86,542 research outputs found
iFree: design and evaluation of a pointing method for disabled users on mobile devices
No full textWe present the design and evaluation of a pointing method for disabled people, called iFree, which can run on mobile devices such as smartphones and tablets. The method is based on face recognition and supports target selection (click) in two different modes: by opening and closing the mouth (mouth click) and by making a sound (sound click).The method was experimented on a smartphone with 14 non-disabled participants in order to evaluate its performance and to compare the two above mentioned modes. In particular, we measured its performance using ISO 9241-411 standard task. The throughput grand mean was 0.86 bit/s. The sound click mode had a greater throughput and accuracy, a lower movement time and was preferred by participants
Analisi statistica su macro metastasi linfonodali dopo biopsia del linfo nodo sentinella nel trattamento chi rurgico del carcinoma mammario
No full textQuesto articolo ha analizzato eventuali variabili che potrebbero essere prese in considerazione nella linfoadenectomia ascellare dopo biopsia positiva del linfonodo nel trattamento del carcinoma mammario. Gli autori hanno voluto verifi care se nelle pazienti da sottoporre a trattamento chirurgico con un solo linfonodo
sentinella positivo (LNS +) macrometastatico (con numero di copie di mRNA di citocheratina-19>5000),valutato con metodiche biomolecolari OSNA (one step nucleic acid amplification), si possano individuare caratteristiche in grado di far prevedere l’eventuale negatività dei restanti linfonodi che verrebbero rimossi attra verso l’asportazione ascellare in modo da poter evitare un overtreatment e le possibili conseguenze che ciò comporterebbe. I risultati derivanti dal presente studio suggeriscono a loro volta di valutare un nuovo cut-off del numero di copie di mRNA (RNA messaggero) di citocheratina-19 nel linfonodo sentinella utile per personalizzare i trattamenti chirurgici ed evitare di sottoporre le pazienti con un solo linfonodo metastatico a dissezioni ascellari non necessarie
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Analisi statistica sulla patologia nodulare tiroidea
No full textLa tiroide è una ghiandola endocrina situata nella regione anteriore del collo, specializzata nella produzione e secrezione di ormoni tiroidei. La patologia nodulare tiroidea prevede la presenza di formazioni nodulari nel contesto della tiroide, singole o multiple, che possono alterare la funzionalità e le dimensioni della ghiandola. Tale patologia colpisce il 4-7% circa della popolazione adulta. La tireopatia nodulare può evolversi in patologia maligna: circa 1 nodulo su 20, sottoposto a trattamento chirugico, risulta essere un carcinoma all’esame istologico definitivo. Al fine di individuare il ruolo di alcune variabili nell’evoluzione della malattia, è stato preso in esame un campione di 401 pazienti, di età compresa tra i 17 e gli 84 anni, sottoposti ad intervento chirurgico nel periodo che va dal 2018 al 2021. Obiettivo iniziale è stato quello di stabilire quali variabili influiscono maggiormente sulla diagnosi. Inoltre, sono state individuate le variabili che contribuiscono maggiormente a spiegare la variabilità del fenomeno, e, tramite il modello Logit, quali sono i fattori di rischio, individuabili nel pre-operatorio, che portano a definire una patologia maligna piuttosto che benigna. Per determinare tali fattori di rischio ci si è serviti del software R (un linguaggio di programmazione specifico per la statistica e la grafica computazionale), attraverso cui sono state condotte anche le altre analisi
High stability of AnchoisOil extracted with limonene from anchovy fillet leftovers
No full textTo investigate the vitamin content in an AnchoisOil sample stored at − 20 °C under N2 for more than four years, we have developed a new HPLC method for simultaneous identification and quantification of vitamins in anchovy fish oil that is efficient and applicable in practice. Coupled to full retention of the original visual appearance (orange color and transparency), the relatively high concentrations of lipid-soluble vitamin Q (coenzyme Q10) and vitamin A (retinol) in AnchoisOil extracted with d-limonene from European anchovy fillet leftovers more than four years after extraction point to remarkable chemical stability of this marine oil. These findings further support the practical use of the “LimoFish” process to extract valued fish oil from the leftovers of the world’s most caught fish species. Graphical Abstract: (Figure presented.
Follow-up of differentiated thyroid carcinoma.
No full textThyroid cancer is the most common endocrine malignancy. More than 90% of primary thyroid cancers are differentiated papillary or follicular types. The treatment of differentiated thyroid carcinoma (DTC) consists of total thyroidectomy and radioactive iodine ablation therapy, followed by L-thyroxine therapy. The extent of initial surgery, the indication for radioiodine ablation therapy and the degree of TSH-suppression are all issues that are still being debated cancers are in relation to the risk of recurrence. Total thyroidectomy reduces the risk of recurrence and facilitates (131)I ablation of thyroid remnants. The aim of radioiodine ablation is to destroy any normal or neoplastic residuals of thyroid tissue. These procedures also improve the sensitivity of thyroglobulin (Tg) as a marker of disease, and increase the sensitivity of (131)I total body scan (TBS) for the detection of persistent or recurrent disease. The aim of TSH-suppressive therapy is to restore euthyroidism and to decrease serum TSH levels, in order to reduce the growth and progression of thyroid cancer. After initial treatment, the objectives of the follow-up of DTC is to maintain adequate thyroxine therapy and to detect persistent or recurrent disease through the combined use of neck ultrasound (US) and serum Tg and (131)I TBS after TSH stimulation. The follow-up protocol should be adapted to the risk of recurrence. Recent advances in the follow-up of DTC are related to the use of recombinant human TSH (rhTSH) in order to stimulate Tg production and the ultrasensitive methods for Tg measurement. Undetectable serum Tg during TSH suppressive therapy with L-T4 does not exclude persistent disease, therefore serum Tg should be measured after TSH stimulation. The results of rhTSH administration and L-thyroxine therapy withdrawal are equivalent in detecting recurrent thyroid cancer, but the use of rhTSH helps to avoid the onset of hypothyroid symptoms and the negative effects of acute hypothyroidism on cardiovascular, hepatic, renal and neurological function. In low-risk DTC patients serum Tg after TSH stimulation, together with ultrasound of the neck, should be used to monitor persistent disease, avoiding diagnostic TBS which has a poor sensitivity. These recommendations do not apply when Tg antibodies are present in the serum, in patients with persistent or recurrent disease or limited thyroid surgery. Low-risk patients may be considered to be in remission when undetectable Tg after TSH stimulation and negative US evaluation of the neck are present. On the contrary, detectable Tg after TSH stimulation is an indicator in selecting patients who are candidates for further diagnostic procedure
[Newspaper Clipping: Author Claims Evidence of Second JFK Assassin #1]
No full textNewspaper article titled "Author Claims Evidence of Second JFK Assassin." The article states that author Richard J. Whalen concluded "that there is circumstantial evidence to support the theory of a second assassin in the shooting of President John F. Kennedy.
Also By The Same Author: AKTiveAuthor, a Citation Graph Approach to Name Disambiguation
No full textThe desire for definitive data and the semantic web drive for inference over heterogeneous data sources requires co-reference resolution to be performed on those data. In particular, name disambiguation is required to allow accurate publication lists, citation counts and impact measures to be determined. This paper describes a graph-based approach to author disambiguation on large-scale citation networks. Using self-citation, co-authorship and document source analyses, AKTiveAuthor clusters papers, achieving precision of 0.997 and recall of 0.818 over a test group of eight surname clusters
Improvement of resveratrol permeation through sublingual mucosa: Chemical permeation enhancers versus spray drying technique to obtain fast-disintegrating sublingual mini-tablets
No full textResveratrol (RSV) is a natural polyphenol with several interesting broad-spectrum pharmacological properties. However, it is characterized by poor oral bioavailability, extensive first-pass effect metabolism and low stability. Indeed, RSV could benefit from the advantage of the sublingual route of administration. In this view, RSV attitudes to crossing the porcine sublingual mucosa were evaluated and promoted both by six different chemical permeation enhancers (CPEs) as well as by preparing four innovative fast-disintegrating sublingual mini-tablets by spray drying followed by direct compression. Since RSV by itself exhibits a low permeation aptitude, this could be significantly enhanced by the use of CPEs as well as by embedding RSV in a spray-dried powder to be compressed in order to prepare fast-disintegrating mini-tablets. The most promising observed CPEs (menthol, lysine and urea) were then inserted into the most promising spray-dried excipients’ compositions (RSV-B and RSV-C), thus preparing CPE-loaded mini-tablets. However, this procedure leads to unsatisfactory results which preclude the possibility of merging the two proposed approaches. Finally, the best spray-dried composition (RSV-B) was further evaluated by SEM, FTIR, XRD and disintegration as well as dissolution behavior to prove its effectiveness as a sublingual fast-disintegrating formulation
John F. Kennedy telegram to Roosevelt
No full textJersey Homesteads (later the Borough of Roosevelt) was established in the 1930s as an agro-industrial cooperative community. It was established specifically for urban Jewish garment workers, many of whom had emigrated from Europe. President John F. Kennedy sent a telegram to the citizens of Roosevelt, New Jersey, apologizing for not being able to attend the memorial dedication in honor of former President Franklin Delano Roosevelt. (Jersey Homesteads became Roosevelt in 1945 in honor of the president.) President Kennedy expressed his gratitude to the people of Roosevelt for constructing the memorial, and commented that it will serve as a constant reminder of Roosevelt's good works
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