overview of the literature on continuous approximation models in the context of distribution management. It first describes the seminal contributions of Beardwood, Halton and Hammersley, and of Daganzo and Newell. This is followed by a summary of various extensions, and by applications to districting, location, fleet sizing and vehicle routing
Dal reale al virtuale. L’architettura indagata, rappresentata e comunicata ... nell’esperienza didattica
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Lo sviluppo delle competenze nella pubblica amministrazione: obiettivi e finalità di una ricerca-azione
No full textIn relazione alla ricerca-azione per lo sviluppo delle comptenze nella PA, si descrivono le fasi del progetto nell'ambito delle attività della Struttura Sistemi formativi, finalizzate a: 1) sistematizzare le informazioni prodotte sul tema dei fabbisogni formativi; 2) definire un modello di rilevazione dei fabbisogni formativi nella PA; 3) progettare e realizzare, in forma sperimentale, percorsi formativi per rispondere ai fabbisogni rilevati.in relazione alla ricerca-azione per lo sviluppo delle comptenze nella pa, si descrivono le fasi del progetto nell'ambito delle attività della struttura sistemi formativi, finalizzate a: 1) sistematizzare le informazioni prodotte sul tema dei fabbisogni formativi; 2) definire un modello di rilevazione dei fabbisogni formativi nella pa; 3) progettare e realizzare, in forma sperimentale, percorsi formativi per rispondere ai fabbisogni rilevati. lo sviluppo delle competenze nella pubblica amministrazione: obiettivi e finalità di una ricerca-azione roberto angotti anna d'arcangelo massimiliano franceschetti saverio lovergin
Itraconazole-ciprofloxacin interaction on the pharmacokinetics of the intestinal compartment: preliminary results in rats
No full textAmong their pharmacokinetic characteristics fluoroquinolones (FQs) ex-hibit transintestinal and biliary elimination; moreover, they may interferewith hepatic metabolism. Interactions of FQs with enzymeinhibitors orinducers could be possible during therapy. The inhibitory effects on thehepatic metabolism of Itraconanzole (Itz) should be considered in thekinetics of FQs.Objectives: To study the effect of Itz on intestinal kinetics ofCiprofloxacin (Cpx) following different administration schedule.Methods: Wistar rats (weight 174.0+12.5 g, mean+SD) divided inthree groups were treated as follows: group 1: Cpx, 15 mg/kg/day,orally administered by gavage for three days; group 2: Cpx two hoursafter oral administration of Itz (10 mg/kg/day) for three days; group3: Cpx for 3 days and Itz (10 mg/kg/day) on the 2nd and 3rd day ofCpx administration. Samples of blood, intestinal and hepatic tissuesand faeces were collected after three days of treatment, two hoursafter the last Cpx administration. Cpx concentrations were deter minedby microbiological assay (agar-well diffusion method, K. pneumoniae,Isosensistest agar).Results: reported in the table as mean+SDAfter three days of Itz administration the levels of Cpx increasedsignificantly in liver and faeces (not significantly) while decreased inserum (1/4 positive samples) and intestinal tissues. The administrationof Itz for 2 days in rats in treatment with Cpx induced a significantincrease of Cpx serum levels, a reduction of intestinal levels and amarked decrease in faeces in comparison to Cpx alone.Drugs Serum (mg/L) Intestinaltissue(mg/kg)Liver(mg/kg)Faeces(mg/kg)Cpx 0.05±0.01 (5/5) 10.4±12.2 0.0±0.0 231.6±279.9Cpx + Itz 3 days 0.06 (1/5) 4.2±2.7 1.0±0.3** 367.3±264.9Cpx + Itz 2nd-3rd d 0.2±0.2* (5/5) 7.2±2.4 0.0±0.0 111.8±29.7*p < 0.05, **p < 0.01 Students t test versus Cpx aloneConclusions: These preliminary results suggest a possible involvementof Itz on the intestinal secretory mechanisms of Cpx and changes inthe enterohepatic circulation. The inhibitory effects of Itz on the Cpxintestinal pharmacokinetics seems different according to timing of Itzadministration.MIUR PRIN 2003-Prot. N. 2003051858_00
Interazione itraconazolo-ciprofloxacina nel compartimento intestinale del ratto: dati preliminari
No full textDiverso effetto del pretrattamento con fenobarbital sull'eliminazione transintestinale di moxifloxacina e ciprofloxacina: dati preliminari
No full textDenoising Near Infrared Spectroscopy Signals with Principal Component Analysis Improves the Detection of Metabolic Foci
No full textIn this work Principal Component Analysis (PCA) was applied, in order to denoise Near-InfraRed Spectroscopy data recorded from 10 subjects performing visual tasks at different flickering frequencies. Due to the poor signal quality, indeed, the sole application of General Linear Model had not been able to extract any metabolic focus of activation, at the group level. Nevertheless, after pre-processing with PCA, the same dataset could provide stable, bilateral occipital pattern of activation at group level, by means of the same General Linear Model used before. Overall, the employment of Principal Component Analysis during the preprocessing stage provided improved detection of the metabolic foci
Esplorando le aziende mafiose legalmente registrate: un approccio predittivo economico-finanziario.
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