1,721,000 research outputs found
Glycyrrhetinic Acid Liposomes and Hyalurosomes on Spanish Broom, Flax, and Hemp Dressings to Heal Skin Wounds
Full text linkThe focus of this work was to prepare Spanish Broom, flax, and hemp dressings impregnated with glycyrrhetinic acid (GA) liposomes or hyalurosomes to promote the healing process and protect the skin wounds. Vesicles were prepared by the film hydration method and characterized in terms of size, particle size distribution, ζ potential, encapsulation efficiency, in vitro release, and biocompatibility on 3T3 fibroblasts. Loaded liposomes and hyalurosomes showed nanometric size (355 ± 19 nm and 424 ± 32 nm, respectively), good size distribution (lower than 0.3), and appropriate encapsulation efficiency (58.62 ± 3.25% and 59.22 ± 8.18%, respectively). Hyalurosomes showed good stability during the storage period, which can be correlated to the negative ζ potential, and allowed a fast and complete release of GA. Preliminary biological studies revealed that both kinds of loaded vesicles were not cytotoxic and that hyalurosomes could exert a slight stimulating effect on fibroblast proliferation. Finally, in vitro release studies from the different dressings impregnated with the loaded vesicles demonstrated that a high amount of GA could be reached at the wound site after 60 min from application. In conclusion, the results suggested that the developed dressings, especially those impregnated with hyalurosomes, can be efficiently used to promote the healing process
Cromolyn-crosslinked chitosan nanoparticles for the treatment of allergic rhinitis
No full textThe aim of this work was to prepare new mucoadhesive nasal decongestant nanoparticles obtained by direct crosslinking between the cationic polymer chitosan and the anionic drug cromolyn. Different chitosan/cromolyn molar ratios were used in order to obtain nanoparticles of suitable size, encapsulation efficiency/drug loading and mucoadhesion. Moreover, the ability of the nanoparticles to deliver cromolyn into and through the nasal mucosa was evaluated. The obtained positively charged nanoparticles, sized 180-400 nm, showed interesting properties in terms of yield, mucoadhesion, encapsulation efficiency and drug loading. Release and permeation/penetration data indicated the ability of the nanoparticles to retain a high amount of cromolyn inside the mucosa, which is rich in mast cells. These findings suggest developing decongestant nanoparticles for potential treatment of allergic rhinitis
GinExtraMed: NUOVA MEDICAZIONE ECOSOSTENIBILE E BIOCOMPATIBILE A BASE DI GINESTRA E ROSA CANINA L.
No full textLa gestione delle ferite ha un sostanziale impatto sul Sistema Sanitario Nazionale imponendo notevoli costi
alla società. Nonostante i recenti progressi nel settore del wound-care, il trattamento delle ferite rimane
ancora una sfida importante [1]. Inoltre, la crescente consapevolezza ecologica incentiva lo sviluppo di nuovi
prodotti per le medicazioni che siano sostenibili e a basso impatto ambientale [2]. Nel contesto dei prodotti
biorinnovabili, vantaggiosi per la salute ed environmental friendly, la fibra di ginestra risulta una valida alter nativa all’utilizzo del cotone per la preparazione di medicazioni per il trattamento delle ferite. A differenza
del cotone, la ginestra (Spartium jiunceum L.) cresce spontaneamente in tutti i paesi dell’area mediterranea;
la sua coltivazione non richiede concimi, pesticidi e diserbanti ed oltretutto può essere coltivata in terreni
non adatti a coltivazioni alimentari [3].
L’obiettivo di questo lavoro è quello di sviluppare una medicazione innovativa, ecosostenibile e biocompati bile per il trattamento delle ferite superficiali e delle lesioni della cute. Le medicazioni in fibra di ginestra sono
state impregnate con l’estratto idroalcolico di Rosa canina L., incapsulato in sistemi vescicolari in grado di
proteggerlo e migliorarne la propria attività. La Rosa canina L. è conosciuta fin dai tempi antichi per il suo
alto contenuto di acido ascorbico e per le sue proprietà antiossidanti e antiinfiammatorie [2].
L’estratto idroalcolico è stato incapsulato in sistemi vescicolari, glicetosomi, preparati con il metodo solvent
injection e caratterizzati in termini di dimensioni, potenziale ζ ed efficienza di incapsulazione. Sono stati
eseguiti, inoltre, gli studi di rilascio in vitro ed è stata valutata la stabilità nel tempo. La biocompatibilità delle
medicazioni in fibra di ginestra impregnate con i glicetosomi è stata valutata sulla linea cellulare WS1 (fibro blasti di derma umano). Infine, è stata valutata la capacità di cicatrizzazione delle medicazioni mediante lo
scratch test.
I risultati ottenuti hanno dimostrato che i glicetosomi carichi di estratto di Rosa canina L. hanno dimensioni
nanometriche (150- 250 nm), potenziale ζ negativo e un’alta efficienza di incapsulazione (~ 90%). Tali si stemi vescicolari sono, inoltre, stabili e biocompatibili. Infine, le cellule trattate con le medicazioni impregnate
con i glicetosomi carichi di estratto mostrano una significativa riduzione dei tempi di chiusura della ferita. In
conclusione, sulla base dei risultati ottenuti, la medicazione GinExtraMed potrebbe rappresentare un inte ressante alternativa alla garza di cotone per il trattamento delle ferite superficiali
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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