69 research outputs found
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No full textStudio del film "Lo smemorato" di Gennaro Righelli con Angelo Musco alla luce dei rapporti con il fascismo, "Il fu Mattia Pascal" di Luigi Pirandello e il caso giudiziario Bruneri-Canella
La marionetta, la maschera e l'attore. Alcune riflessioni su Angelo Musco
No full textL'estetica deformante dell'Opera dei Pupi siciliana - I film di Musco, un repertorio di indizi per la recitazione teatrale di Musco. Analisi linguistica: gesto e parola - La recitazione contaminata dell'attore siciliano - Oralità e scrittura nel teatro di Musco. Osservando Musco, Antonio Gramsci arrivò non lontano dal formulare l'idea di un attore demiurgo, un attore in grado di assimilare totalmente l'opera del drammaturgo, di scomporla nei suoi elementi primari e di ricomporla infine in "una sintesi di movimenti, danza elementare, atteggiamento plastico". In questo modo si ricollegava ad uno dei temi fondamentali delle avanguardie storiche, quello dell'attore creativo, nucleo centrale ed originario del corpo scenico del teatro. All'inizio del Novecento l'arte degli attori siciliani apparve selvaggia e naif ma essa non fu certamente spontanea e improvvisata, almeno nel senso che comunemente si dà a questi termini. La storiografia teatrale, alla luce delle attuali acquisizioni della teatrologia, dovrebbe rivedere alcuni giudizi che i critici diedero sui grandi attori del teatro siciliano. L'analisi dei loro statuti recitativi non può infatti fermarsi all'impressione di primitivismo ma deve poter sondare glia aspetti tecnici di un'arte certo originale ma che non nacque dal nulla essendo piuttosto il risultato di un processo di confluenza di differenti pratiche e culture teatrali
Dissecting intrinsic and ligand-induced structural communication in the β3 headpiece of integrins
No full textBackground: Graph theory is widely used to dissect structural communication in biomolecular systems. Here, graph theory-based approaches were applied to the headpiece of integrins, adhesion cell-surface receptors that transmit signals across the plasma membranes. Methods: Protein Structure Network (PSN) analysis incorporating dynamic information either from molecular dynamics simulations or from Elastic Network Models was applied to the β3 domains from integrins αVβ3 and αIIbβ3 in their apo and ligand-bound states. Results: Closed and open states of the β headpiece are characterized by distinct allosteric communication pathways involving highly conserved amino acids at the two different α/β interfaces in the βI domain, the closed state being prompted to the closed-to-open transition. In the closed state, pure antagonism is associated with the establishment of communication pathways that start from the ligand, pass through the β1/α3,α4 interface, and end up in the hybrid domain by involving the Y110-Q82 link, which is weakened in the agonist-bound states. Conclusions: Allosteric communication in integrins relies on highly conserved and functionally relevant amino acid residues. The αβα-sandwich architecture of integrin βI domain dictates the structural communication between ligand binding site and hybrid domain. Differently from agonists, pure antagonists are directly involved in allosteric communication pathways and exert long-distance strengthening of the βI/hybrid interface. Release of the structure network in the ligand binding site is associated with the close-to-open transition accompanying the activation process. General significance: The study strengthens the power of graph-based analyses to decipher allosteric communication intrinsic to protein folds and modified by functionally different ligands
Mediterranean Syllidae (Annelida : Polychaeta) revisited: biogeography, diversity and species fidelity to environmental features
No full textThe species diversity of Syllidae (Annelida: Polychaeta) on different coastlines within the Mediterranean Basin was analysed, including along the Salento Peninsula (Italy), which is thought to play a crucial role as a crossroads between different biogeographic areas. Analysis of biogeography, the assignment of species into 6 bioclimatic categories, a novel method to assess inter-matrix correlation significance and the correlation between species distribution, and some environmental variables provided relevant tools to investigate the influence of a suite of ecological and historical factors on syllid distribution. Data showed that Syllidae could be considered a useful taxon for biogeographic speculations, even though bioclimatic and environmental analyses appeared significantly more informative. The Salento Peninsula revealed an affinity with some eastern Mediterranean coastlines. Syllid distribution suggested the existence of an 'Atlantism' gradient, decreasing eastwards and possibly corresponding to a temperature gradient when bioclimatic categories were analysed. In contrast to previous results, the Eastern and Western Basins did not show great differences in species diversity. The observed differences could, in part, be due to an 'author effect', due to the differing taxonomic updating of the available faunistic lists. Syllidae were found to be effective faunistic and ecological indicators, able to characterize different areas inside the Mediterranean Sea; thus, the present results could be used to stimulate further research on different aspects of the famil
CHROMOGRANIN A-DERIVED PEPTIDES AND USES THEREOF
No full textThe present invention refers to chromogranin A-derived peptides that are potent dual ligands for integrins αvβ6 and αvβ8, their therapeutic and diagnostic uses and relative compositions
Effectiveness of the combined MMRV Priorix-TetraTM vaccine against varicella in a large Italian region: A case-control study
No full text
Hypnum velutinum. Musco
No full textSecondo volume di un’opera in tre volumi dell’abate Franciosi, raffigurante piante che crescono spontanee in Veneto, nel litorale e piante ornamentali o che si coltivano negli orti.
Ogni volume è suddiviso in fascicoli con circa 100 tavole ciascuno, ogni fascicolo si conclude con un prospetto cronologico con il giorno di raccolta delle piante e il nome scientifico e volgare ed è seguito da un capitolo relativo alle proprietà medicinali delle piante e a poesie ed allegorie botaniche di diversi autori.
Le tavole, di pregevole fattura artistica, sono scientificamente precise e permettono una facile identificazione delle piante raffigurate; in alcune sono presenti anche figure analitiche dello spaccato dei fiori e dei frutti.Secondo volume di un’opera in tre volumi dell’abate Franciosi, raffigurante piante che crescono spontanee in Veneto, nel litorale e piante ornamentali o che si coltivano negli orti.
Ogni volume è suddiviso in fascicoli con circa 100 tavole ciascuno, ogni fascicolo si conclude con un prospetto cronologico con il giorno di raccolta delle piante e il nome scientifico e volgare ed è seguito da un capitolo relativo alle proprietà medicinali delle piante e a poesie ed allegorie botaniche di diversi autori.
Le tavole, di pregevole fattura artistica, sono scientificamente precise e permettono una facile identificazione delle piante raffigurate; in alcune sono presenti anche figure analitiche dello spaccato dei fiori e dei frutti
Exogone sophiae Langeneck & Musco & Busoni & Conese & Aliani & Castelli 2018, n. sp.
No full textExogone sophiae Langeneck, Musco & Castelli n. sp. (Figures 3–4) Material examined. Holotype (MSNP: P/3879): St. 8, Northern Tyrrhenian Sea, 110 m. Paratypes: St. 8: 1 individual (MSNP: P/001/SEM); St. 10: 2 individuals (MSNP: P/242/V; P/246/V). Additional material: St. 8: 1 individual. Description. Holotype complete specimen, 6 mm long for 47 chaetigers, 0.30 mm wide. All paratypes incomplete. Prostomium short, rectangular, distinctly broader than long, with four rounded, small eyes in trapezoidal arrangement, reddish, sometimes difficult to distinguish in preserved material. Antennae absent in all examined individuals (Fig. 4a). Palps long, broad, fused for their total length, with barely noticeable distal notch. Dorsal cirri very small, oval, slightly longer in the posterior region, lacking at chaetiger 2 (Fig. 3a). First four parapodia with 2 compound spiniger-like chaetae and 3–4 falcigers, after chaetiger 5 only 1 spiniger-like and 3 falcigers (Fig. 4c). Anterior spiniger-like compound chaetae with thick, distally spinulous shaft (Figs 3c, 4d), and thin, elongated blades 25–35 µm long; blades sometimes slightly curved with several long teeth on basal part (Figs 3c, 4d), difficult to see with the light microscope. Posterior spinigers-like chaetae similar but shorter and thinner, 15–20 µm long blades. Anterior falcigers with 7.5–10 µm long blade, with very small distal tooth, massive, strong proximal tooth, and relatively short, coarse serration along ventral edge (Figs 3d, 4e). Posterior falcigers shorter, blades 3.8–5 µm long, with thicker basal part. Anterior dorsal simple chaetae unidentate, smooth; posterior dorsal simple chaetae become distinctly thicker, with a subdistal notch (Fig. 3e). Ventral simple chaetae absent. Pharynx long, relatively wide, extending through six chaetigers, with a large, triangular distal tooth. Proventricle barrelshaped, as long as pharynx, with 20–23 muscle cell rows. Pygidium sub-triangular with two very long, tapering anal cirri (Fig. 3b). Etymology. This species is dedicated to Sophie Langeneck, sister of the first author. Distribution. Tyrrhenian Sea, at a depth between 100 and 110 m. Remarks. Exogone sophiae n. sp. is chiefly characterised by the absence of antennae; albeit preservation may cause the loss of antennae in some syllid species, we believe that this character is not a preservation artefact, as all the sampled individuals do not show any trace of antennae, nor of scars indicating the lost of antennae. Moreover, dorsal cirri are perfectly preserved, suggesting that preservation should not have altered the soft appendages of the collected specimens. Until now two species of Exogone without prostomial antennae have been described, namely Exogone acerata San Martín & Parapar, 1990, and Exogone oculata (Hartman & Fauchald, 1971) (San Martín, 1991). E. sophiae differs from E. acerata in the absence of dorsal cirri at chaetiger 2 (present in E. acerata), in the less pronounced spinulation on shafts of spiniger-like chaetae and in the longer spines on blades of spiniger-like chaetae (San Martín & Parapar, 1990). Exogone sophiae appears closer to E. oculata, as both species lack the dorsal cirrus at chaetiger 2, but E. oculata lacks spiniger-like chaetae on the first four chaetigers. Moreover, both species are provided of ventral simple chaetae, that are absent in all examined individuals of the new species. Among Mediterranean species, E. sophiae appears particularly close to Exogone verugera (Claparède, 1868) and Exogone dispar (Webster, 1879) in size and overall body shape and number of proventricle cell rows. Apart from the absence of antennae, this species differs from E. verugera as E. sophiae has smaller, non-coalescent eyes, longer blades of falciger chaetae, with a higher number of marginal teeth, and slightly shorter blades of spinigerlike chaetae with a more pronounced spinulation along the ventral edge; moreover E. sophiae lacks ventral simple chaetae. Exogone dispar has similar blades of falciger chaetae, and a more pronounced spinulation along the ventral edge of spiniger-like blades (San Martín, 2003); however, in E. sophiae such spinulation is even more pronounced (Fig. 3d). Moreover, E. dispar has dorsal cirri at the second chaetiger. Lastly, E. sophiae might resemble Exogone lopezi San Martín, Ceberio & Aguirrezabalaga, 1996, since this last species apparently lacks ventral simple chaetae, and has very small antennae that are difficult to see. However, E. lopezi has falciger chaetae with long, thread-like marginal teeth that outgrow the chaetal tip, whereas in E. sophiae the marginal serration of falcigers is coarser and less developed.Published as part of Langeneck, Joachim, Musco, Luigi, Busoni, Giulio, Conese, Ilaria, Aliani, Stefano & Castelli, Alberto, 2018, Syllidae (Annelida: Phyllodocida) from the deep Mediterranean Sea, with the description of three new species, pp. 197-220 in Zootaxa 4369 (2) on pages 202-204, DOI: 10.11646/zootaxa.4369.2.3, http://zenodo.org/record/113567
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