79 research outputs found
Clinicoprognostical features of endometrial cancer patients with somatic mtDNA mutations
No full textSomatic mitochondrial DNA (mtDNA) mutations
have been found in a subset of endometrial cancers (EC) from
different populations. We have investigated the relationship
between mtDNA changes and clinical and pathological
variables of women affected by EC. mtDNA mutations were
detected both in early (3/32; 9%) and in advanced (1/8;
12%) stages of uterine tumors. However, patients carrying
the mtDNA mutations or the normal mtDNA sequence had
indistinguishable clinicopathological data, including age,
clinical stage, histological grade and type or depth of myometrial
invasion. It is noteworthy that mtDNA mutations
were not detected in hyperplastic endometrial tissues or in
ECs coexisting with hyperplasia, nor in a single case of
endometrial stromal sarcoma. LOH at the tumor suppressor
genes RB1 and TP53 as well as p16INK4A alterations (LOH,
gene deletion) were found in tumors carrying mtDNA
mutations. These results suggest that somatic mtDNA
mutations are detected in a subset of ECs, although they are
unrelated to clinicopathological variables of cancer
Pregnant woman infected with SARS-COV-2 – diagnosis and treatment
No full textBorowik Joanna, Kaziród Karolina, Miturski Andrzej, Semczuk-Sikora Anna. Pregnant woman infected with SARS-COV-2 – diagnosis and treatment. Journal of Education, Health and Sport. 2022;12(9):193-201. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.09.024
https://apcz.umk.pl/JEHS/article/view/39537
https://zenodo.org/record/7034677
The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.
Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).
Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.
Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).
© The Authors 2022;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 08.08.2022. Revised: 10.08.2022. Accepted: 28.08.2022.
Pregnant woman infected with SARS-COV-2 – diagnosis and treatment
Ciężarna zakażona SARS-COV-2- diagnostyka i leczenie
Joanna Borowik1, Karolina Kaziród1, Andrzej Miturski2, Anna Semczuk-Sikora2
1. Student’s Scientific Group at the Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland
2. Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, Staszica 16, 20-081 Lublin, Poland
ORCID ID:
Joanna Borowik: https://orcid.org/0000-0001-8369-6207, [email protected]
Karolina Kaziród: https://orcid.org/0000-0002-6305-6488, [email protected]
Andrzej Miturski: https://orcid.org/0000-0002-3550-7747, [email protected]
Anna Semczuk- Sikora: https://orcid.org/0000-0001-9602-5904, [email protected]
Correspondence: Joanna Borowik, [email protected]
Abstrakt:
Wprowadzenie: COVID-19 to infekcja wywołana przez nowego wirusa SARS-CoV-2. U kobiet ciężarnych chorych na COVID-19 w porównaniu do nie ciężarnych występuje zwiększone ryzyko ciężkiego przebiegu infekcji. Ciężarne częściej są hospitalizowane w Oddziale Intensywnej Terapii i wymagają zastosowania mechanicznej wentylacji. W przebiegu infekcji COVID-19 u ciężarnych, w porównaniu do zdrowych rówieśniczek w ciąży, występuje większe ryzyko poronienia, porodu przedwczesnego czy urodzenia dziecka z małą masą urodzeniową.
Cel pracy: Przedstawienie na podstawie dostępnego piśmiennictwa zasad postępowania z ciężarną zakażoną wirusem SARS-CoV-2.
Stan wiedzy: Dowodem zakażenia jest wykrycie wirusa w materiale klinicznym potwierdzone badaniem PCR. Tomografia komputerowa klatki piersiowej może być przydatna w diagnostyce, zwłaszcza gdy wynik testu PCR jest ujemny. Szczególną uwagę należy zwrócić na leczenie farmakologiczne, które powinno być zarówno skuteczne jak i bezpieczne dla płodu. W terapii COVID-19 zastosowanie znajdują niektóre leki przeciwwirusowe i środki przeciwzapalne, a także leki hamujące krzepnięcie. Istotna jest również tleno- i płynoterapia. Należy regularnie monitorować stanu płodu. Zaleca się pomiar akcji serca płodu, wykonanie kardiotokografii, ultrasonografii ciąży z oceną objętości płynu owodniowego. Decyzję o czasie i sposobie porodu należy podejmować indywidualnie na podstawie wskazań położniczych oraz stanu matczyno-płodowego.
Podsumowanie: Terapia pacjentki ciężarnej zakażonej SARS-CoV-2 powinna być dopasowana indywidualnie w zależności od stanu zdrowia kobiety. W działaniach terapeutycznych należy mieć na uwadze zarówno dobro matki, jak i płodu.
Słowa kluczowe: SARS-CoV-2; COVID-19; ciąża; pandemia
Abstract:
Introduction: COVID-19 is an infection caused by the new SARS-CoV-2 virus. In pregnant women with COVID-19, compared to non-pregnant women, there is an increased risk of a severe course of the infection. Pregnant women are more often hospitalized in the Intensive Care Unit and require mechanical ventilation. In the course of COVID-19 infection, pregnant women have a greater risk of miscarriage, premature birth or having a baby with low birth weight, compared to their healthy pregnancy peers.
The aim of the study: To present, based on the available literature, the principles of management of a pregnant woman infected with SARS-CoV-2 virus.
State of knowledge: The evidence of infection is the detection of the virus in the clinical specimen confirmed by PCR. Chest computer tomography can be useful in diagnosis, especially when the PCR test result is negative. Particular attention should be paid to pharmacological treatment, which should be both effective and safe for the fetus. Certain antiviral and anti-inflammatory drugs as well as anticoagulants drugs are used in COVID-19 therapy. Oxygen and fluid therapy is also important. The condition of the fetus should be monitored regularly. It is recommended to measure the fetal heart rate, perform cardiotocography, pregnancy ultrasound and assess the volume of amniotic fluid. The decision about the time and method of delivery should be made individually on the basis of obstetric indications and the maternal-fetal condition.
Summary: The therapy of a pregnant patient infected with SARS-CoV-2 should be adjusted individually depending on the woman's health condition. In therapeutic interventions, the welfare of both the mother and the fetus should be taken into account.
Keywords: SARS-CoV-2; COVID-19; pregnancy; pandem
The role of obstetricians and neonatologists in childcare in the time of the COVID-19 pandemic
No full textBorowik, Joanna, Kaziród, Karolina, Brodowski, Wojciech, Miturski, Andrzej, Semczuk-Sikora, Anna. The role of obstetricians and neonatologists in childcare in the time of the COVID-19 pandemic. Journal of Education, Health and Sport. 2022;12(9):399-406. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2022.12.09.045
https://apcz.umk.pl/JEHS/article/view/39671
https://zenodo.org/record/7044618
The journal has had 40 points in Ministry of Education and Science of Poland parametric evaluation. Annex to the announcement of the Minister of Education and Science of December 21, 2021. No. 32343.
Has a Journal's Unique Identifier: 201159. Scientific disciplines assigned: Physical Culture Sciences (Field of Medical sciences and health sciences); Health Sciences (Field of Medical Sciences and Health Sciences).
Punkty Ministerialne z 2019 - aktualny rok 40 punktów. Załącznik do komunikatu Ministra Edukacji i Nauki z dnia 21 grudnia 2021 r. Lp. 32343. Posiada Unikatowy Identyfikator Czasopisma: 201159.
Przypisane dyscypliny naukowe: Nauki o kulturze fizycznej (Dziedzina nauk medycznych i nauk o zdrowiu); Nauki o zdrowiu (Dziedzina nauk medycznych i nauk o zdrowiu).
© The Authors 2022;
This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike.
(http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.
The authors declare that there is no conflict of interests regarding the publication of this paper.
Received: 15.08.2022. Revised: 20.08.2022. Accepted: 01.09.2022.
The role of obstetricians and neonatologists in childcare in the time of the COVID-19 pandemic
Opieka położników i neonatologów nad dzieckiem w dobie pandemii COVID-19
Joanna Borowik1, Karolina Kaziród1, Wojciech Brodowski2, Andrzej Miturski3,Anna Semczuk-Sikora3
1. Student’s Scientific Group at the Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, Staszica 16 Street, 20-081 Lublin, Poland
2. Independent Public Healthcare Center of the Ministry of Interior and Administration in Lublin, Grenadierow 3 Street, 20-331 Lublin, Poland
3. Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, Staszica 16 Street, 20-081 Lublin, Poland
ORCID ID:Joanna Borowik: https://orcid.org/0000-0001-8369-6207, [email protected] Kaziród: https://orcid.org/0000-0002-6305-6488, [email protected]
Wojciech Brodowski: https://orcid.org/0000-0003-0756-387X, [email protected] Miturski: https://orcid.org/0000-0002-3550-7747, [email protected] Semczuk-Sikora: https://orcid.org/0000-0001-9602-5904, [email protected]
Correspondence: Joanna Borowik, [email protected]
Abstrakt:
Wprowadzenie: Pandemia COVID-19 spowodowała liczne zmiany w systemie opieki zdrowotnej dotyczące opieki nad noworodkami. Wprowadzono wiele ograniczeń w celu zmniejszenia ryzyka transmisji wirusa, zwłaszcza w warunkach szpitalnych, w tym na oddziałach położniczych i neonatologicznych. Kontakt skóra do skóry, karmienie piersią, przebywanie z noworodkiem zostało postawione w opozycji do ustanowionych wytycznych i wzbudziło liczne kontrowersje.
Cel pracy: Celem pracy było stworzenie przejrzystego zbioru zaleceń stosowanych w opiece nad noworodkiem w czasie pandemii wywołanej wirusem SARS-CoV-2.
Stan wiedzy: Mimo niskiego ryzyka zakażenia noworodka w okresie życia płodowego czy podczas porodu drogą pochwową, w nielicznych przypadkach istnieje możliwość transmisji wertykalnej wirusa SARS-CoV-2. Każdy noworodek, u którego matki potwierdzono chorobę COVID-19 powinien mieć wykonane badanie celem wykrycia zakażenia. Noworodki podejrzane o zakażenie powinny być odizolowane od zdrowych dzieci i pozostawać na kwarantannie do czasu uzyskania wyniku badania. Niezbędna jest ciągłe monitorowanie stanu zdrowia dziecka i zwracanie uwagi na potencjalne objawy infekcji. Personel medyczny powinien zadbać o odpowiednią ochronę podczas kontaktów z zakażonym noworodkiem. Zdrowy noworodek, którego dodatnia SARS-Cov-2 matka musi pozostać w szpitalu, może zostać wypisany do domu pod warunkiem, że jego opieką zajmie się zdrowy opiekun.
Podsumowanie: Nowe schematy postępowania w oddziałach położniczych i neonatologicznych wiążą się zmianami, które mogą mieć istotny wpływ na relacje matka-dziecko. Podczas podejmowania decyzji mających na celu ograniczenie szerzenia się zakażenia wirusem SARS-CoV-2 niezbędne jest, aby poszukiwać rozwiązań z uwzględnieniem potrzeb tej szczególnej grupy pacjentów.
Słowa kluczowe: COVID-19; SARS-CoV-2; dziecko; noworodek; neonatologia; położnictwo
Summary of review:
Introduction: The COVID-19 pandemic has caused numerous changes to the healthcare system, including care for the newborns.
Aim of the study: The aim of the study was to create a clear set of recommendations used in the care of a newborn during the SARS-CoV-2 pandemic.
State of knowledge: Despite the low risk of infection of the newborn in utero or during vaginal delivery, in rare cases there is a possibility of vertical transmission of the SARS-CoV-2 virus. Every newborn baby whose mother has been diagnosed with COVID-19 disease should be screened for infection. Suspected neonates should be isolated from healthy children and kept in quarantine until the test result is obtained. It is essential to constantly monitor your baby's health and be alert to any possible signs of infection. Medical personnel should ensure adequate protection when handling an infected newborn. A healthy infant whose mother is SARS-Cov-2 positive may be discharged home provided it is looked after by a healthy caregiver.
Summary: New patterns of management in maternity and neonatal departments are associated with changes that may have a significant impact on the mother-child relationship. When making decisions aimed at reducing the spread of SARS-CoV-2 infection, it is necessary to seek solutions taking into account the needs of this particular group of patients.
Keywords: COVID-19; SARS-CoV-2; child; infant; neonatology; obstetric
Polish Academy of Sciences Review
No full textLiver X receptor (LXR) and the reproductive system – a potential novel target for therapeutic interventio
Endometrial carcinoma with pleural metastasis: a case report
No full textenocarcinoma (EC). A total abdominal hysterectomy with bilateral salpingo-oophorectomy, pelvic lymphadenectomy, appendectomy and omentectomy was performed. Treatment of the pleural malignant effusion consisted of thoracotomy with partial decortication, systemic chemotherapy and radiotherapy. The patient died of circulatory failure 8 months after the primary diagnosis. Conclusion Although the pleura is a rare site of widespread EC, one should recognize the possibility of pleural spread from female genital tract neoplasms presenting with associated symptoms. Cytopathologic examination of the pleural effusion and the finding of carcinoma cells mandate an investigation for the primary site of the neoplasm by a multidisciplinary group
Level of satisfaction in patients giving birth in Poland/Rzeszów and in the Federal Republic of Germany/Gross-Gerau
No full textAim of the study: The main purpose of the study was to examine opinions on perinatal care expressed by women hospitalized after childbirth in Poland and Germany. Different socio-demographic variables were also analyzed in order to evaluate the quality of perinatal care in two different countries. Materials and methods: The study group comprised of postpartum patients from two facilities: the Clinical Ward of Gynecology and Obstetrics of Frideric Chopin Province Specialist Hospital in Rzeszów, Poland, and the Obstetrics-Gynecology Hospital in Gross-Gerau, Germany. The group of randomly selected women, who were initially invited to participate in the study, included 259 Polish and 230 German females. In order to measure the level of satisfaction with perinatal care, the authors used “The Newcastle Satisfaction with Nursing Scale” (originally constructed at the Center for Health Services Research, University of Newcastle upon Tyne, UK, and adopted in Poland by Poznań University of Medical Sciences) and their own questionnaire. Finally, 200 patients, one hundred from Poland and one hundred from Germany, were enclosed. Statistical analysis was performed using the Statistics 8.0 software and a p valued below 0.05 was regarded significant. Results: Generally, perinatal care was assessed as being satisfactory by both Polish (91%) and German (97%) respondents. The study population varied in terms of age, education, place of residence or marital status. Only one socio-demographic variable (education) had a significant impact on the perception of the obtained perinatal care. However, a limited number of patients (25% in Poland and 47% in Germany) participated in the prental and parenting classes. Conclusions: 1. Perinatal care was positively assessed by Polish and German patients of both hospitals. 2. The greatest importance in selecting the location for childbirth was attributed by both Polish and German subjects to such factors as: opinion of their friends, highly qualified personnel, modern medical equipment and instruments on premises. Additionally, Polish respondents found it important that the doctor who had provided care for a given woman during pregnancy was employed at that particular hospital. In turn, German respondents also paid particular attention to the distance between their place of residence and hospital. 3. All study participants, regardless of their nationality, admitted that the hospitals offered to their close relatives the possibility to visit and accompany the patients during childbirth
Doświadczenia niemieckie z wprowadzaniem Centrum Opieki Położniczej według Belegsystem
No full textSummary Recent years have undoubtedly been a time of dynamic changes for German midwives, which had had their source in numerous social, economic and political changes. The medical care cost growth, lack of profitability of medical centers and an increasing number of redundancies have been given lots of attention in various discussions. The abovementioned problems have started to concern the professional group of German midwives, thus giving birth to the introduction of innovatory system of obstetric care in German hospitals, known as Belegsystem. In Europe the Belegsystem has been introduced in certain Scandinavian countries, Great Britain, Austria and Switzerland. In Germany the first labour room within the Belegsystem rules has been opened on 1 June 2003 in Brema (Klinikum Bremerhaven Reinkenheide). The following two Centers have been opened in Hamburg at the beginning of 2004 (Allgemeines Krankenhaus Hamburg-Harburg i Allgemeines Krankenhaus Hamburg-Barmbek). The folllowing article presents the functioning rules and procedures of the Belegsystem labour rooms in Germany, as one of the labour care alternatives.Streszczenie Ostatnie lata były niewątpliwie dla niemieckich położnych okresem dynamicznych zmian, wynikających szczególnie z przemian życia społecznego, gospodarczego i politycznego. Sporo uwagi poświęcono w różnych dyskusjach zagadnieniom: dynamiki wzrostu kosztów opieki medycznej, nierentowności placówek służby zdrowia oraz następującej redukcji pracującej tam kadry. Problematyka ta dotknęła rownież grupę zawodową niemieckich położnych, stad idea wprowadzenia nowatorskiego systemu opieki położniczej, noszącego nazwę Belegsystem, w szpitalach niemieckich. W Europie praca położnych według Belegsystem została przyjęta w wybranych szpitalach krajów Skandynawskich, Wielkiej Brytanii, Austrii i Szwajcarii. W Niemczech pierwszą salę porodową funkcjonującą według przedstawionych reguł, otworzono dnia 1 czerwca 2003 roku w Bremie (Klinikum Bremerhaven Reinkenheide). Następne dwa ośrodki powstały w Hamburgu na początku 2004 roku (Allgemeines Krankenhaus Hamburg-Harburg i Allgemeines Krankenhaus Hamburg-Barmbek). W niniejszym opracowaniu przedstawiono zasady funkcjonowania sal porodowych w Niemczech według Belegsystem, jako jednej z alternatyw opieki okołoporodowej
The most effective but largely ignored target for prostate cancer early detection and intervention
No full textOver the past two decades, the global efforts for the early detection and intervention of prostate cancer seem to have made significant progresses in the basic researches, but the clinic outcomes have been disappointing: (1) prostate cancer is still the most common non-cutaneous cancer in Europe in men, (2) the age-standardized prostate cancer rate has increased in nearly all Asian and African countries, (3) the proportion of advanced cancers at the diagnosis has increased to 8.2% from 3.9% in the USA, (4) the worldwide use of PSA testing and digital rectal examination have failed to reduce the prostate cancer mortality, and (5) there is still no effective preventive method to significantly reduce the development, invasion, and metastasis of prostate cancer… Together, these facts strongly suggest that the global efforts during the past appear to be not in a correlated target with markedly inconsistent basic research and clinic outcomes. The most likely cause for the inconsistence appears due to the fact that basic scientific studies are traditionally conducted on the cell lines and animal models, where it is impossible to completely reflect or replicate the in vivo status. Thus, we would like to propose the human prostate basal cell layer (PBCL) as “the most effective target for the early detection and intervention of prostate cancer”. Our proposal is based on the morphologic, immunohistochemical and molecular evidence from our recent studies of normal and cancerous human prostate tissues with detailed clinic follow-up data. We believe that the human tissue-derived basic research data may provide a more realistic roadmap to guide the clinic practice and to avoid the potential misleading from in vitro and animal studies
Retrospective Comparison of Laparoscopic versus Open Radical Hysterectomy for Early-Stage Cervical Cancer in a Single Tertiary Care Institution from Lithuania between 2009 and 2019
No full textBackground and Objectives: A great debate within the academic arena was evoked by the LACC study, giving rise to doubt regarding the oncological outcomes of the laparoscopic approach for early-stage cervical cancer. This encouraged us to conduct a retrospective analysis of CC treatment surgical approaches applied to the patients at tertiary level Vilnius University Hospital Santaros Clinics, Vilnius, Lithuania, between 2009 and 2019. Materials and Methods: The retrospective study was carried out to evaluate the outcomes after 28 laparoscopic and 62 laparotomic radical hysterectomies for early cervical cancer in a single tertiary care institution performed during the period 2009–2019. For statistical analysis of patients’ parameters, SPSS v. 17.0 was applied, together with the Kaplan–Meier method with a long-rank test and the Cox proportional hazard regression model used for bi-variate analysis determining OS outcomes between MIS and open-surgery groups. Results: After computing data with the Cox regression model, there was no significant difference of the 36-months overall survival between laparoscopy and laparotomy groups, as opposed to the LACC study. Conclusions: Our tertiary institution faces a considerable challenge, and we acknowledge the limitations of the study and also feel a responsibility to follow the latest guidelines. Currently, it appears that the most substantial attention should be focused on the cessation of uterine manipulator use as well as laparoscopic technique learning curves
Combination chemotherapy for Hodgkin's lymphoma during pregnancy: Favorable outcome for mother and child
No full text- …
