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Impianto di condrociti autologhi su membrana collagenica (MACI): analisi a medio termine dei risultati clinici e di imaging
No full textImpianto di condrociti autologhi su membrana collagenica (MACI): analisi a medio termine dei risultati clinici e di imaging
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Matrix-induced autologous chondrocyte implantation (MACI): high-resolution-MRI study at medium term follow-up.
No full textObjective: Evaluation of articular cartilage repair after Matrix-induced autologous chondrocyte implantation (MACI) by high-resolution standard MRI and arthro-MRI.
Material and methods: Thirty patients with a minimum of 5 years follow-up (mean 67 months, range 60 to 84 months) were evaluated with a high-resolution standard MRI and arthro-MRI (1.5-T unit, using GE, T2*, spin-echo T1, FatSat fast spin-echo DP and T2-weighted sequences). The results were classified according to the grading system described by Marlovits that considered the degree of defect repair in width and length, surface, structure and signal intensity of the repair tissue, and status of the subchondral lamina and bone. A score higher than 50 points (max: 100 points) was assumed as a successful repair. The results were then compared to the most common clinical rating scales (ICRS, Lysholm II, Tegner, Cincinnati) to evaluate the possible correspondence.
Results: In 18 patients we observed a complete filling of the defect. Implant integration was evident in 17 cases. Intact surface was found in 18 cases. Arthro-MRI revealed 7 cases of superficial fibrillations and fissures. In 23 implants the signal was isointense and similar to native cartilage. Oedema or cysts were individuated in 9 cases. In 23 patients we recorded an overall value higher than 50 points. Four cases were associated with a clinical failure while 3 cases were not associated.
Conclusions: High-resolution MRI provides a useful tool for studying articular cartilage repair tissue. Arthro-MRI can improve the sensibility of the study to detect any clefts between native cartilage and regenerated tissue and any superficial implant fibrillations. It has to be demonstrated if MRI can be predictive of future clinical failures. Only an higher number of cases and long term studies will allow to confirm these observations
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Imaging of articular cartilage: current concepts
No full textMagnetic resonance imaging (MRI) is the gold standard method for non-invasive assessment of joint cartilage, providing information on the structure, morphology and molecular composition of this tissue. There are certain minimum requirements for a MRI study of cartilage tissue: machines with a high magnetic field (> 1.5 Tesla); the use of surface coils; and the use of T2-weighted, proton density-weighted fast-spin echo (T2 FSE-DP) and 3D fat-suppressed T1-weighted gradient echo (3D-FS T1W GRE) sequences. For better contrast between the different joint structures, MR arthography is a method that can highlight minimal fibrillation or fractures of the articular surface and allow evaluation of the integrity of the native cartilage-repair tissue interface. To assess the biochemical composition of cartilage and cartilage repair tissue, various techniques have been proposed for studying proteoglycans [dGEMRIC, T1rho mapping, sodium (23Na) imaging MRI, etc.], collagen, and water distribution [T2 mapping, "magnetisation transfer contrast", diffusion-weighted imaging (DWI), and so on]. Several MRI classifications have been proposed for evaluating the processes of joint degeneration (WORMS, BLOKS, ICRS) and post-surgical maturation of repair tissue (MOCART, 3D MOCART). In the future, isotropic 3D sequences set to improve image quality and facilitate the diagnosis of disorders of articular structures adjacent to cartilage
Diagnosi e follow-up con risonanza magnetica basale e con MDC delle lesioni traumatiche muscolari nell'atleta professionista
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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