57 research outputs found
Sex differences in congenital heart defects and genetically induced arrhythmias
No full textSex medicine can be applied to define the effect of male or female sex-associated differences on the prevalence of congenital heart defects (CHDs), on clinical manifestation of the latter, on means of dealing with the defects and facing consequent surgical treatment, as well as on the success of surgery. The widespread use of modern databases has undoubtedly enhanced the possibility of these observations compared to the past, when findings were limited to case series from single cardiology or paediatric heart surgery units. The aim of the present review is to assess all publications present in the literature on sex differences and CHD, placing particular emphasis on both contradictory aspects and less acknowledged issues. Furthermore, a section of the review is devoted to the effect of sex differences on cardiac arrhythmias, particularly the largely genetically predetermined electrophysiological differences observed between men and women
On the nature of rainfall intermittency as revealed by different metrics and sampling approaches
No full textA general consensus on the concept of rainfall intermittency has not yet been reached, and intermittency is often attributed to different aspects of rainfall variability, including the fragmentation of the rainfall support (i.e., the alternation of wet and dry intervals) and the strength of intensity fluctuations and bursts. To explore these different aspects, a systematic analysis of rainfall intermittency properties in the time domain is presented using high-resolution (1-min) data recorded by a network of 201 tipping-bucket gauges covering the entire island of Sardinia (Italy). Four techniques, including spectral and scale invariance analysis, and computation of clustering and intermittency exponents, are applied to quantify the contribution of the alternation of dry and wet intervals (i.e., the rainfall support fragmentation), and the fluctuations of intensity amplitudes, to the overall intermittency of the rainfall process. The presence of three ranges of scaling regimes between 1 min to ~ 45 days is first demonstrated. In accordance with past studies, these regimes can be associated with a range dominated by single storms, a regime typical of frontal systems, and a transition zone. The positions of the breaking points separating these regimes change with the applied technique, suggesting that different tools explain different aspects of rainfall variability. Results indicate that the intermittency properties of rainfall support are fairly similar across the island, while metrics related to rainfall intensity fluctuations are characterized by significant spatial variability, implying that the local climate has a significant effect on the amplitude of rainfall fluctuations and minimal influence on the process of rainfall occurrence. In addition, for each analysis tool, evidence is shown of spatial patterns of the scaling exponents computed in the range of frontal systems. These patterns resemble the main pluviometric regimes observed on the island and, thus, can be associated with the corresponding synoptic circulation patterns. Last but not least, we demonstrate how the methodology adopted to sample the rainfall signal from the records of the tipping instants can significantly affect the intermittency analysis, especially at smaller scales. The multifractal scale invariance analysis is the only tool that is insensitive to the sampling approach. Results of this work may be useful to improve the calibration of stochastic algorithms used to downscale coarse rainfall predictions of climate and weather forecasting models, as well as the parameterization of intensity-duration-frequency curves, adopted for land planning and design of civil infrastructures
Diplopimarane, a 20-nor-ent-Pimarane Produced by the Oak PathogenDiplodia quercivora
No full textIn this study a new 20-nor-ent-pimarane, named diplopimarane, was isolated together with sphaeropsidins A (9) and C (10), and (+)-epiepoformin (11) from organic crude extracts of Diplodia quercivora, a recently described oak pathogen originally found on declining Quercus canariensis trees in Tunisia. Diplopimarane was characterized as (1S,2R)-2,8,8-trimethyl-2-vinyl-1,2,3,4,5,6,7,8-octahydrophenanthrene-
1,9,10-triol by spectroscopic, X-ray, optical, and chemical methods. It exhibited a wide range of activities including remarkable phytotoxicity on nonhost plants such as tomato cuttings, moderate antifungal activity against important plant pathogens, and moderate zootoxicity against Artemia salina. Its derivatives (2−4 and 6) were also tested for their phytotoxic and zootoxic activities. All these derivatives proved to be active against A. salina at 200 μg/mL, while 2 and 6 were also active on tomato cuttings. The other secondary metabolites (9, 10, and 11) herein reported for D. quercivora exhibited phytotoxic, antifungal, and
zootoxic activity. This is the first report on the secondary metabolites secreted in vitro by this oak pathogen that could be key components of its adaptative strategies
Integrated treatment of cheese whey and Hi-Tech waste: a demonstration of synergistic waste management in a circular economy perspective
No full textA Case Study of Implementation of Circular Economy Principles to Waste Management: Integrated Treatment of Cheese Whey and Hi-Tech Waste
No full textIn a global context characterized by severe environmental problems and increasing resource scarcity, waste represents both a challenge and an opportunity. This study aims to demonstrate with a real case the potential for optimizing the waste valorization action attainable through the synergic application of different treatments to residues of equally different nature and origin. In particular, bio-chemical (dark fermentation), chemical-physical (selective leaching) and thermo-chemical (hydrothermal carbonization) treatments were applied for the integrated valorization of whey from sheep cheese production and Hi-Tech waste (discarded electrical and electronic equipment). The treatments were applied at a laboratory scale on real samples of these residues. The organic acids used for selective leaching of valuable metals from Hi-Tech waste were obtained by dark fermentation of the cheese whey, while hydrothermal carbonization was used to convert the waste from previous stages into hydrochar feasible as solid fuel or soil improver. The dark fermentation tests have highlighted the possibility of recovering ≈ 100 g of organic acids from 1 L of whey; furthermore, it is also possible to recover bio-hydrogen depending on the operating conditions applied and the type of targeted organic acids. The leaching tests have demonstrated how the organic acids from whey fermentation have selective and quantitative mobilization capacities comparable to those of the same acids available on the market. The carbonization tests produced carbon-enriched hydrochar with promising fuel properties, as well as process waters suitable for anaerobic digestion with methane production. The results of the project led to the filing of an international patent
Randomized Double-Blind Crossover Study for Evaluating a Probiotic Mixture on Gastrointestinal and Behavioral Symptoms of Autistic Children
No full textAutism spectrum disorders (ASDs) represent a diagnostic challenge with a still partially uncertain etiology, in which genetic and environmental factors have now been assessed. Among the hypotheses underlying the involvement of biological and environmental factors, the gut–brain axis is of particular interest in autism spectrum disorders. Several studies have highlighted the related incidence of particular gastrointestinal symptoms (GISs) in children suffering from ASDs. Probiotics have shown success in treating several gastrointestinal dysbiotic disorders; therefore, it is plausible to investigate whether they can alleviate behavioral symptoms as well. On these bases, a randomized double-blind crossover study with a placebo was conducted, evaluating the effects of a mixture of probiotics in a group of 61 subjects aged between 24 months and 16 years old with a diagnosis of ASD. Behavioral evaluation was performed through the administration of a questionnaire including a Parenting Stress Index (PSI) test and the Vineland Adaptive Behavior Scale (VABS). The Psycho-Educational Profile and the Autism Spectrum Rating Scale (ASRS) were also evaluated. Microbial composition analyses of fecal samples of the two groups was also performed. The study showed significant improvements in GISs, communication skills, maladaptive behaviors, and perceived parental stress level after the administration of probiotics. Microbiome alpha diversity was comparable between treatment arms and no significant differences were found, although beta diversity results were significantly different in the treatment group between T0 and T1 time points. Streptococcus thermophilus, Bifidobacterium longum, Limosilactobacillus fermentum, and Ligilactobacillus salivarius species were identified as some of the most discriminant taxa positively associated with T1 samples. This preliminary study corroborates the relationship between intestinal microbiota and ASD recently described in the literature
EXPRESSION OF VESICLE-ASSOCIATED MEMBRANE-PROTEIN-ASSOCIATED PROTEIN B CLEAVAGE PRODUCTS IN PERIPHERAL BLOOD LEUKOCYTES AND CEREBROSPINAL FLUID OF PATIENTS WITH SPORADIC AMYOTROPHIC LATERAL SCLEROSIS
No full textBackground and purpose: Vesicle-associated membrane-protein-associated protein B (VAPB) is an endoplasmic reticulum (ER) resident protein participating in ER function, vesicle trafficking, calcium homeostasis and lipid transport. Its N-terminal domain, named MSP, is cleaved and secreted, serving as an extracellular ligand. VAPB mutations are linked to autosomal-dominant motor neuron diseases, including amyotrophic lateral sclerosis (ALS) type 8. An altered VAPB function is also suspected in sporadic ALS (SALS). Methods: The expression pattern of VAPB cleavage and secreted products in the peripheral blood leukocytes (PBL) and cerebrospinal fluid (CSF) of SALS patients and neurological controls was assessed. PBL from healthy controls were also analyzed. Assays were carried out through western blotting, using an anti-VAPB (N-terminal) antibody. Results: Two VAPB fragments containing the MSP domain (17 kDa and 14 kDa molecular sizes) were identified in PBL of SALS and controls, with no significant differences amongst groups. In CSF, only the 14 kDa VAPB MSP fragment was expressed and a corresponding VAPA fragment was not detected. The CSF VAPB fragment was absent in 58.7% of SALS patients, of whom 79.2% were bulbar onset (P = 0.001, bulbar versus spinal). Conclusions: The absence of the CSF VAPB MSP fragment from most bulbar-onset SALS patients suggests a specific alteration of brain-derived VAPB cleavage and secretion in this group of patients, and hints at a role of VAPB in the pathophysiology of this motor neuron disease. © 2013 The Author(s). European Journal of Neurology © 2013 EFNS
The production of glocality in the context of local development. The case of an Ngo in San Cristobal de las Casas
No full textThe author analyzes the production of glocalities through a case study of an Ngo in the city of San Cristóbal de las Casas, Chiapas, Mexico. The organization aims at integrating various layers of the population in its development project, which is based on an alternative pedagogical model, gender equity and empowerment. The analysis is built around the study of discourse and practices of the organization and of the interactions between the Ngo members and the beneficiaries of the project.L’autore analizza la produzione di glocalità attraverso lo studio di una organizzazione non governativa nella città di San Cristóbal de las Casas, in Chiapas, Messico. L’organizzazione presa in esame si propone di integrare vari strati della popolazione nel suo progetto di sviluppo basato su un modello pedagogico alternativo, l’equità di genere e l’empowerment. La riflessione si sviluppa con riferimento all’analisi teorica, alle pratiche e alle interazioni tra i componenti dell’Ong e i destinatari del progetto.El autor analiza la producción de glocalidad a través un estudio de caso sobre una organización no gubernamental en la ciudad de San Cristóbal de las Casas, en Chiapas, México. La organización se propone integrar varios sectores de la población en su proyecto de desarrollo basado sobre un modelo pedagógico alternativo, el enfoque de género y el apoderamiento. El análisis se desarrolla alrededor del estudio del discurso de y de las prácticas de la organización y de la interacción entre los componentes de la Ong y los destinatarios del proyecto
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