100,654 research outputs found
Theratta mannavan Anilkumar & Wesener & Moritz 2022, n. sp.
No full textTheratta mannavan n. sp. Anilkumar, Wesener & Moritz Figs 2–6 Diagnosis. Head pointed (Fig. 3A) rather than broad and slightly stout as in Theratta eravikulam n. sp. (Fig. 8A) and Theratta shola n. sp. (Fig. 10A). T. mannavan n. sp. shares with T. shola n. sp. the wave-like curve centrally on the posterior margin of the prozonites (Fig. 4A), while such a curve is absent in T. eravikulam n. sp. (Fig. 8E). Differs from T. eravikulam n. sp. and T. shola n. sp. by the absence of the line fold at the anterior region, separating the ganthochilarium from the rest of the head (Fig. 3F). T. mannavan n. sp. differs from T. eravikulam n. sp. by the mesal process and lamellar process of the anterior gonopod each being triangular distally (Fig. 5E), whereas these processes are rounder and broader in T. eravikulam n. sp. (Figs 9D, F). Posterior gonopod consisting of four podomeres (Fig. 6I), while it consists of six podomeres in T. eravikulam n. sp. (Fig. 9C) and T. shola n. sp. (Fig. 11F). T. mannavan n. sp. shows a genetic p-distance in the COI gene of 20.9 % to T. eravikulam n. sp. and 21. 7 % to T. shola n. sp.. Etymology. The species epithet mannavan, noun in apposition, refers to the type locality of the species, the Mannavan Shola of Annamudi Shola National Park. Materials examined. 1 M holotype (ZFMK-MYR 9482 B1), 1 F paratype (ZFMK-MYR 9482 C), 3 M paratypes (ZFMK-MYR 9482 B2, 9483A, 11393), 7 F paratypes (ZFMK-MYR 9483), 14 F paratypes (ZFMK-MYR 9482), 13 M paratypes (ZFMK-MYR 9482; 9482A, 9482A1, 9482A2, 9482A3, 9482B), India, Province Kerala, Idukki District, Munnar, Annamudi Shola National Park, Mannavan Shola, 10º10’54.5”N, 77º11’25.8”E, 2140 m, high altitude montane forest, hand collection, leg. A. A. Pooja, K. S. Nafin, P. P. Sudhin, 25 Mar 2019.Published as part of Anilkumar, Pooja Avinipully, Wesener, Thomas & Moritz, Leif, 2022, First record of the order Polyzoniida from the Indian subcontinent with an integrative description of a new genus (Diplopoda, Colobognatha, Siphonotidae), pp. 401-428 in Zootaxa 5182 (5) on pages 407-412, DOI: 10.11646/zootaxa.5182.5.1, http://zenodo.org/record/705956
Theratta eravikulam Anilkumar & Wesener & Moritz 2022, n. sp.
No full textTheratta eravikulam n. sp. Anilkumar, Wesener & Moritz Figs 7–9 Diagnosis. Dark purple in color (Figs 7A, B), while T. mannavan n. sp. (Fig. 2A) and T. shola n. sp. are light purple. More than 50 segments (Fig. 7A). T. eravikulam n. sp. differs from T. mannavan n. sp. by a stouter head (Fig. 8A). Ozopore on 5th body-ring with posterior spine-like projection and not elevated (Fig. 8F), while the spine-like projection is absent, elevated and thicker around in the other two species of Theratta (Figs 3G, 10F). Wave-like curve in the center of the posterior margin of the prozonites is absent in T. eravikulam n. sp. (Fig. 8E), while it is present in the other two species of Theratta (Figs 4A, 10E). Tergites are fully covered with deeper striae in T. eravikulam n. sp. (Fig. 8E), while the striae are less pronounced in T. mannavan n. sp. (Fig. 4A) and T. shola n. sp. (Fig. 10E), a unique character for the genus. Differs from T. mannavan n. sp. (Fig. 3B) and T. shola n. sp. (Fig. 10B) by the absence of striae at the anterior margin of antennomeres (Fig. 8A). Distal part of mesal process and lamellar process of podomere II of anterior gonopod rather roundish and broader than in T. mannavan n. sp.. Distal process of mesal process smaller and less lobular than in T. mannavan n. sp.. Podomere II of anterior gonopod with a remnant of a division posteriolaterally (Figs 9D–F). Posterior gonopod with six podomeres (Fig. 9C). T. eravikulam n. sp. shows a genetic p-distance in the COI gene of 25.3% to T. shola n. sp.. Note. The anterior body-rings, including the head and posterior gonopod of the holotype were damaged. Therefore, some features are described using an immature male paratype. It is a common phenomenon that the number of antennomeres increase in Colobognathan and other millipedes (see David & Couret 1983; Wong et al. 2020). Etymology. Species epithet, eravikulam, noun in apposition, after the name of the type locality, the Eravikulam National Park. Materials examined. 1 M holotype (ZFMK-MYR 9752 A), 1 F paratype (ZFMK-MYR 9752 C), 1 immature M paratype (ZFMK-MYR 9752 B), 1 immature F paratype (ZFMK-MYR 9752), India, Province Kerala, Idukki District, Munnar, Eravikulam National Park, Kadalar Shola, 10º08’24.3”N, 77º02’39.3”E, 1703 m, high altitude montane forest, Winkler extraction, leg. A. A. Pooja, J. Jithin, 12 Dec 2019.Published as part of Anilkumar, Pooja Avinipully, Wesener, Thomas & Moritz, Leif, 2022, First record of the order Polyzoniida from the Indian subcontinent with an integrative description of a new genus (Diplopoda, Colobognatha, Siphonotidae), pp. 401-428 in Zootaxa 5182 (5) on page 413, DOI: 10.11646/zootaxa.5182.5.1, http://zenodo.org/record/705956
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Pelevin’s Trinity in the novel “t”: author – protagonist – reader
No full textThe article attempts to interpret Pelevin's artistic strategy in the novel "T" by exploring its subject organization and addressing the key problems of the author, the protagonist, and the reader as they are seen by the researcher. The article analyzes the peculiarities of constructing the narrative reality in the novel "T", and goes on to discuss Pelevin's philosophic models of the development of the humankind, and the emergence of his new anthropology
Measuring industry-science links through inventor-author relations: A profiling method
No full textIn this pilot study we examine the performance of text-based profiling in recovering a set of validated inventor-author links. In a first step we match patents and publications solely based on their similarity in content. Next, we compare inventor and author names on the highest ranked matches for the occurrence of name matches. Finally, we compare these candidate matches with the names listed in a validated set of inventor-author names. Our text-based profile methodology performs significantly better than a random matching of patents and publications, suggesting that text-based profiling is a valuable complementary tool to the name searches used in previous studies.innovation; industry-science links; text-based profiling;
Wave turbulence of a rotating array of quantized vortices in the T → 0 temperature limit
No full textThe dynamics of quantized vortices in the zero temperature limit is currently of great interest, particularly in the case of the Fermi superfluid He-B. Here we study wave turbulence, generated by the librating motion of a rotating cylindrical container filled with He-B, in the limit of vanishing viscous forces at temperatures . The polarization of the quantized vortices with respect to the axis of rotation is measured using non-invasive NMR techniques. We observe a decrease of the polarization when the librating motion is started, and a two-stage relaxation process when the modulation of the rotation velocity is stopped. The first relaxation process is associated with the dissipation of large-scale flow stored in inertial waves and the solid body rotation of the vortex array. From the decay of these energy reservoirs we determine the rate of energy dissipation of large-scale flow. The later second process is related to the relaxation of Kelvin waves on individual vortices. This process is monitored by the recovery of the polarization. The existence of a Kelvin wave cascade at the lowest temperatures is currently a central open question. We supply some evidence for the cascade
DNA fusion gene vaccination mobilizes effective anti-leukemic cytotoxic T lymphocytes from a tolerized repertoire
No full textThe majority of known human tumor-associated antigens derive from non-mutated self proteins. T cell tolerance, essential to prevent autoimmunity, must therefore be cautiously circumvented to generate cytotoxic T cell responses against these targets. Our strategy uses DNA fusion vaccines to activate high levels of peptide-specific CTL. Key foreign sequences from tetanus toxin activate tolerance-breaking CD4+ T cell help. Candidate MHC class Ibinding tumor peptide sequences are fused to the C terminus for optimal processing and presentation. To model performance against a leukemia-associated antigen in a tolerized setting, we constructed a fusion vaccine encoding an immunodominant CTL epitopederived from Friend murine leukemia virus gag protein (FMuLVgag) and vaccinated tolerant FMuLVgag-transgenic (gag-Tg) mice. Vaccination with the construct induced epitopespecificIFN-c-producing CD8+ T cells in normal and gag-Tg mice. The frequency and avidity of activated cells were reduced in gag-Tg mice, and no autoimmune injury resulted. However, these CD8+ T cells did exhibit gag-specific cytotoxicity in vitro and in vivo. Also, epitope-specific CTL killed FBL-3 leukemia cells expressing endogenous FMuLVgag antigen and protected against leukemia challenge in vivo. These results demonstrate a simple strategy to engage anti-microbial T cell help to activate epitope-specific polyclonal CD8+ T cell responses from a residual tolerized repertoire
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