1,721,126 research outputs found
DOSSIER
No full textISSUE DESCRIPTION: Starting from the possibilities of transferring into the Architecture the so-called KETs (Key-Enabling Technologies), both tangible and intangible, the issue 25 of TECHNE addressed the question of the enabling roles of Technology in the different areas of design. KETs have already extensively entered in the field of Architecture and the governance of city and territory, but they were often pandered to the logics of technocratic production and in an uncritical manner.
In its function as a medium, however, Technology can enable new ideational, adaptive, implementing, and managing processes applied to the transformation of the built environment at different scales. This is to overcome a purely instrumental and distorted dimension of KETs that risk overriding the very purpose of the project, opening the way to exclusively algorithmic and parametric technicalities. These drifts tend to generate reductionist readings, automated and merely quantitative standardizations of design goals and outcomes, failing instead to recognize its inherent complexity and the purposeful and critical design thinking that must underlie it.
The contributions received for this issue confirm, instead, that Technology is capable of playing an enabling role 'upstream, throughout and downstream' in the process of design and construction research and experimentation, according to an open, heuristic, innovative, inter and pluridisciplinary vision, proper to architectural design. The key themes proposed to prompt the development of the different contributions concern: 'Technology to foresight and support decisions'; 'Technology to generate quality habitats'; 'Technology for the proper use of resources’.
DOSSIER DESCRIPTION: The definition of enabling technologies highlights a still partially unsolved question. The so-called KETs are identified and remodulated according to the variability of financial markets and leading industrial production sectors. It is not surprising that the debate and experimentation on them has affected the field of Architecture with a preference for the digitization aspects.
In the disciplines of Architecture, however, it is important to focus on the technology that not only anticipates or solves problems thanks to the digital processes and devices, but it also contributes to enabling multiple states of co-evolutionary adaptivity between bios and techne.
On these questions, the issue of the enabling role of technology has been brought to the attention of some researchers who deal with the multiple challenges posed by technological innovations with respect to the complexities of doing Architecture. The contributions of Nicola Emery, Maurizio Ferraris, and Paolo Tombesi highlighted that the problem is not to classify, reorientate, deny, or exalt techniques as more or less enabling resources. A much more complex scenario emerges concerning the theoretical, anthropological, and methodological aspects of designing. The real challenge is to regain possession of the technological skills to connect or recompose different technical levels in an enabling, plural, and multidimensional organic vision, to guarantee, consolidate and improve our behavioral and housing attitudes
La sicurezza del territorio come obiettivo di sviluppo
No full textIl nostro territorio manifesta con sempre più drammatica evidenza l'incapacità per la nostra società di coesistere con quanto ci è stato consegnato dalla natura e dalla storia.
Le trasformazioni connesse a un modello fortemente dissipativo di crescita quantitativa, difatti, hanno comportato un processo lento, quanto costante, di insensato sfruttamento e di degradazione fisica e ambientale del territorio.
Negli ultimi cinquant'anni, le trasformazioni fisiche e socioeconomiche che hanno essenzialmente riguardato
il tessuto delle colture, i modelli insediativi, l'assetto dei centri urbani e degli insediamenti, l'armatura delle infrastrutture
viarie e la diffusione di attività produttive industriali a esse connesse, hanno deterninato consistenti effetti nell'aggravamento e nella produzione di condizioni di rischio naturale e antropico.
Il mantenimento dell'equilibrio idrogeologico e ambientale all'interno del territorio si configura allora come una funzione pubblica di fondamentale importanza e pertanto è indifferibile prevedere modalità di intervento volte al ripristino e al mantenimento della sicurezza rispetto alle condizioni di rischio, come condizione ineludibile di qualsiasi processo volto al perseguimento della qualità dell'ambiente costruito
Resilienza e qualità dell’ambiente costruito. Il progetto tecnologico tra nuovi valori e vulnerabilità
No full textIl presente paper intende affrontare il nodo problematico della necessità di un ritorno alla costruzione dell’habitat umano secondo una visione simbiotica di adattamento co-evolutivo degli utenti e dei loro sistemi di artefatti con l’ambiente naturale. Una condizione operativa che richiede interventi di costante cura e manutenzione dei valori ecologico-ambientali, azioni protese a favorire cambiamenti dinamici nei comportamenti delle utenze e soluzioni spaziali adeguate al mantenimento e alla rigenerazione delle qualità dell’habitat. Si pone così al centro del processo propositivo-costruttivo una diversa concezione delle risorse naturali/artificiali e del patrimonio ambientale/culturale di un territorio nel fluire del tempo: considerandoli cioè non come beni/prodotti di consumo, ma come capitale (naturale, culturale, umano) da conservare, mantenere, rigenerare per le attuali e future generazioni. Facendo cioè convivere, in una visione integrata e coordinata, azioni di mantenimento e rigenerazione delle risorse (capitale naturale), azioni di adattamento degli individui (capitale sociale/umano) e azioni di produzione di nuovi valori e redditività (capitale culturale/artistico)
Un approccio tecnologico per l’ambiente urbano resiliente
No full textAbstract che sintettizza una riflessione sull’approccio metodologico-operativo del gruppo di ricerca di area tecnologica BETHA, dell’Ateneo d’Annunzio che, nell’ambito di esperienze nazionali/internazionali sta affrontando le seguenti tematiche:
- implementazione di un processo di progettazione universale per il miglioramento della vivibilita';
- riattivazione di una progettualita' sistemica integrata, mirata alla qualità totale dell’ambiente urbano;
- valorizzazione delle capacita' di resilienza dell’ambiente urbano, per sistemi e sub-sistemi di intervento
Behavioural effects of deltorphins in rats
No full textWhen given i.c.v. in rats deltorphins induced a syndrome of behavioural stimulation consisting of increased locomotion rearing and sniffing. The increased locomotor activity and rearing were dose-related over the range of 0.13 to 3.8 nmol/rat for [D-Ala2]deltorphin II (DADELT II) and 1.04 to 20.8 nmol/rat for deltorphin. The delta-selective antagonist, naltrindole (10 mg/kg i.p.), completely abolished the behavioural stimulation induced by 1.3 nmol/rat of DADELT II and shifted the dose-response curve to the right, without decreasing the maximum effect. The mu-preferring antagonist, naloxone, was able to antagonize the DADELT II-induced locomotor activity but only at very high doses (10 and 20 mg/kg i.p.). The i.v. administration of a large dose (10 mg/kg) of the mu-1-selective antagonist, naloxonazine, did not affect the DADELT II response. At doses up to 38 nmol/rat, the i.c.v. injection of DADELT II never induced analgesia. At doses over 20.8 nmol/rat, deltorphin always induced spontaneous controlateral barrel rotations and circling, responses which were not blocked by prior administration of naloxone or haloperidol. In studies performed on the social behaviour of rats, i.c.v. administration of 0.38 nmol/rat of DADELT II was ineffective, while 1.3 nmol/rat increased the number of social contacts. Regression analysis showed that the increase in social contacts was a primary effect of the peptide, not correlated with the increased locomotor activity
Enabling variations and dimensions of Technology in architecture: a complex debate
Full text linkLa definizione di tecnologie abilitanti evidenzia ancora alcune questioni parzialmente irrisolte. Le cosiddette KETs sono individuate e rimodulate secondo la variabilità dei mercati finanziari e dei settori produttivi industriali trainanti. Non sorprende che il dibattito e la sperimentazione su di esse abbia interessato il campo dell’Architettura prediligendo gli aspetti legati alla digitalizzazione.
Nelle discipline dell’Architettura, è però importante soffermarsi sulla tecnologia che non solo anticipa e risolve problemi grazie a processi e dispositivi digitali, ma che contribuisce anche ad abilitare stati multipli di adattività co-evolutiva fra bios e techne.
Su tali questioni, il tema del ruolo abilitante della tecnologia è stato posto all’attenzione di alcuni studiosi che si occupano delle molteplici sfide poste dalle innovazioni tecnologiche rispetto alle complessità del fare Architettura. Dai contributi di Nicola Emery, Maurizio Ferraris e Paolo Tombesi si evidenzia che il problema non è classificare, riorientare, negare o esaltare le tecniche come risorse più o meno abilitanti. Emerge uno scenario molto più complesso che coinvolge aspetti teoretici, antropologici e metodologici del fare progetto. La vera sfida è riappropriarsi delle capacità tecnologiche di connettere o ricomporre differenti livelli tecnici in una visione organica abilitante, plurale e multidimensionale, per garantire, consolidare e migliorare le nostre attitudini comportamentali e abitative.The definition of enabling technologies highlights a still partially unsolved question. The so-called KETs are identified and remodulated according to the variability of financial markets and leading industrial production sectors. It is not surprising that the debate and experimentation on them has affected the field of Architecture with a preference for the digitization aspects.
In the disciplines of Architecture, however, it is important to focus on the technology that not only anticipates or solves problems thanks to the digital processes and devices, but it also contributes to enabling multiple states of co-evolutionary adaptivity between bios and techne.
On these questions, the issue of the enabling role of technology has been brought to the attention of some researchers who deal with the multiple challenges posed by technological innovations with respect to the complexities of doing Architecture. The contributions of Nicola Emery, Maurizio Ferraris, and Paolo Tombesi highlighted that the problem is not to classify, reorientate, deny, or exalt techniques as more or less enabling resources. A much more complex scenario emerges concerning the theoretical, anthropological, and methodological aspects of designing. The real challenge is to regain possession of the technological skills to connect or recompose different technical levels in an enabling, plural, and multidimensional organic vision, to guarantee, consolidate and improve our behavioral and housing attitudes
Lithium/Valproic Acid Combination and L-Glutamate Induce Similar Pattern of Changes in the Expression of miR-30a-5p in SH-SY5Y Neuroblastoma Cells
No full textIt has been proposed that Lithium (Li) and valproic acid (VPA) may be useful to treat neurodegenerative disorders because they protect neurons against excitotoxic insults both in vitro and in vivo models. Moreover, these two drugs may exert their effects by regulating microRNAs (miRNAs), single-stranded and non-coding RNAs able to control gene expression. A subset of the miR-30a family (miR-30a-5p) is involved in the fine-tuning of neuroprotective molecules such as the neurotrophin brain-derived neurotrophic factor (BDNF). Thus, there is the possibility that Li and VPA may alter miR-30a-5p and in turn affect BDNF production. However, data on miR-30a-5p levels in presence of Li and VPA and/or a neurotoxic insult are not yet available. Thus, the aim of this study was to investigate whether exposure to Li and VPA may influence miR-30a-5p expression in an in vitro model of neurodegeneration generated by the exposure of a human neuroblastoma cell line (SH-SY5Y) to neurotoxic concentration of L-glutamate. The results showed that both L-glutamate and Li-VPA caused an increase in miR-30a-5p expression at 24 h of incubation and a decrease at 48 h. Moreover, Li-VPA alone caused a decrease in miR-30a-5p expression also in cells not exposed to the toxic effect of glutamate. These data indicate that changes in miR-30a-5p expression induced by Li-VPA are not related to the cytoprotective action of BDNF and suggest alternative function for this miR. These findings also indicate that miRNA changes are present in in vitro models of neurodegeneration, although the significance of these changes warrants further investigation
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Responsive design e abitare contemporaneo. Tecnologie abilitanti per la definizione di uno Smart Environment
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