1,721,459 research outputs found
The first Chinese guidelines on the Management of Ascites and its Related Complications in Cirrhosis: a great goal for a great country
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Terlipressin for Hepatorenal Syndrome: Novel Strategies and Future Perspectives
No full textType 1 hepatorenal syndrome (HRS) is a functional renal failure that often occurs in patients with cirrhosis and ascites. Type 1 HRS develops as the consequence of a severe reduction of effective circulating volume due to both extreme splanchnic arterial vasodilatation and reduction of cardiac output. Several pilot studies and two randomized control studies have shown that terlipressin plus albumin improves renal function in patients with type 1 HRS. Terlipressin plus albumin can also improve short-term survival in these patients. Terlipressin was most commonly given in intravenous boluses starting from an initial dose of 0.5-1 mg every 4 h to 3 mg every 4 h in case of nonresponse. While there is evidence that terlipressin alone may be less effective than terlipressin combined with intravenous albumin in improving renal function in patients with type 1 HRS, the best way to use terlipressin in these patients is still under evaluation. In particular, some preliminary data show that terli..
Indagine sperimentale sul comportamento di giunti di contimuità di volte in legno lamellare a nervature incrociate
No full textBacterial Infections in Cirrhosis as a Cause or Consequence of Decompensation?
No full textBacterial infections are ominous events in liver cirrhosis. Cirrhosis-associated immune dysfunction and pathologic bacterial translocation are responsible for the increased risk of infections. Bacteria induce systemic inflammation, which worsens circulatory dysfunction and induces oxidative stress and mitochondrial dysfunction. Bacterial infections, frequently associated with decompensation, are the most common precipitating event of acute-on-chronic liver failure (ACLF). After decompensation, patients with cirrhosis have an increased risk of developing infections. Bacterial infections should be ruled out in these patients and strategies to prevent infections should be implemented to prevent further decompensation. We review infections as a cause and consequence of decompensation in cirrhosis
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Bacterial Infections in Cirrhosis
Full text linkBacterial infections are the most common trigger of acute decompensation of cirrhosis. The occurrence of infections in cirrhosis is associated with the development of organ dysfunctions, failures, and acute on chronic liver failure. The combination of infections and organ dysfunction/acute on chronic liver failure dramatically increases the mortality risk in these patients. Infections in cirrhosis are a big challenge for clinicians, since the mortality from sepsis is increasing in these patients worldwide. The rapid and progressive spread of multiresistant bacteria has been blamed for the increased mortality rate. Several studies have shown that early diagnosis and appropriate administration of antibiotic treatment are crucial for improving prognosis in these patients. Moreover, the prevention and treatment of acute kidney injury and organ failures are fundamental parts of management of infections in cirrhosis. Herein we provided a concise and updated review of the literature on bacterial infections in patients with cirrhosis
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