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Peningkatan Kelarutan Ketokonazol dengan Teknik Dispersi Padat Menggunakan Eudragit® E 100
No full textKetoconazole is an antifungal azole synthetic which derivatived from imidazole. Ketoconazole is practically insoluble in water and its bioavailability depend on pH condition of the gastrointestinal tract. The purpose of the research is to increase the solubility of ketoconazole by solid dispersion method using Eudragit® E 100, PEG 6000, and glycerol. Solid dispersion was evaluated with respect to solubility, cristalinity, complexation and morphology of solid dispersion. The optimum formulation with the highest solubility was resulted by solid dispersion with ratio ketoconazole - Eudragit® E 100 - glycerol of 1:8:0.5. X-ray diffraction test revealed the change of crystalline ketoconazole and similar to Eudragit® E 100. This result was also supported by spectrum of infrared and endothermic peak of differential scanning calorimetry. Based on scanning electron microscopy morphology of pure Eudragit® E 100 and solid dispersion was similar. Solid dispersion of ketoconazole with Eudragit® E 100 and glycerol improved solubilty.
Keywords : ketoconazole, solid dispersion, Eudragit® E 100
ABSTRAK
Ketokonazol merupakan zat antijamur sintetik golongan azol yang merupakan turunan imidazol.Ketokonazol praktis tidak larut dalam air dan ketersediaan hayati melalui rute oral sangat beragam tergantung dari kondisi pH saluran pencernaan.Penelitian ini bertujuan untuk meningkatkan kelarutan ketokonazol dengan cara pembuatan dispersi padat mengunakan Eudragit® E 100, PEG 6000, serta gliserol. Dispersi padat di evaluasi dengan uji kelarutan jenuh, kristalinitas, kompleksasi, dan morfologinya.Formula optimal dengan peningkatan kelarutan tertinggi dihasilkan oleh perbandingan dispersi padat ketokonazol - Eudragit® E 100 - gliserol 1:8:0,5. Pengujian difraksi sinar-X menunjukkan adanya perubahan kristalinitas ketokonazol yaitu sama seperti Eudragit® E 100.Hasil ini juga didukung oleh hasil pengujian spetkrofotometer infra merah dan puncak endotermik differential scanning calorimetry.Berdasarkan hasil scanning electrom microscopyterlihat morfologi dari Eudragit® E 100 murni dan dispersi padatnya yang hampir sama..Pembentukan dispersi padat ketokonazol dengan Eudragit® E 100 dan gliserol dapat meningkatkan kelarutan.
Kata Kunci : ketokonazol, dispersi padat, Eudragit® E 10
Formulation and Stability Tests of Hair Tonic from Oil Palm (Elaeis guineensis Jacq.) Leaves Extract and Effectiveness in Protecting Hair
No full textHair loss is a condition that unavoidable process, where the hair is detached more than 100 strands per day that occurs continuously. Oil palm leaf with their compounds can be used to treat hair loss and damage. The purpose of this study was to formulate oil palm leaf extract into hair tonic preparations and evaluate the effectiveness in preventing hair damage. Hair tonic formula from oil palm leaf extract contains 96% ethanol, menthol, propylene glycol, phenoxyethanol, and aquades. The evaluation of hair tonic preparations included organoleptic, homogeneity, pH, and viscosity tests, as well as tests of antioxidant activity and effectiveness of hair tonic preparations. The results of the antioxidant activity test of oil palm leaf extract hair tonic showed the IC50 value at room temperature (25°C) indicating an average value of 37.2519±8.535 ppm, warm temperature (50°C) 40.5459±9.086 ppm, and cold temperature (4°C) 36.8257±6.928 ppm, which belongs to the category of very strong antioxidant activity, with the results of the evaluation of the oil palm leaf hair tonic slightly colored. greenish to dark green, has a distinctive menthol aroma, has a pH and viscosity that meets the requirements of a good hair tonic preparation, with pH between 3-7 and viscosity less than 5 cPs. Hair tonic preparations of oil palm leaf extract can prevent hair decolorization due to sun exposure at concentrations of 25 ppm to 200 ppm
PENINGKATAN KELARUTAN KETOKONAZOL DENGAN TEKNIK DISPERSI PADAT MENGGUNAKAN EUDRAGIT® E 100
No full textAktivitas Gel Mulut Berbahan Aktif Ekstrak Daun Sirih Hitam Kalimantan sebagai Antimikroba Penyebab Radang Gusi (Gingivitis) dan Gigi Berlubang (Caries)
No full textThis study aimed to test the activity of active ingredient mouth gel preparation of kalimantan black piper betle leaf extract with the main base of Hydroxy Ethyl Cellulose namely (HEC) as a mucoadhesive polymer that is able to increase the attractive forces between the active material with a layer of mucus that will extend the contact time with the active ingredient tissue targets, moreover would be increase the effectiveness of antimicrobial activity causes inflammation of the gums (gingivitis) and tooth decay (caries). Activities that have been implemented are mouth gel activity assays with Kalimantan black piper betle leaf extract as in- vitro using the agar diffusion method pitting. In testing with active oral gel preparation of black piper betle leaf extract with the main base of Hydroxy Ethyl Cellulose namely (HEC) as in vitro, it can be seen that the sample may provide the inhibitory effect of the fungus Candida albicans and the bacterium Streptococcus mutans in the presence of a clear zone indicated on the medium. Furthermore, at this stage of the dilution of the gel in twice causing decline in the effectiveness of the inhibition of both the fungus Candida albicans and the bacterium Streptococcus mutans. The results of in- vitro testing without dilution is 19.8 mm in bacteria Streptococcus mutans and 34.4 mm in the fungus Candida albicans.
Keywords: antimicrobial, oral gel, black piper betle, gingivitis , cavities
ABSTRAK
Penelitian ini bertujuan untuk menguji aktivitas sediaan gel mulut berbahan aktif ekstrak daun sirih hitam Kalimantan dengan basis utama yakni Hydroxy Ethyl Cellulose (HEC) sebagai mucoadhesive polymer yang mampu meningkatkan gaya tarik menarik antara bahan aktif dengan lapisan mukus sehingga akan memperpanjang waktu kontak bahan aktif dengan jaringan target, selanjutnya akan meningkatkan efektivitas aktivitas antimikroba penyebab radang gusi (gingivitis) dan gigi berlubang (caries). Kegiatan yang telah dilaksanakan adalah pengujian aktivitas gel mulut berbahan aktif ekstrak daun sirih hitam Kalimantan secara in vitro dengan menggunakan metode difusi agar teknik sumuran. Pada pengujian sediaan gel mulut berbahan aktif ekstrak daun sirih hitam Kalimantan dengan basis utama yakni Hydroxy Ethyl Cellulose (HEC) secara in vitro, dapat diketahui bahwa sampel dapat memberikan efek penghambatan jamur Candida albicans dan bakteri Streptococcus mutans dengan ditunjukkan adanya zona bening pada agar. Namun pada tahap dua kali pengenceran terhadap gel terjadi penurunan efektivitas kerja penghambatan baik pada jamur Candida albicans maupun pada bakteri Streptococcus mutans. Hasil pengujian in-vitro tanpa pengenceran adalah 19.8 mm pada bakteri Streptococcus mutans dan 34.4 mm jamur Candida albicans.
Kata kunci: antimkroba, gel mulut, sirih hitam, radang gusi, gigi berluban
Formulation of Hand Sanitizer Gel Jatropha Sap (Jatropha curcas L) as Antiseptic
No full textJatropha curcas (Jatropha curcas L) is a medicinal plant that is often used, especially its sap. Jatropha sap contains secondary metabolite compounds in the form of saponins, flavonoids, and tannins which have antibacterial activity. This study aims to determine the antibacterial activity of Jatropha sap against Escherichia coli and Staphylococcus aureus, to determine the antibacterial activity of jatropha hand sanitizer gel preparation against Escherichia coli and Staphylococcus aureus, and to find out the best formula for hand sanitizer gel from jatropha that has antibacterial effectiveness against Escherichia coli and Staphylococcus aureus. This research was conducted by formulating hand sanitizer gel from jatropha sap with various concentrations. Based on the research data, the best data obtained for the concentration of jatropha sap which has antibacterial activity against Escherichia coli and Staphylococcus aureus is 10% with inhibition values of 13,33 ± 0,57 and 12,86 ± 0,51 the best concentrations of gel preparations. Hand sanitizer from jatropha sap which has antibacterial activity against Escherichia coli and Staphylococcus aureus is 10% with inhibitory value of 12,63 ± 0,35 and 12,10 ± 0,17 and the best formula for hand sanitizer gel contains jatropha sap fence with a concentration of 5% with a diameter value of 6,36 cm, pH 4,89, a viscosity of 4,60 ± 0,14 Pa.S, a clear whitish color with a gel-shaped texture and a homogeneous preparation
AKTIVITAS GEL MULUT BERBAHAN AKTIF EKSTRAK DAUN SIRIH HITAM KALIMANTAN SEBAGAI ANTIMIKROBA PENYEBAB RADANG GUSI (Gingivitis) DAN GIGI BERLUBANG (Caries)
No full textFORMULASI DAN EVALUASI GRANUL EKSTRAK ETANOL RIMPANG KUNYIT (Curcuma longa L.) DENGAN METODE GRANULASI BASAH
Full text linkTurmeric Rhizome (Curcuma longa L.) is a plant from the Zingiberaceae family that is commonly used as a food coloring and fragrance. Turmeric rhizome extract which has the chemical content of turmeric, including curcuminoid compounds, provides benefits as a medicine for body health. This study aims to develop a granule preparation containing turmeric rhizome extract (Curcuma longa L.), determine the physical properties of the resulting granules and determine the level of panelist preference for the turmeric rhizome extract granule preparation. Granules are made using the wet granulation method, the mass of the resulting granules is then evaluated with several tests such as: organoleptic test, flow rate test, angle of repose test, density and compressibility test, water content test, and granule size distribution test. The resulting granules have a slight turmeric odor and a yellowish color from the extract and are in the form of coarse granules. The turmeric rhizome extract formula meets the requirements for flow rate, angle of repose, compressibility, water content, but for the granule size distribution test it does not meet the requirements. Turmeric rhizome extract was formulated into a granular preparation with the results of the flow rate test of 17.85 g/second, angle of repose of 17.21º, compressibility index value of 13.2%, water content of 3.63%, particle size distribution value produced a percentage of fines of 38.18% indicating a percentage of fines that did not meet the requirements. And the level of panelists\u27 preference for the preparation of turmeric rhizome extract granules can be accepted well.
Keywords: Turmeric Rhizome, Wet Granulation, Evaluation of Granular Preparations
Pengaruh Propilen Glikol terhadap Laju Difusi Krim Natrium Diklofenak dengan Basis Hidrofobik Secara Invitro
Full text linkABSTRACT
The research on effect of propylene glycol in diffusion of cream diclofenac sodium from hydrophobic base with in-vitro. The research has been used for concentrations propylene glycol (0, 3, 5, and 7%). The stability test included organoleptic, pH, viscosity, consistency, flow type for 56 days of storge, and diffusion test used diffusion franz cell and membrane spangler. The result showed that formula diclofenac sodium cream contained propylene glycol 7% was the one best in diffusion of 0.0203 ppm/menit.
Key words : Propylene glycol, diffusion, hydrophobic base
ABSTRAK
Telah dilakukan penelitian mengenai pengaruh propilen glikol terhadap laju difusi krim natrium diklofenak basis hidrofobik secara invitro. Dalam penelitian ini dibuat formula dengan variasi konsentrasi propilen glikol yaitu 0, 3, 5, dan 7%. Pengujian stabilitas fisik sediaan krim meliputi organoleptis, pH, viskositas, konsistensi, dan uji sifat aliran selama 56 hari penyimpanan, serta uji difusi menggunakan alat difusi Franz dan membran spangler. Dari hasil penelitian ini didapat bahwa formula krim natrium diklofenak yang mengandung propilen glikol 7% memiliki laju difusi paling baik yaitu 0,0203 ppm/menit.
Kata kunci : Propilen glikol, laju difusi, basis hidrofobik
Formulation and Evaluation of Tablet From the Extract of Persea Americana Mill. for Nephrolithiasis
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