1,721,112 research outputs found
The beta c receptor family - Structural insights and their functional implications
No full textAbstract not availableSophie E. Broughton, Tracy L. Nero, Urmi Dhagat, Winnie L. Kan, Timothy R. Hercus, Denis Tvorogov, Angel F. Lopez, Michael W. Parke
Analysis of a factor controlling the formation and func tion of white blood cells
No full textProf Angel F Lopez$AUD 80,794.28NHMRC Project GrantsStandard Project Gran
Studies of white blood cells involved in allergy
No full textProf Angel F Lopez$AUD 83,473.01NHMRC Project GrantsStandard Project Gran
The transcriptional program, functional heterogeneity, and clinical targeting of mast cells
Get PDFMast cells are unique tissue-resident immune cells that express an array of receptors that can be activated by several extracellular cues, including antigen-immunoglobulin E (IgE) complexes, bacteria, viruses, cytokines, hormones, peptides, and drugs. Mast cells constitute a small population in tissues, but their extraordinary ability to respond rapidly by releasing granule-stored and newly made mediators underpins their importance in health and disease. In this review, we document the biology of mast cells and introduce new concepts and opinions regarding their role in human diseases beyond IgE-mediated allergic responses and antiparasitic functions. We bring to light recent discoveries and developments in mast cell research, including regulation of mast cell functions, differentiation, survival, and novel mouse models. Finally, we highlight the current and future opportunities for therapeutic intervention of mast cell functions in inflammatory diseases.Gökhan Cildir, Harshita Pant, Angel F. Lopez, Vinay Tergaonka
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mechanisms of vitamin D₃ metabolite repression of IgE-dependent mast cell activation
No full textAbstract not available.Kwok-Ho Yip, Natasha Kolesnikoff, Chunping Yu, Nicholas Hauschild, Houng Taing, Lisa Biggs, David Goltzman, Philip A. Gregory, Paul H. Anderson, Michael S. Samuel, Stephen J. Galli, Angel F. Lopez, and Michele A. Grimbaldesto
Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling
No full textAbstract not availableSophie E. Broughton, Timothy R. Hercus, Tracy L. Nero, Mara Dottore, Barbara J. McClure, Urmi Dhagat, Houng Taing, Michael A. Gorman, Jack King-Scott, Angel F. Lopez, Michael W. Parke
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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