106,215 research outputs found
Joshua Davis: Author of Spare Parts
No full textCitation: K-State First (2016). Joshua Davis: Author of Spare Parts [Flier]. Manhattan, Kansas: K-State First.Flyer advertising Joshua Davis's author talk at Kansas State University
Steven Johnson Author Talk Poster
No full textK-State Book NetworkA poster advertising an author talk by Steven Johnson at Kansas State University on September 3, 2014. Steven Johnson's book "The Ghost Map" was the 2014-2015 common book
Angiotensin II induces soluble fms-Like tyrosine kinase-1 release via calcineurin signaling pathway in pregnancy
No full textMaternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular endothelial growth factor and placental growth factor. Angiotensin II (Ang II) is a potent vasoconstrictor that increases concomitant with sFlt-1 during pregnancy. Therefore, we speculated that Ang II may promote the expression of sFlt-1 in pregnancy. Here we report that infusion of Ang II significantly increases circulating levels of sFlt-1 in pregnant mice, thereby demonstrating that Ang II is a regulator of sFlt-1 secretion in vivo. Furthermore, Ang II stimulated sFlt-1 production in a dose- and time-dependent manner from human villous explants and cultured trophoblasts but not from endothelial cells, suggesting that trophoblasts are the primary source of sFlt-1 during pregnancy. As expected, Ang II-induced sFlt-1 secretion resulted in the inhibition of endothelial cell migration and in vitro tube formation. In vitro and in vivo studies with losartan, small interfering RNA specific for calcineurin and FK506 demonstrated that Ang II-mediated sFlt-1 release was via Ang II type 1 receptor activation and calcineurin signaling, respectively. These findings reveal a previously unrecognized regulatory role for Ang II on sFlt-1 expression in murine and human pregnancy and suggest that elevated sFlt-1 levels in preeclampsia may be caused by a dysregulation of the local renin/angiotensin system
Effects of ANG II and K+ on Ca efflux and aldosterone production in adrenal glomerulosa cells
No full textA comparison was made of the effects of angiotensin II (ANG II) and K+ on aldosterone secretion and calcium efflux from porcine adrenal glomerulosa cells. In the presence of 1.25 mM Ca2+ in the perifusion medium, both 1 x 10(-9) M ANG II and 12 mM K+ caused a 3-fold increase in rate of aldosterone secretion. ANG II caused a 3.5-fold increase in the fractional efflux ratios of radiocalcium from cells prelabeled with 45Ca, but K+ caused only a 1.5-fold increase. When the perifusate contained no Ca2+ or the Ca2+ was replaced by 0.6 mM Sr2+, the effects of K+ on both 45Ca efflux and aldosterone production were abolished. On the other hand, ANG II still caused approximately the same increase in the fractional efflux ratio of radiocalcium and 25-50% of the normal increase in aldosterone production rate. When the perifusate contained 1.25 mM calcium and 25 microM dantrolene, K+ produced the same 1.5-fold increase in calcium efflux and the same maximal rate of aldosterone production as seen in the absence of dantrolene. In contrast, dantrolene greatly inhibited ANG II-induced increase in the fractional efflux ratio of calcium, 1.5-fold compared with 3.5-fold in the absence of dantrolene. Likewise, dantrolene delayed the onset of the ANG II-induced increase in aldosterone secretion and reduced the maximal rate of secretion to 50%. Cells incubated with both dantrolene and media containing no Ca2+ or containing Sr2+ in place of Ca2+ showed no response to ANG II either in terms of calcium efflux or aldosterone production.(ABSTRACT TRUNCATED AT 250 WORDS)</jats:p
Ang II-mediated blockage of K<sup>+</sup> currents lies downstream of AT2R/ERK pathway.
No full text<p>A) Representative K<sup>+</sup> current traces showing response of Ang II, Ang II+ PD123319, Ang II+Losartan, CGP42112A or Ang II+U0126 in NSCs evoked from −80 to 80 mV. NSCs were pre-treated with vehicle, Losartan, PD123319, or U0126 for 1 hour followed by incubation with Ang II or CGP42112A for 24 hours. B) Mean data of peak K<sup>+</sup> current change from −80 to 80 mV. C) Peak K<sup>+</sup> current change at +80 mV. *P<0.05 <i>vs</i> untreated control group, <sup>#</sup>P<0.05 <i>vs</i> Ang II- treated group; n = 10 in each group.</p
Ang Pagtuturo ng Wika at Kulturang Filipino sa Disiplinang Filipino (Konteksto ng K-12)
No full textnakagawiang pagtuturo na may diin sa gramatika at komunikasyon. Ang ipinapanukalang dulog ay nagpapatingkad sa ugnayan ng wika at kulturang Filipino. May iba’t ibang aspekto ang ugnayang ito ngunit itinatampok ang pagtingin sa wika bilang “daluyan” o “sisidlan” ng kultura. Gayumpaman, hindi humihinto ang pananaw na ito sa enumerasyon lamang ng mga tao, lugar, bagay, pangyayari, konsepto, at iba pang sagisag-kulturang Filipino, at sa halip, laging iginigiit na ang kultura ay dinamiko, kolektibo, at may ginagalawang konteksto. Naglatag din ng isang kongkretong modelo, at halimbawang aplikasyon, sa pagsusuri ng mga cultural domain o pangkulturang larang na nakatuon sa wika. Sa huling bahagi ng papel ay iminungkahi kung paano puwedeng ituro sa konteksto ng K-12 ang wika at kultura na nakabalangkas ayon sa wika ng paglalarawan, wika ng pagbuo ng kahulugan, wika ng pagtugon, at wika ng paglahok
Ang Pagtuturo ng Wika at Kulturang Filipino sa Disiplinang Filipino (Konteksto ng K-12)
No full textNaglalahad sa papel ng isang dulog sa pagtuturo ng wika na lumilihis na nakagawiang pagtuturo na may diin sa gramatika at komunikasyon. Ang ipinapanukalang dulog ay nagpapatingkad sa ugnayan ng wika at kulturang Filipino. May iba’t ibang aspekto ang ugnayang ito ngunit itinatampok ang pagtingin sa wika bilang “daluyan” o “sisidlan” ng kultura. Gayumpaman, hindi humihinto ang pananaw na ito sa enumerasyon lamang ng mga tao, lugar, bagay, pangyayari, konsepto, at iba pang sagisag-kulturang Filipino, at sa halip, laging iginigiit na ang kultura ay dinamiko, kolektibo, at may ginagalawang konteksto. Naglatag din ng isang kongkretong modelo, at halimbawang aplikasyon, sa pagsusuri ng mga cultural domain o pangkulturang larang na nakatuon sa wika. Sa huling bahagi ng papel ay iminungkahi kung paano puwedeng ituro sa konteksto ng K-12 ang wika at kultura na nakabalangkas ayon sa wika ng paglalarawan, wika ng pagbuo ng kahulugan, wika ng pagtugon, at wika ng paglahok
HORI7ON at ang Pangakong Post-P-pop
No full textSa kasalukuyang yugto ng hyphenated identity isinilang ang HORI7ON (호라이즌), ang kauna-unahang Filipino boy band na nagdebut sa South Korea noong 24 Hulyo 2023. Kinabibilangan nina Jeromy Batac, Marcus Cabais, Kyler Chua, Vinci Malizon, Reyster Yton, Kim Ng, at Winston Pineda ang grupo. Sila ang pitong nanguna sa animnapu’t dalawang kalahok ng survival competition series na Dream Maker na inere sa A2Z at Kapamilya Channel—sa cable at satellite TV, Facebook, at YouTube—mula 19 Nobyembre 2022 hanggang 12 Pebrero 2023. Nang pirmahan ng ABS-CBN at ng mga South Korean na entidad na MLD Entertainment at KAMP Global ang kontrata sa paglulunsad ng Dream Maker, G-pop o Global Pop ang marketing sa mabubuong grupo, at hindi isang K-pop o Korean Pop group. Gayunman, kinukutya ng ilang fans ng P-pop o Pinoy Pop ang HORI7ON, sapagkat hindi diumano isang tunay na P-pop group ang HORI7ON, at ni hindi sila dapat nagtanghal sa Pinoy Pop Convention and Concert (PPOPCON) noong Hulyo 2023. Sisikapin ng papel na ito na suriin ang pagbuo sa at pag-iral ng HORI7ON bilang kadugtong ng Hallyu o Korean Wave sa postkolonyal na kalagayan ng Pilipinas. Tutukuyin at paghahambingin ang mga lokal na pag-unawa sa P-pop at ihahambing ang mga ito sa mga konsepto ng K-pop at G-pop, upang linawin kung manipestasyon ba ang grupo ng posibilidad ng isang bagong penomenon na maaari nang tawaging “post-P-pop.
J. K. Ang and C. W. Bamforth
No full textAlthough there are product-to-product differences, the majority of the crystal and caramel malts tested have been shown to have a net destabilizing impact on foam. A foaming test using a model beer has been developed to quantify the magnitude of this inhibitory effect. Lipid analysis using thin-layer chromatography reveals that there are elevated levels of triglycerides in problematic malts. There also appear to be oxidized lipids in the specialty malts, probably produced in the heating stage of malt production with higher levels in more intensely heated products. However some specialty malts, such as black malt, while containing such foam-negative entities, do display superior foaming properties, probably because they develop even more powerful foam-positive components in the severe heating events. © 2014 The Institute of Brewing & Distilling
Effect of ANG II on the K<sub>Ca</sub> channel activity in renal VSM cells.
No full text<p>The upper panel presents a representative current recording of the effects of ANG II on of the K<sub>Ca</sub> channel activity recorded using a cell-attached patches of VSM cells freshly isolated from renal microvessels at a pipette potential -40 mV in high K<sup>+</sup> solution with 140 mM KCl in the pipette to null membrane potential (panel A) or in normal PSS with 140 mM KCL in the pipette at the resting membrane potential (pipette potential = 0 mV, panel B). The middle panel summarizes the cell-attached patch clamp recording mode. The lower panel presents a summary of the effects of ANG II on the activity of K<sub>Ca</sub> channel recorded in depolarized cells (panel A) in a high K+ solution and in cells bathed in PSS at a normal depolarized membrane potential (panel B). Recordings were obtained from 6-8 cells under each condition. </p
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