8 research outputs found
PERBEDAAN KERUSAKAN OTOT JANTUNG TIKUS WISTAR AKIBAT PAPARAN ARUS LISTRIK SECARA LANGSUNG DAN MELALUI MEDIA AIR
No full textLatar Belakang: Paparan arus listrik pada tubuh dapat berakibat fatal yaitu
kematian. Mekanisme terbanyak penyebab kematian akibat sengatan listrik
adalah terpengaruhnya kelistrikan normal jantung oleh arus listrik dari luar.
Kematian tidak hanya terjadi saat tubuh berkontak langsung dengan sumber
listrik, tetapi dapat juga terjadi saat arus listrik mengalir di dalam air. Air
menyebabkan tahanan kulit turun namun air sebagai penghantar juga memiliki
tahanan terhadap arus listrik yang melewatinya.
Tujuan: Mengetahui perbedaan kerusakan otot jantung tikus Wistar akibat
paparan arus listrik secara langsung dan melalui media air.
Metode: Penelitian eksperimental laboratorik dengan rancangan the post test only
group design. Sampel 10 tikus Wistar dibagi dalam 2 kelompok. Tiap kelompok
terdiri 5 ekor tikus. Kelompok perlakuan 1 (P1) diberi paparan arus listrik 200mA
selama 20 detik secara langsung. Kelompok perlakuan 2 (P2) diberi paparan arus
listrik 200mA selama 20 detik melalui media air. Pengamatan dilakukan secara
mikroskopis terhadap otot jantung tikus Wistar yang telah diberi pengecatan
Hematoksilin Eosin. Kerusakan otot jantung dinilai dari prosentase inti sel yang
berbentuk persegi (MFB) dalam satu preparat.
Hasil: Uji hipotesis independent t-test didapatkan hasil p=0,000 yang berarti
terdapat perbedaan bermakna antara prosentase kerusakan otot jantung tikus
Wistar akibat paparan arus listrik secara langsung dan melalui media air.
Kesimpulan: Terdapat perbedaan kerusakan otot jantung tikus Wistar akibat
paparan arus listrik secara langsung dan melalui media air
PENGUATAN KONEKTIVITAS LINTAS BATAS DALAM KERJA SAMA EKONOMI SUBREGIONAL ( Author: Indriana Kartini, Awani Irewati, Agus R Rahman, Tri Nuke Pudjiastuti, CPF. Luhulima, Rosita Dewi, Sandy Nur Ikfal Raharjo, Hayati Nufus)
No full textIndriana Kartini, Awani Irewati, Agus R Rahman, Tri Nuke Pudjiastuti, CPF. Luhulima, Rosita Dewi, Sandy Nur Ikfal Raharjo, Hayati Nufu
inggris
No full textBackground
Zwolle, TIMI, and GRACE risk scores have been proven to predict mayor adverse cardiovascular events (MACE) in STEMI patients undergoing primary percutaneous coronary intervention (PCI). However, they were developed over a long time ago which many advances have been made in the cardiovascular field today. The scores were also developed in the non-Asian majority population and their accuracy for Indonesian population remains unknown. We aimed to validate and compare these scores for Indonesian population.
Methods
An analytical observational study was conducted on 193 patients undergoing primary PCI. The Zwolle, GRACE, and TIMI risk scores were calculated for each patient. Then, the risk score validation was carried out with the calibration test using Hosmer Lemeshow test and discrimination test using the AUC ROC. Furthermore, the comparisons between the risk scores were carried out using the DeLong test.
Results
The three scores have good results in the Hosmer Lemeshow calibration test (p > 0.05). The discrimination test also indicated good results with AUC ROC Zwolle, TIMI and GRACE risk scores respectively 0.776; 0.782; 0.831 (p<0.05). There was no significant difference in the prediction accuracy of the three risk scores in the DeLong test.
Conclusions
The Zwolle, TIMI, and GRACE risk scores had good validity for predicting major adverse cardiovascular events in STEMI patients undergoing primary PCI. There was no significant difference in the prediction accuracy of the three risk scores.
This article has a related Erratum
Validation and Comparison of Zwolle, TIMI, and GRACE Risk Scores for STEMI Patients Undergoing Primary Percutaneous Coronary Intervention in The Indonesian Population.
No full textIn “Validation and Comparison of Zwolle, TIMI, and GRACE Risk Scores for STEMI Patients Undergoing Primary Percutaneous Coronary Intervention in The Indonesian Population” (Indonesian Journal of Cardiology, 43(2), 56-63. https://doi.org/10.30701/ijc.1324), there is an error noted.
An error has been found in the PDF version of this article. The DOI printed in the PDF is incorrect. The correct DOI is https://doi.org/10.30701/ijc.1324. The error occurs only in the PDF; the DOI listed in the article metadata is already correct.The publisher apologizes for any inconvenience caused by this error.DOI of original article: https://doi.org/10.30701/ijc.132
Bimbingan Kelompok dengan Teknik Problem Solving dalam Meningkatkan Penyesuain Diri di Lingkungan Baru
No full textIn addition to using policies from the government, there are also policies from the administrators of the pesantren, known as students who study in Islamic boarding schools. Many problems occur to students, especially new students who cannot adjust to their new environment. They will, have difficulties in social and learning. Group guidance services use problem-solving techniques expected to help students solve problems that occur, so that students are accustomed to solving their own problems. The author uses a pre-research method that collects various main informatprimaryabout hidden themes by using various sources. What needs to be observed is how the scheme works on the object, the environmental conditions, and also what problems are going on in the object; after the observation, the researcher interviewed the auto to know how the thing was. The aim was to find what obstapurposes and kinds of obstacles were, hota were who were threats involved,and how the concepts and methods were wanted t develop further
Effect of Dapagliflozin on Patients with Rheumatic Heart Disease Mitral Stenosis
No full text(1) Background: Mitral stenosis is the most common rheumatic heart disease (RHD). Inflammation and fibrosis are the primary pathophysiology, resulting in left atrial stress and dysfunction. Dapagliflozin is a new heart failure treatment with anti-inflammation and anti-fibrosis effects from previous studies. However, the specific role of dapagliflozin in RHD mitral stenosis is unknown. This study aims to investigate (i) the effect of dapagliflozin on biomarkers of fibrosis, NT-pro BNP levels and left atrial function; (ii) the relationship between the changes in fibrosis biomarkers with left atrial function and NT-pro BNP levels. (2) Methods: An open-label randomized study was conducted on 33 RHD mitral stenosis patients divided into a dapagliflozin group which received 10 mg dapagliflozin and standard therapy, and a control group which only received standard therapy. All patients were examined for levels of PICP, MMP-1/TIMP-1 ratio, TGF-β1, NT-proBNP, mitral valve mean pressure gradient (MPG), and net atrioventricular compliance (Cn) pre- and post-intervention. (3) Results: This study found a significant increase in PICP and TGF-β1 and a reduction in the MMP-1/TIMP-1 ratio in the dapagliflozin group and the control group (p < 0.05). In the dapagliflozin group, the levels of NT-pro BNP decreased significantly (p = 0.000), with a delta of decreased NT-pro BNP levels also significantly greater in the dapagliflozin group compared to the control (p = 0.034). There was a significant increase in Cn values in the dapagliflozin group (p = 0.017), whereas there was a decrease in the control group (p = 0.379). Delta of changes in Cn values between the dapagliflozin and control groups also showed a significant value (p = 0.049). The decreased MPG values of the mitral valve were found in both the dapagliflozin and control groups, with the decrease in MPG significantly greater in the dapagliflozin group (p = 0.031). There was no significant correlation between changes in the value of fibrosis biomarkers with Cn and NT-pro BNP (p > 0.05). (4) Conclusions: This study implies that the addition of dapagliflozin to standard therapy for RHD mitral stenosis patients provides benefits, as evidenced by an increase in net atrioventricular compliance and decreases in the MPG value of the mitral valve and NT-pro BNP levels (p < 0.05). This improvement was not directly related to changes in fibrosis biomarkers, as these biomarkers showed ongoing fibrosis even with dapagliflozin administration
Correlation between circulating fibrosis biomarkers with left atrial function and left atrial volume index in rheumatic mitral stenosis
No full textMitral stenosis is the most common rheumatic heart disease (RHD) disorder worldwide, including in Indonesia. This pathological condition causes left atrial pressure, leading to left atrial fibrosis that affects the structure and function of the left atrial as well as the clinical condition. The aim of this study was to assess the correlation between circulating fibrosis biomarkers with net atrioventricular compliance (Cn) as a parameter of left atrial function, and left atrial volume index (LAVI) as a parameter left atrium structure of changes. A cross-sectional study was conducted at Panti Rahayu Hospital and Permata Bunda Hospital, Purwodadi, Central Java, with a total of 40 RHD patients with severe mitral stenosis. The ELISA was used to measure the levels of carboxy-terminal propeptide of type I procollagen (PICP), matrix metalloproteinase I (MMP-1), tissue inhibitor matrix metalloproteinase 1 (TIMP-1), and transforming growth factor-β1 (TGF-β1). The left atrial function was assessed by measuring Cn, and the LAVI parameters were measured to assess left atrium structure/size. The mean levels of circulating fibrosis biomarkers were as follows: PICP 153.96±89.12 ng/mL; MMP-1 1.44±2.12 ng/mL; MMP-1/TIMP-1 ratio 0.38±0.54 and TGF-β1 2.66±1.96 pg/mL. From the echocardiographic evaluation, the mean Cn was 5.24±1.93 mL/mmHg and the mean LAVI was 152.55±79.36 mL/m2. There were significant correlation between MMP-1 and MMP-1/TIMP-1 ratio with Cn (r=0.345 and r=0.333, respectively; both had p<0.05). PICP and TGF-β1 biomarkers did not significantly correlate with Cn (p>0.05). Meanwhile, none of the biomarkers had a significant correlation with LAVI (p>0.05). This study highlights that MMP-1 and MMP-1/TIMP-1 ratio are potentially to be used as markers to determine the Cn in RHD patients with severe mitral stenosis. However, further studies with a higher sample size are needed to confirm this finding
