1,720,998 research outputs found
Osteoblastoma of the jaw: Report of two cases and review of the literature
No full textOsteoblastoma is a benign bone tumor of osteoblastic origin. Two cases, an 8-year-old boy and a 24-year-old man, are presented. Both tumors were resected with wide surgical margins and neither patient had adjuvant radiation or chemotherapy. The patients showed no evidence of local recurrence after six to seven years. The clinical, radiological, histological and immunohistochemical features are described. Differential diagnosis and immunohistochemical features potentially useful for refining diagnosis of osteoblastoma are also discussed
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Complex odontoma at the upper right maxilla: Surgical management and histomorphological profile
No full textBACKGROUND: Odontomas are hamartomatous developmental malformations of the dental tissues. Usually asymptomatic, their presence is often revealed on routine radiographs. The study aimed to establish the efficacy of this conventional approach in treating odontomas, analysing clinical outcome, follow-up, and histomorphological profile. CASE REPORT: A case is presented with a review of the international literature. The patient, aged 8 years, had a complex odontoma localised on the front upper jaw. She was treated following the conventional surgical procedure. Post-operative course and healing were uneventful. Orthodontic treatment was necessary to realign the teeth. At the 12-month follow-up there was no recurrence or failure. Healing was excellent. CONCLUSION: Variations in normal tooth eruption are a common finding, but significant deviations from established norms should alert the clinician to further investigate the patient's health and development
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Advanced 3D Models Cultured to Investigate Mesenchymal Stromal Cells of the Human Dental Follicle
No full textThe human dental follicle (hDF) contains the developing tooth and is involved in regulating tooth maturation and eruption. To investigate the mesenchymal stromal cells of the dental follicle, 2 three-dimensional (3D) culture models were used, based on a dynamic bioreactor: the Rotary Cell Culture System (RCCSTM) and the 3D culture of precursor cells isolated from follicular tissue (human dental follicle cells [hDFCs]). The hDFCs were obtained from impacted third molars of 20 patients. Two 3D culture models were tested. In the first model, intact hDF explants were cultured in 3D conditions, preserving the original tissue architecture; they were studied using histomorphological and molecular analyses. The second model involved the 3D culture of hDFCs, which were characterized to evaluate their multipotency in terms of differentiation capability. Of the biomarkers known to characterize hDFCs, hDF precursors were selected for our study. The immunophenotype and in situ immunocytochemistry were evaluated for markers CD44, CD90, CD146, CD105, CD31, CD34, and CD45 Ag. The results show that the conditions provided by the RCCS preserve the original organizational architecture of the cells. The 3D conditions of the model enhanced differentiation in response to adipogenic, osteogenic, and chondrogenic inductive growth media. The immunophenotype and the immunocytochemistry showed generally high expression of CD90, CD44, and CD105, while CD146 expression was more restricted to ∼30% of cells. No expression was observed for CD31, CD34, and CD45 Ags. Two 3D tissue- and cell-based ex vivo models of the hDF supported the long-term maintenance of hDF-specific cell phenotypes and their ability to recapitulate typical cellular differentiation states. As such, these ex vivo models could be used to study the physiopathology of human odontogenesis. In addition, in a therapeutic context, they could be used to examine the role of specific chemical signals (e.g., new therapeutic agents) in the processes of dental tissue repair and regeneration
PHYSICO-CHEMICAL CHARACTERIZATION OF A SMART THERMO-RESPONSIVE FLUORIDE-RELEASING POLOXAMER-BASED GEL
No full textThe effective role of fluoride in the prevention of dental demineralization has been widely documented over the last 80 years. Many studies report substanzial reductions in dental caries in developed countries after the use of both systemic and topical fluoride applications became widespread.
Systemic fluoride intake during the pre-eruptive phase appears to give remarkable benefits on dental tissue mineralization, preventing decay in dental grooves and interproximal areas. Fluoride remains in the oral cavity after topical application, in the form of deposits of calcium-fluoride complexes covered by a protein layer. When the oral pH decreases, the slow releases of fluoride from protein-covered deposits begins. Augmented fluoride concentration allows the re-mineralization of tooth surfaces, preventing caries.
The paper presents an innovative thermo-responsive fluoride-releasing dental material, based on a smart poloxamer, capable of releasin fluoride when applied to the teeth.
Due to their temperature-dependent physical state, poloxamers doped with fluoride might be an interesting product for delivering topical fluoride
Mieloma multiplo a sede orale primitivo o secondario? Presentazione di un caso e revisione della letteratura
No full textMultiple myeloma is a malignant tumor characterized by the proliferation of plasma cells derived from a single done. Although the tumor chiefly involves the skeletal hemopoietic bone marrow, the mandible or maxilla are secondary sites in 70% to 95% of cases and the primary site in about 12% of all malignant plasma cell tumors. A 66-year-old woman presented with a mass of the mandible (gingiva/alveolus),reddened gums and hypermobility of the adjacent teeth. Orthopantomographic examination showed a lytic radiotranslucent area of the right mandible; histology revealed a plasma cells neoplasia characterized by positive gamma plasma cells. Blood chemistry tests detected elevated serum monoclonal protein (M component) and urine tests showed Bence Jones protein. The article reports a case of primary-site multiple myeloma in the mandible and describes the clinical course, the approach to treatment and the implications of this tumor in the oral cavity
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