50 research outputs found
Recommended from our members
Documentation Related to a 1991 Observation of Sturgeon in the Rio Grande – Río Bravo, USA (Texas) and Mexico (Coahuila)
No full textThis digital archive provides a compilation of previously unpublished information regarding a 1991 observation of a live sturgeon (Family Acipenseridae) in the Rio Grande-Río Bravo of the USA and Mexico. Though a few specimens collected in the 19th century support occurrence of sturgeon in this river basin, lack of credible, recent records has often led to this species not being recognized as part of the basin’s native fish fauna, and certainly not part of its modern fish community.
The second and third authors of this document manage the Fishes of Texas Project (Hendrickson, Dean A., & Cohen, Adam E. (2015). Fishes of Texas Project Database (version 2.0). Texas Advanced Computing Center, University of Texas at Austin. http://doi.org/10.17603/C3WC70) and knew of the unpublished 1991 observation of sturgeon reported here. They requested the content provided here from first author (Platania) who provided what follows below (verbatim as received in April 2018) and permission to archive it for public access.Integrative Biolog
Sensitivity of CE-MRI in detecting local recurrence after radical prostatectomy
No full textAim: The aim of our study was to evaluate the sensitivity of contrast-enhanced magnetic resonance (CE-MR) with phased array coil in the diagnosis of local recurrence in patients with prostate cancer after radical prostatectomy and referred for salvage radiotherapy (SRT).
Materials and methods: This retrospective study included 73 patients treated with SRT after radical prostatectomy in the period between September 2006 and November 2017. All patients performed a CE-MRI with phased array coil before the start of SRT. A total of 213 patients treated at the ASST Grande Ospedale Metropolitano Niguarda in the period between September 2006 and November 2017 with SRT after radical prostatectomy were reviewed. Seventy-three patients with a CE-MRI with phased array coil of the pelvis before the start of SRT were included in the present study.
Results: At imaging review, recurrence local recurrent disease was diagnosed in 48 of 73 patients. By considering as reference standard the decrease in prostate-specific antigen (PSA) value after radiotherapy, we defined: 41 true positive (patients with MRI evidence of local recurrence and PSA value decreasing after SRT), 7 false positive (patients with MRI evidence of local recurrence without biochemical response after SRT), 3 true negative (patients without MRI evidence of local recurrence and stable or increased PSA value after SRT) and 22 false negative (patients without MRI evidence of local recurrence and PSA value decreasing after SRT) cases. The sensitivity values were calculated in relation to the PSA value before the start of treatment, obtaining a value of 74% for PSA above 0.2 ng/mL.
Conclusion: The sensitivity of CE-MRI in local recurrence detection after radical prostatectomy increases with increasing PSA values. CE-MRI with phased array coil can detect local recurrences after radical prostatectomy with a good sensitivity in patients with pre-RT PSA value above 0.2 ng/mL
Concerto inaugurale di MITO 2011, Angelo Benessia, Anna Martina e Maurizio Braccialarghe
No full textNurse-led physical health interventions for people with mental illness: an integrative review of international literature
No full textPublished online: 16 Aug 2024Background: People experiencing mental illness receive physical healthcare from nurses in a variety of settings including acute inpatient, secure extended care, forensic, and community services. hile nurse-led clinical practice addressing sub-optimal consumer physical health is salient, a detailed understanding and description of the contribution by nurses to physical health interventions in people experiencing mental illness is not clearly articulated in the literature. Aims: he aim of this integrative review is to describe the state of knowledge on nurse-led physical health intervention for consumers, focusing on nursing roles, nursing assessment, and intervention settings. Methods: A systematic search of six databases using Medical Subject Headings from 2001 and 2022 inclusive was conducted. he Mixed Methods Appraisal ool (MMA) was utilised for quality appraisal. Results: Seventy-four studies were identified as “nurse-led”. nterventions were most common among community settings (n=34, 46%). Nurses performed varied roles, often concurrently, including the collection of 341 physical health outcomes, and multiple roles with 225 distinct nursing actions identified across the included studies. A nurse as lead author was common among the included studies (n=46, 62%). However, nurses were not always recognised for their efforts or contributions in authorship. Conclusions: here is potential gap in role recognition that should be considered when designing and reporting nurse-led physical health interventions.Brenda Happell, Alycia Jacob, Trentham Furness, Alisa Stimson, Jackie Curtis, Andrew Watkins, Chris Platania-Phung, Brett Scholz, Robert Stanto
Ischemic injury precipitates neuronal vulnerability in Parkinson{'}s disease: Insights from PINK1 mouse model study and clinical retrospective data
No full textIntroduction: Increasing evidence demonstrates the relevant association between Parkinson's disease (PD) and vascular diseases/risk factors, as well as a worse clinico-pathological progression in those patients with vascular comorbidity. The mechanisms underlying this relationship have not been clarified yet, although their comprehension is critical in a perspective of disease-modifying treatments development or prevention.Methods: We performed an experimental protocol of ischemic injury (glucose-oxygen deprivation, OGD) on PTEN-induced kinase 1 knockout (PINK1(-/-)) mice, a well-established PD model, looking at both electrophysiological and morphological changes in basal ganglia. In addition, 253 PD patients were retrospectively analysed, to estimate the prevalence of vascular risk factors.Results: In PINK1(-/-) mice, the OGD protocol induced electrophysiological (prolonged depolarization) and morphological alterations (picnotic cells, cellular loss and swelling, thickening of nuclear chromatin) in striatal medium spiny neurons and nigral dopaminergic neurons. Vascular comorbidity occurred in 75% of PD patients.Conclusions: The ischemic injury precipitates neuronal vulnerability in basal ganglia of PINK1(-/-) mice, prob- ably through an impairment of mitochondrial metabolism and higher oxidative stress. These experimental data may provide a potential mechanistic explanation for both the association between vascular diseases and PD and their reciprocal interactions in determining the clinico-pathological burden of PD patients
New options and open issues in the management of unresectable stage III and in early-stage NSCLC: A report from an expert panel of Italian medical and radiation oncologists – INTERACTION group
No full textImportance: After the PACIFIC trial, concurrent chemo-radiotherapy followed by consolidation therapy with durvalumab for 1 year (limited to PD-L1 tumour proportion score ≥ 1% in the EMA region) is the firmly established standard of care treatment for unresectable NSCLC patients. Several relevant questions are emerging with the growing use of this approach, posing novel challenges in clinical practice. Treatment of oncogene-addicted NSCLCs, management of mediastinal disease recurrence after surgery and the optimal management of patients progressing during or after durvalumab are now some of the most clinically relevant issues. Observations: Patients with unresectable NSCLC harbouring EGFR and HER2 mutations or ALK/ROS1/RET /NTRK1,2,3 rearrangements are unresponsive to immunotherapy. Importance of knowing the tumour genotyping (NGS, preferable DNA and RNA) from the earliest stages of NSCLC, also for the possible use of immunotherapy both in the adjuvant and perioperative setting. In case of mediastinal disease recurrence after surgery, re-biopsy is essential to re-determine the histological and biological characteristics of the disease and the distinction of recurrence in curable and non-curable disease is of pivotal important for the optimal management of subsequent treatments. Conclusions and relevance: Treatment of stage III NSCLC has always been controversial and challenging: Multidisciplinary approach is mandatory and defining resectability is a critical issue. Chemo-radiotherapy followed by maintenance Durvalumab is now the standard of treatment. Herein, we provide a comprehensive overview of the key challenges and open questions that we are currently facing in clinical practice, in unresectable stage III and in early-stage NSCLC, identifying the knowledge gaps and the possible solutions
Guerra, Fascismo, Resistenza. Avvenimenti e dibattito storiografico nei manuali di storia
No full text2009 - 2010Nel 1996 il Ministro della Pubblica istruzione Luigi Berlinguer emana un decreto che modifica la
suddivisione annuale del programma di Storia, considerato che le vigenti disposizioni “riservano
generalmente all’ultimo anno di ogni ciclo lo svolgimento di un programma troppo esteso e tale da non
consentire comunque un adeguato sviluppo degli eventi succedutisi nel corso del Novecento; attesa altresì
l’esigenza pedagogico-culturale di dedicare un ampio spazio alla trattazione di avvenimenti recenti di
notevole rilievo storico-politico”
Autori ed editori cominciano a pubblicare, fin dal 1997, “nuovissime edizioni” di manuali “per i
nuovi programmi”. Ma, come sono fatti questi testi? Cosa contengono? In che modo viene trattata la storia
del Novecento? Qual è la loro impostazione didattica? Che rapporto c’è tra storia e storiografia? E, infine:
viene colta l’occasione offerta dal decreto del ministro Berlinguer per rinnovare lo studio e l’insegnamento
della storia?
L’analisi di 32 manuali di storia per i licei, pubblicati tra il 1997 e il 2009, può fornire qualche
risposta. Si è pensato analizzare capitolo dedicato alla Seconda guerra mondiale per comprendere il modo in
cui viene affrontato, in termini di avvenimenti e di dibattito storiografico, il periodo 1940-1940 e in
particolare il passaggio dalla guerra dichiarata alla guerra combattuta; la crisi del regime e la caduta del
fascismo; il 25 luglio e l’8 settembre 1943; la continuità ambigua del Regno del Sud e la rottura ambiziosa
della Repubblica Sociale Italiana; le stragi nazifasciste; il complesso fenomeno della Resistenza; il ruolo
degli Alleati e delle forze politiche, sociali, spirituali che agiscono nella società italiana; la Liberazione;
Piazzale Loreto; il sangue dei vinti e il sangue dei vincitori; la resa dei conti e i conti con il passato;
l’influenza di tutto questo sulla dissoluzione della Monarchia e sulla nascita della Repubblica.
L’analisi della struttura e dei contenuti dei manuali di storia è stata condotta anche in riferimento alle
opportunità offerte dalle tecnologie per la didattica. [a cura dell'Autore]In 1996, Luigi Berlinguer Minister of Education issued a decree amending the division's annual program of history, given that the existing provisions "generally reserved to the last year of each cycle the action of a program that was too long and does not allow, however, adequate development of the events that occurred during the twentieth century, also waiting for the educational and cultural needs to devote a large space to discussion of recent events of great historical importance-political "
Authors and publishers are beginning to publish, since 1997, "brand new editions" of books "for new programs." But, as these texts are made? What do they contain? How is it treated the history of the twentieth century? What is their teaching approach? What is the relationship between history and historiography? And, finally, is seized the opportunity offered by the Decree of the Minister Berlinguer to renew the study and teaching of history?
The analysis of 32 history textbooks for high schools, published between 1997 and 2009, may provide some answers. It is designed to analyze the chapter on World War II to understand the way in which
it is addressed, in terms of events and historical debate, the period 1940-1940 and in particular the transition from war declared war fought, the crisis of the regime and the fall of Fascism, 25 July and 8 September 1943; ambiguous continuity of the Southern Kingdom and the failure of the ambitious Italian Social Republic, the Nazi-Fascist massacres, the complex phenomenon of resistance, the role of the Allies and the political, social , spiritual act in Italian society, the Liberation; Piazzale Loreto, the blood of the vanquished and the victors of the blood, the yield of the accounts and accounts with the past, the influence of this on the dissolution of the monarchy and the birth of the Republic.
The analysis of the structure and content of history textbooks was conducted in reference to the opportunities offered by technology for teaching. [edited by Author]IX n.s
Κοινωνικό - ιστορική προσέγγιση των εκπαιδευτικών δομών πριν απο το Δημοτικό Σχολείο
No full textΗ Προσχολική Αγωγή στην Ελλάδα δεν έχει μακροχρόνια ιστορία. Η σημαντικότητα της ίδιας όμως είναι κάτι παραπάνω από σίγουρη όσον αφορά την ολόπλευρη ανάπτυξη των νηπίων. Η Προσχολική Αγωγή ξεκίνησε να αναπτύσσεται αρκετές δεκαετίες μετά την ίδρυση του νεοελληνικού κράτους και πέρασε από πολλά εμπόδια μέχρι να αναγνωριστεί επίσημα από το κράτος και να εισαχθεί ως βαθμίδα στην τυπική εκπαίδευση. Στην παρούσα διπλωματική εργασία λοιπόν επιχειρείται μια κοινωνικό – ιστορική προσέγγιση των δομών πριν από το Δημοτικό σχολείο από την ίδρυση του νεοελληνικού κράτους μέχρι τις αρχές του 21ου αιώνα. Η μεθοδολογία που επιλέχθηκε είναι ιστορική – ερμηνευτική καθώς σκοπός είναι να κατανοηθεί μέσα από τις ιστορικές πηγές η εξέλιξη του θεσμού σε σχέση με τις κοινωνικές αλλαγές κάθε περιόδου στην Ελλάδα.Pre - school Education in Greece has no long history. But its importance is something beyond certain as regard to the whole child’s development. Pre - school Education began to develop several decades after the founding of the Modern Greek state and overcame many obstacles until it was formally recognized and introduced as a step in formal education. Through this present thesis, the author attempts a social and historical approach of the structures before the elementary school from the establishment of the Modern Greek state until the beginning of the 21st century. The methodology chosen was historical – interpretive, taking advantage of the historical sources in order to present the evolution of the institution in relation to the social changes of each period
